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ClinicalTrials.gov public records Last synced Oct 4, 2026, 11:40 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 25–48 of 135 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Sham Therapeutic Ultrasound Clear all
Recruiting Not applicable Interventional

Low-Intensity Focused Ultrasound Pulsation (LIFUP) for the Treatment of Generalized Anxiety Disorder (GAD)

NCT04557891
View directory record Official record
Conditions
Generalized Anxiety Disorder
Interventions
Active LIFUP Treatment, Sham LIFUP Treatment
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
3
States / cities
Los Angeles, California • Boston, Massachusetts • Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 10, 2026 · Synced Oct 4, 2026, 11:40 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

A Study of the Effects of Mid-Thoracic Spinal Manipulation and Spinal Mobilization on Heart Rate Variability

NCT02380599
View directory record Official record
Conditions
Physiology of Manipulation / Mobilization in Healthy Adults
Interventions
Spinal Manipulation, Spinal Mobilization, Sham Ultrasound
Other
Lead sponsor
Mount St. Mary's College, Los Angeles, CA
Other
Eligibility
18 Years to 55 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 15, 2015 · Synced Oct 4, 2026, 11:40 AM EDT
Not yet recruiting Not applicable Interventional

Visual Restoration Using Focused Ultrasound Stimulation and Immersive Virtual Reality After Stroke

NCT06875206
View directory record Official record
Conditions
Stroke, Visual Field Defect, Visual Field Defect Following Cerebrovascular Accident, Hemianopia, Quadrantanopia, Occipital Lobe Infarct, Visual Fields Hemianopsia
Interventions
Low-intensity focused ultrasound, Immersive virtual reality, Inactive Low-intensity focused ultrasound
Device
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Oct 4, 2026, 11:40 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Looking Beyond the Immediate Effects of Lumbar Spinal Manipulation Using Pain Pressure Threshold in Asymptomatic Individuals

NCT06156605
View directory record Official record
Conditions
Lumbar Spine Injury, Pain
Interventions
Sidelying lumbar manipulation
Procedure
Lead sponsor
University of Mary
Other
Eligibility
18 Years to 50 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Bismarck, North Dakota
Source: ClinicalTrials.gov public record
Updated Dec 5, 2023 · Synced Oct 4, 2026, 11:40 AM EDT
Recruiting Not applicable Interventional

Personalized Ultrasonic Brain Stimulation for Fibromyalgia

NCT07361328
View directory record Official record
Conditions
Fibromyalgia (FM)
Interventions
Low-intensity ultrasound brain stimulation, Sham (No Treatment)
Device
Lead sponsor
University of Utah
Other
Eligibility
22 Years to 70 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jan 23, 2026 · Synced Oct 4, 2026, 11:40 AM EDT
Completed Not applicable Interventional Results available

Feasibility of an Analgesic Device Enabling Local Anesthetic Delivery and Neuromodulation After Shoulder/Foot Surgery

NCT06818708
View directory record Official record
Conditions
Rotator Cuff Injuries, Shoulder Disease, Hallux Valgus, Ankle Arthropathy
Interventions
Experimental Treatment
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Nov 18, 2025 · Synced Oct 4, 2026, 11:40 AM EDT
Not listed Not applicable Interventional Results available

Feasibility Study of ExAblate Thalamotomy for Treatment of Chronic Trigeminal Neuropathic Pain

NCT03309813
View directory record Official record
Conditions
Trigeminal Neuropathic Pain
Interventions
Transcranial ExAblate, Sham Transcranial ExAblate, Crossover Transcranial Exablate
Device
Lead sponsor
InSightec
Industry
Eligibility
18 Years to 75 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 3, 2023 · Synced Oct 4, 2026, 11:40 AM EDT
Enrolling by invitation Not applicable Interventional

LIFU for Chronic Pain

NCT06628180
View directory record Official record
Conditions
Chronic Pain
Interventions
LIFU, Sham LIFU
Device
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Oct 4, 2026, 11:40 AM EDT
Terminated Not applicable Interventional

