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ClinicalTrials.gov public records Last synced Nov 15, 2026, 1:04 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 228 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Smoking abstinence Clear all

Conditions: Nicotine Dependence
Interventions: Placebo, Varenicline; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 65 Years
Enrollment: 62 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2007
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Smoking
Interventions: Web+Mobile, Web Only; Behavioral
Lead sponsor: Oregon Research Institute; Other
Eligibility: 18 Years and older
Enrollment: 1,266 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2018
U.S. locations: 1
States / cities: Eugene, Oregon

Conditions: Smoking
Interventions: Smoking Abstinence; Behavioral
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 50 Years
Enrollment: 62 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2009
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Smoking, Cigarette, Breastfeeding
Interventions: Integrated intervention of smoking cessation and breastfeeding, Attention placebo control; Behavioral
Lead sponsor: Xiaozhong Wen; Other
Eligibility: 18 Years and older · Female only
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Buffalo, New York

Conditions: Cigarette Smoking, Tobacco Smoking, Smoking, Tobacco
Interventions: nicotine patch plus nicotine gum/lozenge, Intensive Alcohol Intervention; Drug · Behavioral
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 75 Years
Enrollment: 352 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2018
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Cigarette Smoker, Tobacco Use Disorder
Interventions: Nicotine Lozenge, Nicotine Patch, Placebo, Tobacco Cessation Counseling, Varenicline; Drug · Other
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years to 75 Years
Enrollment: 631 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2026
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Smoking Cessation, Cervical Cancer, High Grade Cervical Dysplasia
Interventions: Smoking Cessation treatment delivered by Tobacco Free Florida Quitline, Nicotine patch, Nicotine Lozenge, Motivation and Problem Solving (MAPS) intervention; Behavioral · Drug
Lead sponsor: H. Lee Moffitt Cancer Center and Research Institute; Other
Eligibility: 18 Years and older · Female only
Enrollment: 360 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2028
U.S. locations: 1
States / cities: Tampa, Florida

Conditions: Atrial Fibrillation
Interventions: Liraglutide, RFM, Anti Arrhythmics, Afib Catheter Ablation; Drug · Other · Procedure
Lead sponsor: University of Miami; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2026
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Smoking, Withdrawal Nicotine, ADHD
Interventions: Cigarette smoking, Abstinence; Behavioral
Lead sponsor: University of California, Irvine; Other
Eligibility: 18 Years to 45 Years
Enrollment: 89 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2016
U.S. locations: 1
States / cities: Santa Ana, California

Conditions: Smoking
Interventions: Nicotine Lozenge, Placebo Lozenge, Abstinence Advisement; Drug · Behavioral
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 46 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2013
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Head and Neck Cancer, Smoking Cessation
Interventions: Acceptance and Commitment Therapy, Motivational and Behavioral Counseling, Varenicline; Behavioral · Drug
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 51 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2027
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Smoking Cessation
Interventions: Mindfulness with Contingency Management, Active Control; Behavioral
Lead sponsor: Fordham University; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2018
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Smoking Cessation, Smoking, Tobacco Cessation
Interventions: NicVAX vaccine, Placebo vaccine; Biological
Lead sponsor: Nabi Biopharmaceuticals; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 1,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 22
States / cities: Tucson, Arizona • Los Angeles, California • Newport Beach, California + 19 more

Conditions: Cigarette Smoking
Interventions: E-cigarette Switching, Financial Incentives; Behavioral
Lead sponsor: University of Oklahoma; Other
Eligibility: 21 Years to 100 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Smoking Cessation, Alcohol Drinking
Interventions: Nicotine Replacement Therapy, Bupropion, Cognitive Behavioral Treatment, Mobile Contingency Management, Mobile Monitoring; Other · Drug · Behavioral
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 80 Years
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2020
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Tobacco Use, Smoking
Interventions: Nicotine Pouch P1312914, 4 mg nicotine, Nicotine Pouch P1312915, 8 mg nicotine, Nicotine Pouch P1013215, 8 mg nicotine, Nicotine Pouch P1013218, 10 mg nicotine, Nicotine Pouch P1012919, 12 mg nicotine, Smoking Abstinence, Continued UB cigarette smoking; Other
Lead sponsor: RAI Services Company; Industry
Eligibility: 21 Years to 60 Years
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 5
States / cities: Bentonville, Arkansas • Lexington, Kentucky • Springfield, Missouri + 2 more

