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Conditions: Prostate Carcinoma
Interventions: Swedish Massage Therapy (SMT), Light Touch (LT) Control, Waitlist Control (WLC); Procedure · Other
Lead sponsor: University of Utah; Other
Eligibility: 45 Years and older · Male only
Enrollment: 28 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Depression, Depressive Disorder
Interventions: Transcranial Direct Current Stimulation, Mindful Breathing, Sham; Device · Behavioral · Other
Lead sponsor: University of Minnesota; Other
Eligibility: 16 Years to 24 Years
Enrollment: 68 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Behavior, Child, Disruptive Behavior, Executive Dysfunction, Attention-deficit, Anxiety, Depression, Stress
Interventions: Treatment App, Sham app; Behavioral
Lead sponsor: New York University; Other
Eligibility: 6 Years to 12 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 1
States / cities: New York, New York

Conditions: Parkinson's Disease
Interventions: Transcranial direct current stimulation; Device
Lead sponsor: Spaulding Rehabilitation Hospital; Other
Eligibility: 40 Years to 90 Years
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2013
U.S. locations: 2
States / cities: Boston, Massachusetts

Conditions: Acute Back Pain
Interventions: Battlefield auricular acupressure, Sham; Procedure
Lead sponsor: Hackensack Meridian Health; Other
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Hackensack, New Jersey

Conditions: Low Back Pain, Herniation, Disc, Sciatic Radiculopathy, Intervertebral Disc Stenosis of Neural Canal, Intervertebral Disc Injury
Interventions: NSSD, Sham NSSD; Device
Lead sponsor: University of South Florida; Other
Eligibility: 18 Years to 65 Years
Enrollment: 42 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 2
States / cities: Stanford, California • Tampa, Florida

Conditions: Anxiety Disorder, Breast Cancer, Depression, Fatigue, Hot Flashes, Pain, Sleep Disorders
Interventions: acupuncture therapy, sham intervention; Procedure
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 18 Years and older · Female only
Enrollment: 51 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2011
U.S. locations: 2
States / cities: Baltimore, Maryland

Conditions: Substance Use Disorder (SUD), Opioid Use Disorder (OUD)
Interventions: Deep Brain Stimulation; Device
Lead sponsor: University of California, San Francisco; Other
Eligibility: 22 Years to 75 Years
Enrollment: 6 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2031
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Epilepsy
Interventions: Temporal Interference Electrical Stimulation; Device
Lead sponsor: University of California, Davis; Other
Eligibility: 18 Years to 65 Years
Enrollment: 15 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Sacramento, California

Conditions: Healthy Adults, Mechanical Ventilation Dependence, Hypoxia, Exercise Training, Exercise Intolerance, Dietary Supplement, Nitrate Supplementation, Inspiratory Muscle Training
Interventions: Respiratory Muscle Training (RMT), Sham Respiratory Muscle Training, Dietary Supplement: Beetroot Juice Concentrate, placebo beverage; Device · Dietary Supplement
Lead sponsor: Embry-Riddle Aeronautical University; Other
Eligibility: 18 Years to 40 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Daytona Beach, Florida

Conditions: Attention Deficit Disorder With Hyperactivity
Interventions: Intermittent Theta-Burst Stimulation, Sham Stimulation; Device
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 65 Years
Enrollment: 35 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Post-traumatic Stress Disorder
Interventions: Stellate Ganglion Block, Sham Stellate Ganglion Block; Procedure
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 80 Years
Enrollment: 410 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 6
States / cities: Long Beach, California • Tampa, Florida • Minneapolis, Minnesota + 3 more

Conditions: Primary Progressive Aphasia
Interventions: tDCS + language therapy, sham TDCS + language therapy; Combination Product
Lead sponsor: University of Arizona; Other
Eligibility: 45 Years to 80 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2027
U.S. locations: 1
States / cities: Tucson, Arizona

Conditions: Type 2 Diabetes
Interventions: Duodenal Mucosal Resurfacing (DMR), Duodenal Mucosal Resurfacing Sham (Sham); Device
Lead sponsor: Fractyl Health Inc.; Industry
Eligibility: 28 Years to 65 Years
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 6
States / cities: Orlando, Florida • Boston, Massachusetts • Lebanon, New Hampshire + 3 more

Conditions: Autonomic Dysfunction, Autonomic Imbalance, Autonomic Nervous System Diseases, Vagus Nerve Autonomic Disorder
Interventions: Standing-Squatting-Standing Test, Deep Breathing Test, Cold Pressor Test, Cold Face Test, Valsalva Maneuver, Transcutaneous Auricular Vagus Nerve Stimulation (taVNS); Other · Device
Lead sponsor: Northwell Health; Other
Eligibility: 18 Years to 60 Years
Enrollment: 48 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2027
U.S. locations: 1
States / cities: Manhasset, New York

