Independent directory Public ClinicalTrials.gov records United States
Clear filters

These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Oct 4, 2026, 9:20 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 49–56 of 56 matching trials from the live ClinicalTrials.gov search.
Completed Not applicable Interventional Accepts healthy volunteers

Effects of an Oral Nicotine Product in Smokeless Tobacco Users

NCT05280769
Conditions
Tobacco Use
Interventions
oral nicotine pouch - 2 mg, oral nicotine pouch - 4 mg, oral nicotine pouch - 8 mg, Smokeless tobacco
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 55 Years
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Richmond, Virginia
Conditions
Adverse Effect of Other Agents Primarily Affecting the Cardiovascular System, Initial Encounter
Interventions
Cigarette, NIDA test type with 16.6 mg nicotine, Cigarette, NIDA test type with <0.45 mg nicotine, Electronic cigarette with 18 mg/ml nicotine, Electronic Cigarette with no nicotine, Moist snuff, Sham Smoking, Secondhand cigarette smoke (SHS), Conditioned, filtered air, Sham Moist Snuff
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 50 Years
Enrollment
81 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2021
U.S. locations
1
States / cities
San Francisco, California
Active, not recruiting Phase 1 Interventional Accepts healthy volunteers

Nornicotine in Smokeless Tobacco as a Precursor for Carcinogen Exposure

NCT03998735
Conditions
Smokeless Tobacco
Interventions
Herbal Snuff (Smokeless Tobacco)
Drug
Lead sponsor
Masonic Cancer Center, University of Minnesota
Other
Eligibility
18 Years to 65 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Minneapolis, Minnesota
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Text-based Reduction Intervention for Smokeless Tobacco Cessation

NCT04315506
Conditions
Smokeless Tobacco Cessation
Interventions
#EnufSnuff.TXT Intervention, Enough Snuff Intervention
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
532 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Durham, North Carolina
Completed Phase 2 Interventional Accepts healthy volunteers Results available

A Pilot Study Evaluating Nicotine Lozenges and Self Help

NCT00888459
Conditions
Smokeless Tobacco Use
Interventions
nicotine replacement therapy, placebo NRT
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older · Male only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
2
States / cities
Rochester, Minnesota • Eugene, Oregon
Conditions
Smokeless Tobacco Cessation
Interventions
Scheduled Gradual Reduction (SGR), Text Messages
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Durham, North Carolina
Conditions
Tobacco Use
Interventions
A19010-F, B19010-F
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
6
States / cities
Rogers, Arkansas • Lexington, Kentucky • Springfield, Missouri + 3 more
Conditions
Smokeless Tobacco Cessation
Interventions
Extended Scheduled Gradual Reduction (SGR), Quit Coach
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
69 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Durham, North Carolina