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ClinicalTrials.gov public records Last synced Oct 7, 2026, 4:08 AM EDT

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Showing 25–48 of 136 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Silicone hydrogel contact lenses Clear all
Completed Not applicable Interventional Results available

Clinical Evaluation of Two Daily Disposable Lenses in Neophytes

NCT00987623
View directory record Official record
Conditions
Myopia
Interventions
nelfilcon A contact lens, narafilcon A contact lens
Device
Lead sponsor
CIBA VISION
Industry
Eligibility
Up to 45 Years
Enrollment
326 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Fort Washington, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 10, 2012 · Synced Oct 7, 2026, 4:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of Enfilcon A Soft Contact Lens When Compared to Galyfilcon A Soft Contact Lens

NCT01706770
View directory record Official record
Conditions
Ametropia
Interventions
enfilcon A, galyfilcon A
Device
Lead sponsor
CooperVision, Inc.
Industry
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
3
States / cities
Pismo Beach, California • San Diego, California • East Lansing, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 5, 2020 · Synced Oct 7, 2026, 4:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of a New Silicone Hydrogel Contact Lens

NCT01309880
View directory record Official record
Conditions
Myopia
Interventions
Test lens, Air Optix Aqua
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Feb 23, 2015 · Synced Oct 7, 2026, 4:08 AM EDT
Completed Not applicable Interventional Results available

Clinical Performance Assessment of a Daily Wear Monthly Replacement Soft Silicone Hydrogel Contact Lens

NCT04055519
View directory record Official record
Conditions
Refractive Errors
Interventions
Lehfilcon A contact lenses, Comfilcon A contact lenses, Multi-purpose disinfection solution
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
3
States / cities
Maitland, Florida • Bloomington, Illinois • Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated May 13, 2021 · Synced Oct 7, 2026, 4:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Silicone Hydrogel Soft Contact Lens 7-Day Extended Wear Basis

NCT02939950
View directory record Official record
Conditions
Myopia
Interventions
Bausch + Lomb Samfilcon A Soft Contact Lens, Bausch + Lomb Pure Vision Soft Contact Lens
Device
Lead sponsor
Bausch Health Americas, Inc.
Industry
Eligibility
18 Years to 40 Years
Enrollment
816 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Cicero, New York
Source: ClinicalTrials.gov public record
Updated Dec 23, 2019 · Synced Oct 7, 2026, 4:08 AM EDT
Completed Not applicable Interventional Results available

Clinical Evaluation of Stenfilcon A Soft Contact Lens When Compared to Ocufilcon B Soft Contact Lens

NCT01354223
View directory record Official record
Conditions
Myopia
Interventions
stenfilcon A contact lens, ocufilcon B contact lens
Device
Lead sponsor
CooperVision, Inc.
Industry
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
4
States / cities
San Diego, California • East Lansing, Michigan • Beachwood, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 29, 2020 · Synced Oct 7, 2026, 4:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of A Marketed Silicone Hydrogel Spherical Lens Used for Monovision Correction of Presbyopia

NCT04073186
View directory record Official record
Conditions
Visual Acuity
Interventions
ACUVUE® OASYS with Transitions™
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
40 Years to 70 Years
Enrollment
91 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
5
States / cities
Jacksonville, Florida • Raytown, Missouri • New York, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 10, 2022 · Synced Oct 7, 2026, 4:08 AM EDT
Completed Not applicable Interventional Results available

Clinical Assessment of a Daily Wear Monthly Replacement Soft Silicone Hydrogel Contact Lens

NCT04476784
View directory record Official record
Conditions
Myopia
Interventions
Lehfilcon A contact lenses, Comfilcon A contact lenses, CLEAR CARE
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
5
States / cities
Maitland, Florida • Bloomington, Illinois • Pittsburg, Kansas + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 26, 2021 · Synced Oct 7, 2026, 4:08 AM EDT
Completed No phase listed Observational