Conditions: Anxiety Disorders, Depression, Post Traumatic Stress Disorder
Interventions: COGENT, Sham Program; Behavioral · Other
Lead sponsor: University of California, San Diego; Other
Eligibility: 21 Years to 55 Years
Enrollment: 128 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: San Diego, California

Conditions: Major Depressive Disorder
Interventions: Stimulation-ON, Stimulation-OFF, Stimulation-ON Active Control; Device
Lead sponsor: Andrew Krystal; Other
Eligibility: 22 Years to 70 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2035
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Retinitis Pigmentosa, Usher Syndrome Type 2, Deaf Blind, Retinal Disease, Eye Diseases, Eye Diseases, Hereditary, Eye Disorders Congenital, Vision Disorders
Interventions: Ultevursen, Sham-procedure; Drug · Other
Lead sponsor: Laboratoires Thea; Industry
Eligibility: 12 Years and older
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 10
States / cities: San Diego, California • San Francisco, California • Miami, Florida + 7 more

Conditions: Pain, Back, Pain, Acute, Sleep Disorder, Sleep Disorders, Circadian Rhythm, Sleep, Sleep Deprivation, Insomnia
Interventions: Drug- free, non-invasive patch (FREEDOM or REM Patch) with haptic vibrotactile trigger technology (VTT) Other Names:, Sham Patch without haptic vibrotactile trigger technology (VTT); Device
Lead sponsor: SuperPatch Limited LLC; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Tyrone, Georgia

Conditions: Neuropathic Pain, Chronic Pain
Interventions: Ultrasound, Sham (No Treatment); Device
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Stanford, California

Conditions: Functional Movement Disorder
Interventions: MagStim, Sham Comparator; Device · Other
Lead sponsor: National Institutes of Health Clinical Center (CC); NIH
Eligibility: 18 Years to 80 Years
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Depression - Major Depressive Disorder, Transcranial Alternating Current Stimulation
Interventions: Closed-loop tACS, Sham Comparator; Device
Lead sponsor: Pulvinar Neuro, LLC; Industry
Eligibility: 18 Years to 70 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Hypertension, High Blood Pressure
Interventions: ROX Coupler, Sham procedure; Device · Other
Lead sponsor: ROX Medical, Inc.; Industry
Eligibility: 22 Years to 85 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 13
States / cities: Birmingham, Alabama • Gainesville, Florida • Atlanta, Georgia + 9 more

Conditions: Obesity, Weight Change Trajectory, Weight Change, Body
Interventions: Revita Duodenal Mucosal Resurfacing (DMR), Sham; Device
Lead sponsor: Fractyl Health Inc.; Industry
Eligibility: 21 Years to 70 Years
Enrollment: 315 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2027
U.S. locations: 32
States / cities: Phoenix, Arizona • Scottsdale, Arizona • Newport Beach, California + 24 more

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Massage for Prostate Cancer-Related Fatigue (mPROSTATE)

Mindful Breathing and tDCS for Depression

Randomized Controlled Trial of a Behavioral Training App

Use of Noninvasive Brain Stimulation in Parkinson's Disease

Battlefield Acupressure for Acute Back Pain Management in the Emergency Department

Non-surgical Spinal Decompression Therapy and Outcomes

Acupuncture in Reducing Muscle and Bone Symptoms in Women Receiving Letrozole, Exemestane, or Anastrozole for Stage 0, Stage I, Stage II, or Stage III Breast Cancer

Individualized Adaptive Deep Brain Stimulation in Opioid Use Disorder

Cognitive and Electrophysiological Assessment of Non-Invasive Temporally-Interfering Electric Fields Stimulation (TIEFS)

Effects of Breathing Training and Nitrate on Exercise at Simulated Altitude

Accelerated and Extended-iTBS Targeting Inhibitory Control in Veterans With ADHD

Stellate Ganglion Block for PTSD

Enhancing Language Function in Primary Progressive Aphasia

Safety & Effectiveness of Duodenal Mucosal Resurfacing (DMR) Using the Revita™ System in Treatment of Type 2 Diabetes

Non-Invasive Bioelectronic Analytics

Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol (R33)

Closed-Loop Deep Brain Stimulation for Major Depression

Study to Evaluate the Efficacy Safety and Tolerability of Ultevursen in Subjects With RP Due to Mutations in Exon 13 of the USH2A Gene (Sirius)

Relieving Pain and Improving Sleep: Evaluating Topical Pain Relief and Sleep Patches

Ultrasound for Peripheral Nerve Modulation

Non-invasive Intermittent Theta Burst Stimulation of the Dorsolateral Prefrontal Cortex in Functional Movement Disorders

Individualized Non-invasive Brain Stimulation for the Treatment of Major Depressive Disorder

A Multicenter Study to Evaluate the ROX Coupler in Subjects With Hypertension

Evaluation of the Safety and Efficacy of Revita® DMR on Body Weight Maintenance in Subjects With Obesity Who Have Achieved at Least 15% Weight Loss on Tirzepatide