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ClinicalTrials.gov public records Last synced Nov 15, 2026, 12:55 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 25–48 of 1,165 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Sham-device Clear all

Conditions: Cigarette Smoker, Tobacco Use Disorder
Interventions: Nicotine Lozenge, Nicotine Patch, Placebo, Tobacco Cessation Counseling, Varenicline; Drug · Other
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years to 75 Years
Enrollment: 631 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2026
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Sepsis
Interventions: Acupuncture, Sham Acupuncture; Procedure · Other
Lead sponsor: University of California, Irvine; Other
Eligibility: 18 Years and older
Enrollment: 78 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Irvine, California

Conditions: Neuropathy, Paraneoplastic
Interventions: MC-5A, Sham device; Device · Drug
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years and older
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Mild Cognitive Impairment, Amnestic Mild Cognitive Disorder, Amnestic Mild Cognitive Impairment, Mild Traumatic Brain Injury, Concussion, Brain
Interventions: High Definition Transcranial Direct Current Stimulation; Device
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 55 Years and older
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Obsessive Compulsive Disorder (OCD)
Interventions: Low Intensity Focused Ultrasound; Device
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 60 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Knee Osteoarthritis
Interventions: iovera°, Sham Comparator; Device
Lead sponsor: Pacira Pharmaceuticals, Inc; Industry
Eligibility: 35 Years to 75 Years
Enrollment: 180 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2016
U.S. locations: 17
States / cities: Covina, California • Sacramento, California • Bradenton, Florida + 14 more

Conditions: Chronic Obstructive Pulmonary Disease
Interventions: Acapella Vibratory PEP Therapy Device plus usual care, Sham Acapella Vibratory PEP Device plus usual care; Device
Lead sponsor: New York Presbyterian Brooklyn Methodist Hospital; Other
Eligibility: 18 Years and older
Enrollment: 91 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Brooklyn, New York

Conditions: Raynaud Disease, Raynaud Phenomenon, Raynaud Syndrome
Interventions: Blue Light Therapy, Sham Light Therapy; Device
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 50 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Sleep, Sleep Disorders Not Due to A Substance or Known Physiological Condition
Interventions: Powersleep, Sham Powersleep; Device
Lead sponsor: Philips Respironics; Industry
Eligibility: 21 Years to 50 Years
Enrollment: 62 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 4
States / cities: Atlanta, Georgia • Chesterfield, Missouri • St Louis, Missouri + 1 more

Conditions: Bipolar Depression
Interventions: Medtronic Percept RC System, One Month Blinded Discontinuation Period; Device · Behavioral
Lead sponsor: Wayne Goodman MD; Other
Eligibility: 22 Years to 64 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2030
U.S. locations: 4
States / cities: Boston, Massachusetts • Houston, Texas • Seattle, Washington

Conditions: Aging
Interventions: tDCS, cognitive training; Device · Behavioral
Lead sponsor: University of Florida; Other
Eligibility: 65 Years to 89 Years
Enrollment: 33 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Migraine
Interventions: DC Stimulator (Transcranial Direct Current Stimulator); Device
Lead sponsor: Beth Israel Deaconess Medical Center; Other
Eligibility: 18 Years to 65 Years
Enrollment: 13 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2012
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Insomnia, Insomnia Chronic, Sleep
Interventions: Fisher Wallace Neurostimulation Device; Device
Lead sponsor: ProofPilot; Industry
Eligibility: 21 Years and older
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: New York, New York

Conditions: Amyotrophic Lateral Sclerosis
Interventions: BiPAP® S/T System, sham-NIPPV; Device · Other
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years to 79 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2012
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Depressive Disorder, Depression, Depressive Disorder, Major, Depressive Episode, Major Depressive Disorder
Interventions: Synchronized Transcranial Magnetic Stimulation (sTMS), Sham Stimulation; Device
Lead sponsor: Wave Neuroscience; Industry
Eligibility: 22 Years to 65 Years
Enrollment: 121 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 14
States / cities: La Jolla, California • Los Angeles, California • Stanford, California + 11 more

Conditions: Insomnia
Interventions: PeakSleep, Sham; Device
Lead sponsor: Uniformed Services University of the Health Sciences; Federal
Eligibility: 18 Years to 70 Years
Enrollment: 78 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Obesity
Interventions: TransPyloric Shuttle, Sham procedure, Lifestyle Counseling; Device · Behavioral
Lead sponsor: BaroNova, Inc.; Industry
Eligibility: 22 Years to 60 Years
Enrollment: 302 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2018
U.S. locations: 9
States / cities: Scottsdale, Arizona • San Diego, California • Miami, Florida + 6 more

