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ClinicalTrials.gov public records Last synced Nov 15, 2026, 5:17 AM EST

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Showing 97–120 of 228 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Smoking abstinence Clear all

Conditions: Smoking Cessation
Interventions: Nicotine Patch, Telephone Counseling, Placebo, Self-Help Materials; Drug · Behavioral · Other
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 4,200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: San Diego, California

Conditions: Smoking Cessation
Interventions: Telephone counseling, Nicotine patches, Incentive; Behavioral · Drug
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 3,816 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: San Diego, California

Conditions: Smoking Cessation
Interventions: Not listed
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 50 Years
Enrollment: 119 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2000 – 2012
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Tobacco Use Disorder
Interventions: Cognitive Behavioral Therapy for Smoking Cessation, Nicotine Replacement Therapy, Bupropion, Varenicline, Mobile Contingency Management, Clinic-Based Smoking Cessation Counseling; Behavioral · Drug
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2030
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Tobacco Smoking
Interventions: Cognitive-Behavioral Smoking Cessation, Heart Rate Variability Biofeedback, Nicotine patch; Behavioral · Biological · Drug
Lead sponsor: Rutgers, The State University of New Jersey; Other
Eligibility: 21 Years to 50 Years
Enrollment: 28 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: New Brunswick, New Jersey

Conditions: Smoking, Tobacco
Interventions: FT25614, FT25615, FT25616; Other
Lead sponsor: RAI Services Company; Industry
Eligibility: 21 Years to 65 Years
Enrollment: 480 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 5
States / cities: Fort Lauderdale, Florida • Atlanta, Georgia • Chicago, Illinois + 2 more

Conditions: Cigarette Smoking Among Patients Currently Receiving Methadone or Buprenorphine Treatment for Opioid Dependence
Interventions: incentive-based contingency management; Behavioral
Lead sponsor: University of Vermont Medical Center; Other
Eligibility: 18 Years to 65 Years
Enrollment: 170 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2013
U.S. locations: 1
States / cities: Burlington, Vermont

Conditions: THC, Cannabis, Cannabis Smoking, Cannabis Use, Unspecified, Cigarette Smoking, Tobacco Use, Nicotine Dependence, Nicotine Withdrawal, Cardiovascular Risk Factor
Interventions: Smoked Cannabis, Vaped Cannabis, Tobacco Cigarette; Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 21 Years and older
Enrollment: 14 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2024
U.S. locations: 2
States / cities: San Francisco, California

Conditions: Smoking, Nicotine, Tobacco, Addiction, Substance Use Disorders, Insomnia, Sleep
Interventions: Daridorexant 50 mg, Placebo; Drug · Other
Lead sponsor: Legacy Health System; Other
Eligibility: 18 Years to 55 Years
Enrollment: 44 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Smoking
Interventions: Abstain from smoking for 24 hours; Behavioral
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 55 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: HIV, AIDS, Nicotine Dependence
Interventions: Bupropion, Brief Counseling, High-magnitude prize contingency management, Monitored support to quit smoking, No additional treatment, Prize contingency management for abstinence, Low intensity prize contingency management; Drug · Behavioral
Lead sponsor: Wayne State University; Other
Eligibility: 18 Years to 80 Years
Enrollment: 165 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2021
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: Smoking Cessation
Interventions: NicVAX Vaccine, Placebo Vaccine; Biological
Lead sponsor: Nabi Biopharmaceuticals; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 1,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 25
States / cities: Encino, California • Los Alamitos, California • Denver, Colorado + 22 more

Conditions: Smoking
Interventions: Web+phone; Behavioral
Lead sponsor: Oregon Research Institute; Other
Eligibility: 18 Years to 60 Years · Female only
Enrollment: 62 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Eugene, Oregon

Conditions: Magnetic Resonance Imaging, Functional
Interventions: Not listed
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 45 Years
Enrollment: 27 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2009
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Nicotine Dependence
Interventions: Tolcapone, Placebo; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 55 Years
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2009
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Nicotine Addiction
Interventions: Nicotine polacrilex, Placebo, satiety, abstinence; Drug · Other
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 55 Years
Enrollment: 54 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Smoking Cessation
Interventions: Contingency Management (CM), Standard of Care (SC); Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 2
States / cities: New Haven, Connecticut • Charleston, South Carolina

