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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Sleep deprivation Clear all
Terminated Not applicable Interventional

Chronotherapy Randomized Controlled Trial

NCT02176824
View directory record Official record
Conditions
Major Depressive Disorder, Bipolar Depression, Suicidal Ideation
Interventions
Total Sleep deprivation, Sleep Phase Advance, and Bright Light Therapy, Partial Sleep deprivation, Sleep Phase Delay, and Low amber light., Treatment as usual
Behavioral · Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 90 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated May 29, 2019 · Synced Sep 26, 2026, 1:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Virtual Reality and tACS for Performance Enhancement

NCT03636126
View directory record Official record
Conditions
Law Enforcement Officers
Interventions
VR + TACS
Device
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Garland, Texas
Source: ClinicalTrials.gov public record
Updated Jul 25, 2021 · Synced Sep 26, 2026, 1:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Modulation of CSF Amyloid-beta Concentrations Via Behavioral Sleep Deprivation and Pharmacological Sleep Induction

NCT02063217
View directory record Official record
Conditions
Amyloid-beta
Interventions
Sodium Oxybate, Sleep deprivation
Drug · Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 60 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 25, 2018 · Synced Sep 26, 2026, 1:49 AM EDT
Completed Not applicable Interventional

Integrated Chronotherapy for Perinatal Depression

NCT02053649
View directory record Official record
Conditions
Depression, Major Depressive Disorder, Postpartum Depression
Interventions
Triple Chronotherapy, Usual Care
Behavioral · Other
Lead sponsor
Rhode Island Hospital
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated May 28, 2019 · Synced Sep 26, 2026, 1:49 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Sleep Restriction and Parental History of Hypertension

NCT06482814
View directory record Official record
Conditions
Hypertension
Interventions
Partial sleep deprivation (sleep restriction), Normal sleep
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 35 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 12, 2026 · Synced Sep 26, 2026, 1:49 AM EDT
Completed Phase 2 Interventional Results available

Repeated Partial Sleep Deprivation to Augment SSRI Response in Depression

NCT01545843
View directory record Official record
Conditions
Depression
Interventions
Sleep scheduling, Fluoxetine
Behavioral · Drug
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 65 Years
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 29, 2023 · Synced Sep 26, 2026, 1:49 AM EDT
Completed Phase 4 Interventional

Sleep Deprivation Plus Paroxetine for Treating Major Depression in Elderly Individuals

NCT00178035
View directory record Official record
Conditions
Depression
Interventions
paroxetine, One night of Total Sleep Deprivation
Drug · Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
60 Years and older
Enrollment
158 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2003
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 1, 2013 · Synced Sep 26, 2026, 1:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Physiologic Effects of Sleep Restriction

NCT01433315
View directory record Official record
Conditions
Sleep Deprivation
Interventions
sleep restriction
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 40 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2017
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 19, 2022 · Synced Sep 26, 2026, 1:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Olfactory Decision-making and Deprived Sleep

NCT05093413
View directory record Official record
Conditions
Sleep Deprivation
Interventions
Sleep deprivation
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 12, 2022 · Synced Sep 26, 2026, 1:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Continuous Measurement of Glymphatic Activity in the Human Brain During Sleep-Wake States

NCT06060054
View directory record Official record
Conditions
Healthy
Interventions
Device measurements
Diagnostic Test
Lead sponsor
Applied Cognition
Industry
Eligibility
50 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Dec 28, 2023 · Synced Sep 26, 2026, 1:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Sleep Disruption Induced Impairments in Bone Formation

NCT03733483
View directory record Official record
Conditions
Healthy
Interventions
Sleep Deprivation
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
20 Years to 65 Years · Male only
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 11, 2021 · Synced Sep 26, 2026, 1:49 AM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Modafinil to Optimize the Performance of Cold-Stressed Sleep-Deprived Personnel

NCT07830056
View directory record Official record
Conditions
Sleep Deprivation, Cold Exposure
Interventions
Modafinil (M), 200 mg Microcrystalline Cellulose
Drug
Lead sponsor
United States Army Research Institute of Environmental Medicine
Federal
Eligibility
17 Years to 39 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Natick, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 20, 2026 · Synced Sep 26, 2026, 1:49 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Immune Status After Being on Call for 24 Hrs

