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ClinicalTrials.gov public records Last synced Nov 15, 2026, 7:18 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 697–720 of 1,165 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Sham-device Clear all

Conditions: Postoperative Pain, Acute
Interventions: Active Percutaneous Auricular Neuromodulation with NSS-2 Bridge, Sham Treatment; Device
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 122 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: San Diego, California

Conditions: Mild Cognitive Impairment
Interventions: tDCS, Sham tDCS; Device
Lead sponsor: The University of Texas at Dallas; Other
Eligibility: 50 Years to 80 Years
Enrollment: 22 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Lower Extremity Edema, Lower Extremity Edema Chronic, CHF - Congestive Heart Failure, CHF Exacerbation, Chronic Venous Insufficiency, CVI
Interventions: Pedal Pump, Pedal Pump Sham; Device
Lead sponsor: Hillcrest; Industry
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Tulsa, Oklahoma

Conditions: Hip Surgery Corrective, Anesthesia; Functional
Interventions: Drug group Fascia iliaca nerve block, Control group sham nerve block; Procedure
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 12 Years to 35 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Subjective Tinnitus
Interventions: rTMS; Device
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 18 Years to 60 Years
Enrollment: 55 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2011
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Functional Gastrointestinal Disorders
Interventions: Active Auricular Neurostimulation, Sham Auricular Neurostimulation; Device
Lead sponsor: Medical College of Wisconsin; Other
Eligibility: 11 Years to 18 Years
Enrollment: 109 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: Milwaukee, Wisconsin

Conditions: Opioid-use Disorder
Interventions: Transcranial Alternating Current Stimulation (tACS); Device
Lead sponsor: Laureate Institute for Brain Research, Inc.; Other
Eligibility: 18 Years to 61 Years · Male only
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Tulsa, Oklahoma

Conditions: Mild Dementia, Aging Well
Interventions: Neurolith Transcranial Pulse Stimulation Active, Neurolith Transcranial Pulse Stimulation Sham; Device
Lead sponsor: University of Florida; Other
Eligibility: 65 Years to 84 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Gastroesophageal Reflux Disease (GERD), Reflux, Gastroesophageal, Gastroesophageal Reflux, Acid Reflux
Interventions: Laparoscopic implantation surgery with or without crural repair, EndoStim stimulation for first six months of study, EndoStim stimulation from Month 6 thru end of study, Sham EndoStim stimulation for first six months of study; Procedure · Device
Lead sponsor: EndoStim Inc.; Industry
Eligibility: 22 Years to 75 Years
Enrollment: 161 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 18
States / cities: Phoenix, Arizona • Scottsdale, Arizona • Los Angeles, California + 13 more

Conditions: Multiple Sclerosis
Interventions: transcranial direct current stimulation or SHAM; Device
Lead sponsor: University of Iowa; Other
Eligibility: 18 Years to 70 Years
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Pediatric Obesity
Interventions: Pro2 - 75% of participant's MIP, Pro2 - 15% of participant's MIP; Device
Lead sponsor: Duke University; Other
Eligibility: 8 Years to 17 Years
Enrollment: 27 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Restless Legs Syndrome
Interventions: NTX100 Neuromodulation System - Active, NTX100 Neuromodulation System - Sham, NTX100 Neuromodulation System - Open-Label; Device
Lead sponsor: Noctrix Health, Inc.; Industry
Eligibility: 22 Years to 79 Years
Enrollment: 133 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 7
States / cities: San Leandro, California • Colorado Springs, Colorado • Atlanta, Georgia + 4 more

Conditions: Cluster Headache
Interventions: GammaCore, Sham GammaCore device; Device
Lead sponsor: ElectroCore INC; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 20
States / cities: Santa Monica, California • Stanford, California • Englewood, Colorado + 17 more

Conditions: Keratoconus
Interventions: The VEGA UV-A Illumination System, Riboflavin; Device · Drug
Lead sponsor: Topcon Medical Systems, Inc.; Industry
Eligibility: 12 Years and older
Enrollment: 127 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 9
States / cities: Phoenix, Arizona • Atlanta, Georgia • Bloomington, Minnesota + 4 more

Conditions: Unipolar Depression, Bipolar Depression
Interventions: Sham tDCS device, Soterix tDCS device; Device
Lead sponsor: The University of New South Wales; Other
Eligibility: 18 Years and older
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 5
States / cities: Atlanta, Georgia • Towson, Maryland • Cherry Hill, New Jersey + 2 more

