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ClinicalTrials.gov public records Last synced Oct 8, 2026, 5:59 AM EDT

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Showing 49–72 of 136 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Silicone Hydrogel Contact Lens Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparison of a Silicone Hydrogel Daily Disposable Multifocal Contact Lens to a Marketed Product

NCT05258149
View directory record Official record
Conditions
Visual Acuity
Interventions
JJVC Investigational Multifocal Contact Lenses, Dailies Total 1® Multifocal Contact Lenses
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
40 Years to 70 Years
Enrollment
143 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
12
States / cities
Jacksonville, Florida • Longwood, Florida • Maitland, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated May 19, 2023 · Synced Oct 8, 2026, 5:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Performance Evaluation of Two Silicone Hydrogel Toric Lens Designs in Habitual Soft Contact Lens Wearers

NCT05933772
View directory record Official record
Conditions
Astigmatism
Interventions
Lens A (comfilcon A toric lens), Lens B (lehfilcon A toric lens)
Device
Lead sponsor
CooperVision International Limited (CVIL)
Industry
Eligibility
18 Years to 39 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
3
States / cities
Pittsburg, Kansas • Vestal, New York • Granville, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 11, 2025 · Synced Oct 8, 2026, 5:59 AM EDT
Completed Not applicable Interventional Results available

Clinical Validation of DACP Digital Design

NCT03567005
View directory record Official record
Conditions
Refractive Errors
Interventions
Nelfilcon A digital contact lenses, Nelfilcon A contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years to 35 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
5
States / cities
Bloomington, Illinois • Powell, Ohio • Brentwood, Tennessee + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 18, 2019 · Synced Oct 8, 2026, 5:59 AM EDT
Completed Not applicable Interventional Results available

Product Performance of a New Silicone Hydrogel Contact Lens

NCT04901897
View directory record Official record
Conditions
Myopia
Interventions
kalifilcon A, delefilcon A, senofilcon A
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years to 40 Years
Enrollment
805 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
35
States / cities
Birmingham, Alabama • Scottsdale, Arizona • Azusa, California + 31 more
Source: ClinicalTrials.gov public record
Updated Jul 8, 2021 · Synced Oct 8, 2026, 5:59 AM EDT
Completed Not applicable Interventional Results available

Evaluation of Investigational (Frequent Replacement) FRP Lens for Daily Wear

NCT02362724
View directory record Official record
Conditions
Ametropia
Interventions
Sapphire, Pearl
Device
Lead sponsor
CooperVision, Inc.
Industry
Eligibility
18 Years and older
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
6
States / cities
San Diego, California • Torrance, California • Denver, North Carolina + 3 more
Source: ClinicalTrials.gov public record
Updated Oct 14, 2020 · Synced Oct 8, 2026, 5:59 AM EDT
Completed Not applicable Interventional Results available

Clinical Performance of Two Commercial, Daily Disposable Contact Lenses

NCT05010512
View directory record Official record
Conditions
Refractive Errors, Ametropia, Myopia
Interventions
Delefilcon A contact lenses, Kalifilcon A contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
112 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
8
States / cities
Orlando, Florida • Tallahassee, Florida • Bloomington, Illinois + 4 more
Source: ClinicalTrials.gov public record
Updated Nov 8, 2022 · Synced Oct 8, 2026, 5:59 AM EDT
Completed Not applicable Interventional Results available

Clinical Assessment of Two Reusable Silicone Hydrogel Contact Lenses

NCT05050578
View directory record Official record
Conditions
Refractive Errors
Interventions
Lehfilcon A contact lenses, Senofilcon A contact lenses, CLEAR CARE
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
166 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
10
States / cities
Oakland, California • San Francisco, California • Longwood, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated Mar 16, 2023 · Synced Oct 8, 2026, 5:59 AM EDT
Not yet recruiting Not applicable Interventional

Evaluation of Two Monthly Silicone Hydrogel Multifocal Toric in Soft Contact Lens Wearers

