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ClinicalTrials.gov public records Last synced Oct 6, 2026, 5:07 PM EDT

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Showing 25–48 of 106 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Sham transcutaneous vagal nerve stimulation Clear all
Recruiting Not applicable Interventional

Home-based Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) for IBS Pain

NCT06847360
View directory record Official record
Conditions
Pain, Chronic, Irritable Bowel Syndrome, Symptom Cluster
Interventions
Home-based taVNS intervention
Device
Lead sponsor
Yale University
Other
Eligibility
18 Years to 29 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Oct 6, 2026, 5:07 PM EDT
Completed Not applicable Interventional Results available

Post-stroke Pain taVNS

NCT06456385
View directory record Official record
Conditions
Stroke, Pain
Interventions
Transcutaneous Auricular Vagus Nerve Stimulation (taVNS), Sham Auricular Stimulation
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 80 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 22, 2025 · Synced Oct 6, 2026, 5:07 PM EDT
Not yet recruiting Not applicable Interventional

Modulating Inflammation in Neuro-Trauma

NCT07510074
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Nurosym taVNS, Nurosym (sham)
Device
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 75 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Oct 5, 2026 · Synced Oct 6, 2026, 5:07 PM EDT
Active, not recruiting Phase 1 Interventional

Vagal Stimulation in POTS

NCT03124355
View directory record Official record
Conditions
Postural Tachycardia Syndrome
Interventions
placebo sugar pill, Pyridostigmine Pill, Galantamine Pill, Vagal stimulation, Sham vagal stimulation
Drug · Device
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2027
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Oct 6, 2026, 5:07 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Vagus Nerve Stimulation and Stress Reduction Training for Migraine

NCT03592329
View directory record Official record
Conditions
Migraine
Interventions
Stress Reduction Training A, active tVNS, Stress Reduction Training B, sham tVNS
Behavioral · Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
193 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 25, 2026 · Synced Oct 6, 2026, 5:07 PM EDT
Completed Not applicable Interventional

Delivering Transcutaneous Auricular Neurostimulation to Improve Relapse Prevention in Opioid Use Disorder

NCT05053503
View directory record Official record
Conditions
Opioid-use Disorder, Opioid Withdrawal
Interventions
Sparrow Ascent Therapy System, Lofexidine, Extended-release injectable naltrexone
Device · Drug
Lead sponsor
Spark Biomedical, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
4
States / cities
Rancho Mirage, California • Crownsville, Maryland • Center City, Minnesota + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 4, 2025 · Synced Oct 6, 2026, 5:07 PM EDT
Terminated Not applicable Interventional

Effect of Transcutaneous Electrical Auricular Stimulation of the Vagus Nerve in Kidney Transplant Recipients

NCT04256837
View directory record Official record
Conditions
Vagus Nerve Stimulation
Interventions
Transcutaneous electrical auricular vagus nerve stimulation (VNS)
Device
Lead sponsor
Northwell Health
Other
Eligibility
18 Years and older
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Dec 14, 2022 · Synced Oct 6, 2026, 5:07 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Treatment of Mild Cognitive Impairment With Transcutaneous Vagal Nerve Stimulation

NCT03359902
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Transcutaneous vagal nerve stimulation, Sham stimulation
Device
Lead sponsor
University of Florida
Other
Eligibility
60 Years to 89 Years
Enrollment
59 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
3
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 24, 2023 · Synced Oct 6, 2026, 5:07 PM EDT
Completed Not applicable Interventional Results available

Neuromodulation to Treat Patients With Heart Failure With Preserved Ejection Fraction

NCT03327649
View directory record Official record
Conditions
Heart Failure With Normal Ejection Fraction
Interventions
low level transcutaneous vagus nerve stimulation
Device
Lead sponsor
University of Oklahoma
Other
Eligibility
21 Years to 90 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jan 23, 2026 · Synced Oct 6, 2026, 5:07 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Stress and Sleep Study

NCT05218109
View directory record Official record
Conditions
Stress, Psychological, Sleep, Transcutaneous Electric Nerve Stimulation, Vagus Nerve Stimulation, Mindfulness
Interventions
tVNS, Mindfulness, sham tVNS, Number Puzzle
Device · Behavioral · Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 30 Years
Enrollment
76 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 4, 2024 · Synced Oct 6, 2026, 5:07 PM EDT
Recruiting Not applicable Interventional

The Path Study: Cognitive and Inflammation Targeted Gut-brain Interventions in Alcohol; Probiotics, Alcohol, Transcutaneous Vagus Nerve Stimulation, and HIV Study

NCT05090267
View directory record Official record
Conditions
Cognition, Gut Microbiome
Interventions
Probiotic Supplement, Transcutaneous Vagal Nerve Stimulation (tVNS)
Dietary Supplement · Device
Lead sponsor
University of Florida
Other
Eligibility
35 Years to 70 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Coral Gables, Florida
Source: ClinicalTrials.gov public record
Updated Aug 6, 2026 · Synced Oct 6, 2026, 5:07 PM EDT
Not yet recruiting Not applicable Interventional

TENS of Auricular Vagal Nerve for Radiation Necrosis

NCT07680127
View directory record Official record
Conditions
Radiation Necrosis, Cerebral Edema
Interventions
Transcutaneous auricular vagal nerve stimulation (taVNS), Sham
Device
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 4, 2026 · Synced Oct 6, 2026, 5:07 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

taVNS Cold Pressor

NCT05254080
View directory record Official record
Conditions
taVNS, Brain Stimulation
Interventions
Active taVNS, Sham taVNS
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 17, 2024 · Synced Oct 6, 2026, 5:07 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Transcutaneous Vagus Nerve Stimulation on Pain and Brain Activity in Healthy Adults

