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Showing 1–24 of 93 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Sleep deprivation Clear all
Completed Not applicable Interventional

Feasibility and Tolerability of Adjunct Chronotherapy in Depressed Inpatients

NCT02088580
View directory record Official record
Conditions
Non-Psychotic Unipolar Depression, Bipolar Depression
Interventions
Triple Chronotherapy
Procedure
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Oct 1, 2015 · Synced Sep 3, 2026, 5:59 AM EDT
Completed Not applicable Interventional Results available

Poor Sleep and Inflammation in HIV-Infected Adults

NCT03848325
View directory record Official record
Conditions
HIV-1-infection, Sleep Deprivation, Inflammation
Interventions
Sleep deprivation
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 28, 2023 · Synced Sep 3, 2026, 5:59 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

To Determine if Sleep Deprivation Results in Increased Esophageal Acid Exposure

NCT01093339
View directory record Official record
Conditions
Gastroesophageal Disease
Interventions
Not listed
Lead sponsor
Southern Arizona VA Health Care System
Federal
Eligibility
18 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2010
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Aug 18, 2010 · Synced Sep 3, 2026, 5:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Sleep & Stress in Healthcare Providers After Defined Music Intervention Measure by 7-Tesla fMRI & Actigraphy

NCT05980429
View directory record Official record
Conditions
Stress, Psychological, Burnout, Professional, Sleep Deprivation, Music Therapy
Interventions
Music Therapy, prescribed, Music Therapy, self-selected
Other
Lead sponsor
The Methodist Hospital Research Institute
Other
Eligibility
30 Years to 65 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 14, 2024 · Synced Sep 3, 2026, 5:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Stable Sleep Pattern Before Sleep Loss

NCT06201390
View directory record Official record
Conditions
Sleep
Interventions
Sleep consistency
Behavioral
Lead sponsor
Texas Tech University
Other
Eligibility
35 Years to 64 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Lubbock, Texas
Source: ClinicalTrials.gov public record
Updated Mar 24, 2025 · Synced Sep 3, 2026, 5:59 AM EDT
Enrolling by invitation Phase 4 Interventional

Evaluating Worksite Sleep Health Coaching in Firefighters: The Sleep Assistance for Firefighters Study

NCT06684444
View directory record Official record
Conditions
Cognitive Behavioral Therapy, Sleep Initiation and Maintenance Disorders, Sleep Deprivation, Sleep Disorders, Intrinsic
Interventions
firefighter Sleep Health Coaching Intervention (ffSHC), Control (Minimally Enhanced Usual Care)
Behavioral
Lead sponsor
University of Arizona
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Jul 15, 2026 · Synced Sep 3, 2026, 5:59 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Acoustic Stimulation During Restricted Sleep After Sleep Deprivation

NCT05309473
View directory record Official record
Conditions
Sleep Deprivation, Sleep Restriction, Acoustic Stimulation, Performance, Alertness
Interventions
Philips SmartSleep Acoustic Stimulation Device, Sham (no Acoustic Stimulation)
Device
Lead sponsor
Walter Reed Army Institute of Research (WRAIR)
Federal
Eligibility
18 Years to 39 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Silver Spring, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 22, 2024 · Synced Sep 3, 2026, 5:59 AM EDT
Completed No phase listed Observational

Activating Effects of Sleep Deprivation on Synchronized MEG-EEG Recordings of Epilepsy Patients With Non-Diagnostic EEG

NCT00071370
View directory record Official record
Conditions
Epilepsy
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
Not listed
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2005
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Sep 3, 2026, 5:59 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

The Effect of Sleep Deprivation and Recovery Sleep on Emotional Memory and Affective Reactivity

NCT03767426
View directory record Official record
Conditions
Sleep Deprivation, Sleep
Interventions
Sleep Deprivation, Daytime nap
Behavioral
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years to 35 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 5, 2024 · Synced Sep 3, 2026, 5:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Evolution of Memories Across Wake and Sleep

NCT03227406
View directory record Official record
Conditions
Sleep Deprivation, Sleep
Interventions
Sleep deprivation, Nap
Behavioral
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years to 40 Years
Enrollment
276 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 2, 2023 · Synced Sep 3, 2026, 5:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Comparison Across Multiple Types of Sleep Deprivation

NCT04211506
View directory record Official record
Conditions
Sleep Deprivation, Sleep Restriction
Interventions
Controlled sleep
Behavioral
Lead sponsor
Civil Aerospace Medical Institute
Federal
Eligibility
20 Years to 45 Years
Enrollment
59 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
2
States / cities
Boston, Massachusetts • Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Sep 28, 2023 · Synced Sep 3, 2026, 5:59 AM EDT
Completed Phase 4 Interventional