NCT07829419
View directory record Official record
Conditions
Astigmatism, Myopia
Interventions
Lens A ( comfilcon A), Lens B ( lehfilcon A)
Device
Lead sponsor
CooperVision International Limited (CVIL)
Industry
Eligibility
40 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
3
States / cities
New York, New York • Granville, Ohio • Corpus Christi, Texas
Source: ClinicalTrials.gov public record
Updated Sep 21, 2026 · Synced Oct 8, 2026, 5:59 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Clinical Performance of Verofilcon A Toric Contact Lenses

NCT07586982
View directory record Official record
Conditions
Contact Lenses, Presbyopia
Interventions
Total 30 multi foric contact lenses
Device
Lead sponsor
Southern College of Optometry
Other
Eligibility
18 Years to 40 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Oct 8, 2026, 5:59 AM EDT
Completed Not applicable Interventional

Clinical Performance Evaluation of Two Daily Disposable Silicone Hydrogel Toric Contact Lenses

NCT04254003
View directory record Official record
Conditions
Refractive Errors
Interventions
DT1 Toric contact lenses, AO1DfA contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
2
States / cities
Maitland, Florida • Eden Prairie, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 18, 2020 · Synced Oct 8, 2026, 5:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of Enfilcon A Soft Contact Lens When Compared to Galyfilcon A Soft Contact Lens

NCT01706770
View directory record Official record
Conditions
Ametropia
Interventions
enfilcon A, galyfilcon A
Device
Lead sponsor
CooperVision, Inc.
Industry
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
3
States / cities
Pismo Beach, California • San Diego, California • East Lansing, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 5, 2020 · Synced Oct 8, 2026, 5:59 AM EDT
Completed Not applicable Interventional Results available

Assessment of an Investigational Frequent Replacement Silicone Hydrogel Lens

NCT04085328
View directory record Official record
Conditions
Refractive Ametropia
Interventions
LID015385 soft contact lenses, Comfilcon A soft contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
675 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
42
States / cities
Campbell, California • Fullerton, California • Los Angeles, California + 34 more
Source: ClinicalTrials.gov public record
Updated Jun 13, 2023 · Synced Oct 8, 2026, 5:59 AM EDT
Completed Not applicable Interventional Results available

A Bilateral Dispensing Clinical Trial of Sapphire Lens Against Senofilcon A Lens Over 2 Weeks

NCT02345811
View directory record Official record
Conditions
Myopia, Hyperopia
Interventions
Sapphire, senofilcon A
Device
Lead sponsor
CooperVision, Inc.
Industry
Eligibility
17 Years and older
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Berkeley, California
Source: ClinicalTrials.gov public record
Updated Sep 16, 2020 · Synced Oct 8, 2026, 5:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Corneal Barrier Function With Multi-Purpose Solutions

NCT00407238
View directory record Official record
Conditions
Contact Lens Care
Interventions
Multi-purpose solutions (polyquaternium-1 and PHMB)
Device
Lead sponsor
Southern California College of Optometry at Marshall B. Ketchum University
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2007
U.S. locations
1
States / cities
Fullerton, California
Source: ClinicalTrials.gov public record
Updated Oct 23, 2007 · Synced Oct 8, 2026, 5:59 AM EDT
Completed Not applicable Interventional

A Safety and Effectiveness Study of a New Multi-Purpose Contact Lens Care Solution

NCT03537248
View directory record Official record
Conditions
Contact Lens Wear
Interventions
ASP-57, ReNu® Multiplus
Device
Lead sponsor
Asepticys LLC
Industry
Eligibility
18 Years and older
Enrollment
315 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
14
States / cities
Irvine, California • San Diego, California • Longwood, Florida + 11 more
Source: ClinicalTrials.gov public record
Updated Feb 11, 2019 · Synced Oct 8, 2026, 5:59 AM EDT
Completed Not applicable Interventional Results available

