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ClinicalTrials.gov public records Last synced Nov 15, 2026, 6:05 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 121–144 of 228 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Smoking abstinence Clear all

Conditions: Schizophrenia, Tobacco Use Disorder, Nicotine Dependance
Interventions: Varenicline; Drug
Lead sponsor: Nathan Kline Institute for Psychiatric Research; Other
Eligibility: 18 Years to 65 Years
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2010
U.S. locations: 1
States / cities: New York, New York

Conditions: Smoking Cessation
Interventions: Mobile Contingency Management, Standard Care; Behavioral
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years to 100 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Nicotine Dependence
Interventions: Transcranial Direct Current Stimulation, sham, Nicotine patch, Placebo patch, Varenicline Pill, Placebo pill, Motivational Interviewing; Device · Drug · Behavioral
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 65 Years
Enrollment: 112 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2020
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Smoking Cessation
Interventions: Telephone Counseling, Self-Help Materials; Behavioral
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years to 75 Years
Enrollment: 2,277 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2008
U.S. locations: 1
States / cities: San Diego, California

Conditions: Nicotine Addiction, Smoking Cessation
Interventions: Quit Center cessation program; Behavioral
Lead sponsor: Quit Center LLC; Industry
Eligibility: 18 Years and older
Enrollment: 371 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Naples, Florida

Conditions: Smoking Cessation Intervention, Pain, Smoking (Tobacco) Addiction
Interventions: Smoking Cessation; Behavioral
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years and older
Enrollment: 150 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Tulsa, Oklahoma

Conditions: Copd, Smoking Cessation, Nicotine Dependence, Tobacco Use, Cigarette Smoking
Interventions: Unified Protocol adapted for smoking cessation; Behavioral
Lead sponsor: Rush University Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Cigarette Smoking, Marijuana Abuse
Interventions: bupropion, transdermal nicotine patch, Nicotine polacrilex, nicotine lozenge, counseling for marijuana and smoking cessation, mobile contingency management; Drug · Behavioral
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Smoking Cessation
Interventions: Removal of Financial Barriers, Financial Incentives, Mobile Health Application; Behavioral
Lead sponsor: Abramson Cancer Center at Penn Medicine; Other
Eligibility: 18 Years and older
Enrollment: 3,228 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 5
States / cities: Oakland, California • Detroit, Michigan • Danville, Pennsylvania + 2 more

Conditions: Tobacco Use Cessation
Interventions: Nicotine Patch, Questionnaires, Pamphlet, Phone Counseling Sessions, Saliva Test, Smart phone; Drug · Behavioral · Other + 1 more
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 8 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Smoking, Stress Disorders, Post-Traumatic
Interventions: Smoking Cessation Cognitive Behavioral Therapy (CBT), Bupropion, Cognitive Processing Therapy, Smoking Abstinence Reinforcement Therapy, Yoked Contingency Management; Behavioral · Drug
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 80 Years
Enrollment: 115 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2025
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Cigarette Smoking, Post Traumatic Stress Disorder, Signs and Symptoms, Respiratory
Interventions: CBT-A, CBT-S; Behavioral
Lead sponsor: Stony Brook University; Other
Eligibility: 18 Years and older
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: Stony Brook, New York

Conditions: Smoking, Tobacco
Interventions: P2613422, P2611222, P2615522, P2615122, P2615422; Other
Lead sponsor: RAI Services Company; Industry
Eligibility: 21 Years to 65 Years
Enrollment: 1,280 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 7
States / cities: Maitland, Florida • Atlanta, Georgia • St Louis, Missouri + 4 more