Air Optix® Night and Day® Aqua Daily Wear

NCT05976750
View directory record Official record
Conditions
Refractive Errors, Myopia, Hyperopia
Interventions
Lotrafilcon A contact lenses, Balafilcon A contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Aug 9, 2024 · Synced Oct 7, 2026, 4:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Central Corneal Swelling With Silicone Hydrogel Materials

NCT02328937
View directory record Official record
Conditions
Corneal Swelling
Interventions
etafilcon A, lotrafilcon B, comfilcon A
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 19, 2018 · Synced Oct 7, 2026, 4:08 AM EDT
Completed Not applicable Interventional Results available

Assessment of Daily Disposable Silicone Hydrogel Lens Wear

NCT01093625
View directory record Official record
Conditions
Myopia
Interventions
Narafilcon B Contact Lens, Spectacles
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
15 Years to 39 Years
Enrollment
157 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 19, 2018 · Synced Oct 7, 2026, 4:08 AM EDT
Not yet recruiting Not applicable Interventional

Evaluation of Two Monthly Silicone Hydrogel Multifocal Toric in Soft Contact Lens Wearers

NCT07829419
View directory record Official record
Conditions
Astigmatism, Myopia
Interventions
Lens A ( comfilcon A), Lens B ( lehfilcon A)
Device
Lead sponsor
CooperVision International Limited (CVIL)
Industry
Eligibility
40 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
3
States / cities
New York, New York • Granville, Ohio • Corpus Christi, Texas
Source: ClinicalTrials.gov public record
Updated Sep 21, 2026 · Synced Oct 7, 2026, 4:08 AM EDT
Completed Not applicable Interventional Results available

Lens Wearing Experience and Biocompatibility of a Multi-Purpose Disinfecting Solution (MPDS)

NCT01476722
View directory record Official record
Conditions
Healthy
Interventions
OPTI-FREE PureMoist multipurpose disinfecting solution
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Nov 19, 2012 · Synced Oct 7, 2026, 4:08 AM EDT
Completed Not applicable Interventional Results available

Pilot Evaluation of a New Galyfilcon A Contact Lens Compared to a Marketed Galyfilcon A Contact Lens

NCT01094730
View directory record Official record
Conditions
Myopia
Interventions
galyfilcon A prototype lens, marketed galyfilcon A lens
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 39 Years
Enrollment
185 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
9
States / cities
Cupertino, California • Huntington Beach, California • Los Angeles, California + 6 more
Source: ClinicalTrials.gov public record
Updated Jun 19, 2018 · Synced Oct 7, 2026, 4:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Study to Evaluate the Safety and Effectiveness of a Silicone Hydrogel Custom Contact Lens When Compared to Alden Optical HP Sphere Lens

NCT03897712
View directory record Official record
Conditions
Contact Lens Wear
Interventions
Custom Samfilcon B Contact Lenses, Alden Optical HP Sphere Contact Lens, ReNu MultiPlus Lubricating and Rewetting Drops, Biotrue Multi-Purpose Solution
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years to 40 Years
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
7
States / cities
San Francisco, California • Denver, Colorado • Sarasota, Florida + 4 more
Source: ClinicalTrials.gov public record
Updated Nov 14, 2022 · Synced Oct 7, 2026, 4:08 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Assessing Patient Comfort With Two Different Multi-Purpose Disinfecting Solutions

NCT01847105
View directory record Official record
Conditions
Contact Lens Solution Toxicity
Interventions
RevitaLens, OptiFree PureMoist
Other
Lead sponsor
Hom, Milton M., OD, FAAO
Individual
Eligibility
18 Years and older
Enrollment
54 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
3
States / cities
Azusa, California • Morrow, Georgia • Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated May 29, 2013 · Synced Oct 7, 2026, 4:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Safety and Efficacy of an Investigational Multi-Purpose Disinfecting Solution

