Search | Clinical Trials Finder

These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Nov 7, 2026, 4:42 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 81 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Sham breathing device Clear all

Conditions: COPD
Interventions: PrO2, Threshold Inspiratory Muscle Trainer; Device
Lead sponsor: Miami VA Healthcare System; Federal
Eligibility: 40 Years and older
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Muscle Weakness
Interventions: Neuromuscular electrical Stimulation (NMES), Sham Stimulation; Device
Lead sponsor: RML Specialty Hospital; Other
Eligibility: 18 Years and older
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2022
U.S. locations: 1
States / cities: Hinsdale, Illinois

Conditions: Disruptive Behavior, Attention-deficit Hyperactivity, Oppositional Defiant Disorder
Interventions: Garmin; Device
Lead sponsor: Mayo Clinic; Other
Eligibility: 3 Years to 99 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Glycogen Storage Disease Type II
Interventions: RMT therapy using modified RMT device, Sham-RMT therapy using modified RMT device; Device
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Cognition Improvement, Emotion Regulation
Interventions: Active transcranial photobiomodulation, Active MCT dietary supplementation, Sham photobiomodulation, Sham dietary supplementation; Device · Dietary Supplement
Lead sponsor: Francisco Gonzalez-Lima, PhD; Other
Eligibility: 18 Years to 85 Years
Enrollment: 180 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Chronotropic Incompetence
Interventions: Blended Sensor Optimization (BSO), Accelerometer Alone (AA); Device
Lead sponsor: Vivek Reddy; Other
Eligibility: 18 Years and older
Enrollment: 2 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: New York, New York

Conditions: Localized Lung Carcinoma, Stage I Lung Cancer AJCC v8, Stage II Lung Cancer AJCC v8, Stage III Lung Cancer AJCC v8
Interventions: Biospecimen Collection, Electronic Health Record Review, Medical Device Usage and Evaluation, Questionnaire Administration, Respiratory Muscle Training, Sham Intervention; Procedure · Other
Lead sponsor: Roswell Park Cancer Institute; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Buffalo, New York

Conditions: Upper Respiratory Infection
Interventions: SinuSonic Device, Sham SinuSonic Device; Device
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years and older
Enrollment: 95 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Obstructive Sleep Apnea
Interventions: Therapeutic HGNS, Subtherapeutic 'Sham' HGNS; Device
Lead sponsor: University of Pennsylvania; Other
Eligibility: 22 Years and older
Enrollment: 63 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2022
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Spinal Cord Injury, Chronic, Spinal Cord Injury Cervical, Spinal Cord Injury Thoracic, Incomplete Spinal Cord Injury
Interventions: Active Comparator: Single Intervention 1, Active Comparator: Single Intervention 2, Respiratory Resistance Exercise; Other · Behavioral
Lead sponsor: Thomas Jefferson University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Amyotrophic Lateral Sclerosis
Interventions: BiPAP® S/T System, sham-NIPPV; Device · Other
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years to 79 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2012
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Chronic Low Back Pain, Musculoskeletal Pain
Interventions: intermittent theta burst stimulation, LoveYourBrain Yoga Program; Device · Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 22 Years and older
Enrollment: 213 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2031
U.S. locations: 2
States / cities: Chicago, Illinois • Hines, Illinois

Conditions: Diabetes Mellitus Type 2
Interventions: Inspiratory Muscle Strength Training (IMST), Sham Training; Device
Lead sponsor: Seattle Children's Hospital; Other
Eligibility: 14 Years to 40 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 2
States / cities: Seattle, Washington

Conditions: Heavy Drinking
Interventions: Active RAVANS, Brief Mindfulness-Based Intervention; Device · Behavioral
Lead sponsor: Cambridge Health Alliance; Other
Eligibility: 21 Years to 29 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: Malden, Massachusetts

Conditions: Chronic Pain, Opioid Use Disorder
Interventions: RelieVRx, Sham VR; Device
Lead sponsor: Albert Einstein College of Medicine; Other
Eligibility: 18 Years and older
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Obstructive Sleep Apnea
Interventions: Upper Airway Muscle Exercise, Sham Exercise; Behavioral
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years to 79 Years
Enrollment: 134 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2019
U.S. locations: 1
States / cities: San Diego, California

Conditions: Systolic Blood Pressure, Blood Pressure, Depression - Major Depressive Disorder, Anxiety, Sleep Quality, Physical Function, Cognitive Function
Interventions: Inspiratory Muscle Strength Training High-Resistance, Inspiratory Muscle Strength Training Low-Resistance; Device
Lead sponsor: Florida State University; Other
Eligibility: 60 Years to 80 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Tallahassee, Florida