Clinical Assessment of a HYDRAGLYDE® Regimen

NCT03026257
View directory record Official record
Conditions
Refractive Errors, Myopia, Hypermetropia
Interventions
Lotrafilcon B contact lenses with added wetting agent, Samfilcon A contact lenses, POLYQUAD/ALDOX-preserved contact lens solution with added wetting agent, Hydrogen peroxide-based contact lens solution with added wetting agent, Senofilcon C contact lenses, Senofilcon A contact lenses, Comfilcon A contact lenses, Habitual Multi-Purpose Solution (HMPS)
Device
Lead sponsor
Alcon, a Novartis Company
Industry
Eligibility
18 Years and older
Enrollment
323 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
5
States / cities
Birmingham, Alabama • Cleveland, Ohio • Columbus, Ohio + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 14, 2018 · Synced Oct 8, 2026, 5:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Assessment of a Daily Disposable Soft Silicone Hydrogel Contact Lens

NCT06044948
View directory record Official record
Conditions
Refractive Errors
Interventions
Delefilcon A contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
97 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
6
States / cities
Tallahassee, Florida • Eden Prairie, Minnesota • Garner, North Carolina + 3 more
Source: ClinicalTrials.gov public record
Updated Nov 20, 2024 · Synced Oct 8, 2026, 5:59 AM EDT
Completed No phase listed Observational

Air Optix® Night and Day® Aqua Daily Wear

NCT05976750
View directory record Official record
Conditions
Refractive Errors, Myopia, Hyperopia
Interventions
Lotrafilcon A contact lenses, Balafilcon A contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Aug 9, 2024 · Synced Oct 8, 2026, 5:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of Dryness in a Silicone Hydrogel Daily Disposable Contact Lens

NCT04849780
View directory record Official record
Conditions
Visual Acuity
Interventions
ACUVUE Oasys 1-Day, Habitual Lens
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 59 Years
Enrollment
95 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
9
States / cities
Jacksonville, Florida • Longwood, Florida • Maitland, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated Oct 10, 2022 · Synced Oct 8, 2026, 5:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of a New Silicone Hydrogel Contact Lens

NCT01309880
View directory record Official record
Conditions
Myopia
Interventions
Test lens, Air Optix Aqua
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Feb 23, 2015 · Synced Oct 8, 2026, 5:59 AM EDT
Completed Not applicable Interventional Results available

Pilot Evaluation of a New Galyfilcon A Contact Lens Compared to a Marketed Galyfilcon A Contact Lens

NCT01094730
View directory record Official record
Conditions
Myopia
Interventions
galyfilcon A prototype lens, marketed galyfilcon A lens
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 39 Years
Enrollment
185 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
9
States / cities
Cupertino, California • Huntington Beach, California • Los Angeles, California + 6 more
Source: ClinicalTrials.gov public record
Updated Jun 19, 2018 · Synced Oct 8, 2026, 5:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Comparison of 12 Month Daily Wear of Two Novel O2 Permeable Silicone Hydrogel CLs (HOP/SiH) and A Control, Standard O2 Lens

NCT00344643
View directory record Official record
Conditions
Contact Lenses, Extended-Wear
Interventions
Silicone Hydrogel Soft Contact Lenses
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 38 Years
Enrollment
187 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2006
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jun 23, 2008 · Synced Oct 8, 2026, 5:59 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Daily Wear Corneal Infiltrative Event Study

NCT00937105
View directory record Official record
Conditions
Myopia, Hyperopia, Corneal Infiltrative Events
Interventions
lotrafilcon A contact lenses, Renu Multiplus, Clear Care
Device
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
15 Years and older
Enrollment
218 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 10, 2014 · Synced Oct 8, 2026, 5:59 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Longitudinal Evaluation of Silicone Hydrogel (LASH) Study

NCT00727402
View directory record Official record
Conditions
Corneal Infiltrates
Interventions
Not listed
Lead sponsor
National Eye Institute (NEI)
NIH
Eligibility
15 Years and older
Enrollment
205 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2009
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 15, 2012 · Synced Oct 8, 2026, 5:59 AM EDT