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ClinicalTrials.gov public records Last synced Sep 25, 2026, 10:56 PM EDT

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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Sham Transcranial Alternating Current Stimulation Clear all
Recruiting Not applicable Interventional

Neurostimulation for the Treatment of Post-Stroke Aphasia

NCT05194566
View directory record Official record
Conditions
Post-stroke Aphasia
Interventions
tACS
Device
Lead sponsor
QVITI S.A.
Industry
Eligibility
18 Years to 80 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
2
States / cities
Chicago, Illinois • New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Sep 25, 2026, 10:56 PM EDT
Recruiting Not applicable Interventional

Exploring the Feasibility of an Exercise and Noninvasive Brain Stimulation Intervention in Breast Cancer Survivors

NCT07587957
View directory record Official record
Conditions
Breast Cancer
Interventions
Exercise + transcranial alternating current stimulation (Ex+tACS), Control
Behavioral
Lead sponsor
Florida Atlantic University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Boca Raton, Florida
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Sep 25, 2026, 10:56 PM EDT
Recruiting Not applicable Interventional

Causal Role of Delta-beta Coupling for Goal-directed Behavior in Anhedonic Depression

NCT06132581
View directory record Official record
Conditions
Major Depressive Disorder, Anhedonia
Interventions
Delta-beta tACS via the Neurocare Direct Current Stimulator Multi-Channel 4, Theta-gamma tACS via the Neurocare Direct Current Stimulator Multi-Channel 4, Sham tACS via the Neurocare Direct Current Stimulator Multi-Channel 4
Device
Lead sponsor
Florida State University
Other
Eligibility
18 Years to 65 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Aug 30, 2026 · Synced Sep 25, 2026, 10:56 PM EDT
Completed Not applicable Interventional Results available

Transcranial Alternating Current Stimulation in Back Pain- Pilot Sudy

NCT03243084
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
XCSITE100 Stimulator Sham, XCSITE100 Stimulator tACS
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 65 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 11, 2018 · Synced Sep 25, 2026, 10:56 PM EDT
Recruiting Not applicable Interventional

CARED : A Novel Rapid Treatment Paradigm for Depression

NCT07507370
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Intermittent Theta Burst Stimulation (iTBS), Transcranial Alternating Current Stimulation (tACS), Psychotherapy, Sham (Placebo) Transcranial Alternating Current Stimulation (tACS)
Device · Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 70 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 24, 2026 · Synced Sep 25, 2026, 10:56 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Application of Transcranial Alternating Current Stimulation for Modulation of Sleep and Cognitive Performance

NCT03112902
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Application of Transcranial Alternating Current Stimulation for Modulation of Sleep and Cognitive Performance
Device
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 80 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Dec 16, 2021 · Synced Sep 25, 2026, 10:56 PM EDT
Completed Phase 1Phase 2 Interventional

Gamma Induction for Alzheimer's Disease

NCT03880240
View directory record Official record
Conditions
Alzheimer Disease, Mild Cognitive Impairment
Interventions
Transcranial Alternating Current Stimulation (tACS), Sham Transcranial Alternating Current Stimulation
Device · Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
45 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 10, 2026 · Synced Sep 25, 2026, 10:56 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Noninvasive Brain Stimulation to Enhance Reading Comprehension Ability in Adults

NCT05523505
View directory record Official record
Conditions
Reading Disability
Interventions
Sham intervention, RLN real non-invasive brain stimulation intervention, RLN and CCN real non-invasive brain stimulation intervention
Device
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years to 40 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jul 31, 2025 · Synced Sep 25, 2026, 10:56 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Modulating Cortical Dynamics of Dual-task Standing in MCI

NCT05680701
View directory record Official record
Conditions
Aging, Mild Cognitive Impairment
Interventions
real tACS, sham tACS
Other
Lead sponsor
Hebrew SeniorLife
Other
Eligibility
65 Years to 95 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 14, 2023 · Synced Sep 25, 2026, 10:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Use of Transcranial Direct Current Stimulation (tDCS) Coupled With Constraint Induced Movement Therapy in Stroke Patient

NCT01143649
View directory record Official record
Conditions
Stroke, Healthy
Interventions
transcranial direct current stimulation (tDCS), constraint induced movement therapy (CIMT), transcranial alternating current stimulation (tACS)
Device · Procedure
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years to 90 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 23, 2020 · Synced Sep 25, 2026, 10:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Cognitive Enhancement Through Model-based and Individualized Neurostimulation

NCT06235970
View directory record Official record
Conditions
Transcranial Electrical Stimulation (tES)
Interventions
Transcranial electrical stimulation (tES) including SHAM
Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 45 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Sep 25, 2026, 10:56 PM EDT
Withdrawn Not applicable Interventional

Transcranial Electrical Stimulation for Mal de Debarquement Syndrome

NCT02540616
View directory record Official record
Conditions
Mal de Debarquement Syndrome
Interventions
Transcranial Electrical Stimulation
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2022
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 15, 2023 · Synced Sep 25, 2026, 10:56 PM EDT
Recruiting Not applicable Interventional

