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Filters: Intervention: Simulated altitude Clear all

Conditions: Gastrointestinal Injury, Acute Mountain Sickness
Interventions: FP, Placebo, High altitude, Sea level; Dietary Supplement · Other
Lead sponsor: United States Army Research Institute of Environmental Medicine; Federal
Eligibility: 17 Years to 39 Years
Enrollment: 33 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Natick, Massachusetts

Conditions: Trauma, Brain
Interventions: Soccer heading; Behavioral
Lead sponsor: Indiana University; Other
Eligibility: 18 Years to 26 Years
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Bloomington, Indiana

Conditions: Hypoxia, Altitude
Interventions: Cetirizine, Placebo oral capsule, Hypoxia; Drug · Other
Lead sponsor: Indiana University; Other
Eligibility: 18 Years to 35 Years
Enrollment: 13 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Bloomington, Indiana

Conditions: Microvascular Coronary Dysfunction
Interventions: Handgrip, Altitude simulation, Leg exercise; Other
Lead sponsor: Cedars-Sinai Medical Center; Other
Eligibility: 18 Years to 60 Years · Female only
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2030
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Altitude Hypoxia
Interventions: Hypoxic breathing conditions; Other
Lead sponsor: University of Texas, El Paso; Other
Eligibility: 18 Years to 40 Years
Enrollment: 17 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: El Paso, Texas

Conditions: Hypoxia
Interventions: Ketone ester, Placebo; Dietary Supplement · Other
Lead sponsor: Florida Institute for Human and Machine Cognition; Other
Eligibility: 18 Years and older · Male only
Enrollment: 17 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023
U.S. locations: 1
States / cities: Pensacola, Florida

Conditions: Type 2 Diabetes
Interventions: Hypoxico Altitude Training Systems; Device
Lead sponsor: Pennington Biomedical Research Center; Other
Eligibility: 20 Years to 65 Years
Enrollment: 8 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2020
U.S. locations: 2
States / cities: Baton Rouge, Louisiana

Conditions: Altitude Hypoxia
Interventions: Simulated altitude, Placebo simulated altitude; Other
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 70 Years
Enrollment: 71 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Scottsdale, Arizona

Conditions: Exercise Performance
Interventions: Placebo, Creatine; Dietary Supplement
Lead sponsor: California Polytechnic State University-San Luis Obispo; Other
Eligibility: 18 Years to 40 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: San Luis Obispo, California

Conditions: Acute Mountain Sickness and Fatigue
Interventions: Aminophylline 400 mg, Ambrisentan 5 mg, Placebo; Drug · Other
Lead sponsor: Robert J Noveck, M.D.; Other
Eligibility: 18 Years to 50 Years
Enrollment: 92 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2014
U.S. locations: 2
States / cities: Durham, North Carolina

Conditions: Altitude Hypoxia, Ventilation, Sleep, Oxidative Stress, Neurocognitive Dysfunction
Interventions: Melatonin, Hypoxia; Dietary Supplement · Other
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years to 65 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: San Diego, California

Conditions: Decompression Sickness
Interventions: Altitude, 100% Oxygen; Other · Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 50 Years
Enrollment: 19 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Hypoxia, Exercise Performance, Cognitive Function, Dexterity
Interventions: Acetazolamide Pill, Placebo pill; Drug
Lead sponsor: United States Army Research Institute of Environmental Medicine; Federal
Eligibility: 18 Years to 45 Years
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Natick, Massachusetts

Conditions: Obesity, Breast Cancer
Interventions: Walking+simulated-altitude, Walking (control); Other · Behavioral
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 18 Years to 70 Years · Female only
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Healthy Adults, Mechanical Ventilation Dependence, Hypoxia, Exercise Training, Exercise Intolerance, Dietary Supplement, Nitrate Supplementation, Inspiratory Muscle Training
Interventions: Respiratory Muscle Training (RMT), Sham Respiratory Muscle Training, Dietary Supplement: Beetroot Juice Concentrate, placebo beverage; Device · Dietary Supplement
Lead sponsor: Embry-Riddle Aeronautical University; Other
Eligibility: 18 Years to 40 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Daytona Beach, Florida

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Gut-microbiota Targeted Nutritional Intervention for Gut Barrier Integrity at High Altitude

The Role of Hypoxia on Subconcussive Head Impacts

Effect of an H1 Receptor Antagonist on Exercise Performance in Hypoxia

Development of a Novel Stress Testing Protocol to Define the Relationship Between Coronary Microvascular Dysfunction and Diastology in Women With Angina But No Evidence of Obstructive Coronary Artery Disease

The Physiological Effects of Acute and Ramp Simulated Altitude Exposure During Simulated Flight Tasks

Ketone Esters for Optimization of Operator Performance in Hypoxia

Effect of 2-Week Nightly Moderate Hypoxia on Glucose Tolerance in Individuals With Type 2 Diabetes

Physiological Adaptations to Simulated Intermittent Altitude on Human Health and Performance

Creatine Supplementation At Simulated Altitude

A Study to Test the Safety of Combined Dosing With Aminophylline and Ambrisentan in Exercising Healthy Human Volunteers at Simulated High Altitude

Effects of Melatonin on Sleep, Ventilatory Control and Cognition at Altitude.

NASA Prebreathe Study

Acetazolamide and Exercise Performance at Altitude

Simulated-altitude to Optimize Aerobic Exercise Among Breast Cancer Survivors With Limited Mobility

Effects of Breathing Training and Nitrate on Exercise at Simulated Altitude