Conditions: Dyspareunia
Interventions: Mollie device; Device
Lead sponsor: JSP Innovations; Other
Eligibility: 18 Years and older · Female only
Enrollment: 111 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Decatur, Illinois

Conditions: Choroidal Melanoma, Indeterminate Lesions, Uveal Melanoma, Ocular Melanoma
Interventions: Bel-sar, Suprachoroidal Microinjector, Infrared Laser, Sham Infrared Laser, Sham Microinjector; Drug · Device
Lead sponsor: Aura Biosciences; Industry
Eligibility: 18 Years and older
Enrollment: 108 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2028
U.S. locations: 25
States / cities: Los Angeles, California • Palo Alto, California • Sacramento, California + 20 more

Conditions: Substance Use Disorders, Posttraumatic Stress Symptom, Anxiety
Interventions: Safe and Sound Protocol; Device
Lead sponsor: Caron Treatment Centers; Other
Eligibility: 18 Years to 75 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Wernersville, Pennsylvania

Conditions: Tourette Syndrome
Interventions: Active Treatment, Sham Treatment; Device
Lead sponsor: Children's Mercy Hospital Kansas City; Other
Eligibility: 8 Years to 20 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Kansas City, Missouri

Conditions: Depression
Interventions: Intermittent Theta Burst Stimulation, Continuous Theta Burst Stimulation, Sham Theta Burst Stimulation; Device
Lead sponsor: Erika Forbes; Other
Eligibility: 18 Years to 25 Years
Enrollment: 29 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Dry Eye Syndrome
Interventions: IPL, Sham IPL, MGX; Device · Procedure
Lead sponsor: Lumenis Be Ltd.; Industry
Eligibility: 22 Years to 85 Years
Enrollment: 88 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 2
States / cities: Nashville, Tennessee • Austin, Texas

Conditions: Other Reconstructive Surgery
Interventions: Sham PEMF Device, Ivivi Torino II PEMF Device; Device
Lead sponsor: Columbia University; Other
Eligibility: 18 Years to 85 Years · Female only
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2014
U.S. locations: 1
States / cities: New York, New York

Search by objective public record fields.

Varenicline and Combined NRT for Smoking Cessation

An Acupuncture Study for People At High Risk for Sepsis

MC-5A for Chemotherapy Induced Peripheral Neuropathy

Pathways Relating Amnestic MCI to a Mild Traumatic Brain Injury History

OCD LIFU Target Engagement

Study to Evaluate the Iovera° Device for Temporary Relief From Knee Pain

Vibratory PEP Device and Hospital Length of Stay for Acute Exacerbation of COPD

Phototherapy For Treatment Of Raynaud's Phenomenon

Feasibility, Effectiveness and Efficacy of the PowerSleep Device

Deep Brain Stimulation of Treatment-Resistant Bipolar Depression

SMART Stimulation: Precision Neuromodulation of Cognition in Older Adults

Migraine--Investigational Treatment of Migraine With Noninvasive Brain Stimulation. (tDCS- Migraine)

Evaluation of a Neurostimulation Device for Insomnia: A Randomized Trial

Trial of Early Noninvasive Ventilation for Amyotrophic Lateral Sclerosis (ALS)

Adaptive Design Study of NEST sTMS in Subjects With Major Depressive Disorder

Wearable Transcranial Electrical Stimulation (tES) for Insomnia

ENDObesity® II Study: TransPyloric Shuttle® System for Weight Loss

The Mollie Study, a Study to Evaluate the Safety and Efficacy of the Mollie Medical Device

A Phase 3 Randomized, Masked, Controlled Trial to Evaluate Efficacy and Safety of Belzupacap Sarotalocan (AU-011) Treatment Compared to Sham Control in Subjects With Primary Indeterminate Lesions or Small Choroidal Melanoma

Safe & Sound Protocol in Adults With Trauma and SUD

Multi-site Transcranial Magnetic Stimulation Therapy of the Supplementary Motor Area in Children With Tourette Syndrome

Theta Burst Stimulation in Young Adults With Depression

Effectiveness of Intense Pulsed Light for Improving Dry Eye Syndrome

Use of Pulsed Electromagnetic Fields (PEMF) After Breast Reconstruction Surgery