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Showing 1–18 of 18 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Slow-Wave Activity Clear all
Terminated Not applicable Interventional

The Nightmare Augmented Protocol for Treatment of Nightmares in Veterans With PTSD

NCT05120674
View directory record Official record
Conditions
PTSD
Interventions
NAP, CPT, ERRT, Cognitive Behavioral Therapy for Insomnia
Behavioral
Lead sponsor
VA Eastern Kansas
Federal
Eligibility
18 Years to 99 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Leavenworth, Kansas
Source: ClinicalTrials.gov public record
Updated Nov 14, 2021 · Synced Sep 2, 2026, 2:10 PM EDT
Completed Not applicable Interventional

Sleep, Pain and Inflammatory Processes in Older Adults With Osteoarthritis

NCT01683799
View directory record Official record
Conditions
Osteoarthritis of the Knee, Insomnia, Knee Pain
Interventions
Cognitive Behavioral Therapy for Insomnia
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
50 Years to 75 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Sep 29, 2016 · Synced Sep 2, 2026, 2:10 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of tDCS Applied During Sleep on Memory Consolidation

NCT02596568
View directory record Official record
Conditions
Sleep
Interventions
transcranial direct current stimulation (tDCS), Sham
Device · Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 60 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Mar 29, 2023 · Synced Sep 2, 2026, 2:10 PM EDT
Not listed Not applicable Interventional

Slow Wave Sleep As a Biomarker of Rehabilitation-induced Cognitive Improvement in PD

NCT04796506
View directory record Official record
Conditions
Parkinson Disease
Interventions
Progressive Resistance Training (PRT), Delayed Exercise Training (DE), Endurance Training (ET)
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
45 Years to 100 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 30, 2024 · Synced Sep 2, 2026, 2:10 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Neural Injury in Adolescents With Concussion

NCT03011983
View directory record Official record
Conditions
Mild Traumatic Brain Injury, Concussion, Mild, Acute Brain Injury
Interventions
MEG, MRI, Neuropsychology assessment
Device · Behavioral
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
12 Years to 17 Years
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 23, 2018 · Synced Sep 2, 2026, 2:10 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Polycystic Ovary Syndrome (PCOS) and Sleep Apnea

NCT00203996
View directory record Official record
Conditions
Polycystic Ovary Syndrome, Obstructive Sleep Apnea
Interventions
continuous positive airway pressure (CPAP), depot leuprolide plus estrogen/progestin replacement, pioglitazone, REM frag, SWS supp
Device · Drug · Procedure
Lead sponsor
University of Chicago
Other
Eligibility
18 Years to 40 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2008
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 20, 2023 · Synced Sep 2, 2026, 2:10 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Neurophysiologic Correlates of Hypersomnia

NCT01719315
View directory record Official record
Conditions
Major Depressive Disorder, Primary Hypersomnia, Bipolar Disorder, Narcolepsy, Primary Insomnia
Interventions
Acoustical slow wave induction
Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 60 Years
Enrollment
76 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2018
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Dec 23, 2018 · Synced Sep 2, 2026, 2:10 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Electrical Synchronization of Slow Oscillations to Enhance Deep Sleep

NCT04461769
View directory record Official record
Conditions
Sleep, Sleep Hygiene
Interventions
Transcranial Electrical Stimulation
Device
Lead sponsor
Brain Electrophysiology Laboratory Company
Industry
Eligibility
18 Years to 80 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Jul 7, 2020 · Synced Sep 2, 2026, 2:10 PM EDT
Not yet recruiting Not applicable Interventional

Sleep Interventions and Neurocognitive Outcomes

NCT05987007
View directory record Official record
Conditions
Sleep Disturbance, Amnestic Mild Cognitive Impairment
Interventions
Acoustic slow-wave activity enhancement, Cognitive behavioral therapy for insomnia
Device · Behavioral
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
60 Years to 85 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 2, 2026 · Synced Sep 2, 2026, 2:10 PM EDT
Completed Phase 1 Interventional Results available

Slow Wave Induction by Propofol to Eliminate Depression (SWIPED) I

NCT04680910
View directory record Official record
Conditions
Treatment-resistant Depression
Interventions
Propofol, Electroencephalography (EEG), Slow-Wave Activity
Drug · Diagnostic Test
Lead sponsor
Washington University School of Medicine
Other
Eligibility
60 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 22, 2026 · Synced Sep 2, 2026, 2:10 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Role of Slow-wave Activity and Plasticity in MDD

NCT04150718
View directory record Official record
Conditions
Depression
Interventions
slow-wave disruption
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
25 Years to 50 Years
Enrollment
77 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 26, 2024 · Synced Sep 2, 2026, 2:10 PM EDT
Recruiting Not applicable Interventional

Enhancing Slow Wave Sleep in Depression

NCT07143838
View directory record Official record
Conditions
Depression - Major Depressive Disorder
Interventions
Transcranial Electrical Stimulation (TES)
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
40 Years to 80 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 28, 2026 · Synced Sep 2, 2026, 2:10 PM EDT
Recruiting Not applicable Interventional

Acoustic Stimulation, Sleep, and Cognitive-Emotional Processes in Young Adults With Anxiety and Depression Symptoms

NCT05802004
View directory record Official record
Conditions
Acoustic Stimulation
Interventions
Acoustic Stimulation (STIM), No Acoustic Stimulation (SHAM), Daily acoustic stimulation (STIM2), No daily acoustic stimulation (SHAM2)
Device
Lead sponsor
Michelle Stepan
Other
Eligibility
18 Years to 25 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 17, 2025 · Synced Sep 2, 2026, 2:10 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Application of Transcranial Alternating Current Stimulation for Modulation of Sleep and Cognitive Performance

NCT03112902
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Application of Transcranial Alternating Current Stimulation for Modulation of Sleep and Cognitive Performance
Device
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 80 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Dec 16, 2021 · Synced Sep 2, 2026, 2:10 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Traveling-wave Transcranial Electric Stimulation

NCT05399381
View directory record Official record
Conditions
Working Memory
Interventions
Transcranial alternating current stimulation (tACS)
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 45 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Sep 2, 2026, 2:10 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Restoring Spindle and Thalamocortical Efficiency in Early-Course Schizophrenia Patients Using Auditory Stimulation

NCT05956951
View directory record Official record
Conditions
Schizophrenia
Interventions
Closed-loop auditory stimulation, Sham auditory stimulation
Device
Lead sponsor
Fabio Ferrarelli
Other
Eligibility
18 Years to 40 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Sep 2, 2026, 2:10 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Noninvasive Markers of Functional Nausea in Children

NCT03593811
View directory record Official record
Conditions
Nausea
Interventions
Questionnaires, 4 channel electrogastrogram (EGG), 36 channel high resolution electrogastrogram (HR-EGG), Magnetogastrogram (MGG), Electrocardiogram (EKG), Ondansetron, Cyproheptadine Oral Tablet
Diagnostic Test · Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
8 Years to 17 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 21, 2026 · Synced Sep 2, 2026, 2:10 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Home Sleep Therapy for Older Adults With MCI

NCT05771844
View directory record Official record
Conditions
Mild Cognitive Impairment, Sleep, Transcranial Electrical Stimulation, Machine Learning, Memory
Interventions
Transcranial Electrical Stimulation
Device
Lead sponsor
Brain Electrophysiology Laboratory Company
Industry
Eligibility
40 Years to 85 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
2
States / cities
Winston-Salem, North Carolina • Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Feb 16, 2025 · Synced Sep 2, 2026, 2:10 PM EDT