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ClinicalTrials.gov public records Last synced Nov 15, 2026, 3:20 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 313–336 of 1,165 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Sham-device Clear all

Conditions: Juvenile Idiopathic Arthritis (JIA)
Interventions: Active tcVNS, Sham tcVNS; Device
Lead sponsor: National Institute of Allergy and Infectious Diseases (NIAID); NIH
Eligibility: 5 Years to 18 Years
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 7
States / cities: San Francisco, California • Orlando, Florida • Indianapolis, Indiana + 4 more

Conditions: Motion Sickness
Interventions: Transcutaneous Auricular Neurostimulation device; Device
Lead sponsor: 59th Medical Wing; Federal
Eligibility: 18 Years to 50 Years
Enrollment: 36 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025
U.S. locations: 1
States / cities: San Antonio, Texas

Conditions: Acute Migraine
Interventions: Relivion active, Relivion Sham; Device
Lead sponsor: Neurolief Ltd.; Industry
Eligibility: 18 Years and older
Enrollment: 187 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 6
States / cities: Tempe, Arizona • Hartford, Connecticut • New Haven, Connecticut + 3 more

Conditions: Fat Reduction
Interventions: Sham Comparator; Device
Lead sponsor: Ward Photonics LLC; Industry
Eligibility: 18 Years and older · Female only
Enrollment: 52 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 4
States / cities: Cape Coral, Florida • Cocoa Beach, Florida • Lake Mary, Florida + 1 more

Conditions: Mild Cognitive Impairment, Early Alzheimer's Disease, Memory Impairment
Interventions: COT, Sham; Drug
Lead sponsor: Evon Medics LLC; Industry
Eligibility: 55 Years to 95 Years
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 3
States / cities: Washington D.C., District of Columbia

Conditions: Sleep
Interventions: Phototherapy device; Device
Lead sponsor: University of Arizona; Other
Eligibility: 30 Years to 60 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Tucson, Arizona

Conditions: Chronic Pain, Chronic Pain Syndrome, Widespread Chronic Pain
Interventions: Verum stimulation with Diadem prototype, Sham stimulation with Diadem prototype; Device
Lead sponsor: University of Utah; Other
Eligibility: 18 Years to 65 Years
Enrollment: 47 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Parkinson Disease
Interventions: Active NIR-PBM (MedX 1116, MCT502), Sham NIR-PBM (MedX 1116, MCT502); Device
Lead sponsor: University of Florida; Other
Eligibility: 62 Years to 89 Years
Enrollment: 23 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Peripheral Arterial Disease
Interventions: Intermittent pneumatic leg compressions, Sham; Device
Lead sponsor: Indiana University; Other
Eligibility: 18 Years and older
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Restless Legs Syndrome
Interventions: AirCast Sequential Compression Device; Device
Lead sponsor: Walter Reed Army Medical Center; Federal
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2007
U.S. locations: 1
States / cities: Sleep Disorders Center, Walter Reed Army Medical Center, District of Columbia

Conditions: Essential Tremor, Neuromodulation
Interventions: Focused Ultrasound Neuromodulation - Sham Control, Focused ultrasound neuromodulation; Device
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Depressive Symptoms, Urinary Incontinence, Sexual Dysfunction
Interventions: EXOMIND (BTL-699-2) Active Treatment, EMSELLA (HPM-6000UF) ActiveTreatment, EXOMIND (BTL-699-2) Sham Treatment, EMSELLA (HPM-6000UF) Sham Treatment; Device
Lead sponsor: BTL Industries Ltd.; Industry
Eligibility: 40 Years and older · Female only
Enrollment: 41 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 2
States / cities: Winter Garden, Florida • Wellesley, Massachusetts

Conditions: Hyperglycemia, Hypertension
Interventions: AVACEN 100, AVACEN 100 Heat Only, AVACEN Sham; Device
Lead sponsor: Jeff Moore; Other
Eligibility: 18 Years to 40 Years
Enrollment: 17 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019
U.S. locations: 1
States / cities: San Diego, California

Conditions: Chronic Low Back Pain
Interventions: Distraction-Based VR, Sham VR, Skills-Based VR, Activity Tracker; Device
Lead sponsor: Cedars-Sinai Medical Center; Other
Eligibility: 13 Years and older
Enrollment: 413 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Healthy Subjects
Interventions: Percutaneous Electrical Nerve Field Stimulation (PENFS); Device
Lead sponsor: Indiana University; Other
Eligibility: 18 Years to 80 Years
Enrollment: 23 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Keratoconus
Interventions: Riboflavin and Sodium Iodide solution and Ultraviolet-A treatment, Placebo and sham treatment; Combination Product
Lead sponsor: Epion Therapeutics; Industry
Eligibility: 8 Years to 45 Years
Enrollment: 398 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 12
States / cities: Scottsdale, Arizona • Tucson, Arizona • Murrieta, California + 9 more

