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ClinicalTrials.gov public records Last synced Nov 15, 2026, 2:27 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 217–240 of 1,165 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Sham-device Clear all
Recruiting Not applicable Interventional

Tibial Nerve Stimulation for Pediatric Spina Bifida Neurogenic Bladder

NCT07136688
View directory record Official record
Conditions
Neurogenic Bladder Due to Spina Bifida
Interventions
Stamobil electric stimulator, sham tTNS device
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
4 Years to 17 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 10, 2026 · Synced Nov 15, 2026, 2:27 AM EST
Completed Not applicable Interventional

Investigate the Effect of the CREON2000A on Asthma Control in Children With Mild to Moderate Persistent Asthma

NCT02715375
View directory record Official record
Conditions
Asthma
Interventions
CREON2000A
Device
Lead sponsor
General Innovations and Goods, Inc.
Industry
Eligibility
6 Years to 18 Years
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
8
States / cities
Homestead, Florida • Lexington, Kentucky • Cincinnati, Ohio + 4 more
Source: ClinicalTrials.gov public record
Updated Nov 3, 2020 · Synced Nov 15, 2026, 2:27 AM EST
Recruiting Not applicable Interventional

Freedom-1 Study for Chronic Knee Pain

NCT03877653
View directory record Official record
Conditions
Osteoarthritic Knee Pain
Interventions
Wireless neuromodulation
Device
Lead sponsor
Curonix LLC
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
13
States / cities
Placentia, California • Denver, Colorado • Fort Lauderdale, Florida + 10 more
Source: ClinicalTrials.gov public record
Updated Feb 13, 2025 · Synced Nov 15, 2026, 2:27 AM EST
Terminated Not applicable Interventional Results available

A Non-Invasive Neuromodulation Device for Prevention of Episodic Migraine Headache

NCT02991430
View directory record Official record
Conditions
Intervention
Interventions
active neuromodulation for episodic migraine headache, placebo neuromodulation for episodic migraine headache
Device
Lead sponsor
Scion NeuroStim
Industry
Eligibility
18 Years to 65 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
8
States / cities
Scottsdale, Arizona • West Palm Beach, Florida • Chicago, Illinois + 5 more
Source: ClinicalTrials.gov public record
Updated Jun 19, 2019 · Synced Nov 15, 2026, 2:27 AM EST
Completed Not applicable Interventional

Pivotal-Safety and Therapeutic Measures of tDCS in Patients With Refractory Focal Epilepsy

NCT04770337
View directory record Official record
Conditions
Refractory Epilepsy, Focal Seizure, Seizures, Focal, Seizures, Epilepsy in Children, Epilepsy, Epilepsy, Tonic-Clonic
Interventions
STARSTIM device, Sham Device
Device
Lead sponsor
Neuroelectrics Corporation
Industry
Eligibility
9 Years and older
Enrollment
127 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
18
States / cities
Phoenix, Arizona • Loma Linda, California • Los Angeles, California + 13 more
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Nov 15, 2026, 2:27 AM EST
Active, not recruiting Not applicable Interventional

Nexalin Therapy as a Viable Adjunctive Treatment for Substance Use Disorders

NCT03540745
View directory record Official record
Conditions
Depression, Anxiety, Insomnia, Substance Abuse
Interventions
TES Treatment, TES-SHAM Treatment
Device
Lead sponsor
University of Arizona
Other
Eligibility
18 Years to 65 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Belle Mead, New Jersey
Source: ClinicalTrials.gov public record
Updated Oct 11, 2018 · Synced Nov 15, 2026, 2:27 AM EST
Recruiting Not applicable Interventional

Neuromodulating Cortical Regions Involved in Neurogenic Bladder in MS

NCT06072703
View directory record Official record
Conditions
Neurogenic Bladder, Multiple Sclerosis, Overactive Bladder
Interventions
Magstim Rapid2 System
Device
Lead sponsor
The Methodist Hospital Research Institute
Other
Eligibility
18 Years and older · Female only
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 23, 2026 · Synced Nov 15, 2026, 2:27 AM EST
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effect of Vestibular Stimulation on Fat Consumption and Energy Expenditure as Assessed Using Indirect Calorimetry