NCT06636318
View directory record Official record
Conditions
Sleep Deprivation
Interventions
Blood Sample Collection, Actigraph (GT9X-BT) Monitor
Diagnostic Test · Device
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 8, 2025 · Synced Sep 26, 2026, 1:49 AM EDT
Completed Not applicable Interventional

A Prolonged Nightly Fasting for Men on ADT for PCa

NCT07462403
View directory record Official record
Conditions
Prostate Cancer
Interventions
Prolonged Nightly Fasting (PNF+), Healthy Diet Text Messaging
Behavioral
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years and older · Male only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Sep 26, 2026, 1:49 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Caffeine Optimization Versus Standard Caffeine Dosage (2B-2)

NCT05588934
View directory record Official record
Conditions
Sleep Deprivation, Caffeine
Interventions
Caffeine Gum, Placebo Gum
Dietary Supplement · Other
Lead sponsor
University of Arizona
Other
Eligibility
18 Years to 39 Years
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
2
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Nov 3, 2025 · Synced Sep 26, 2026, 1:49 AM EDT
Completed Phase 1Phase 2 Interventional

Single Dose Pharmacokinetic and Pharmacodynamic Evaluation of Three Different Doses of Zolpidem in Children

NCT00494468
View directory record Official record
Conditions
Insomnia, Sleep Disorder
Interventions
Zolpidem
Drug
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
2 Years to 18 Years
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2004
U.S. locations
11
States / cities
Little Rock, Arkansas • La Jolla, California • Denver, Colorado + 8 more
Source: ClinicalTrials.gov public record
Updated Jun 28, 2007 · Synced Sep 26, 2026, 1:49 AM EDT
Completed Phase 3 Interventional Results available

A Randomized Controlled Trial of Mandatory Naps for Physicians in Training

NCT00874510
View directory record Official record
Conditions
Fatigue
Interventions
Mandatory Naps
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
Not listed
Enrollment
352 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 18, 2016 · Synced Sep 26, 2026, 1:49 AM EDT
Completed Not applicable Interventional

Improving Sleep Quality in Flap Patients in the SICU

NCT03957317
View directory record Official record
Conditions
Sleep Deprivation
Interventions
Eye mask and ear plugs
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Oct 13, 2019 · Synced Sep 26, 2026, 1:49 AM EDT
Completed Early Phase 1 Interventional

Brain Amyloid- Retention During Wakefulness and Following Emergence From Sleep in Healthy People

NCT02669225
View directory record Official record
Conditions
Normal Physiology
Interventions
[18F]florbetaben
Other
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
18 Years to 40 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 13, 2026 · Synced Sep 26, 2026, 1:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Phenotypic and Genotypic Markers of Performance Vulnerability to Sleep Loss

NCT02130791
View directory record Official record
Conditions
Sleep Restriction Then Total Sleep Deprivation, Total Sleep Deprivation Then Sleep Restriction
Interventions
Sleep
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
21 Years to 50 Years
Enrollment
170 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 1, 2015 · Synced Sep 26, 2026, 1:49 AM EDT
Completed Not applicable Interventional Results available

Study of the Effects of HIRREM-SOP for Insomnia

NCT03607994
View directory record Official record
Conditions
Insomnia, Sleep Deprivation
Interventions
HIRREM-SOP, NCC
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 30, 2022 · Synced Sep 26, 2026, 1:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Sleep Deprivation and Energy Balance

NCT01334788
View directory record Official record
Conditions
Sleep Deprivation
Interventions
sleep deprivation, Normal sleep
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 11, 2023 · Synced Sep 26, 2026, 1:49 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effects of Chronic Sleep Restriction in Young and Older People

NCT00506428
View directory record Official record
Conditions
Aging, Sleep Deprivation, Metabolic Syndrome
Interventions
chronic sleep restriction
Behavioral
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
18 Years to 70 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2011
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 28, 2009 · Synced Sep 26, 2026, 1:49 AM EDT
Completed No phase listed Observational

Sleep in Hospitalized Children at MSKCC

NCT02836041
View directory record Official record
Conditions
Pediatric Cancer Patients
Interventions
questionnaires, actigraph
Behavioral · Device
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
0 Months to 18 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 27, 2021 · Synced Sep 26, 2026, 1:49 AM EDT