A Study of the Ulthera® System for the Treatment of Axillary Hyperhidrosis

NCT01722461
View directory record Official record
Conditions
Primary Axillary Hyperhidrosis
Interventions
Ulthera System, Sham treatment
Device
Lead sponsor
Ulthera, Inc
Industry
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
6
States / cities
Roseville, California • Aventura, Florida • Chicago, Illinois + 3 more
Source: ClinicalTrials.gov public record
Updated Nov 24, 2017 · Synced Oct 4, 2026, 11:40 AM EDT
Terminated Phase 1Phase 2 Interventional

Ultrasonic Neuromodulation for Treatment of PTSD

NCT06135064
View directory record Official record
Conditions
PTSD
Interventions
Diadem
Device
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated May 25, 2025 · Synced Oct 4, 2026, 11:40 AM EDT
Completed Phase 1Phase 2 Interventional

Deep Brain Therapy With Low-intensity Ultrasound for Generalized Chronic Pain

NCT05674903
View directory record Official record
Conditions
Chronic Pain, Chronic Pain Syndrome, Widespread Chronic Pain
Interventions
Verum stimulation with Diadem prototype, Sham stimulation with Diadem prototype
Device
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 65 Years
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated May 25, 2025 · Synced Oct 4, 2026, 11:40 AM EDT
Not listed Not applicable Interventional

Enhanced Ultrasound Treatment of Chronic Wounds With Monitoring of Healing and Quality of Life Outcomes

NCT03041844
View directory record Official record
Conditions
Diabetic Foot Ulcer, Venous Ulcer
Interventions
Low Frequency, Low Intensity Ultrasound, Sham Applicator
Device
Lead sponsor
Drexel University
Other
Eligibility
18 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 6, 2022 · Synced Oct 4, 2026, 11:40 AM EDT
Completed Not applicable Interventional

A Non-significant Risk Clinical Study to Assess Perfusion Changes With Application of a TUS for Patients With PAD

NCT05100745
View directory record Official record
Conditions
Peripheral Arterial Disease
Interventions
Therapeutic Device
Device
Lead sponsor
Vibrato Medical, Inc.
Industry
Eligibility
22 Years and older
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated Jun 17, 2025 · Synced Oct 4, 2026, 11:40 AM EDT
Completed Not applicable Interventional

Sustained Acoustic Medicine for Chronic Low Back Pain Secondary to Herniated Nucleus Pulposus or Other Conditions

NCT02609854
View directory record Official record
Conditions
Chronic Low Back Pain (CLBP), Intervertebral Disc Displacement
Interventions
Sustained Acoustic Medicine (SAM), Sham Device
Device
Lead sponsor
ZetrOZ, Inc.
Industry
Eligibility
18 Years to 60 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
3
States / cities
Dryden, New York • Chapel Hill, North Carolina • Ogden, Utah
Source: ClinicalTrials.gov public record
Updated Jan 31, 2017 · Synced Oct 4, 2026, 11:40 AM EDT
Recruiting Not applicable Interventional

Non-Invasive Low Intensity Focused Ultrasound Stimulation for Drug-Resistant Epilepsy

NCT07680842
View directory record Official record
Conditions
Drug-Resistant Epilepsy, Epilepsy, Epilepsy (Treatment Refractory), Epilepsy Comorbidities, Epilepsy, Drug Resistant, Epilepsy, Generalized, Epilepsy, Focal
Interventions
Target optimization using LIFU, Serial LIFU stimulation
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 2, 2026 · Synced Oct 4, 2026, 11:40 AM EDT
Completed Phase 3 Interventional Results available

Osteopathic Health Outcomes in Chronic Low Back Pain (OSTEOPATHIC) Trial

NCT00315120
View directory record Official record
Conditions
Low Back Pain
Interventions
A. Active OMT and active UST, B. Sham OMT and active UST, C. Active OMT and sham UST, D. Sham OMT and sham UST
Procedure
Lead sponsor
University of North Texas Health Science Center
Other
Eligibility
21 Years to 69 Years
Enrollment
455 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Jul 6, 2016 · Synced Oct 4, 2026, 11:40 AM EDT
Recruiting Phase 2 Interventional

