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ClinicalTrials.gov public records Last synced Nov 15, 2026, 6:31 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 577–600 of 1,165 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Sham-device Clear all

Conditions: Major Depressive Disorder
Interventions: TMS: single session intermittent theta burst stimulation (iTBS) to dorsomedial prefrontal target in individuals with major depressive disorder, via MagVenture MagPro R30 device / Cool-DB80 A/P coil, SHAM (inactive) TMS stimulation; Device
Lead sponsor: San Francisco Veterans Affairs Medical Center; Federal
Eligibility: 18 Years to 65 Years
Enrollment: 98 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Major Depressive Episode
Interventions: Diadem prototype; Device
Lead sponsor: University of Utah; Other
Eligibility: 18 Years to 65 Years
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Spinal Cord Injuries
Interventions: auricular nerve stimulation (aVNS), sham aVNS; Device
Lead sponsor: University of Miami; Other
Eligibility: 18 Years to 65 Years
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Mild Cognitive Impairment, Amnestic Mild Cognitive Disorder, Deep Brain Stimulation, Mild Alzheimer's Disease
Interventions: Low-Intensity Focused Ultrasound Pulsation (LIFUP); Device
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 50 Years to 90 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Uncontrolled Hypertension
Interventions: RPD, Active hypertension medical therapy; Device · Drug
Lead sponsor: Verve Medical, Inc; Industry
Eligibility: 21 Years to 80 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 9
States / cities: Birmingham, Alabama • Surprise, Arizona • Los Angeles, California + 6 more

Conditions: Visual Display Users With Previously Undiagnosed Dry Eye
Interventions: iTEAR100; Device
Lead sponsor: Olympic Ophthalmics, Inc.; Industry
Eligibility: 18 Years to 69 Years
Enrollment: 35 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Anxiety, Depression, Insomnia, Sleep Quality
Interventions: Alpha-Stim AID CES (Active Comparator), Alpha-Stim AID CES (Sham Comparator); Device
Lead sponsor: Christina Murphey, RN, PhD; Individual
Eligibility: 18 Years to 45 Years · Female only
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2026
U.S. locations: 2
States / cities: Austin, Texas • Corpus Christi, Texas

Conditions: Heavy Drinking
Interventions: Active RAVANS, Brief Mindfulness-Based Intervention; Device · Behavioral
Lead sponsor: Cambridge Health Alliance; Other
Eligibility: 21 Years to 29 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: Malden, Massachusetts

Conditions: Traumatic Brain Injury, Closed Head Injury, Cognitive Dysfunction
Interventions: Real LED Intervention, Sham LED Intervention; Device
Lead sponsor: Boston VA Research Institute, Inc.; Other
Eligibility: 18 Years to 65 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Long COVID, Long Covid19, Long Covid-19
Interventions: BrainHQ/Active Comparator Activity, BrainHQ, PASC CoRE, tDCS-active, tDCS-sham; Other · Device
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older
Enrollment: 328 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Posttraumatic Stress Disorder, Opioid Use Disorder
Interventions: Sparrow Ascent tAN, Sparrow Ascent Active Sham; Device
Lead sponsor: University of Cincinnati; Other
Eligibility: 18 Years to 65 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Cape Girardeau, Missouri

Conditions: Alcohol Use Disorder, Alcohol Abuse, Substance Use Disorders, Substance Use Disorders Alcohol Use Withdrawal State
Interventions: Sparrow Ascent, Sparrow Ascent (Sham); Device
Lead sponsor: Spark Biomedical, Inc.; Industry
Eligibility: 18 Years to 64 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Traumatic Brain Injury
Interventions: Repetitive Transcranial Magnetic Stimulation; Device
Lead sponsor: University of New Mexico; Other
Eligibility: 18 Years to 55 Years
Enrollment: 21 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Albuquerque, New Mexico

Conditions: Rheumatoid Arthritis
Interventions: Study device treatment, Sham device treatment; Device
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Insomnia, Insomnia Chronic
Interventions: SleepSpaceRx CBT-I-IoT-AI, SleepEZ CBTi, Sleep Hygiene IoT; Behavioral
Lead sponsor: Proactive Life Inc; Industry
Eligibility: 55 Years and older
Enrollment: 180 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Heart Failure With Reduced Ejection Fraction
Interventions: Powerbreathe; Device
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2030
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Critically Ill, Respiratory Failure
Interventions: Inspiratory Muscle Trainer; Device
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years to 90 Years
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Diabetic Foot Ulcer
Interventions: TWO2 Device, Placebo Device; Device
Lead sponsor: AOTI Ltd.; Industry
Eligibility: 18 Years to 89 Years
Enrollment: 73 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2018
U.S. locations: 10
States / cities: Phoenix, Arizona • Vacaville, California • Washington D.C., District of Columbia + 6 more