Conditions: Tobacco Dependence
Interventions: Combination nicotine replacement therapy (Nicotine patch + nicotine mini-lozenge); Drug
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 21 Years and older
Enrollment: 232 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Nicotine Addiction
Interventions: Galantamine ER; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 60 Years
Enrollment: 13 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Smoking
Interventions: Smoking Abstinence; Behavioral
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 50 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2009
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Smoking Cessation
Interventions: Intervention, Enhanced Traditional Care control; Behavioral · Other
Lead sponsor: Boston Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 352 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Acute Abstinence From Cigarettes vs E-cigarettes (ENDS)
Interventions: Acute (24-hour) abstinence, Ad libitum smoking/vaping; Behavioral
Lead sponsor: State University of New York at Buffalo; Other
Eligibility: 21 Years to 50 Years
Enrollment: 64 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Buffalo, New York

Conditions: Smoking
Interventions: Updating Existing Smartphone App, Quitline Services, Quitline Services and Smartphone App; Behavioral
Lead sponsor: H. Lee Moffitt Cancer Center and Research Institute; Other
Eligibility: 18 Years and older
Enrollment: 1,051 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Tampa, Florida

Conditions: Nicotine Addiction
Interventions: ABT-089, Placebo; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 65 Years
Enrollment: 17 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Smoking
Interventions: Methylphenidate, Placebo; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 65 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2009
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Substance Dependence
Interventions: GSK598809, Nicotine Replacement Transdermal Patch, Placebo; Drug
Lead sponsor: GlaxoSmithKline; Industry
Eligibility: 18 Years to 65 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008
U.S. locations: 10
States / cities: DeLand, Florida • Pembroke Pines, Florida • Stockbridge, Georgia + 7 more

Conditions: Efficacy of Financial Incentives
Interventions: Voucher-based incentives; Behavioral
Lead sponsor: University of Vermont; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 166 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2011
U.S. locations: 1
States / cities: Burlington, Vermont

Conditions: Tobacco Use Disorder/Cigarette Smoking, HIV
Interventions: nicotine patch, nicotine gum, nicotine lozenge, varenicline, bupropion, Multi-target Contingency Management, Teamlet booster; Drug · Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 794 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2031
U.S. locations: 5
States / cities: Bridgeport, Connecticut • New Haven, Connecticut • Jersey City, New Jersey + 2 more

Search by objective public record fields.

Varenicline Effects In Schizophrenic Smokers

Automated Mobile Contingency Management for Smoking Cessation: A Pilot RCT (SCC PREVAILgo)

Nicotine Withdrawal Symptoms and Smoking Relapse

Smokers' Quitline for Asian Language Speakers

Evaluation of a Smoking Cessation Program for Long-Term Abstinence

Oklahoma Study of Native American Pain Risk IV: Smoking Cessation and Pain

Addressing Psychological Risk Factors Underlying Smoking Persistence in COPD Patients: The Fresh Start Study

Mobile Contingency Management for Marijuana and Tobacco Cessation

Comparing Smoking Cessation Interventions Among Underserved Patients Referred for Lung Cancer Screening

Mobile Media-Rich Interactive Guideline System (MMRIGS) Pilot Study

CPT-SMART for Treatment of PTSD and Cigarette Smoking

Enhanced Smoking Cessation Intervention for Smokers Exposed to the World Trade Center (WTC) Disaster

A Study to Determine the Effects of ENDS Flavor Availability on Abstinence Within Smokers

UW Withdraw From Tobacco Study

Effect of Galantamine on Smoking Abstinence

Neuroimaging Attentional Impairment During Abstinence

Patient Navigation and Financial Incentives to Promote Smoking Cessation

Vaping and Smoking Project in People With Schizophrenia

App for Reducing Cravings to Smoke

Effects of ABT-089 on Smoking Abstinence Symptoms and Reward

Testing Methylphenidate for Smoking Abstinence

Relapse Prevention Study in Newly Abstinent Smokers

Voucher Based Incentives to Treat Pregnant Smokers

Smoking Cessation Medication And Rewards Using a Teamlet to Treat Tobacco Use Disorder (SMARTTT 2.0) Among Persons With HIV: A Multi-site Hybrid Type 2 Effectiveness-implementation Trial