Conditions: Maintenance of Smoking Cessation
Interventions: rimonabant (SR141716); Drug
Lead sponsor: Sanofi; Industry
Eligibility: 18 Years and older
Enrollment: 4,850 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2005
U.S. locations: 1
States / cities: Bridgewater, New Jersey

Conditions: Smoking Cessation, Smoking, Nicotine Dependence
Interventions: CIS - telephone cessation quitline counseling, Lozenge - nicotine mini-lozenges, Emails - Brief smoking prevention messages, Full website - standard smokefree.gov website content, Lite website - lite version of smokefree.gov, Full mailed booklet - NCI's detailed 36-page quit guide, brief mailed booklet - smaller version of NCI's booklet; Other
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years and older
Enrollment: 1,034 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Smoking Cessation
Interventions: rimonabant (SR141716); Drug
Lead sponsor: Sanofi; Industry
Eligibility: 18 Years and older
Enrollment: 755 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2005
U.S. locations: 1
States / cities: Bridgewater, New Jersey

Conditions: Smoking, Veterans
Interventions: Nicotine gum, mobile contingency management, Telephone counseling, Nicotine patch, Nicotine lozenge, Smart phone, Carbon monoxide monitor; Other · Behavioral
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older
Enrollment: 291 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2019
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Acute Abstinence From Cigarettes vs E-cigarettes (ENDS)
Interventions: Acute (24-hour) abstinence, Ad libitum smoking/vaping; Behavioral
Lead sponsor: State University of New York at Buffalo; Other
Eligibility: 21 Years to 50 Years
Enrollment: 370 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Buffalo, New York

Conditions: Tobacco Use Disorder, Substance Use Disorder
Interventions: Focus Group, Contingency Management (CM), TUD Treatment as Usual (TAU); Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 108 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2031
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Nicotine Dependence
Interventions: Smoking Cessation Counseling; Behavioral
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 65 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2013
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

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Telephone Counseling and the Distribution of Nicotine Patches to Smokers

A Randomized Trial of Medi-Cal Beneficiaries Calling the California Smokers' Helpline

Physiological, Cognitive and Cerebral Activity Changes as a Function of Cigarette Smoking (With or Without Nicotine) and Tobacco Abstinence

Abstinence Reinforcement Therapy for Veterans Who Smoke Tobacco and Are Experiencing Homelessness

Heart Rate Variability Biofeedback for Smoking Cessation Treatment

A Study to Determine the Effect of Access to Multiple Tobacco Flavor Options on Smoking Abstinence Among Primary Cigarette Smokers Using an Electronic Nicotine Delivery System

Incentive-based Smoking Cessation for Methadone Patients

THC Crossover Study

Impact of Daridorexant on Sleep, Daytime Alertness, and Smoking

The Effects of Smoking Withdrawal On Resting State Functional Connectivity

Smoking Cessation for People Living With HIV/AIDS

A Second Study of NicVAX/Placebo as an Aid for Smoking Cessation

Web and Phone Intervention to Maintain Postpartum Tobacco Abstinence

Neural, Behavioral and Physiological Correlates of Feeding in Humans

Pilot Study of Tolcapone in Smokers

Acute and Chronic Nicotine Modulation of Reinforcement Learning

Novel Treatment to Enhance Smoking Cessation Before Cancer Surgery

Efficacy and Safety of Rimonabant as an Aid to Maintenance of Smoking Cessation

Evaluation of National Cancer Institute (NCI) Smoking Intervention Resources

Efficacy and Safety of Rimonabant as an Aid to Smoking Cessation With or Without Nicotine Patch

Mobile Contingency Management for Smoking Cessation in Returning US Veterans

Vaping and Smoking Withdrawal Project

Smoking Cessation CM for Veterans With or at Risk for Cancer

Brain Activity and Smoking Cessation