Conditions: Peripheral Artery Disease
Interventions: intermittent pneumatic compression, exercise, Sham device, Health Education; Device · Behavioral
Lead sponsor: Northwestern University; Other
Eligibility: 55 Years and older
Enrollment: 211 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2026
U.S. locations: 4
States / cities: Chicago, Illinois • Detroit, Michigan • Minneapolis, Minnesota

Conditions: Primary Cervical Dystonia, Dystonia
Interventions: NeuroStar TMS therapy, Sham NeuroStar TMS therapy, Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS), Craniocervical Dystonia Questionnaire (CDQ-24), Cerebellar-brain Inhibition (CBI), Botulinum toxin injections; Device · Other · Procedure
Lead sponsor: University of Florida; Other
Eligibility: 30 Years to 75 Years
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2021
U.S. locations: 2
States / cities: Gainesville, Florida

Conditions: PTSD
Interventions: Diadem; Device
Lead sponsor: University of Utah; Other
Eligibility: 18 Years to 65 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Substance Use Disorders, Substance Abuse, Substance Use
Interventions: tDCS, tDCS Sham; Device
Lead sponsor: University of Arizona; Other
Eligibility: 18 Years to 79 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023
U.S. locations: 1
States / cities: Tucson, Arizona

Conditions: Chronic Migraine, Headache
Interventions: NTI-tss, Placebo; Device
Lead sponsor: ChairsideSplint.com; Industry
Eligibility: 18 Years and older
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Solana Beach, California

Conditions: Insomnia
Interventions: Transcranial Magnetic Stimulation (TMS), Sham; Device · Other
Lead sponsor: University of Arizona; Other
Eligibility: 18 Years to 60 Years
Enrollment: 144 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Tucson, Arizona

Search by objective public record fields.

Using Electrophysiology to Index Non-invasive Brain Stimulation Effects on Reward System Functioning in Depression

Personalized Ultrasonic Brain Stimulation for Depression

Auricular Vagus Nerve Stimulation (aVNS) in Chronic Spinal Cord Injuries (SCI)

Low Intensity Focused Ultrasound for Mild Cognitive Impairment and Mild Alzheimer's Disease

Renal Pelvic Denervation Pilot Trial

Study of External Neuromodulation to Improve Signs and Symptoms of Dry Eye in Visual Display Terminal Users

New Mothers Alpha-Stim

Exploring the Effects of Brief Mindfulness Training With Vagal Nerve Stimulation on Alcohol Cue Reactivity Among Young Adult Heavy Drinkers

Photobiomodulation to Improve Cognition in TBI, With fMRI

RECOVER-NEURO: Platform Protocol, Appendix_A to Measure the Effects of BrainHQ, PASC CoRE and tDCS Interventions on Long COVID Symptoms

tAN for PTSD and OUD in Buprenorphine Therapy

tAN for Substance Use Disorder

Noninvasive Modulation of Motivational Brain Regions in Healthy Volunteers

Ultrasound Treatment of Rheumatoid Arthritis

Deep Sleep in Older Adults

A Study Investigating the Impact of IMT With CR On Exercise Responses In HF

A Randomized, Controlled Trial of Inspiratory Muscle Training (IMT)in the ICU and CCU

Efficacy, Safety and Economic Benefits of Topical Wound Oxygen Therapy in the Treatment of Chronic Diabetic Foot Ulcers

Intermittent Pneumatic Compression With and Without Exercise to Improve Functioning in Peripheral Artery Disease

rTMS and Botulinum Toxin in Primary Cervical Dystonia

Ultrasonic Neuromodulation for Treatment of PTSD

tDCS and Impulsivity

Adjunctive Treatment of Chronic Migraine Using an Oral Dental Device

Effectiveness of Transcranial Magnetic Stimulation of the Default Mode Network to Improve Sleep - Clinical Trial