NCT07827690
View directory record Official record
Conditions
Acute Pain, Pain Perception, Healthy Adult Participants
Interventions
Active transcutaneous vagus nerve stimulation, Sham transcutaneous vagus nerve stimulation, Cold pressor test
Device · Other
Lead sponsor
David A. Purger
Other
Eligibility
18 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 18, 2026 · Synced Oct 6, 2026, 5:07 PM EDT
Recruiting Phase 2 Interventional

Investigation to Understand and Optimize Psilocybin

NCT06512194
View directory record Official record
Conditions
Depression
Interventions
Psilocybin, Transcutaneous Auricular Vagus Nerve Stimulation (taVNS), Sham taVNS
Drug · Device
Lead sponsor
Charles Raison
Other
Eligibility
18 Years to 70 Years
Enrollment
141 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Edwards, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 10, 2026 · Synced Oct 6, 2026, 5:07 PM EDT
Not yet recruiting Not applicable Interventional

Trans Auricular Vagal Nerve Stimulation in Patients With IBS-C

NCT07662083
View directory record Official record
Conditions
Irritable Bowel Syndrome (IBS-C)
Interventions
Transcutaneous Auricular Vagus Nerve Stimulation (ta-VNS), Sham Transcutaneous Auricular Vagus Nerve Stimulation
Device
Lead sponsor
West Virginia University
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Jun 23, 2026 · Synced Oct 6, 2026, 5:07 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Wandering Nerve: Gateway to Boost Alzheimer's Disease Related Cognitive Performance

NCT04908358
View directory record Official record
Conditions
Aging
Interventions
Active transcutaneous vagus nerve stimulation respiratory-gated non-painful electrical stimulation of the auricle for 10 minute sessions, Sham transcutaneous vagus nerve stimulation respiratory-gated non-painful electrical stimulation of the auricle for 10 minute sessions
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
60 Years to 85 Years
Enrollment
126 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 9, 2026 · Synced Oct 6, 2026, 5:07 PM EDT
Completed Not applicable Interventional

Transcutaneous VNS to Treat Pediatric IBD

NCT03863704
View directory record Official record
Conditions
Crohn Disease, Ulcerative Colitis
Interventions
Transcutaneous Electrical Nerve Stimulation (TENS)
Device
Lead sponsor
Northwell Health
Other
Eligibility
10 Years to 21 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
New Hyde Park, New York
Source: ClinicalTrials.gov public record
Updated Oct 1, 2024 · Synced Oct 6, 2026, 5:07 PM EDT
Completed Not applicable Interventional Results available

Safety and Efficacy of Non-invasive Vagus Nerve Stimulation in the Treatment of Headache in Subarachnoid Hemorrhage

NCT04126408
View directory record Official record
Conditions
Subarachnoid Hemorrhage, Aneurysmal
Interventions
gammaCore
Device
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Jan 9, 2024 · Synced Oct 6, 2026, 5:07 PM EDT
Not yet recruiting Early Phase 1 Interventional

Understanding Non-invasive Vagus Nerve Stimulation Effects in PTSD

NCT06953388
View directory record Official record
Conditions
PTSD - Post Traumatic Stress Disorder
Interventions
transcutaneous auricular vagus nerve stimulation, sham transcutaneous auricular vagus nerve stimulation
Device
Lead sponsor
Wayne State University
Other
Eligibility
18 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2031
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Oct 6, 2026, 5:07 PM EDT
Not listed Not applicable Interventional

Effect of taVNS on Heart Rate in Persistent Atrial Fibrillation

NCT05944575
View directory record Official record
Conditions
Atrial Fibrillation, Persistent
Interventions
active taVNS, sham-taVNS
Device
Lead sponsor
Burrell College of Health Sciences
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Las Cruces, New Mexico
Source: ClinicalTrials.gov public record
Updated Jul 14, 2023 · Synced Oct 6, 2026, 5:07 PM EDT
Recruiting Not applicable Interventional

Mindfulness in Chronic Kidney Disease

NCT04099992
View directory record Official record
Conditions
Chronic Kidney Diseases
Interventions
Mindfulness-based stress reduction (MBSR), Health enhancement program (HEP), Transcutaneous Vagus Nerve Stimulation (tVNS), Sham-transcutaneous Vagus Nerve Stimulation (tVNS)
Behavioral · Device
Lead sponsor
Emory University
Other
Eligibility
40 Years to 80 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 21, 2025 · Synced Oct 6, 2026, 5:07 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Imaging Brain Fluids During Breathing

NCT05180981
View directory record Official record
Conditions
Healthy
Interventions
Transcutaneous vagal nerve stimulation, Breathing task
Device · Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years to 70 Years
Enrollment
81 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 27, 2026 · Synced Oct 6, 2026, 5:07 PM EDT
Terminated Not applicable Interventional Results available

A Study of Randomized Sham-control Auricular TENS Unit Stimulation in Pediatric Functional Gastrointestinal Disorders

NCT04247100
View directory record Official record
Conditions
Functional Gastrointestinal Disorders, Vagus Nerve Autonomic Disorder, Irritable Bowel Syndrome, Nausea, Dyspepsia
Interventions
Transcutaneous Electrical Nerve Stimulation (TENS), Sham Transcutaneous Electrical Nerve Stimulation
Device
Lead sponsor
Gisela Grotewold Chelimsky
Other
Eligibility
12 Years to 18 Years · Female only
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 12, 2023 · Synced Oct 6, 2026, 5:07 PM EDT