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ClinicalTrials.gov public records Last synced Nov 15, 2026, 4:01 AM EST

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Showing 73–96 of 228 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Smoking abstinence Clear all

Conditions: Smoking Cessation
Interventions: Motivational Interviewing (MI), Nicotine Replacement Therapy (NRT), Nicotine Lozenge, Message Framing, saliva sample; Behavioral · Drug · Other
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Eligibility: 50 Years to 80 Years
Enrollment: 807 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2027
U.S. locations: 18
States / cities: Los Angeles, California • Walnut Creek, California • La Grange, Georgia + 14 more

Conditions: Tobacco Dependence
Interventions: Standard brief advice, Quitline intervention; Behavioral
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2011
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Tobacco Addiction
Interventions: Extended Duration Behavioral Smoking Cessation Counseling; Behavioral
Lead sponsor: Harvard University Faculty of Medicine; Other
Eligibility: 18 Years to 80 Years
Enrollment: 450 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2013
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Cigarette Smoking
Interventions: Best practices, financial incentives; Behavioral
Lead sponsor: University of Vermont; Other
Eligibility: 18 Years and older · Female only
Enrollment: 257 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2020
U.S. locations: 1
States / cities: Burlington, Vermont

Conditions: Cigarette Smoking
Interventions: Not listed
Lead sponsor: Philip Morris Products S.A.; Industry
Eligibility: 30 Years to 65 Years
Enrollment: 1,184 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2018
U.S. locations: 1
States / cities: Charlotte, North Carolina

Conditions: Tobacco Use Disorder
Interventions: Bupropion, Smoking Abstinence Program; Drug · Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 252 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2000 – 2006
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Tobacco Use Cessation, Perioperative/Postoperative Complications, Tobacco Smoking
Interventions: Brief behavioral intervention, SMS Program; Behavioral · Other
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Smoking, Discrimination, Racial
Interventions: Microaggression Recall and Relapse Analogue Task; Behavioral
Lead sponsor: University of Houston; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Smoking, Tobacco
Interventions: 31237616, 31237617, 31237571, 31237581; Other
Lead sponsor: RAI Services Company; Industry
Eligibility: 21 Years to 65 Years
Enrollment: 1,060 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 9
States / cities: Brandon, Florida • Coral Springs, Florida • Aurora, Illinois + 5 more

Conditions: Secondhand Smoke
Interventions: Quitline Delivered Treatment; Behavioral
Lead sponsor: Children's Hospital of Philadelphia; Other
Eligibility: 18 Years and older
Enrollment: 484 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Nicotine Dependence
Interventions: Oral Nicotine Pouch, Smoking Cue Reactivity Task; Other · Behavioral
Lead sponsor: University of Southern California; Other
Eligibility: 21 Years to 55 Years
Enrollment: 45 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Tobacco Use, Chronic Pain
Interventions: Smoking as usual fMRI session, Abstinent fMRI session; Behavioral
Lead sponsor: Duke University; Other
Eligibility: 21 Years to 65 Years
Enrollment: 132 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2030
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Behavior
Interventions: smoking abstinence, smoking satiety; Other
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years to 55 Years
Enrollment: 5 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Smoking Cessation
Interventions: Financial Incentive Rewards; Behavioral
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 1,312 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Anchorage, Alaska

Conditions: Cigarette Smoking, Smoking Cessation
Interventions: Contingency Management (CM), Transdermal nicotine skin patches (i.e. Habitrol), Supportive Counseling; Behavioral · Drug · Other
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 55 Years
Enrollment: 33 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Smoking
Interventions: Smartphone App; Behavioral
Lead sponsor: H. Lee Moffitt Cancer Center and Research Institute; Other
Eligibility: 18 Years and older
Enrollment: 14 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023
U.S. locations: 1
States / cities: Tampa, Florida

