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ClinicalTrials.gov public records Last synced Sep 11, 2026, 4:28 PM EDT

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Showing 1–24 of 48 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Sham diet Clear all
Completed Not applicable Interventional Results available

ESSENTIAL Trial™ Sham Cross-over

NCT02279420
View directory record Official record
Conditions
Obesity
Interventions
g-Cath EZ™ Suture Anchor Delivery Catheter
Device
Lead sponsor
USGI Medical
Industry
Eligibility
23 Years to 61 Years
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
11
States / cities
Scottsdale, Arizona • Miami, Florida • Dalton, Georgia + 8 more
Source: ClinicalTrials.gov public record
Updated May 11, 2017 · Synced Sep 11, 2026, 4:28 PM EDT
Completed Not applicable Interventional Results available

Resin Infiltration to Arrest Early Tooth Decay

NCT01584024
View directory record Official record
Conditions
Dental Caries
Interventions
Resin infiltration, Sham treatment
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 24 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
West Point, New York
Source: ClinicalTrials.gov public record
Updated Feb 11, 2019 · Synced Sep 11, 2026, 4:28 PM EDT
Recruiting Not applicable Interventional

Low FODMAP Plus PEG 3350 for the Treatment of Patients with Irritable Bowel Syndrome-Constipation

NCT03687814
View directory record Official record
Conditions
Irritable Bowel Syndrome Characterized by Constipation
Interventions
Low FODMAP diet/PEG 3350, sham diet/PEG 3350
Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 3, 2025 · Synced Sep 11, 2026, 4:28 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Increasing Mitochondrial Respiration as a Novel Mechanism for Cognitive Augmentation

NCT07793604
View directory record Official record
Conditions
Cognition Improvement, Emotion Regulation
Interventions
Active transcranial photobiomodulation, Active MCT dietary supplementation, Sham photobiomodulation, Sham dietary supplementation
Device · Dietary Supplement
Lead sponsor
Francisco Gonzalez-Lima, PhD
Other
Eligibility
18 Years to 85 Years
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2030
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Sep 11, 2026, 4:28 PM EDT
Completed Not applicable Interventional

The Health Effects of a Blueberry Enriched Diet on Obese Children

NCT01809795
View directory record Official record
Conditions
Obesity
Interventions
Blueberry Smoothie, Sham Smoothie
Other
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
12 Years to 17 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 17, 2014 · Synced Sep 11, 2026, 4:28 PM EDT
Recruiting Not applicable Interventional

THREAT: Testing Harms Related to Exposure to Allergenic and Epithelial Toxins

NCT07271381
View directory record Official record
Conditions
Allergic, Inflammatory
Interventions
Environmental Exposures, Control Exposures
Other
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years to 80 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 10, 2026 · Synced Sep 11, 2026, 4:28 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Breathing Training and Nitrate on Exercise at Simulated Altitude

NCT07216755
View directory record Official record
Conditions
Healthy Adults, Mechanical Ventilation Dependence, Hypoxia, Exercise Training, Exercise Intolerance, Dietary Supplement, Nitrate Supplementation, Inspiratory Muscle Training
Interventions
Respiratory Muscle Training (RMT), Sham Respiratory Muscle Training, Dietary Supplement: Beetroot Juice Concentrate, placebo beverage
Device · Dietary Supplement
Lead sponsor
Embry-Riddle Aeronautical University
Other
Eligibility
18 Years to 40 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Daytona Beach, Florida
Source: ClinicalTrials.gov public record
Updated Oct 14, 2025 · Synced Sep 11, 2026, 4:28 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Engaging Men in Weight Loss With a Game-based mHealth and Neurotraining Program

NCT05408494
View directory record Official record
Conditions
Obesity, Weight Loss
Interventions
Gamified behavioral weight loss treatment, mHealth behavioral weight loss treatment
Behavioral
Lead sponsor
Drexel University
Other
Eligibility
18 Years to 65 Years
Enrollment
228 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 22, 2026 · Synced Sep 11, 2026, 4:28 PM EDT
Recruiting Not applicable Interventional

