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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Sham manipulation Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Effect of Manipulation of the Cervical Spine on Pain Biomarkers

NCT03176654
View directory record Official record
Conditions
Neck Pain, Posterior
Interventions
HVLAT manipulation, Sham HVLAT manipulation
Procedure
Lead sponsor
Loma Linda University
Other
Eligibility
20 Years to 45 Years · Female only
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jul 31, 2019 · Synced Sep 15, 2026, 9:03 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Chiropractic Adjustments on Brain Function Using Quantitative Encephalography

NCT01953614
View directory record Official record
Conditions
Brain Function
Interventions
Chiropractic adjustment, Sham adjustment
Other
Lead sponsor
Life University
Other
Eligibility
10 Years to 99 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Marietta, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 19, 2016 · Synced Sep 15, 2026, 9:03 AM EDT
Recruiting Not applicable Interventional

Effects of Osteopathic Manipulative Treatment Protocol on Sleep Quality in Parkinson's Disease Subjects

NCT06671600
View directory record Official record
Conditions
Parkinsons Disease, Sleep
Interventions
Osteopathic Manipulative Treatment, Sham (No Treatment)
Procedure
Lead sponsor
New York Institute of Technology
Other
Eligibility
Not listed
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Old Westbury, New York
Source: ClinicalTrials.gov public record
Updated Jun 28, 2026 · Synced Sep 15, 2026, 9:03 AM EDT
Completed Not applicable Interventional

Effect of Osteopathic Manipulative Medicine (OMM) on Pulmonary Function and Speech in Parkinson's Disease

NCT01636011
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Osteopathic Manipulative Medicine Treatment, Light Touch sham
Other
Lead sponsor
New York Institute of Technology
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Old Westbury, New York
Source: ClinicalTrials.gov public record
Updated Oct 15, 2017 · Synced Sep 15, 2026, 9:03 AM EDT
Completed Not applicable Interventional Results available

Chiropractic Management of Chronic Lower Back Pain in Older Adults

NCT00475787
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Spinal Manipulation, Detuned Ultrasound
Procedure
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
65 Years and older
Enrollment
136 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
2
States / cities
Buffalo, New York • Canandaigua, New York
Source: ClinicalTrials.gov public record
Updated Dec 29, 2014 · Synced Sep 15, 2026, 9:03 AM EDT
Recruiting Not applicable Interventional

AAT for Alcohol Use Disorder in Veterans

NCT05372029
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Approach Avoidance Training, Sham Training
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 65 Years
Enrollment
176 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Sep 15, 2026, 9:03 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Transcranial Direct Current Stimulation and Modulation of Affect and Pain

NCT06989749
View directory record Official record
Conditions
We Are Not Studying a Disease or Condition
Interventions
Anodal tDCS, Cathodal tDCS, Sham tDCS
Other
Lead sponsor
Trustees of Dartmouth College
Other
Eligibility
18 Years to 55 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Hanover, New Hampshire
Source: ClinicalTrials.gov public record
Updated May 24, 2025 · Synced Sep 15, 2026, 9:03 AM EDT
Completed Not applicable Interventional Results available

Approach Bias Modification for the Treatment of Cannabis Use Disorder

NCT03629990
View directory record Official record
Conditions
Cannabis Use Disorder
Interventions
Approach Bias Modification (ABM), Sham ABM, Psychosocial therapy for cannabis use disorder.
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Dec 16, 2024 · Synced Sep 15, 2026, 9:03 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Lumbopelvic Manipulation on Neuromuscular Activity of Back & Hip Muscles in Adults With Chronic Low Back Pain

NCT01861418
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Lumbopelvic Manipulation, Sham manipulation
Other
Lead sponsor
Texas Woman's University
Other
Eligibility
20 Years to 60 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Oct 11, 2017 · Synced Sep 15, 2026, 9:03 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Osteopathic Cranial Manipulative Medicine on Visual Function

NCT02728713
View directory record Official record
Conditions
Visual Function
Interventions
Cranial Manipulation, Sham/Placebo
Procedure
Lead sponsor
Nova Southeastern University
Other
Eligibility
18 Years to 35 Years
Enrollment
113 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2005
U.S. locations
1
States / cities
Fort Lauderdale, Florida
Source: ClinicalTrials.gov public record
Updated Apr 4, 2016 · Synced Sep 15, 2026, 9:03 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Stress, Sex, and the Generalization of Fear

NCT03786952
View directory record Official record
Conditions
Psychological Stress
Interventions
Stress immediately before learning in males, Sham control immediately before learning in males, Stress 30 minutes before learning in males, Sham control 30 minutes before learning in males, Stress immediately before learning in females, Sham control immediately before learning in females, Stress 30 minutes before learning in females, Sham control 30 minutes before learning in females
Behavioral
Lead sponsor
Ohio Northern University
Other
Eligibility
18 Years and older
Enrollment
606 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Ada, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 22, 2023 · Synced Sep 15, 2026, 9:03 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

ImmunoBoost: The Lymphatic Osteopathic Manipulative Treatment Protocol Study

NCT06565065
View directory record Official record
Conditions
Healthy
Interventions
Osteopathic Manipulative Treatment (OMT), Sham Light Touch, Exercise Protocol
Procedure · Other
Lead sponsor
Western University of Health Sciences
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Pomona, California
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Sep 15, 2026, 9:03 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Effect of Manipulation of the Ankle Joint on Gait

