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ClinicalTrials.gov public records Last synced Nov 15, 2026, 6:36 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 193–216 of 228 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Smoking abstinence Clear all

Conditions: Cigarette Smoking
Interventions: Best Practices, Financial Incentives, Nicotine Replacement Therapy; Behavioral · Drug
Lead sponsor: University of Vermont; Other
Eligibility: 18 Years and older · Female only
Enrollment: 198 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2020
U.S. locations: 1
States / cities: Burlington, Vermont

Conditions: Nicotine Dependence
Interventions: Cognitive Behavioural Therapy, Contingency Management, Nicotine Transdermal Patch; Behavioral · Drug
Lead sponsor: Yale University; Other
Eligibility: 14 Years to 19 Years
Enrollment: 154 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2015
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Smoking
Interventions: Placebo, AB-free kava; Drug
Lead sponsor: University of Florida; Other
Eligibility: 21 Years to 75 Years
Enrollment: 76 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Smoking
Interventions: Varenicline, Placebo; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 40 Years · Male only
Enrollment: 19 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2010
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Tobacco Use Cessation
Interventions: Quitline-Delivered Proactive Telephone Counseling, Follow-Up Phone Call, Smoking Cessation Training, Qualitative Interviews Concerning the Implementation of AAC; Behavioral
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 5,212 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2049
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Waterpipe Smoking
Interventions: Contingency Management; Behavioral
Lead sponsor: Washington State University; Other
Eligibility: 18 Years and older
Enrollment: 39 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Spokane, Washington

Conditions: Tobacco Use Disorder, Substance Use Disorder (SUD)
Interventions: Contingency Management (CM), Treatment as Usual (TAU); Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Tobacco Use Cessation
Interventions: web-based video game (Quit IT), Questionnaires, Evaluation Interview; Other · Behavioral
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Eligibility: 30 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2011
U.S. locations: 1
States / cities: New York, New York

Conditions: Smoking Cessation, Diabetes Type 2
Interventions: Contingency Management, Usual Care smoking cessation; Behavioral
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years to 75 Years
Enrollment: 29 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Smoking Cessation, Tobacco Use Disorder
Interventions: Nicotine patches, Telephone counseling, iQuit Smoking website; Drug · Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years and older
Enrollment: 2,485 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2014
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Smoking Cessation
Interventions: Contingency Management, Standard Care; Combination Product
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years and older
Enrollment: 282 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2025
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Smoking, Tobacco
Interventions: P2611222, P2615022, P2615122, P2613422; Other
Lead sponsor: RAI Services Company; Industry
Eligibility: 21 Years to 65 Years
Enrollment: 668 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 27
States / cities: Chandler, Arizona • Fort Smith, Arkansas • Altamonte Springs, Florida + 21 more

Conditions: Tobacco Use Disorder
Interventions: Nicotine polacrilex, Bupropion; Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 50 Years and older
Enrollment: 403 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2001 – 2009
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Tobacco Use Disorder, Tobacco Dependence
Interventions: Quitbuddy, Control, SDoH Augmentation, SDoH Control; Other
Lead sponsor: Bryan W. Heckman; Other
Eligibility: 21 Years and older
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Smoking Cessation
Interventions: E-cigarette free access, E-cigarette/NRT/Zyban/Chantix Choice, Outcome Incentive arm, Loss framing incentive arm, Control; Behavioral
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 99 Years
Enrollment: 6,006 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Veterans, Tobacco Use Disorder, Cigarette Smoking, Tobacco Dependence
Interventions: Motivation-Phase Varenicline, Motivation-Phase Nicotine Mini-Lozenge, Cessation-Phase Combination Nicotine Replacement Therapy (NRT), Cessation-Phase Varenicline, Motivation-Phase Counseling, Cessation-Phase Counseling; Drug · Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 21 Years and older
Enrollment: 400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 4
States / cities: San Diego, California • Minneapolis, Minnesota • Durham, North Carolina + 1 more