IBS Skin Patch Test Food Allergy Study

NCT06288672
View directory record Official record
Conditions
Irritable Bowel Syndrome
Interventions
True avoidance diet, Sham avoidance diet
Other
Lead sponsor
IBS-80, LLC
Industry
Eligibility
18 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
2
States / cities
North Wales, Pennsylvania • Barboursville, West Virginia
Source: ClinicalTrials.gov public record
Updated Dec 16, 2025 · Synced Sep 11, 2026, 4:28 PM EDT
Completed Not applicable Interventional

Endpoint Determination Study Protocol

NCT03459482
View directory record Official record
Conditions
Irritable Bowel Syndrome
Interventions
Food Elimination Diet
Other
Lead sponsor
Biomerica
Industry
Eligibility
21 Years and older
Enrollment
556 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
8
States / cities
Scottsdale, Arizona • Jacksonville, Florida • Wauconda, Illinois + 4 more
Source: ClinicalTrials.gov public record
Updated Aug 4, 2024 · Synced Sep 11, 2026, 4:28 PM EDT
Completed Phase 2Phase 3 Interventional Results available

VTS-270 to Treat Niemann-Pick Type C1 (NPC1) Disease

NCT02534844
View directory record Official record
Conditions
Niemann-Pick Disease, Type C
Interventions
Parts A/B: Adrabetadex, Parts A/B: Sham Control
Drug · Other
Lead sponsor
Mandos LLC
Industry
Eligibility
4 Years to 21 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
14
States / cities
Birmingham, Alabama • Orange, California • San Francisco, California + 11 more
Source: ClinicalTrials.gov public record
Updated Feb 21, 2023 · Synced Sep 11, 2026, 4:28 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Healthy Behaviors Learning Task and Sleep

NCT02910648
View directory record Official record
Conditions
Overweight/Obese Population
Interventions
Modified Go/No-Go Task
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
20 Years to 55 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2022
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 7, 2022 · Synced Sep 11, 2026, 4:28 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Treatment of Mild Gestational Diabetes With Glyburide Versus Placebo

NCT00744965
View directory record Official record
Conditions
Mild Gestational Diabetes
Interventions
Glyburide, Placebo
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
16 Years to 45 Years · Female only
Enrollment
395 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2016
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Mar 11, 2020 · Synced Sep 11, 2026, 4:28 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Fiber and Fish Oil Supplements for the Prevention of Colorectal Cancer

NCT04211766
View directory record Official record
Conditions
Healthy Subject
Interventions
Dietary Fiber, Fish Oil, Comparator
Dietary Supplement · Other
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
50 Years to 75 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Sep 26, 2024 · Synced Sep 11, 2026, 4:28 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Omega-3 Supplementation in Prevention of Aromatase Inhibitor-Induced Toxicity in Patients With Stage I-III Breast Cancer

NCT02831582
View directory record Official record
Conditions
Arthralgia, Breast Neoplasms
Interventions
Omega-3 Fatty Acid, Placebo
Dietary Supplement · Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
18 Years and older · Female only
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
3
States / cities
Duarte, California • Cleveland, Ohio • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 26, 2023 · Synced Sep 11, 2026, 4:28 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Spices for Cultivating a Healthy Gut Microbiome and Cardiometabolic Profile

NCT06313580
View directory record Official record
Conditions
Cardiometabolic Syndrome
Interventions
Yogurt with added Spices, Yogurt without added Spices
Other
Lead sponsor
University of Alabama, Tuscaloosa
Other
Eligibility
50 Years to 69 Years · Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Tuscaloosa, Alabama
Source: ClinicalTrials.gov public record
Updated Mar 19, 2024 · Synced Sep 11, 2026, 4:28 PM EDT
Not yet recruiting Not applicable Interventional

Evaluation of the Migraceutics® Phase-Specific Dietary Supplement Regimen on Quality of Life, Work Productivity, and Biomarkers in Adult Migraineurs: The Migraceutics® START Study

NCT07634146
View directory record Official record
Conditions
Migraine, Migraine Disease, Migraine Disorder, Migraine Headache, Migraine Disability, Migraine in Adults, Menstrual Migraine, Menstrual Migraine (MM) Headaches
Interventions
Foundational dietary supplement, Luteal phase dietary supplement add-on, Migraine phase dietary supplement add-on, Reference dietary supplement
Dietary Supplement
Lead sponsor
Miracle Wellness LLC
Other
Eligibility
18 Years to 65 Years
Enrollment
920 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Lutherville-Timonium, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 7, 2026 · Synced Sep 11, 2026, 4:28 PM EDT
Completed Not applicable Interventional

