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ClinicalTrials.gov public records Last synced Oct 9, 2026, 4:14 PM EDT

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Showing 97–120 of 136 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Silicone Hydrogel Contact Lens Clear all
Completed Not applicable Interventional Results available

Subjective Comfort With Multipurpose Care Solutions in Soft Contact Lens Wearers

NCT01211535
View directory record Official record
Conditions
Myopia, Astigmatism, Refractive Error
Interventions
OPTI-FREE RepleniSH multipurpose solution, ReNu Biotrue multipurpose solution, Silicone hydrogel contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Nov 12, 2012 · Synced Oct 9, 2026, 4:14 PM EDT
Completed Not applicable Interventional Results available

Performance Comparison of Two Monthly Replacement Silicone Hydrogel Multifocal Lens Types

NCT06232590
View directory record Official record
Conditions
Presbyopia
Interventions
Control Lens (comfilcon A), Test Lens (lehfilcon A)
Device
Lead sponsor
CooperVision International Limited (CVIL)
Industry
Eligibility
42 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
4
States / cities
Medina, Minnesota • Vestal, New York • Granville, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 12, 2025 · Synced Oct 9, 2026, 4:14 PM EDT
Completed Not applicable Interventional Results available

Clinical Performance Evaluation of Two Frequent Replacement Silicone Hydrogel Multifocal Toric Contact Lenses

NCT06461455
View directory record Official record
Conditions
Presbyopia, Astigmatism
Interventions
Lehfilcon A multifocal for astigmatism contact lenses, Samfilcon A multifocal for astigmatism contact lenses, CLEAR CARE® Cleaning & Disinfecting Solution
Device
Lead sponsor
Alcon Research
Industry
Eligibility
40 Years and older
Enrollment
95 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
11
States / cities
Oakland, California • San Francisco, California • Maitland, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated Dec 24, 2025 · Synced Oct 9, 2026, 4:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of a New Silicone Hydrogel Contact Lens

NCT01309880
View directory record Official record
Conditions
Myopia
Interventions
Test lens, Air Optix Aqua
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Feb 23, 2015 · Synced Oct 9, 2026, 4:14 PM EDT
Completed No phase listed Observational

Air Optix Night and Day Aqua (AONDA) Retrospective Study 1

NCT05790928
View directory record Official record
Conditions
Refractive Ametropia, Hyperopia, Myopia
Interventions
Lotrafilcon A spherical contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
108 participants
Timeline
2023
U.S. locations
4
States / cities
Tallahassee, Florida • Franklin Park, Illinois • Eden Prairie, Minnesota + 1 more
Source: ClinicalTrials.gov public record
Updated May 25, 2023 · Synced Oct 9, 2026, 4:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Evaluation of Two Silicone Hydrogel Daily Disposable Contact Lenses

NCT02595502
View directory record Official record
Conditions
Vision Disorders
Interventions
JJVC Marketed Contact Lens (Test), Competitor Marketed Contact Lens (Control)
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 39 Years
Enrollment
286 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
13
States / cities
Montgomery, Alabama • Fruit Cove, Florida • Sarasota, Florida + 10 more
Source: ClinicalTrials.gov public record
Updated Jul 5, 2017 · Synced Oct 9, 2026, 4:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of A Marketed Silicone Hydrogel Spherical Lens Used for Monovision Correction of Presbyopia

NCT04073186
View directory record Official record
Conditions
Visual Acuity
Interventions
ACUVUE® OASYS with Transitions™
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
40 Years to 70 Years
Enrollment
91 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
5
States / cities
Jacksonville, Florida • Raytown, Missouri • New York, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 10, 2022 · Synced Oct 9, 2026, 4:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Validation of Senofilcon A With New UV / HEV Filter

