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ClinicalTrials.gov public records Last synced Oct 10, 2026, 8:02 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 121–144 of 210 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Sham ultrasound Clear all
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Study of Low-intensity Focused Ultrasound Effects on Human Memory

NCT06628193
View directory record Official record
Conditions
Memory
Interventions
Low intensity focused ultrasound, Sham (No Treatment)
Device
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Oct 10, 2026, 8:02 PM EDT
Recruiting Phase 2 Interventional

Focused Ultrasound for PTSD in Veterans

NCT06820138
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Brainsonix Ultrasound Device
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
22 Years to 70 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Sep 15, 2026 · Synced Oct 10, 2026, 8:02 PM EDT
Completed Not applicable Interventional

Randomized Study of an Analgesic Device Enabling Local Anesthetic Delivery and Neuromodulation After Shoulder/Foot Surgery

NCT07052721
View directory record Official record
Conditions
Rotator Cuff Tears, Shoulder Injuries, Hallux Valgus, Ankle Arthropathy, Clavicle Fracture
Interventions
Experimental Treatment, Sham Comparator
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jul 27, 2026 · Synced Oct 10, 2026, 8:02 PM EDT
Recruiting Not applicable Interventional

Trial for Treating Painful Degenerative Disc Disease

NCT05287867
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Platelet-rich plasma (PRP), Platelet lysate (PL), and Platelet Poor Plasma (PPP), Sham procedure
Biological · Other
Lead sponsor
Regenexx, LLC
Industry
Eligibility
25 Years to 65 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
2
States / cities
Broomfield, Colorado • Lone Tree, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 6, 2025 · Synced Oct 10, 2026, 8:02 PM EDT
Not listed Not applicable Interventional

Enhanced Ultrasound Treatment of Chronic Wounds With Monitoring of Healing and Quality of Life Outcomes

NCT03041844
View directory record Official record
Conditions
Diabetic Foot Ulcer, Venous Ulcer
Interventions
Low Frequency, Low Intensity Ultrasound, Sham Applicator
Device
Lead sponsor
Drexel University
Other
Eligibility
18 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 6, 2022 · Synced Oct 10, 2026, 8:02 PM EDT
Terminated Not applicable Interventional Results available

Low Intensity Shockwaves Therapy for the Treatment of Erectile Dysfunction. 12- Month Follow-Up

NCT03670628
View directory record Official record
Conditions
Erectile Dysfunction
Interventions
Shockwave therapy, Sham shockwave therapy
Device · Other
Lead sponsor
University of Miami
Other
Eligibility
30 Years to 70 Years · Male only
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jul 10, 2023 · Synced Oct 10, 2026, 8:02 PM EDT
Completed Not applicable Interventional

Sham-Controlled Prospective Study Characterizing Erectile Tissue Ultrasound Changes Resulting From Penile LiSWT

NCT06600893
View directory record Official record
Conditions
Erectile Dysfunctions
Interventions
Low intensity shockwave therapy (LiSWT), Sham
Device
Lead sponsor
San Diego Sexual Medicine
Other
Eligibility
21 Years to 80 Years · Male only
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Oct 10, 2026, 8:02 PM EDT
Completed Phase 1 Interventional Results available

Shockwave Therapy and Platelet Rich Plasma for the Treatment of Erectile Dysfunction

NCT05048667
View directory record Official record
Conditions
Erectile Dysfunction
Interventions
Shock Wave therapy (SWT), Platelet Rich Plasma (PRP), Sham SWT, Placebo Saline
Device · Drug · Other
Lead sponsor
University of Miami
Other
Eligibility
30 Years to 80 Years · Male only
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated May 22, 2026 · Synced Oct 10, 2026, 8:02 PM EDT
Active, not recruiting Not applicable Interventional