RELIEVE Study: NT 201 Intravesical Administration Using Vibe System (ViXe Combination Product) for the Treatment of Idiopathic Overactive Bladder

NCT07553065
View directory record Official record
Conditions
Overactive Bladder (OAB)
Interventions
NT 201 200U and Vibe System, NT 201 300U and Vibe System, Placebo and sham
Combination Product
Lead sponsor
Vensica Therapeutics Ltd.
Industry
Eligibility
18 Years to 80 Years · Female only
Enrollment
210 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Reno, Nevada
Source: ClinicalTrials.gov public record
Updated Aug 21, 2026 · Synced Oct 4, 2026, 11:40 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

PRINT Trial (Platelet Rich Injection vs Needle Tenotomy)

NCT03504111
View directory record Official record
Conditions
Lateral Epicondylitis, Tendinosis, Elbow, Tennis, Elbows Tendonitis
Interventions
Percutaneous Needle Tenotomy, PRP
Procedure
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 13, 2019 · Synced Oct 4, 2026, 11:40 AM EDT
Terminated Phase 1 Interventional Results available

Stellate Ganglion Blockade in Corona Virus 2019 (COVID-19) Positive Patients

NCT04445337
View directory record Official record
Conditions
COVID 19, ARDS
Interventions
Stellate Ganglion Block
Drug
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years to 85 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Jan 20, 2025 · Synced Oct 4, 2026, 11:40 AM EDT
Completed Not applicable Interventional

Effects of tDCS and tUS on Pain Perception in OA of the Knee

NCT02330315
View directory record Official record
Conditions
Chronic Pain, Osteoarthritis
Interventions
transcranial direct current stimulation (tDCS), transcranial ultrasound (TUS)
Device
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years to 85 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 24, 2020 · Synced Oct 4, 2026, 11:40 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Plantar Fasciitis Randomized Clinical Control Trial

NCT03231150
View directory record Official record
Conditions
Plantar Fascitis
Interventions
Local Steroid Injection into the plantar heel, Ultrasound Guided Injection, Anatomical Guided injection
Procedure
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2026
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 10, 2025 · Synced Oct 4, 2026, 11:40 AM EDT
Completed Not applicable Interventional Results available

Clinical and Microbiologic Outcomes of Adjunctive Antimicrobial Photodynamic Therapy in the Non-surgical and Surgical Treatment of Teeth With Periodontal Disease

NCT05252000
View directory record Official record
Conditions
Periodontal Diseases
Interventions
mechanical debridement, adjunctive aPDT, sham aPDT
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 12, 2026 · Synced Oct 4, 2026, 11:40 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Physical Exam, Static & Dynamic Ultrasound Assessment, & Treatment of Thoracolumbar Fascia (TLF) Mediated Low Back Pain

NCT06818175
View directory record Official record
Conditions
Low Back Pain, Chronic Low-back Pain, Acute Low Back Pain
Interventions
Ultrsound Guided Hydrodissection of the Thoracolumbar Fascia, Osteopathic Manipulative Treatment (OMT)
Procedure
Lead sponsor
Edward Via Virginia College of Osteopathic Medicine
Other
Eligibility
18 Years to 50 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Blacksburg, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 13, 2026 · Synced Oct 4, 2026, 11:40 AM EDT
Recruiting Phase 2 Interventional

Adjuvant Temozolomide ± 5-Aminolevulinic Acid + Low Intensity Diffuse Ultrasound Sonodynamic Therapy System for Newly Diagnosed Glioblastoma

NCT07225621
View directory record Official record
Conditions
Glioblastoma, GBM
Interventions
5-ALA HCl + LIDU SDT, Placebo + Sham SDT
Combination Product
Lead sponsor
Alpheus Medical, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
11
States / cities
Boston, Massachusetts • Rochester, Minnesota • Albany, New York + 6 more
Source: ClinicalTrials.gov public record
Updated Jul 17, 2026 · Synced Oct 4, 2026, 11:40 AM EDT