Conditions: Smokers, Never Smokers
Interventions: Cigarette; Other
Lead sponsor: Philip Morris Products S.A.; Industry
Eligibility: 25 Years to 45 Years · Male only
Enrollment: 14 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017
U.S. locations: 2
States / cities: Neptune City, New Jersey • Newark, New Jersey

Conditions: CBD, Stress, Nicotine Dependence, Tobacco Smoking
Interventions: Epidiolex; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 21 Years to 70 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Smoking Cessation
Interventions: Bupropion; Drug
Lead sponsor: University of Kansas Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 500 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Kansas City, Missouri

Conditions: Tobacco Use Disorder
Interventions: Ramelteon, Placebo; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 65 Years
Enrollment: 140 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2018
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Tobacco Use Disorder, Tobacco Smoking
Interventions: [F18]-ASEM (3-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-6-[18F]fluorodibenzo[b,d]thiophene 5,5-dioxide), Contingency Management; Drug · Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 21 Years to 50 Years
Enrollment: 15 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Smoking
Interventions: Financial counseling, Nicotine Replacement Therapy Agent - Patches, Nicotine Replacement Therapy Agent - Lozenges, Nicotine Replacement Therapy Agent - Gum; Other · Drug
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 100 Years
Enrollment: 602 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2029
U.S. locations: 1
States / cities: New York, New York

Conditions: Smoking Cessation
Interventions: rimonabant; Drug
Lead sponsor: Sanofi; Industry
Eligibility: 18 Years and older
Enrollment: 533 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004
U.S. locations: 1
States / cities: Bridgewater, New Jersey

Conditions: Cigarette Smoking
Interventions: Reinforcement for the abstinence of smoking, Reinforcement for submission of videos with CO sample; Behavioral
Lead sponsor: National Development and Research Institutes, Inc.; Other
Eligibility: 18 Years and older
Enrollment: 96 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2014
U.S. locations: 1
States / cities: New York, New York

Search by objective public record fields.

Financial Incentives for Smoking Cessation Among Mothers

Enhancing a High School Based Smoking Cessation Program

The Potential of Kava in Enabling Tobacco Cessation - Its Holistic Effects in Managing Stress and Insomnia Associated With Abstinence

Endothelial Function and Autonomic Regulation After Short-term Smoking Cessation: Varenicline Versus Placebo

Ask Advise Connect (AAC) Harris Heath CPRIT

The Role of Contingency Management in Waterpipe Smoking Cessation

Contingency Management for Veteran Smokers Undergoing Major Elective Surgery

Quit IT: Development of a Web-based, 3D Coping Skills Game to Increase Self-Efficacy for Maintaining Smoking Abstinence Following Hospitalization

Diabetes Smoking Cessation Incentives Study

A Randomized Trial of Internet Access to Nicotine Patches

Contingency Management to Promote Smoking Abstinence in Cancer Patients

A RCT to Determine the Effect of ENDS Flavor Availability on Abstinence Within Smokers

Maintaining Nonsmoking: Older Smokers - 1

Equitable Smoking Relapse Prevention

Randomized Clinical Trial to Reduce Harm From Tobacco

Varenicline for Smoking Reduction in Veterans Not Ready To Quit

Prefatory Study to Explore Changes in Nasal Mucociliary Clearance and to Standardize Nasal Scraping Procedure

Effects of Cannabidiol on Stress and Nicotine Withdrawal

Improving Smoking Abstinence Outcomes in the African American Community Through Extended Treatment

Effect of Ramelteon on Smoking Abstinence

Brain Imaging in Tobacco Smokers During a Quit Attempt

Integrating Financial Coaching and Smoking Cessation Coaching

Comparison of Efficacy and Safety of Rimonabant 20mg/Day Versus Placebo in Smoking Cessation

Technological Innovations in Behavioral Treatments for Cigarette Smoking