NCT03138382
View directory record Official record
Conditions
Obesity, Metabolic Syndrome
Interventions
Vestibular Nerve Stimulator, Sham stimulator
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jun 27, 2019 · Synced Nov 15, 2026, 2:27 AM EST
Recruiting Not applicable Interventional

Investigation of PEMF Therapy for Female Patients With IC/BPS

NCT05149573
View directory record Official record
Conditions
Interstitial Cystitis, Chronic Interstitial Cystitis, Bladder Pain Syndrome
Interventions
Pulsed Electromagnetic Field (PEMF) Device, Sham Pulsed Electromagnetic Field (PEMF) Device
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 80 Years · Female only
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 28, 2026 · Synced Nov 15, 2026, 2:27 AM EST
Completed Not applicable Interventional

Carolina-ColoWrap® in Colonoscopy Performance and Outcomes Study

NCT02025504
View directory record Official record
Conditions
Performance and Tolerance of Colonoscopy
Interventions
ColoWrap
Device
Lead sponsor
ColoWrap, LLC
Industry
Eligibility
40 Years to 80 Years
Enrollment
350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
3
States / cities
Chapel Hill, North Carolina • Hillsborough, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 3, 2015 · Synced Nov 15, 2026, 2:27 AM EST
Active, not recruiting Not applicable Interventional

Breathing Device in Postural Orthostatic Tachycardia Syndrome (POTS)

NCT00962728
View directory record Official record
Conditions
Postural Tachycardia Syndrome, Postural Orthostatic Tachycardia Syndrome
Interventions
Inspiratory Threshold Device (Res-Q-Gard ITD), Sham Inspiratory Threshold Device
Device
Lead sponsor
Alfredo Gamboa
Other
Eligibility
18 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2026
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 22, 2025 · Synced Nov 15, 2026, 2:27 AM EST
Completed Not applicable Interventional Results available

Clinical Intervention in Alcohol Use Disorder

NCT02168400
View directory record Official record
Conditions
Alcohol Use Disorder, Eligible to go Into the MRI Scanner, Short-term Abstinence From Alcohol Use (2 Week Abstinent)
Interventions
Transcranial Direct Current Stimulation (tDCS)
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 65 Years
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 5, 2024 · Synced Nov 15, 2026, 2:27 AM EST
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

INSIGHT: Insomnia, Nightmares, and Sympathetic Hyperactivity Intervention

NCT07288593
View directory record Official record
Conditions
Nightmare, Insomnia, PTSD, TBI, Sleep Disorder (Disorder), REM Behavior Disorder
Interventions
NightWare smartwatch configured to detect physiological signs of sympathetic activation during sleep, such as heart-rate spikes and movement patterns., Sham (No Treatment)
Device
Lead sponsor
Uniformed Services University of the Health Sciences
Federal
Eligibility
18 Years to 62 Years
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
2
States / cities
Bethesda, Maryland • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Nov 15, 2026, 2:27 AM EST
Recruiting Not applicable Interventional Accepts healthy volunteers

Targeting Language-specific and Executive-control Networks With Transcranial Direct Current Stimulation in Logopenic Variant PPA

NCT03887481
View directory record Official record
Conditions
Logopenic Progressive Aphasia, Primary Progressive Aphasia
Interventions
High-definition active tDCS (HD-tDCS) + "Repeat After Me" (RAM) Treatment, Sham + "Repeat After Me" (RAM) Treatment
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
50 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 9, 2026 · Synced Nov 15, 2026, 2:27 AM EST
Completed Not applicable Interventional

Effect of NeuroAD on the Cognitive Function of Alzheimer Patients

NCT01825330
View directory record Official record
Conditions
Alzheimer's Disease
Interventions
TMS and cognitive stimulation, sham
Device
Lead sponsor
Neuronix Ltd
Industry
Eligibility
60 Years to 90 Years
Enrollment
131 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
9
States / cities
Sun City, Arizona • Costa Mesa, California • Miami, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated Mar 31, 2016 · Synced Nov 15, 2026, 2:27 AM EST
Not listed Not applicable Interventional

Timing of Transcranial Direct Current Stimulation (tDCS) Combined With Speech and Language Therapy (SLT)