NCT01787721
View directory record Official record
Conditions
Gait
Interventions
Ankle manipulation, Sham manipulation
Procedure · Other
Lead sponsor
University of Bridgeport
Other
Eligibility
18 Years to 65 Years
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Bridgeport, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 22, 2014 · Synced Sep 15, 2026, 9:03 AM EDT
Completed Not applicable Interventional

The Use of Manual Therapy to Treat Low-Back and Hip Pain

NCT00410397
View directory record Official record
Conditions
Low Back Pain, Pain
Interventions
Osteopathic Manipulative Medicine, Sham Manipulation
Procedure
Lead sponsor
Oklahoma State University Center for Health Sciences
Other
Eligibility
18 Years to 60 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jan 14, 2008 · Synced Sep 15, 2026, 9:03 AM EDT
Completed Not applicable Interventional

Effects of Osteopathic Manipulative Therapy on Arrhythmias

NCT04004741
View directory record Official record
Conditions
Cardiac Arrhythmia
Interventions
Osteopathic Manipulative Treatment, Light Touch Therapy
Procedure
Lead sponsor
New York Institute of Technology
Other
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Glen Head, New York
Source: ClinicalTrials.gov public record
Updated Apr 5, 2023 · Synced Sep 15, 2026, 9:03 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Efficacy of Osteopathic Manipulative Treatment (OMT) on the Golf Swing

NCT03241095
View directory record Official record
Conditions
Manipulation, Osteopathic
Interventions
OMT (Osteopathic Manipulative Treatment), Sham intervention
Procedure
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Mankato, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 16, 2020 · Synced Sep 15, 2026, 9:03 AM EDT
Not listed Not applicable Interventional

Effects Of Osteopathic Manipulative Medicine(OMM) On Lower Extremity Muscle Characteristics In Parkinson's Disease(PD) Patients

NCT05884944
View directory record Official record
Conditions
Parkinson Disease, Osteopathy in Diseases Classified Elsewhere
Interventions
Sham- Light touch, not reaching restrictive barrier, Experimental: Interventional Group- OMM- Muscle energy
Procedure
Lead sponsor
New York Institute of Technology
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Old Westbury, New York
Source: ClinicalTrials.gov public record
Updated Aug 6, 2024 · Synced Sep 15, 2026, 9:03 AM EDT
Withdrawn Not applicable Interventional

Osteopathic Manipulative Treatment for Recurrent Mastitis

NCT05132426
View directory record Official record
Conditions
Mastitis
Interventions
Osteopathic Manipulative Treatment (OMT)
Procedure
Lead sponsor
Western University of Health Sciences
Other
Eligibility
18 Years to 50 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Pomona, California
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Sep 15, 2026, 9:03 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Efficacy of Osteopathic Manipulation on Breathing Mechanics in a Healthy Population: A Randomized Controlled Study

NCT04975542
View directory record Official record
Conditions
Respiratory Function Impaired
Interventions
Osteopathic Manipulative Medicine, Sham
Other
Lead sponsor
Jayla Bostic
Other
Eligibility
18 Years and older
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 22, 2021 · Synced Sep 15, 2026, 9:03 AM EDT
Enrolling by invitation Not applicable Interventional

Causal Role of Rostromedial Prefrontal Cortex for Positive Savoring in Depression

NCT07467473
View directory record Official record
Conditions
Left Rostromedial Prefrontal Cortex - Accelerated Intermittent Theta Burst, Left Dorsolateral Prefrontal Cortex - Accelerated Intermittent Theta Burst, Left Primary Somatosensory Cortex - Accelerated Intermittent Theta Burst
Interventions
Accelerated Intermittent Theta Burst Transcranial Magnetic Stimulation
Device
Lead sponsor
Florida State University
Other
Eligibility
18 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated May 19, 2026 · Synced Sep 15, 2026, 9:03 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of OMT on Gait Kinematics and Postural Control in Parkinson Disease

NCT04946760
View directory record Official record
Conditions
Parkinson Disease
Interventions
Sham Manipulation
Other
Lead sponsor
University of North Texas Health Science Center
Other
Eligibility
50 Years and older
Enrollment
113 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Jun 30, 2021 · Synced Sep 15, 2026, 9:03 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Non-Specific Effects of Manual Therapy

NCT03017534
View directory record Official record
Conditions
Musculoskeletal Manipulations, Placebo Effect
Interventions
Spinal Manual Therapy
Procedure
Lead sponsor
Shenandoah University
Other
Eligibility
18 Years to 70 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Winchester, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 8, 2017 · Synced Sep 15, 2026, 9:03 AM EDT
Completed Not applicable Interventional Results available

Effects of Chiropractic Care on Cytokine Levels in Multiple Sclerosis

NCT04972929
View directory record Official record
Conditions
Multiple Sclerosis, Relapsing-Remitting
Interventions
Spinal Manipulation, Sham Spinal Manipulation
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 55 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jul 19, 2026 · Synced Sep 15, 2026, 9:03 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of a Thoracic Manipulation on Hip Adductor, Extensor, and Latissimus Dorsi Force in Those With Adductor Weakness

NCT06534931
View directory record Official record
Conditions
Muscle Weakness
Interventions
High velocity low amplitude thoracic spine manipulation, Sham
Procedure
Lead sponsor
University of New England
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Portland, Maine
Source: ClinicalTrials.gov public record
Updated Aug 1, 2024 · Synced Sep 15, 2026, 9:03 AM EDT