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ClinicalTrials.gov public records Last synced Sep 18, 2026, 2:41 AM EDT

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Showing 1–24 of 160 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Sham Vagus Nerve Stimulation Clear all
Not listed Not applicable Interventional

Augmenting Standard-of-care Treatment of Plaque Psoriasis by Neuromodulation

NCT05243303
View directory record Official record
Conditions
Psoriasis Vulgaris
Interventions
Active taVNS, Sham taVNS
Device
Lead sponsor
Burrell College of Health Sciences
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Las Cruces, New Mexico
Source: ClinicalTrials.gov public record
Updated Jul 9, 2023 · Synced Sep 18, 2026, 2:41 AM EDT
Recruiting Not applicable Interventional

Transcutaneous Auricular Vagus Enhanced Recovery in the NeuroICU

NCT07219108
View directory record Official record
Conditions
Acute Neurological Injury, Acute Medical Conditions
Interventions
Auricular Vagus Nerve Stimulation, Sham Auricular Vagus nerve Stimulation
Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 20, 2025 · Synced Sep 18, 2026, 2:41 AM EDT
Recruiting Not applicable Interventional

The Path Study: Cognitive and Inflammation Targeted Gut-brain Interventions in Alcohol; Probiotics, Alcohol, Transcutaneous Vagus Nerve Stimulation, and HIV Study

NCT05090267
View directory record Official record
Conditions
Cognition, Gut Microbiome
Interventions
Probiotic Supplement, Transcutaneous Vagal Nerve Stimulation (tVNS)
Dietary Supplement · Device
Lead sponsor
University of Florida
Other
Eligibility
35 Years to 70 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Coral Gables, Florida
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Sep 18, 2026, 2:41 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

RM1 Project 2 - tAN fMRI

NCT05487664
View directory record Official record
Conditions
Auricular Stimulation
Interventions
Transcutaneous Auricular Neruostimulation (tAN)
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
96 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Dec 17, 2025 · Synced Sep 18, 2026, 2:41 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Understanding the Effects of Transauricular Vagus Nerve Stimulation on Neural Networks and Autonomic Nervous System

NCT05801809
View directory record Official record
Conditions
Healthy Volunteers
Interventions
Transauricular vagus nerve stimulation (taVNS)
Device
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years to 99 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 23, 2026 · Synced Sep 18, 2026, 2:41 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Non-invasive Nerve Stimulation and Cognitive Training to Improve Cognitive Performance in Healthy Older Adults

NCT04276805
View directory record Official record
Conditions
Aging
Interventions
Transcutaneous vagal nerve stimulation (tVNS), Cognitive training
Device · Behavioral
Lead sponsor
University of Florida
Other
Eligibility
65 Years to 90 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
2
States / cities
Tucson, Arizona • Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 26, 2026 · Synced Sep 18, 2026, 2:41 AM EDT
Completed Phase 1 Interventional Results available

Non-invasive Vagal Nerve Stimulation in Alcohol Use Disorder

NCT05226130
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Cervical transcutaneous vagus nerve stimulation (active comparator), Cervical transcutaneous vagus nerve stimulation (sham comparator)
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
21 Years to 65 Years · Male only
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jul 2, 2025 · Synced Sep 18, 2026, 2:41 AM EDT
Recruiting Not applicable Interventional

Mindfulness in Chronic Kidney Disease

NCT04099992
View directory record Official record
Conditions
Chronic Kidney Diseases
Interventions
Mindfulness-based stress reduction (MBSR), Health enhancement program (HEP), Transcutaneous Vagus Nerve Stimulation (tVNS), Sham-transcutaneous Vagus Nerve Stimulation (tVNS)
Behavioral · Device
Lead sponsor
Emory University
Other
Eligibility
40 Years to 80 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 20, 2025 · Synced Sep 18, 2026, 2:41 AM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

The ENHANCE Study: taVNS and Psilocybin

NCT05866471
View directory record Official record
Conditions
Healthy, Psychedelic Experiences, Vagus Nerve Stimulation
Interventions
Psilocybin, Transcutaneous auricular Vagus Nerve Stimulation (taVNS), Psychosocial Support Alone, Sham taVNS
Drug · Device · Behavioral + 1 more
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 70 Years
Enrollment
108 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jul 28, 2026 · Synced Sep 18, 2026, 2:41 AM EDT
Completed Not applicable Interventional Results available

Transcutaneous Electrical Vagus Nerve Stimulation to Suppress Atrial Fibrillation

NCT02548754
View directory record Official record
Conditions
Atrial Fibrillation, Inflammation
Interventions
Parasym device
Device
Lead sponsor
University of Oklahoma
Other
Eligibility
21 Years to 90 Years
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Feb 15, 2022 · Synced Sep 18, 2026, 2:41 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Treatment of Mild Cognitive Impairment With Transcutaneous Vagal Nerve Stimulation

NCT03359902
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Transcutaneous vagal nerve stimulation, Sham stimulation
Device
Lead sponsor
University of Florida
Other
Eligibility
60 Years to 89 Years
Enrollment
59 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
3
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 23, 2023 · Synced Sep 18, 2026, 2:41 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Vagus Nerve Stimulation to Enhance Memory in Aging