Conditions: Aging
Interventions: Ultrasound spa, Sham ultrasound spa; Device · Other
Lead sponsor: The University of Texas Health Science Center at San Antonio; Other
Eligibility: 70 Years and older
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: San Antonio, Texas

Conditions: Healthy Adults, Mechanical Ventilation Dependence, Hypoxia, Exercise Training, Exercise Intolerance, Dietary Supplement, Nitrate Supplementation, Inspiratory Muscle Training
Interventions: Respiratory Muscle Training (RMT), Sham Respiratory Muscle Training, Dietary Supplement: Beetroot Juice Concentrate, placebo beverage; Device · Dietary Supplement
Lead sponsor: Embry-Riddle Aeronautical University; Other
Eligibility: 18 Years to 40 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Daytona Beach, Florida

Conditions: Nicotine Use Disorder, Substance Use Disorders
Interventions: TI-NDBS, Sham TI-NDBS; Device
Lead sponsor: Indiana University; Other
Eligibility: 21 Years to 50 Years
Enrollment: 120 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 2
States / cities: Bloomington, Indiana • Indianapolis, Indiana

Conditions: Chronic Pain
Interventions: rTMS, Sham device; Device
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 70 Years
Enrollment: 17 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Vertigo, Dizziness, Nausea, Balance
Interventions: Transcranial vibrating system, Transcranial vibrating system sham; Device
Lead sponsor: Otolith Labs; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019
U.S. locations: 2
States / cities: Rockville, Maryland

Conditions: Migraine, Patent Foramen Ovale, PFO - Patent Foramen Ovale
Interventions: Actual device PFO closure, Thienopyridine (clopidogrel or prasugrel), Sham device PFO closure; Device · Drug
Lead sponsor: W.L.Gore & Associates; Industry
Eligibility: 18 Years to 55 Years
Enrollment: 7 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2024
U.S. locations: 15
States / cities: Phoenix, Arizona • Los Angeles, California • Santa Barbara, California + 11 more

Conditions: Pain, Chronic, Failed Back Surgery Syndrome
Interventions: Burst-SCS, Sham SCS; Device
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years and older
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Major Depressive Disorder, Anhedonia
Interventions: Cross-frequency transcranial alternating current stimulation via the NeuroConn Direct Current Stimulator Plus; Device
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Years to 65 Years
Enrollment: 35 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Postpartum Depression (PPD)
Interventions: SAINT Neuromodulation System, Sham SAINT Stimulation; Device
Lead sponsor: Magnus Medical; Industry
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 192 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2029
U.S. locations: 4
States / cities: Worcester, Massachusetts • New York, New York • Charleston, South Carolina + 1 more

Search by objective public record fields.

Percutaneous Auricular Neuromodulation for Postoperative Analgesia

Brain and Cognitive Changes After Reasoning Training in Individuals With Mild Cognitive Impairment

Pedal Pump Clinical Trial on Edema V2

Effectiveness of Fascia Iliaca Nerve Block for Post Hip Arthroscopy

Collaborative Tinnitus Research at Washington University

Defining Adolescent Nausea Through Brain Imaging and Neurostimulation Response

Frontoparietal Synchronization to Modulate Drug Craving in Opioid Use Disorder

Transcranial Pulse Stimulation of the Brain

An Investigation of the EndoStim® Lower Esophageal Sphincter (LES) Stimulation System for the Treatment of Reflux

tDCS and Glucose Uptake in Leg Muscles

Inspiratory Muscle Rehabilitation in Children With Obesity

Noninvasive Peripheral Nerve Stimulation for Medication-Refractory Primary RLS (The RESTFUL Study)

Non-invasive Neurostimulation of the Vagus Nerve for the Treatment of Cluster Headache

Safety Study of the VEGA UV-A System to Treat Keratoconus

Investigating tDCS as a Treatment for Unipolar and Bipolar Depression

Ultrasound for Healthy Aging

Effects of Breathing Training and Nitrate on Exercise at Simulated Altitude

Temporal Interference Methods for Addiction Treatment

rTMS for the Treatment of Chronic Pain in GW1 Veterans

Transcranial Vibrating System for Improving Vestibular Physical Therapy

GORE® CARDIOFORM Septal Occluder Migraine Clinical Study

Burst Spinal Cord Stimulation (Burst-SCS) Study

Investigating the Causal Role of Prefrontal Control in Decision-making in Patients With Anhedonia

SAINT in Postpartum Depression (PPD)