Cryoneurolysis for Painful Diabetic Neuropathy of the Foot

NCT06646731
View directory record Official record
Conditions
Painful Diabetic Peripheral Neuropathy (PDPN)
Interventions
cryoneurolysis, sham cryoneurolysis
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Oct 10, 2026, 8:02 PM EDT
Not yet recruiting Not applicable Interventional

LIFU Effects & Outcomes: Mechanisms Evaluating Striatal Systems Imaging (LEO MESSI)

NCT07710989
View directory record Official record
Conditions
Schizophrenia, Auditory Hallucinations
Interventions
LIFU
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 64 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Oct 10, 2026, 8:02 PM EDT
Completed Not applicable Interventional

Blood Flow Within Active Myofascial Trigger Points Following Massage

NCT02389140
View directory record Official record
Conditions
Myofascial Pain, Tension-type Headache
Interventions
Trigger point release, Ultrasound
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
21 Years to 49 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 1, 2017 · Synced Oct 10, 2026, 8:02 PM EDT
Not yet recruiting Not applicable Interventional

Extracorporeal Shockwave Therapy and Platelet-Rich Plasma for Midportion Achilles Tendinopathy

NCT07483320
View directory record Official record
Conditions
Achilles Injuries Tendon, Achilles Tendinopathy (AT), Achilles Tendinitis, Left Leg, Achilles Tendinitis, Right Leg, Achilles Tendon Pain, Achilles Tendonitis
Interventions
Platelet Rich Plasma, Extracorporeal Shockwave Therapy, Sham PRP, Sham ESWT
Device
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 25, 2026 · Synced Oct 10, 2026, 8:02 PM EDT
Terminated Not applicable Interventional

A Study of the Ulthera® System for the Treatment of Axillary Hyperhidrosis

NCT01722461
View directory record Official record
Conditions
Primary Axillary Hyperhidrosis
Interventions
Ulthera System, Sham treatment
Device
Lead sponsor
Ulthera, Inc
Industry
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
6
States / cities
Roseville, California • Aventura, Florida • Chicago, Illinois + 3 more
Source: ClinicalTrials.gov public record
Updated Nov 24, 2017 · Synced Oct 10, 2026, 8:02 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Activating the Cholinergic Anti-Inflammatory Pathway in Healthy Volunteers and People With Inflammatory Arthritis

NCT06555562
View directory record Official record
Conditions
Psoriatic Arthritis, Rheumatoid Arthritis, Ankylosing Spondylitis
Interventions
Ultrasound Stimulation, Non-active ultrasound stimulation
Device
Lead sponsor
Surf Therapeutics
Industry
Eligibility
22 Years to 75 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
2
States / cities
Austin, Texas • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Oct 10, 2026, 8:02 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Analgesic Benefit of PECS Blocks for Biceps Tenodesis Shoulder Surgery

NCT02741713
View directory record Official record
Conditions
Biceps Tendonitis
Interventions
PECS "Pectoralis" 1 and 2 Blocks, Interscalene Block, Sham Block, Solution for Injection in Interscalene Block, Solution for Injection in Sham Block, Solution for Injection PECS Blocks
Procedure · Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 27, 2018 · Synced Oct 10, 2026, 8:02 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Exablate for LIFU Neuromodulation in Patients With Opioid Use Disorder (OUD) and/or Other Substance Use Disorders (SUDs)

NCT04197921
View directory record Official record
Conditions
Opioid-use Disorder, Substance Use Disorders
Interventions
Exablate Model 4000 Type 2.0/2.1
Device
Lead sponsor
InSightec
Industry
Eligibility
18 Years to 60 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2027
U.S. locations
4
States / cities
Tampa, Florida • Baltimore, Maryland • New York, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 26, 2026 · Synced Oct 10, 2026, 8:02 PM EDT
Recruiting Not applicable Interventional