Sleep Deprivation Plus Paroxetine for Treating Major Depression in Elderly Individuals

NCT00178035
View directory record Official record
Conditions
Depression
Interventions
paroxetine, One night of Total Sleep Deprivation
Drug · Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
60 Years and older
Enrollment
158 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2003
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 1, 2013 · Synced Sep 3, 2026, 5:59 AM EDT
Completed Early Phase 1 Interventional

Human Brain Mapping of the Apparent Diffusion Coefficient (ADC) During Sleep and Wakefulness

NCT02311374
View directory record Official record
Conditions
Brain Mapping
Interventions
Brain connectivity and physiology, Brain Wave
Other
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
18 Years to 60 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Sep 3, 2026, 5:59 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Transcranial Electrical Stimulation (TES) at Slow Oscillation (SO) Frequency During NREM Sleep

NCT02945501
View directory record Official record
Conditions
Sleep Deprivation, Mental Competency
Interventions
NeuroConn DC Stimulator PLUS, SHAM TES
Device
Lead sponsor
U.S. Army Medical Research and Development Command
Federal
Eligibility
18 Years to 39 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2027
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 12, 2025 · Synced Sep 3, 2026, 5:59 AM EDT
Completed Not applicable Interventional Results available

Study of the Effects of HIRREM-SOP for Insomnia

NCT03607994
View directory record Official record
Conditions
Insomnia, Sleep Deprivation
Interventions
HIRREM-SOP, NCC
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 30, 2022 · Synced Sep 3, 2026, 5:59 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Efficacy and Safety Study of Propofol Infusion for Refractory Chronic Primary Insomnia

NCT02043977
View directory record Official record
Conditions
Insomnia, Sleep Disorder, Dyssomnia
Interventions
propofol injectable emulsion
Drug
Lead sponsor
Life Extension Foundation Inc.
Other
Eligibility
18 Years to 65 Years
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Fort Lauderdale, Florida
Source: ClinicalTrials.gov public record
Updated Aug 29, 2016 · Synced Sep 3, 2026, 5:59 AM EDT
Completed No phase listed Observational

Effects of Sleep Deprivation and Recovery on Cognitive Functions

NCT00179322
View directory record Official record
Conditions
Sleep Deprivation
Interventions
Not listed
Lead sponsor
National Institute on Deafness and Other Communication Disorders (NIDCD)
NIH
Eligibility
20 Years to 40 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2016
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 16, 2019 · Synced Sep 3, 2026, 5:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Real-Time Caffeine Optimization During Total Sleep Deprivation

NCT04399083
View directory record Official record
Conditions
Caffeine, Sleep Deprivation, Shift-Work Related Sleep Disturbance
Interventions
Caffeine
Dietary Supplement
Lead sponsor
University of Arizona
Other
Eligibility
18 Years to 39 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Sep 16, 2021 · Synced Sep 3, 2026, 5:59 AM EDT
Completed Not applicable Interventional

Slow-wave Sleep Deprivation in Depression

NCT01189591
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Slow-wave deprivation
Device
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 35 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Nov 7, 2017 · Synced Sep 3, 2026, 5:59 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Immune Status After Being on Call for 24 Hrs

NCT06636318
View directory record Official record
Conditions
Sleep Deprivation
Interventions
Blood Sample Collection, Actigraph (GT9X-BT) Monitor
Diagnostic Test · Device
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 8, 2025 · Synced Sep 3, 2026, 5:59 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Neurobehavioral Changes Following Spaceflight Stressors

NCT07293494
View directory record Official record
Conditions
Stressor, Individual, Alcohol Impairment, Sleep Deprivation, Impairment, Cognitive
Interventions
Alcohol Administration, Sleep Deprivation, Control
Other · Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
21 Years to 60 Years
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Sep 3, 2026, 5:59 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Brain Sleep Deprivation MRI Effects (BEDTIME)

NCT02741505
View directory record Official record
Conditions
Alzheimer's Disease
Interventions
Actigraph
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
21 Years to 30 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 12, 2020 · Synced Sep 3, 2026, 5:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Sleep and Social Experiences Study 2

NCT05166590
View directory record Official record
Conditions
Sleep, Blood Pressure
Interventions
Sleep Restriction
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 64 Years
Enrollment
77 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Nov 5, 2025 · Synced Sep 3, 2026, 5:59 AM EDT
Completed Not applicable Interventional Results available

Wake Therapy in the Treatment of Depression

NCT01431573
View directory record Official record
Conditions
Major Depressive Disorder, Bipolar Disorder
Interventions
Wake Therapy, light box, Lithium
Behavioral · Device · Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 75 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
2
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 17, 2021 · Synced Sep 3, 2026, 5:59 AM EDT