Conditions: ADHD, Smoking
Interventions: Osmotic-Release Methylphenidate, Placebo; Drug
Lead sponsor: University of Cincinnati; Other
Eligibility: 18 Years to 55 Years
Enrollment: 255 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2008
U.S. locations: 6
States / cities: Cambridge, Massachusetts • Rochester, Minnesota • New York, New York + 2 more

Conditions: Smoking During Pregnancy and Postpartum, Perinatal Cigarette Smoking
Interventions: Best Practices, Financial Incentives; Behavioral
Lead sponsor: University of Vermont; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 137 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Burlington, Vermont

Conditions: Cigarette Smoking-Related Carcinoma
Interventions: Avoidance, Biospecimen Collection, Cigarette Smoking, Eye Movement Measurement, Healthcare Activity, Questionnaire Administration, Refrain from Smoking, Vaping, Standardized E-Cigarette Nicotine Administration; Behavioral · Procedure · Other + 1 more
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 21 Years to 50 Years
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Nicotine Dependence
Interventions: tobacco abstinent contingent, non-contingent, control; Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 210 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2010
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Smoking Cessation
Interventions: hypnotherapy, Nicotine; Behavioral · Drug
Lead sponsor: North Shore Medical Center; Other
Eligibility: 18 Years to 75 Years
Enrollment: 164 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2009
U.S. locations: 1
States / cities: Salem, Massachusetts

Conditions: Nicotine Addiction
Interventions: Standard smoking cessation counseling; Behavioral
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 65 Years
Enrollment: 119 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2024
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Smoking Cessation
Interventions: All Nations Breath of Life (ANBL), Nontailored program (NT), Pharmacotherapy; Behavioral · Drug
Lead sponsor: Won Choi, PhD, MPH; Other
Eligibility: 18 Years and older
Enrollment: 463 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2014
U.S. locations: 2
States / cities: Kansas City, Kansas • Oklahoma City, Oklahoma

Conditions: Childhood Obesity, Smoking, Cigarette, Pregnancy
Interventions: Multicomponent behavioral intervention, Education only control; Behavioral
Lead sponsor: State University of New York at Buffalo; Other
Eligibility: 18 Years to 39 Years · Female only
Enrollment: 48 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2027
U.S. locations: 1
States / cities: Buffalo, New York

Search by objective public record fields.

Effects of Chantix on Relapse Prevention for Smoking Cessation

Web and Mobile Smoking Cessation

Neuroimaging Decision Making and Response Inhibition During Smoking Abstinence

Lung and Breast Cancer Prevention by an Integrated Intervention of Maternal Smoking Cessation and Breastfeeding

Enhancing Smoking Cessation in the Homeless Population

Varenicline and Combined NRT for Smoking Cessation

Enhancing Long-Term Smoking Abstinence Among Cervical Cancer Survivors (Project ACCESS)

Liraglutide Effect in Atrial Fibrillation

Association Between Smoking, Brain Activity, Genes, and ADHD

Pilot Study: Preoperative Nicotine Lozenges

Smoking Cessation Treatment for Head & Neck Cancer Patients

Smoking Cessation Intervention for Smokers With Depression Receiving Outpatient Psychiatric Treatment

NicVAX/Placebo as an Aid for Smoking Cessation

E-Cigarettes and Financial Incentives to Promote Tobacco Harm Reduction Among Adults Accessing Shelter Services

Mobile Contingency Management for Concurrent Abstinence From Alcohol and Smoking

CSD231005 Nicotine Pouch Biomarkers of Exposure

Smoking Cessation for Adults With Attention Deficit Hyperactivity Disorder (ADHD)

Smartphone-based Incentives Intervention to Increase Smoking Cessation During Pregnancy

Evaluating the Effect of Nicotine on Eye Movements and Related Behaviors in Electronic Cigarette Users, NICS-EYES Trial

Tobacco Use in Opioid Agonist Treated Pregnant Women

Smoking Cessation After Hospitalization for a Cardiopulmonary Illness

Neural Mechanisms Associated With Risk of Smoking Relapse

Smoking Cessation for American Indians

Maternal Smoking Cessation and Pediatric Obesity Prevention