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ClinicalTrials.gov public records Last synced Oct 22, 2026, 2:38 PM EDT

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Showing 1–24 of 1,382 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Smoking cessation therapy Clear all
Recruiting Phase 2 Interventional

Cannabidiol for Reducing Cigarette Use

NCT06218056
View directory record Official record
Conditions
Tobacco Use Disorder, Tobacco Smoking, Tobacco Dependence
Interventions
Cannabidiol (CBD) 800 mg, Placebo
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
North Hollywood, California
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Oct 22, 2026, 2:38 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Oklahoma Study of Native American Pain Risk IV: Smoking Cessation and Pain

NCT07080788
View directory record Official record
Conditions
Smoking Cessation Intervention, Pain, Smoking (Tobacco) Addiction
Interventions
Smoking Cessation
Behavioral
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Oct 22, 2026, 2:38 PM EDT
Completed Not applicable Interventional

Disseminating and Implementing a Smoking Cessation Program for Pregnant and Postpartum Women

NCT02952703
View directory record Official record
Conditions
Smoking, Tobacco Use Disorder
Interventions
brief pre-delivery smoking cessation counseling, additional pre-delivery smoking cessation counseling, post- delivery smoking cessation counseling, incentives
Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
185 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 12, 2018 · Synced Oct 22, 2026, 2:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Promoting Evidenced-Based Tobacco Smoking Cessation Treatment in Community Mental Health Clinics

NCT04796961
View directory record Official record
Conditions
Tobacco Smoking
Interventions
Implementation Intervention
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
91 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 3, 2025 · Synced Oct 22, 2026, 2:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Faith Based Pilot Intervention to Reduce Tobacco Use Among Somali Males

NCT03379142
View directory record Official record
Conditions
Tobacco Use, Faith-Based, Community-engaged, Text Messaging
Interventions
Faith-Based messages
Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 79 Years · Male only
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
2
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 4, 2020 · Synced Oct 22, 2026, 2:38 PM EDT
Completed Phase 2 Interventional Results available

Varenicline vs Placebo for the Treatment of Methamphetamine Dependence

NCT01011829
View directory record Official record
Conditions
Methamphetamine Dependence, Substance Abuse, Methamphetamine Abuse
Interventions
Varenicline, Placebo
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 14, 2013 · Synced Oct 22, 2026, 2:38 PM EDT
Completed Not applicable Interventional Results available

Clinical Trial of Smoking Cessation Mobile Phone Program

NCT02656745
View directory record Official record
Conditions
Nicotine Addiction, Drug Addiction, Drug Dependence, Substance Use Disorder, Tobacco Dependence
Interventions
Mobile Smoking Cessation Solution
Device
Lead sponsor
Click Therapeutics, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
416 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 14, 2018 · Synced Oct 22, 2026, 2:38 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Automated Mobile Contingency Management for Smoking Cessation: A Pilot RCT (SCC PREVAILgo)

NCT03739437
View directory record Official record
Conditions
Smoking Cessation
Interventions
Mobile Contingency Management, Standard Care
Behavioral
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 100 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Apr 4, 2023 · Synced Oct 22, 2026, 2:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Pilot Randomized Controlled Trial of a Smart Phone-Based Smoking Cessation Program

NCT04955639
View directory record Official record
Conditions
Smoking Cessation
Interventions
Control, Pivot
Other
Lead sponsor
Jennifer Marler, MD
Industry
Eligibility
21 Years and older
Enrollment
188 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
San Carlos, California
Source: ClinicalTrials.gov public record
Updated Jul 1, 2024 · Synced Oct 22, 2026, 2:38 PM EDT
Recruiting Phase 4 Interventional

Varenicline and Accelerated Transcranial Magnetic Stimulation (TMS) for Quitting Nicotine Use (Pilot Study)

NCT07145866
View directory record Official record
Conditions
Nicotine Dependence, Transcranial Magnetic Stimulation, Vaping, Smoking Cessation, Smoking (Tobacco) Addiction
Interventions
Varenicline, Transcranial Magnetic Stimulation, Transcranial Magnetic Stimulation Sham, Nicotine Cessation Counseling, D-cycloserine
Drug · Device · Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 15, 2026 · Synced Oct 22, 2026, 2:38 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

EQQUAL-NM for the Promotion of Smoking Cessation in Sexual and Gender Minority Young Adults in New Mexico

NCT06386432
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Smartphone App-delivered Smoking Cessation Intervention, Health Promotion and Education, Biospecimen Collection, Questionnaire Administration
Behavioral · Other
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
18 Years to 30 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Oct 8, 2025 · Synced Oct 22, 2026, 2:38 PM EDT
Not listed Not applicable Interventional

PRISM-GENOMICS-Smoking Cessation for Patients With Coronary Artery Disease Undergoing Cardiac Catheterization or Having a Heart Attack at Barnes Hospital in St. Louis Mo

NCT03383224
View directory record Official record
Conditions
Coronary Artery Disease, Smoking Cessation
Interventions
genotype-guided therapy, Nicotine patch, Smoking cessation counseling
Other · Drug · Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2025
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Nov 1, 2021 · Synced Oct 22, 2026, 2:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Enhancing the Efficacy of Smoking Quit Line in the Military (AFIII Renewal)