Conditions: Healthy Adults, Mechanical Ventilation Dependence, Hypoxia, Exercise Training, Exercise Intolerance, Dietary Supplement, Nitrate Supplementation, Inspiratory Muscle Training
Interventions: Respiratory Muscle Training (RMT), Sham Respiratory Muscle Training, Dietary Supplement: Beetroot Juice Concentrate, placebo beverage; Device · Dietary Supplement
Lead sponsor: Embry-Riddle Aeronautical University; Other
Eligibility: 18 Years to 40 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Daytona Beach, Florida

Conditions: Post-traumatic Stress Disorder, Prehypertension
Interventions: Device-Guided Breathing (DGB), Sham DGB, Transcutaneous Vagal Nerve Stimulation (tVNS), Sham tVNS; Device
Lead sponsor: Emory University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 120 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2027
U.S. locations: 1
States / cities: Decatur, Georgia

Conditions: Healthy
Interventions: Transcutaneous vagal nerve stimulation, Breathing task; Device · Behavioral
Lead sponsor: Boston University Charles River Campus; Other
Eligibility: 18 Years to 70 Years
Enrollment: 81 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2026
U.S. locations: 2
States / cities: Boston, Massachusetts

Conditions: Hypertension, Prehypertension, Aging
Interventions: Inspiratory muscle strength training, Sham training; Other
Lead sponsor: Douglas Seals; Other
Eligibility: 50 Years to 64 Years
Enrollment: 64 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2020
U.S. locations: 1
States / cities: Boulder, Colorado

Conditions: Hodgkin Lymphoma, Non Hodgkin Lymphoma
Interventions: Inspiratory muscle strength training, Sham Inspiratory muscle strength training; Device
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 18 Years to 80 Years
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 2
States / cities: Aurora, Colorado

Conditions: Dysphagia, Heart Transplant Recipients
Interventions: Active respiratory muscle strength training, Sham respiratory muscle strength training; Device
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 18 Years to 90 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Postural Tachycardia Syndrome, Postural Orthostatic Tachycardia Syndrome
Interventions: Inspiratory Threshold Device (Res-Q-Gard ITD), Sham Inspiratory Threshold Device; Device
Lead sponsor: Alfredo Gamboa; Other
Eligibility: 18 Years to 80 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2026
U.S. locations: 1
States / cities: Nashville, Tennessee

Search by objective public record fields.

Inspiratory Muscle Training in COPD

Facilitating Functional Independence in Patients Receiving Prolonged Mechanical Ventilation

Monitoring of Sleep and Behavior of Children 3-7 Years Old Receiving Parent-Child Interaction Therapy With the Help of Artificial Intelligence

Respiratory Muscle Training in L-Onset Pompe Disease (LOPD)

Increasing Mitochondrial Respiration as a Novel Mechanism for Cognitive Augmentation

The Effect of Blended Sensor Efficiency on Relieving the Heart's Inability to Increase Its Rate During Exercise

New York Better Breathing Study

Use of Novel Sinusonic Device for Prevention of Community Acquired Upper Respiratory Infection (URI)

Hypoglossal Nerve Stimulation on Cardiovascular Outcomes

Non-Invasive Interventions for Respiratory Recovery in Chronic Spinal Cord Injury

Trial of Early Noninvasive Ventilation for Amyotrophic Lateral Sclerosis (ALS)

Veterans' Intervention Blending NeuRomodulation and YogA for Chronic Low BackPaiN Treatment: VIBRANT

Effects of High-Resistance Inspiratory Muscle Strength Training on Cardiorenal and Vascular Function in Youth and Young Adults With Type 2 Diabetes

Exploring the Effects of Brief Mindfulness Training With Vagal Nerve Stimulation on Alcohol Cue Reactivity Among Young Adult Heavy Drinkers

Virtual Reality for Chronic Pain and Opioid Use Disorder Pilot

Effects of Upper Airway Muscle Training on OSA

IMST for Dementia Risk Reduction

Effects of Breathing Training and Nitrate on Exercise at Simulated Altitude

Sympathetic Overactivity in Post-traumatic Stress Disorder

Imaging Brain Fluids During Breathing

Inspiratory Muscle Strength Training to Improve Blood Pressure and Physiological Function

Impact of Respiratory Training in Lymphoma Survivors

Respiratory Strength Training in Heart Transplant Recipients

Breathing Device in Postural Orthostatic Tachycardia Syndrome (POTS)