Conditions: E-cigarettes, Oxidative Stress, Inflammation
Interventions: e-cigarette, empty (-cigarette sham control); Other
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 21 Years to 45 Years
Enrollment: 148 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Menopause Related Conditions, Postmenopausal Symptoms
Interventions: VR101 Device (Efficacy), Sham Control Ring, VR101 Device (Safety); Device · Other
Lead sponsor: J3 Bioscience, Inc.; Industry
Eligibility: 35 Years and older · Female only
Enrollment: 72 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017
U.S. locations: 2
States / cities: Meridian, Idaho • West Jordan, Utah

Conditions: Gagging
Interventions: Acupuncture, TENS, Sham-TENS; Procedure · Device
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years to 89 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Sleep, Sleep Disturbance
Interventions: Elemind Neuromodulation (ENMod); Device
Lead sponsor: Elemind Technologies, Inc.; Industry
Eligibility: 21 Years to 55 Years
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: Cambridge, Massachusetts

Conditions: Substance-Related Disorders, Substance Use Disorders, Substance Abuse, Intravenous, Substance Withdrawal, Substance Abuse, Opioid-use Disorder, Opioid Use Disorder, Severe, Opioid Use
Interventions: Non invasive VN stimulation (nVNS), Oxygen (15-O) Water, Sham Stimulation; Device · Drug
Lead sponsor: Emory University; Other
Eligibility: 18 Years to 80 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Self-Injurious Behavior, Suicidal Ideation, Suicide Attempts
Interventions: Therapeutic Evaluative Conditioning, Neutral comparison condition; Behavioral
Lead sponsor: Franciscan Hospital For Children, INC.; Other
Eligibility: 12 Years to 19 Years
Enrollment: 155 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Brighton, Massachusetts

Conditions: Reading Disability
Interventions: Sham intervention, RLN real non-invasive brain stimulation intervention, RLN and CCN real non-invasive brain stimulation intervention; Device
Lead sponsor: Vanderbilt University; Other
Eligibility: 18 Years to 40 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Pain (Visceral, Somatic, or Neuropathic)
Interventions: Experimental NSS, Sham NSS; Device
Lead sponsor: Defense and Veterans Center for Integrative Pain Management; Other
Eligibility: 18 Years and older
Enrollment: 17 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016
U.S. locations: 1
States / cities: Bethesda, Maryland

Search by objective public record fields.

Transcutaneous Cervical Vagus Nerve Stimulation (tcVNS) in JIA

Evaluation of a Device to Reduce Motion Sickness and Spatial Disorientation

The RIME Study - Combined Occipital and Supraorbital Transcutaneous Nerve Stimulation for Treatment of Migraine

Effects of Green Light Therapy on Body Contouring and Cellulite

Development and Evaluation of Computerized Olfactory Training Program for Cognitive Decline in Early Alzheimer's Disease

Phase II Study - Trial of a Phototherapy Light Device to Improve Sleep Health

Deep Brain Therapy With Low-intensity Ultrasound for Generalized Chronic Pain

Revitalize Cognition: Near Infrared Stimulation in Parkinson Patients

Intermittent Pneumatic Compression to Improve Revascularization Outcome

Sequential Compression Devices for Treatment of Restless Legs Syndrome

Ultrasound Neuromodulation in Essential Tremor

BTL-699-2 and HPM-6000UF Devices for the Improvement of Depressive Symptoms and Sexual Function Among Perimenopausal and Postmenopausal Women

AVACEN Hand Heating on Fasting Blood Glucose

Virtual Reality Therapy for Chronic Low Back Pain

ABVN Phase 2 - PENFS

Epithelium-On Corneal Cross-linking in Subjects 8 to 45 Years of Age With Keratoconus

ECigs, Inflammation and Oxidative Stress

Use of J3 Bioscience Lubricating Intravaginal Ring VR101 to Relieve the Symptoms of Vaginal Dryness

Acupuncture vs TENS for Gag Reflex

Sounds Locked to ElectroEncephalogram Phase For the Acceleration of Sleep Onset Time

Non-Invasive Vagal Nerve Stimulation in Opioid Use Disorders

Therapeutic Evaluative Conditioning to Reduce Adolescents' Self-injurious Thoughts and Behaviors During and After Psychiatric Inpatient Hospitalization

Noninvasive Brain Stimulation to Enhance Reading Comprehension Ability in Adults

Effects of Neuro-Stim System on Pain, Sleep, and Opioid Use