Conditions: Smoking Cessation
Interventions: Nicotine Patches, Telephone Counseling, Brief Hospital Counseling; Drug · Behavioral
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 1,270 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2014
U.S. locations: 6
States / cities: Chula Vista, California • Davis, California • La Jolla, California + 1 more

Conditions: Smoking Cessation
Interventions: Varenicline, Oral Nicotine Replacement Therapy (NRT), Medication Reminders, Tobacco Cessation Counseling; Drug · Behavioral
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years to 65 Years
Enrollment: 34 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Substance Abuse Disorders
Interventions: Not listed
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years and older
Enrollment: 210 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2011
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Tobacco Use Disorder
Interventions: Camel Snus, Marlboro Snus, Stonewall, Ariva, General Snus; Other
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 70 Years
Enrollment: 104 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2010
U.S. locations: 2
States / cities: Minneapolis, Minnesota • Eugene, Oregon

Conditions: Insomnia, Nicotine Dependence
Interventions: Eszopiclone, Bupropion; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 4 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2008
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Smoking Cessation
Interventions: Rimonabant; Drug
Lead sponsor: Sanofi; Industry
Eligibility: 18 Years and older
Enrollment: 787 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2003
U.S. locations: 1
States / cities: Malvern, Pennsylvania

Conditions: Smoking Cessation
Interventions: Nicotine patch, in-person counseling and quitline counseling, Preparation Nicotine Mini-Lozenges, Combination NRT (nicotine patch + nicotine mini-lozenges), Intensive In-Person Cessation Counseling, Extended Maintenance Counseling Calls, Automated Adherence Calls; Drug · Behavioral
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years and older
Enrollment: 623 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2018
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Smoking
Interventions: Varenicline, Placebo; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 70 Years
Enrollment: 247 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2013
U.S. locations: 10
States / cities: Birmingham, Alabama • Bloomington, Indiana • Boston, Massachusetts + 6 more

Search by objective public record fields.

Implementing Tobacco Treatment in Low Dose CT Lung Cancer Screening Sites

Quitline Use in Surgical Patients

Duration of Behavioral Counseling Treatment Needed to Optimize Smoking Abstinence

Financial Incentives for Smoking Cessation Among Disadvantaged Pregnant Women

A Smoking Cessation Study to Understand the Biological and Functional Changes After One Year of Smoking Cessation

Framing Messages for Smoking Cessation With Bupropion - 6

Short Messaging Service Program to Help Quit Smoking During Perioperative Period.

Ethnic Microaggressions and Smoking Behaviors Among Latinx Adults

A Multi-Site Study to Assess the Effect of Availability of a Heated Tobacco Product on Smoking Abstinence Among Current Primary Cigarette Smokers

Parent eReferral to Tobacco Quitline

Brain/Craving Response to Smoking Cues After Oral Nicotine Pouch Use

Neural Correlates and Behavioral Impact of Withdrawal-induced Hyperalgesia Among People Who Smoke With and Without Chronic Pain

Effects of Smoking State on Decision Making

Family-Based Financial Incentives Intervention for Smoking Cessation

Contingency Management, Quitting Smoking, and ADHD

Aim 1: App for Reducing Cravings to Smoke

Smoking Cessation in Hospitalized Smokers

Effectiveness of Combination Varenicline and Oral Nicotine Replacement Therapy (COMBO)

Study of Smoking Abstinence

Evaluation of Oral Tobacco as a Harm Reduction Method for Smokers

Study of Lunesta Versus Placebo for Sleep Problems Related to Smoking Cessation and Zyban

Comparison of the Efficacy and Safety of 2 Oral Doses of Rimonabant, 5 mg/Day or 20 mg/Day, Versus Placebo, as an Aid to Smoking Cessation (STRATUS US)

A Comparative Effectiveness RCT of Optimized Cessation Treatments

A Study of Varenicline for Prevention of Relapse to Smoking in Patients With Schizophrenia or Bipolar Disorder