NCT07214194
View directory record Official record
Conditions
Alzheimer Disease, Aging
Interventions
Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 80 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2027 – 2028
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Oct 8, 2025 · Synced Sep 18, 2026, 2:41 AM EDT
Recruiting Not applicable Interventional

taVNS for Breast Cancer Pain and Symptom Management

NCT07500012
View directory record Official record
Conditions
Breast Cancer Survivors
Interventions
Active taVNS, Sham taVNS
Device
Lead sponsor
Florida State University
Other
Eligibility
18 Years to 79 Years · Female only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced Sep 18, 2026, 2:41 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

tVNS During Motor Training in Older Adults

NCT06323954
View directory record Official record
Conditions
Older Adults
Interventions
tVNS stimulation, Sham stimulation
Procedure
Lead sponsor
Georgia Institute of Technology
Other
Eligibility
65 Years to 84 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 21, 2026 · Synced Sep 18, 2026, 2:41 AM EDT
Terminated Not applicable Interventional

Transcutaneous Autonomic Modulation in Thoracic Surgery

NCT02783157
View directory record Official record
Conditions
Atrial Fibrillation, Postoperative, Postoperative Complications, Inflammation
Interventions
Transcutaneous Low-Level Vagal Nerve Stimulation (LLVNS), Sham LLVNS
Device
Lead sponsor
Duke University
Other
Eligibility
40 Years to 90 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 5, 2020 · Synced Sep 18, 2026, 2:41 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Vagus Nerve Stimulation and Stress Reduction Training for Migraine

NCT03592329
View directory record Official record
Conditions
Migraine
Interventions
Stress Reduction Training A, active tVNS, Stress Reduction Training B, sham tVNS
Behavioral · Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
193 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced Sep 18, 2026, 2:41 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

VNS-induced Corticospinal Plasticity

NCT04088565
View directory record Official record
Conditions
Stroke
Interventions
Paired-Associative Stimulation (PAS), Vagus Nerve Stimulation (VNS), Sham Stimulation
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 75 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 31, 2022 · Synced Sep 18, 2026, 2:41 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Improving Speech in Noise Perception for Individuals With Age-related Hearing Loss

NCT07192757
View directory record Official record
Conditions
Presbycusis
Interventions
transcutaneous auricular vagus nerve stimulation, Sham Control
Device
Lead sponsor
University of Florida
Other
Eligibility
55 Years to 80 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Dec 4, 2025 · Synced Sep 18, 2026, 2:41 AM EDT
Recruiting Not applicable Interventional

Transcutaneous Vagus Nerve Stimulation for Attention and Memory

NCT06723743
View directory record Official record
Conditions
Traumatic Brain Injury (TBI) Patients
Interventions
Transcutaneous vagus nerve stimulation for attention in veterans with TBI, Soterix Medical Vagus Nerve Stimulation mini-CT
Other · Device
Lead sponsor
Baylor College of Medicine
Other
Eligibility
25 Years to 64 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Sep 18, 2026, 2:41 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Potential Benefit for Non Invasive Vagus Nerve Stimulation Using GammaCore in the Treatment of Raynaud's Phenomena.

NCT03869008
View directory record Official record
Conditions
Raynaud Phenomenon, Primary Raynaud Phenomenon, Raynaud Disease, Raynaud Syndrome
Interventions
gammaCore Sapphire, Sham Device
Device
Lead sponsor
University of Toledo Health Science Campus
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Toledo, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 14, 2025 · Synced Sep 18, 2026, 2:41 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

How Does Vagus Nerve Stimulation Affect Blood Glucose, Food, and Movement Cravings?

NCT07457372
View directory record Official record
Conditions
Vagus Nerve Stimulation
Interventions
Active taVNS, Sham taVNS
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 35 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Duluth, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 19, 2026 · Synced Sep 18, 2026, 2:41 AM EDT
Completed Phase 1 Interventional

Vagus Nerve Stimulation to Treat Moderate Traumatic Brain Injury

NCT02974959
View directory record Official record
Conditions
Traumatic Brain Injury, Acute Brain Injuries
Interventions
gammaCore active device, gammaCore sham device
Device
Lead sponsor
CentraCare
Other
Eligibility
18 Years to 60 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 3, 2021 · Synced Sep 18, 2026, 2:41 AM EDT
Recruiting Not applicable Interventional

Transcutaneous Auricular Vagus Nerve Stimulation for Insomnia in Survivors of Childhood Acute Lymphoblastic Leukemia

NCT07191119
View directory record Official record
Conditions
Survivor of Childhood Cancer, Insomnia, Acute Lymphoblastic Leukemia (ALL)
Interventions
Soterix tVNS device, Soterix tVNS device (sham programmed), Sleep Quality, Neurocognitive and mental health outcomes
Device · Behavioral
Lead sponsor
St. Jude Children's Research Hospital
Other
Eligibility
20 Years to 50 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Sep 18, 2026, 2:41 AM EDT
Recruiting Not applicable Interventional

Non-invasive VNS in Stroke Recovery

NCT06761404
View directory record Official record
Conditions
Stroke
Interventions
taVNS
Device
Lead sponsor
The Methodist Hospital Research Institute
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 1, 2026 · Synced Sep 18, 2026, 2:41 AM EDT