Transcranial Alternating Current Stimulation (tACS) in Stuttering

NCT06740968
View directory record Official record
Conditions
Stuttering, Adult, Stuttering, Childhood, Stuttering, Developmental
Interventions
transcranial alternating current stimulation (tACS)
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 11, 2025 · Synced Sep 25, 2026, 10:56 PM EDT
Not yet recruiting Not applicable Interventional

Applying Neuromodulation to Boost the Efficacy of Motivational Interviewing

NCT07787572
View directory record Official record
Conditions
Cannabis Use Disorder
Interventions
transcranial alternating current stimulation, sham transcranial alternating current stimulation, Motivational interviewing (MI)
Device · Behavioral
Lead sponsor
The Mind Research Network
Other
Eligibility
21 Years to 65 Years
Enrollment
82 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Sep 25, 2026, 10:56 PM EDT
Completed Not applicable Interventional

Migraine--Investigational Treatment of Migraine With Noninvasive Brain Stimulation. (tDCS- Migraine)

NCT00521196
View directory record Official record
Conditions
Migraine
Interventions
DC Stimulator (Transcranial Direct Current Stimulator)
Device
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 20, 2017 · Synced Sep 25, 2026, 10:56 PM EDT
Recruiting Not applicable Interventional

Non-invasive Brain Stimulation for Cognitive and Motor Dysfunction in Dementia

NCT05661084
View directory record Official record
Conditions
Dementia, Memory Loss, Alzheimer Disease, Executive Dysfunction, Mobility Limitation
Interventions
Transcranial alternating current stimulation (tACS) (active); Transcranial direct current stimulation (tDCS) (active), Transcranial alternating current stimulation (tACS) (sham); Transcranial direct current stimulation (tDCS) (sham), Transcranial alternating current stimulation (tACS) (active); Transcranial direct current stimulation (tDCS) (sham), Transcranial alternating current stimulation (tACS) (sham); Transcranial direct current stimulation (tDCS) (active)
Device
Lead sponsor
Hebrew SeniorLife
Other
Eligibility
55 Years and older
Enrollment
144 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 11, 2026 · Synced Sep 25, 2026, 10:56 PM EDT
Completed Not applicable Interventional Results available

Bipolar Transcranial Alternating Current Stimulation (tACS)

NCT05480124
View directory record Official record
Conditions
Bipolar Disorder
Interventions
tACS brain stimulation treatment, Sham stimulation treatment
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 55 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 13, 2025 · Synced Sep 25, 2026, 10:56 PM EDT
Completed Not applicable Interventional

Individualized Non-invasive Brain Stimulation for the Treatment of Major Depressive Disorder

NCT06874374
View directory record Official record
Conditions
Depression - Major Depressive Disorder, Transcranial Alternating Current Stimulation
Interventions
Closed-loop tACS, Sham Comparator
Device
Lead sponsor
Pulvinar Neuro, LLC
Industry
Eligibility
18 Years to 70 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Sep 25, 2026, 10:56 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Effect of CES on Parasympathetic Tone

NCT02163967
View directory record Official record
Conditions
Autonomic Nervous System Imbalance
Interventions
Cranial Electrical Stimulation Fisher-Wallace Stimulator (Model FW100)
Device
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 65 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 10, 2019 · Synced Sep 25, 2026, 10:56 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Neuromodulation for a Novel OCD Biomarker and Treatment

NCT05994053
View directory record Official record
Conditions
OCD
Interventions
high definition transcranial alternating current stimulation
Device
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 22, 2026 · Synced Sep 25, 2026, 10:56 PM EDT
Active, not recruiting Phase 2 Interventional

Multi-session Transcranial Alternating Current Stimulation to Improve Dual-task Standing and Brain Activity in Older Adults With Mild Cognitive Impairment

NCT07097051
View directory record Official record
Conditions
Mild Cognitive Impairment (MCI)
Interventions
real tACS, sham tACS
Other
Lead sponsor
High Point University
Other
Eligibility
65 Years to 85 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
High Point, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 15, 2026 · Synced Sep 25, 2026, 10:56 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Spectral Characteristics of Memory Transformation

NCT05946616
View directory record Official record
Conditions
Healthy
Interventions
Transcranial alternating current stimulation (tACS) combined with behavioral intervention, Inactive (sham) stimulation combined with behavioral intervention
Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Sep 25, 2026, 10:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Memory Functions in Mild Alzheimer's Disease

NCT04785053
View directory record Official record
Conditions
Alzheimer Disease
Interventions
transcranial alternating current stimulation (tACS)
Device
Lead sponsor
Hebrew SeniorLife
Other
Eligibility
21 Years and older
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 25, 2024 · Synced Sep 25, 2026, 10:56 PM EDT
Withdrawn Not applicable Interventional

Foundations in Developing Precision Cognitive Restoration

NCT05117502
View directory record Official record
Conditions
Moderate Cognitive Impairment, Traumatic Brain Injury, Stroke
Interventions
intermittent Theta Burst Stimulation, Placebo intermittent Theta Burst Stimulation
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Hines, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 28, 2024 · Synced Sep 25, 2026, 10:56 PM EDT