NCT01341977
View directory record Official record
Conditions
Healthy Contact Lens Wearers
Interventions
Alcon MPDS, ReNu Fresh MPS
Device
Lead sponsor
Alcon Research
Industry
Eligibility
Not listed
Enrollment
573 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Sep 23, 2020 · Synced Oct 7, 2026, 4:08 AM EDT
Completed Not applicable Interventional Results available

Lens Wearing Experience and Biocompatibility of a Marketed Multi-Purpose Disinfecting Solution in Silicone Hydrogel and Soft Contact Lens Wearers

NCT01484938
View directory record Official record
Conditions
Refractive Error
Interventions
OPTI-FREE PureMoist
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
175 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Oct 10, 2012 · Synced Oct 7, 2026, 4:08 AM EDT
Completed Not applicable Interventional Results available

Clinical Evaluation of a Daily Wear Monthly Replacement Silicone Hydrogel Lens

NCT04178720
View directory record Official record
Conditions
Refractive Errors
Interventions
Lehfilcon A contact lenses, Comfilcon A contact lenses, CLEAR CARE
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
119 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
8
States / cities
Longwood, Florida • Maitland, Florida • Orlando, Florida + 4 more
Source: ClinicalTrials.gov public record
Updated Oct 19, 2021 · Synced Oct 7, 2026, 4:08 AM EDT
Completed Not applicable Interventional Results available

Evaluation of Investigational (Frequent Replacement) FRP Lens for Daily Wear

NCT02362724
View directory record Official record
Conditions
Ametropia
Interventions
Sapphire, Pearl
Device
Lead sponsor
CooperVision, Inc.
Industry
Eligibility
18 Years and older
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
6
States / cities
San Diego, California • Torrance, California • Denver, North Carolina + 3 more
Source: ClinicalTrials.gov public record
Updated Oct 14, 2020 · Synced Oct 7, 2026, 4:08 AM EDT
Completed Not applicable Interventional Results available

Comparative In-Vivo Wetting Characteristics of Silicone Hydrogel Materials With Selected Lens Care Systems

NCT01699750
View directory record Official record
Conditions
Myopia, Astigmatism, Refractive Error
Interventions
Lotrafilcon B contact lenses, Senofilcon A contact lenses, OPTI-FREE® PUREMOIST® MPDS, BIOTRUE®, Balafilcon A contact lenses, ReNu® Multiplus®
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
109 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Dec 8, 2014 · Synced Oct 7, 2026, 4:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

DAILIES TOTAL1 Versus ACUVUE TruEye - Effects on the Biology of the Ocular Surface and Lid Margin

NCT02347631
View directory record Official record
Conditions
Soft Contact Lenses, Myopia
Interventions
Soft Contact Lens - Daily Disposable Alcon Dailies Total 1 and ACUVUE TruEye, Soft Contact Lens - Acuvue TruEye and Alcon DAILIES TOTAL 1.
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
21 Years to 38 Years
Enrollment
118 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Dec 10, 2020 · Synced Oct 7, 2026, 4:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparison of Two Toric Contact Lenses on Current Toric Wearers

NCT00639379
View directory record Official record
Conditions
Ametropia
Interventions
senofilcon A toric, alphafilcon A toric
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 45 Years
Enrollment
89 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008
U.S. locations
7
States / cities
Jacksonville, Florida • Orlando, Florida • Morrow, Georgia + 4 more
Source: ClinicalTrials.gov public record
Updated May 21, 2015 · Synced Oct 7, 2026, 4:08 AM EDT
Completed Not applicable Interventional Results available

Pilot Clinical Performance of a Silicone Hydrogel Lens for Up to Six Nights of Extended Wear

NCT04403542
View directory record Official record
Conditions
Refractive Errors, Myopia, Hyperopia
Interventions
Lehfilcon A contact lens, Comfilcon A contact lens
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
3
States / cities
Medina, Minnesota • Granville, Ohio • Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 22, 2023 · Synced Oct 7, 2026, 4:08 AM EDT