NCT05099380
View directory record Official record
Conditions
Visual Acuity
Interventions
senofilcon A C3, senofilcon A
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 39 Years
Enrollment
296 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
17
States / cities
Cupertino, California • San Francisco, California • Jacksonville, Florida + 14 more
Source: ClinicalTrials.gov public record
Updated Feb 6, 2023 · Synced Oct 9, 2026, 4:14 PM EDT
Completed Not applicable Interventional Results available

Effect of FID 114675A on Lens Wettability

NCT01342107
View directory record Official record
Conditions
Contact Lens Wettability
Interventions
FID 114675A multi-purpose disinfecting solution (MPDS), Soft contact lens, Blister pack solution
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Apr 13, 2012 · Synced Oct 9, 2026, 4:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Safety and Efficacy of an Investigational Multi-Purpose Disinfecting Solution

NCT01341977
View directory record Official record
Conditions
Healthy Contact Lens Wearers
Interventions
Alcon MPDS, ReNu Fresh MPS
Device
Lead sponsor
Alcon Research
Industry
Eligibility
Not listed
Enrollment
573 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Sep 23, 2020 · Synced Oct 9, 2026, 4:14 PM EDT
Completed Not applicable Interventional Results available

Clinical Performance of a Monthly Replacement Silicone Hydrogel Lens

NCT03586167
View directory record Official record
Conditions
Refractive Errors
Interventions
LID014341 contact lenses, Comfilcon A contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
4
States / cities
Maitland, Florida • Johns Creek, Georgia • Bloomington, Illinois + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 30, 2021 · Synced Oct 9, 2026, 4:14 PM EDT
Completed Not applicable Interventional Results available

Clinical Assessment of Two Reusable Silicone Hydrogel Contact Lenses

NCT05050578
View directory record Official record
Conditions
Refractive Errors
Interventions
Lehfilcon A contact lenses, Senofilcon A contact lenses, CLEAR CARE
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
166 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
10
States / cities
Oakland, California • San Francisco, California • Longwood, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated Mar 16, 2023 · Synced Oct 9, 2026, 4:14 PM EDT
Completed Not applicable Interventional Results available

Pilot Evaluation of a New Galyfilcon A Contact Lens Compared to a Marketed Galyfilcon A Contact Lens

NCT01094730
View directory record Official record
Conditions
Myopia
Interventions
galyfilcon A prototype lens, marketed galyfilcon A lens
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 39 Years
Enrollment
185 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
9
States / cities
Cupertino, California • Huntington Beach, California • Los Angeles, California + 6 more
Source: ClinicalTrials.gov public record
Updated Jun 19, 2018 · Synced Oct 9, 2026, 4:14 PM EDT
Completed No phase listed Observational

Air Optix Daily Wear Contact Lenses

NCT05827224
View directory record Official record
Conditions
Refractive Errors
Interventions
Lotrafilcon B spherical soft contact lenses, Lotrafilcon B spherical soft contact lenses with comfort additive, Lotrafilcon B toric soft contact lenses with comfort additive, Comfilcon A spherical soft contact lenses, Comfilcon A toric soft contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
312 participants
Timeline
2023 – 2024
U.S. locations
5
States / cities
Orlando, Florida • Medina, Minnesota • St Louis, Missouri + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 15, 2024 · Synced Oct 9, 2026, 4:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of a Daily Disposable Silicone Hydrogel Multifocal Contact Lens in Myopes and Hyperopes

NCT05222880
View directory record Official record
Conditions
Visual Acuity
Interventions
JJVC Investigational Multifocal Contact Lenses manufactured in senofilcon A C3
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
40 Years to 70 Years
Enrollment
140 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
12
States / cities
Jacksonville, Florida • Maitland, Florida • Tallahassee, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated Apr 13, 2023 · Synced Oct 9, 2026, 4:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of the Clinical Performance of Daily Disposable Silicone Hydrogel Multifocal Toric Contact Lenses