The USGI Medical ESSENTIAL Study for Weight Loss

NCT01958385
View directory record Official record
Conditions
Obesity
Interventions
placement of g-Cath EZ suture anchors, Sham procedure, Diet and Exercise
Device · Procedure · Behavioral
Lead sponsor
USGI Medical
Industry
Eligibility
22 Years to 60 Years
Enrollment
377 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
11
States / cities
Scottsdale, Arizona • Miami, Florida • Dalton, Georgia + 8 more
Source: ClinicalTrials.gov public record
Updated Apr 3, 2017 · Synced Sep 11, 2026, 4:28 PM EDT
Completed Not applicable Interventional Results available

ENDObesity® II Study: TransPyloric Shuttle® System for Weight Loss

NCT02518685
View directory record Official record
Conditions
Obesity
Interventions
TransPyloric Shuttle, Sham procedure, Lifestyle Counseling
Device · Behavioral
Lead sponsor
BaroNova, Inc.
Industry
Eligibility
22 Years to 60 Years
Enrollment
302 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
9
States / cities
Scottsdale, Arizona • San Diego, California • Miami, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated Jul 16, 2019 · Synced Sep 11, 2026, 4:28 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Dietary Sugar Consumption on Sweet Taste Perception

NCT02090478
View directory record Official record
Conditions
Sweet Taste Perception
Interventions
Low sugar diet, Sham diet manipulation
Other
Lead sponsor
Monell Chemical Senses Center
Other
Eligibility
18 Years to 60 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2010
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 17, 2014 · Synced Sep 11, 2026, 4:28 PM EDT
Completed Not applicable Interventional

Gluten Immunity and Islet Autoimmunity in Type-1 Diabetes

NCT01932476
View directory record Official record
Conditions
Type 1 Diabetes, Celiac Disease
Interventions
Gluten Challenge, Sham Challenge
Dietary Supplement
Lead sponsor
Joslin Diabetes Center
Other
Eligibility
18 Years to 50 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 16, 2017 · Synced Sep 11, 2026, 4:28 PM EDT
Completed Phase 1 Interventional

Treatment of Orthostatic Hypotension in Autonomic Failure

NCT00223691
View directory record Official record
Conditions
Autonomic Failure, Orthostatic Hypotension
Interventions
Atomoxetine, Acarbose, Pyridostigmine Bromide, Yohimbine, Midodrine HCl, placebo, Modafinil, Octreotide, water intake, Diphenhydramine Hydrochloride, Ranitidine HCL, Tranylcypromine, Ergotamine/ Caffeine, Celecoxib, Pseudoephedrine, Methylphenidate, Indomethacin, Ibuprofen, Oxymetazoline 0.05% nasal solution, Bovril, Acetazolamide, Rivastigmine tartrate, Carbidopa/levodopa, Inflatable abdominal binder, inflatable abdominal binder (sham)
Drug · Other · Dietary Supplement + 1 more
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years to 85 Years
Enrollment
389 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2017
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 17, 2017 · Synced Sep 11, 2026, 4:28 PM EDT
Recruiting Not applicable Interventional

The Path Study: Cognitive and Inflammation Targeted Gut-brain Interventions in Alcohol; Probiotics, Alcohol, Transcutaneous Vagus Nerve Stimulation, and HIV Study

NCT05090267
View directory record Official record
Conditions
Cognition, Gut Microbiome
Interventions
Probiotic Supplement, Transcutaneous Vagal Nerve Stimulation (tVNS)
Dietary Supplement · Device
Lead sponsor
University of Florida
Other
Eligibility
35 Years to 70 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Coral Gables, Florida
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Sep 11, 2026, 4:28 PM EDT
Recruiting Phase 2 Interventional

Neuroimaging Correlates and Feasibility of Transcranial Magnetic Stimulation (TMS) to Improve Smoking Cessation Outcomes in Veterans With Comorbid PTSD

NCT05723588
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
active repetitive transcranial magnetic stimulation, sham repetitive transcranial magnetic stimulation, cognitive behavioral therapy for smoking cessation, nicotine replacement therapy
Device · Behavioral · Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 75 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Sep 11, 2026, 4:28 PM EDT