Treatment Validation for Myofascial Pain

NCT07133139
View directory record Official record
Conditions
Chronic Low-back Pain (cLBP), Myofacial Pain
Interventions
Dry Needling, Sham Dry Needling, NUN Biomarker
Device · Other
Lead sponsor
Ajay Wasan, MD, Msc
Other
Eligibility
20 Years to 70 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 1, 2026 · Synced Oct 10, 2026, 8:02 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Low-intensity Focused Ultrasound and Autonomic Response

NCT05834829
View directory record Official record
Conditions
Autonomic Dysfunction
Interventions
Low-intensity focused ultrasound neuromodulation, Sham Low-intensity focused ultrasound
Device
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Oct 10, 2026, 8:02 PM EDT
Completed Not applicable Interventional Results available

LIFUP for Treatment of Motor Deficits in Parkinson's Disease

NCT04593875
View directory record Official record
Conditions
Parkinson Disease
Interventions
Active LIFUP Treatment, Sham LIFUP Treatment
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 85 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 4, 2026 · Synced Oct 10, 2026, 8:02 PM EDT
Completed Not applicable Interventional

Comparing Femoral Nerve Catheters to Single Shot Femoral Nerve Blocks for Total Knee Replacement Surgery

NCT02106481
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Femoral Nerve Catheters, Single Shot Femoral Nerve Blocks
Drug
Lead sponsor
Eastern Maine Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
99 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Bangor, Maine
Source: ClinicalTrials.gov public record
Updated Aug 3, 2016 · Synced Oct 10, 2026, 8:02 PM EDT
Recruiting Not applicable Interventional

Ultrasonic Neuromodulation of Cingulate Cortex for Fibromyalgia

NCT07226648
View directory record Official record
Conditions
Fibromyalgia
Interventions
Focused Ultrasound
Device
Lead sponsor
SPIRE Therapeutics Inc.
Industry
Eligibility
22 Years and older
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
8
States / cities
Ann Arbor, Michigan • Minneapolis, Minnesota • St Louis, Missouri + 5 more
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Oct 10, 2026, 8:02 PM EDT
Terminated Not applicable Interventional Results available

Continuous Lumbar Plexus Block With and Without Parasacral Block in Patients Undergoing Total Hip Replacement

NCT02161484
View directory record Official record
Conditions
Osteoarthritis of Hip, Regional Anesthesia, Other Acute Postoperative Pain, Total Hip Arthroplasty, Peripheral Nerve Block, Lumbar Plexus Nerve Block, Parasacaral (Sciatic) Nerve Block
Interventions
Continuous Lumbar Plexus Block, Parasacral Nerve Block, Ropivacine 0.2%, Bupivacaine 0.0625%
Procedure · Drug
Lead sponsor
Rita Merman
Other
Eligibility
18 Years to 75 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 29, 2018 · Synced Oct 10, 2026, 8:02 PM EDT
Active, not recruiting Not applicable Interventional Results available

A Study of the ReCor Medical Paradise System in Clinical Hypertension

NCT02649426
View directory record Official record
Conditions
Hypertension, Vascular Diseases
Interventions
The Paradise® Renal Denervation Ultrasound System, Sham Procedure
Device
Lead sponsor
ReCor Medical, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
282 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2027
U.S. locations
24
States / cities
Birmingham, Alabama • Los Angeles, California • Sacramento, California + 18 more
Source: ClinicalTrials.gov public record
Updated Apr 21, 2026 · Synced Oct 10, 2026, 8:02 PM EDT
Recruiting Not applicable Interventional

Ultrasound Stimulation for Patients in a Disorder of Consciousness

NCT06939348
View directory record Official record
Conditions
Consciousness Disorders, Disorders of Consciousness Due to Severe Brain Injury
Interventions
The Brainsonix BX Pulsar 1002 was designed to deliver low-intensity focused ultrasound pulsations (LIFUP) to the human brain.
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 79 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
4
States / cities
Los Angeles, California • Pomona, California • Boston, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated May 22, 2026 · Synced Oct 10, 2026, 8:02 PM EDT