NCT06377488
View directory record Official record
Conditions
Visual Acuity
Interventions
JJVC Investigational Multifocal Toric Contact Lens manufactured in Senofilcon A (C3) material with UV blocker / HEV filter
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
40 Years to 70 Years
Enrollment
176 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
15
States / cities
Jacksonville, Florida • Longwood, Florida • Maitland, Florida + 11 more
Source: ClinicalTrials.gov public record
Updated Oct 28, 2025 · Synced Oct 9, 2026, 4:14 PM EDT
Completed Not applicable Interventional Results available

Comparative In-Vivo Wetting Characteristics of Silicone Hydrogel Materials With Selected Lens Care Systems

NCT01699750
View directory record Official record
Conditions
Myopia, Astigmatism, Refractive Error
Interventions
Lotrafilcon B contact lenses, Senofilcon A contact lenses, OPTI-FREE® PUREMOIST® MPDS, BIOTRUE®, Balafilcon A contact lenses, ReNu® Multiplus®
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
109 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Dec 8, 2014 · Synced Oct 9, 2026, 4:14 PM EDT
Completed Not applicable Interventional Results available

A Study to Evaluate the Product Feasibility of a New Silicone Hydrogel Contact Lens

NCT01412983
View directory record Official record
Conditions
Myopia
Interventions
Bausch & Lomb Test lens, Ciba Vision soft contact lens
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Apr 29, 2014 · Synced Oct 9, 2026, 4:14 PM EDT
Completed Not applicable Interventional Results available

A Safety and Effectiveness Study of a New Contact Lens Cleaning and Disinfecting Solution

NCT02701556
View directory record Official record
Conditions
Contact Lens Wear
Interventions
Complete MPS, NNR06
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years and older
Enrollment
396 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Pittsburg, Kansas
Source: ClinicalTrials.gov public record
Updated Feb 8, 2022 · Synced Oct 9, 2026, 4:14 PM EDT
Completed Not applicable Interventional Results available

Effect of an Investigational Multi-Purpose Solution on Lens Moisture

NCT01341990
View directory record Official record
Conditions
Contact Lens Moisture
Interventions
FID 114675A Multi-Purpose Disinfecting Solution (MPDS), ReNu Fresh Lens Comfort Multi-Purpose Solution (MPS), Silicone Hydrogel Contact Lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Apr 13, 2012 · Synced Oct 9, 2026, 4:14 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Daily Wear Corneal Infiltrative Event Study

NCT00937105
View directory record Official record
Conditions
Myopia, Hyperopia, Corneal Infiltrative Events
Interventions
lotrafilcon A contact lenses, Renu Multiplus, Clear Care
Device
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
15 Years and older
Enrollment
218 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 10, 2014 · Synced Oct 9, 2026, 4:14 PM EDT
Completed Not applicable Interventional Results available

Feasibility of a New Silicone Hydrogel Lens

NCT01131130
View directory record Official record
Conditions
Myopia
Interventions
Investigational contact lens, Acuvue Oasys Contact Lens, Air Optix Aqua
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Apr 30, 2014 · Synced Oct 9, 2026, 4:14 PM EDT
Completed Not applicable Interventional Results available

The Clinical Performance of Two Reusable Silicone Hydrogel Contact Lenses

NCT05766787
View directory record Official record
Conditions
Refractive Ametropia
Interventions
Serafilcon A contact lenses, Senofilcon A contact lenses, CLEAR CARE
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
190 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
15
States / cities
Los Angeles, California • Oakland, California • San Francisco, California + 11 more
Source: ClinicalTrials.gov public record
Updated Jun 13, 2024 · Synced Oct 9, 2026, 4:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of a Reusable Silicone Hydrogel Multifocal Contact Lens

NCT04189224
View directory record Official record
Conditions
Presbyopia
Interventions
JJV Investigational Multifocal Contact Lens, 1-Day Acuvue® Moist Brand Multifocal Contact Lens
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
40 Years to 70 Years
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
4
States / cities
Maitland, Florida • Raytown, Missouri • Granville, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 27, 2025 · Synced Oct 9, 2026, 4:14 PM EDT