NCT02201810
View directory record Official record
Conditions
Initial Efficacy of Quit Line, Efficacy of Secondary Reengagement Intervention
Interventions
Rate reduction intervention, Recycling Group, Choice Group, Proactive QL
Behavioral
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
614 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2020
U.S. locations
1
States / cities
Lackland Air Force Base, Texas
Source: ClinicalTrials.gov public record
Updated May 26, 2022 · Synced Oct 22, 2026, 2:38 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Disease Management for Smoking Cessation

NCT00440115
View directory record Official record
Conditions
Smoking Cessation
Interventions
High intensity disease management, Low intensity disease management, Comparison group, Bupropion
Behavioral · Drug
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years and older
Enrollment
750 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Jun 7, 2017 · Synced Oct 22, 2026, 2:38 PM EDT
Completed Phase 4 Interventional Results available

Engagement With an Adaptive Mobile Health Smoking Cessation Intervention

NCT04020718
View directory record Official record
Conditions
Tobacco Use Cessation
Interventions
Brief telephone advice plus tailored text messages, Mailed nicotine replacement therapy, Proactive telephone coaching
Behavioral · Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 10, 2022 · Synced Oct 22, 2026, 2:38 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Harnessing the Power of Technology: MOMBA for Postpartum Smoking

NCT02237898
View directory record Official record
Conditions
Smoking Cessation
Interventions
MoMba Live Long app & Sensordrone™ carbon-monoxide sensor, Office contingency management, Sensordrone™ carbon-monoxide sensor, MoMba Live Long Smartphone application
Behavioral · Device
Lead sponsor
Yale University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated May 21, 2020 · Synced Oct 22, 2026, 2:38 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Beyond the Lung Cancer Diagnosis: Leveraging the Oncology Clinic Setting for Actively Smoking Family Members

NCT03966807
View directory record Official record
Conditions
Lung Cancer
Interventions
Digital-based support, Traditional-based support + Nicotine replacement therapy (NRT)
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jan 18, 2024 · Synced Oct 22, 2026, 2:38 PM EDT
Completed Phase 1Phase 2 Interventional

A Preliminary Study of Sustained-Release Bupropion for Smoking Cessation in Bipolar Affective Disorder

NCT00593099
View directory record Official record
Conditions
Bipolar Disorder
Interventions
Bupropion, Placebo
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 65 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Oct 22, 2026, 2:38 PM EDT
Completed Phase 4 Interventional Results available

Smoking Cessation Medications: Efficacy, Mechanisms and Algorithms

NCT00332644
View directory record Official record
Conditions
Nicotine Dependence
Interventions
nicotine patch, nicotine lozenge, nicotine patch + nicotine lozenge, bupropion, bupropion + lozenge, placebo
Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
1,504 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2010
U.S. locations
2
States / cities
Madison, Wisconsin • Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Nov 30, 2011 · Synced Oct 22, 2026, 2:38 PM EDT
Completed Not applicable Interventional Results available

Financial Incentives for Smoking Cessation Among Disadvantaged Pregnant Women

NCT02210832
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Best practices, financial incentives
Behavioral
Lead sponsor
University of Vermont
Other
Eligibility
18 Years and older · Female only
Enrollment
257 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Aug 24, 2023 · Synced Oct 22, 2026, 2:38 PM EDT
Completed Not applicable Interventional Results available

Smoking Cessation Pilot for People Living With HIV (PLWH)

NCT04808609
View directory record Official record
Conditions
Smoking Cessation, Smoking, Smoking Behaviors, Smoking Reduction, Smoking, Tobacco, Smoking, Cigarette, Hiv, HIV/AIDS
Interventions
Lumme mobile phone application, Standard of Care
Device · Behavioral
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 23, 2023 · Synced Oct 22, 2026, 2:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Empower Korean Families to End Tobacco Use & Smoking Exposure

NCT04079569
View directory record Official record
Conditions
Smoking Cessation, Lifestyle Risk Reduction
Interventions
Tobacco, Healthy Living
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
112 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
San Leandro, California
Source: ClinicalTrials.gov public record
Updated Apr 8, 2021 · Synced Oct 22, 2026, 2:38 PM EDT
Not listed Not applicable Interventional

Development of a Smoking Cessation Video Series

NCT06443294
View directory record Official record
Conditions
Tobacco Use Cessation, Tobacco Smoking
Interventions
Smoking cessation video series.
Behavioral
Lead sponsor
Wayne State University
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 5, 2024 · Synced Oct 22, 2026, 2:38 PM EDT
Completed Not applicable Interventional Results available

iQuit Mindfully: Text Messaging for Smoking Cessation

NCT03029819
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Mindfulness-based Addiction Treatment, iQuit Mindfully, Self-Help guide, Nicotine Patch
Behavioral · Drug
Lead sponsor
Georgia State University
Other
Eligibility
18 Years to 65 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 8, 2019 · Synced Oct 22, 2026, 2:38 PM EDT