NCT03773406
View directory record Official record
Conditions
Aphasia
Interventions
Offline tDCS-before therapy, Sham tDCS, Offline tDCS-after therapy, Online tDCS
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 80 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 26, 2022 · Synced Nov 15, 2026, 2:27 AM EST
Completed Not applicable Interventional

Auriculo-Nerve Stimulation on Post-Operative Opioid Requirement

NCT05506878
View directory record Official record
Conditions
Opioid Use, Auriculotherapy, Pain, Abdominal, Cancer Pain, Liver Transplant
Interventions
NSS-2 BRIDGE, Sham NSS-2 BRIDGE
Device
Lead sponsor
Jacques E. Chelly
Other
Eligibility
18 Years and older
Enrollment
286 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
4
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 24, 2026 · Synced Nov 15, 2026, 2:27 AM EST
Not listed Phase 2 Interventional Accepts healthy volunteers

Treatment of Androgenetic Alopecia in Males With Theradome™ LH80 PRO

NCT02528552
View directory record Official record
Conditions
Androgenetic Alopecia
Interventions
LH80 PRO, Sham Device
Device
Lead sponsor
Theradome, Inc.
Industry
Eligibility
18 Years to 50 Years · Male only
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
4
States / cities
Los Angeles, California • Newnan, Georgia • Portland, Oregon + 1 more
Source: ClinicalTrials.gov public record
Updated Dec 2, 2016 · Synced Nov 15, 2026, 2:27 AM EST
Recruiting Not applicable Interventional

Neuromodulation to Regulate Inflammation and Autonomic Imbalance in Sepsis

NCT03992378
View directory record Official record
Conditions
Septic Shock
Interventions
Low Level Transcutaneous Vagus Nerve Stimulation
Device
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years and older
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Nov 15, 2026, 2:27 AM EST
Completed Not applicable Interventional Results available

High-intensity Inspiratory Muscle Training as a Pre-cardiac Rehabilitation in Heart Disease

NCT06127147
View directory record Official record
Conditions
Coronary Artery Bypass Graft, CABG
Interventions
IMT, Sham-IMT
Device
Lead sponsor
University of Illinois Chicago
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
2
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 21, 2026 · Synced Nov 15, 2026, 2:27 AM EST
Not yet recruiting Not applicable Interventional

NeuroCuple to Mitigate Post-Wisdom Teeth Extraction Opioid Risks

NCT07461506
View directory record Official record
Conditions
Wisdom Teeth, Wisdom Teeth Extraction or Jaw Implant
Interventions
NEUROCUPLE™ Patch, Sham Patch
Device
Lead sponsor
nCap Medical
Industry
Eligibility
18 Years to 50 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Nov 15, 2026, 2:27 AM EST
Completed Not applicable Interventional

Sham-Controlled Prospective Study Characterizing Erectile Tissue Ultrasound Changes Resulting From Penile LiSWT

NCT06600893
View directory record Official record
Conditions
Erectile Dysfunctions
Interventions
Low intensity shockwave therapy (LiSWT), Sham
Device
Lead sponsor
San Diego Sexual Medicine
Other
Eligibility
21 Years to 80 Years · Male only
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Nov 15, 2026, 2:27 AM EST
Completed Not applicable Interventional Results available

A Pilot Study of the Cala ONE Device for Essential Tremor

NCT03152136
View directory record Official record
Conditions
Essential Tremor
Interventions
Cala ONE device
Device
Lead sponsor
Cala Health, Inc.
Industry
Eligibility
22 Years to 80 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
4
States / cities
Oakland, California • Denver, Colorado • Kansas City, Kansas + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 30, 2019 · Synced Nov 15, 2026, 2:27 AM EST
Recruiting Not applicable Interventional

The Apollo Device in Systemic Sclerosis for the Management of fatiguE, Raynaud Phenomenon and qualiTy of Life

NCT06675344
View directory record Official record
Conditions
Systemic Sclerosis (SSc)
Interventions
Apollo Neuro Device, Sham device
Device
Lead sponsor
Robyn T. Domsic, MD, MPH
Other
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
4
States / cities
New Orleans, Louisiana • Ann Arbor, Michigan • Pittsburgh, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 8, 2026 · Synced Nov 15, 2026, 2:27 AM EST