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Showing 1–18 of 18 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Smoking topography Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Smoking Topography and Harm Exposure in Menthol Cigarettes

NCT01329263
View directory record Official record
Conditions
Cigarette Smoking Toxicity
Interventions
Menthol to non-menthol
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
21 Years to 65 Years
Enrollment
87 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 5, 2015 · Synced Sep 8, 2026, 8:01 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Measuring Smoking Behaviors While Using Varenicline

NCT00948155
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Varenicline
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
21 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 15, 2014 · Synced Sep 8, 2026, 8:01 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Characterization of Product Use in Smokers Switching From Cigarettes to a RELX Electronic Nicotine Delivery System

NCT04708106
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
RELX ENDS Tobacco Flavor, RELX ENDS Menthol Flavor, RELX ENDS Tobacco and Menthol Flavors
Other
Lead sponsor
Cheerain HK Limited
Industry
Eligibility
22 Years to 65 Years
Enrollment
194 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
5
States / cities
Bentonville, Arkansas • Lexington, Kentucky • Springfield, Missouri + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 21, 2021 · Synced Sep 8, 2026, 8:01 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Cigarette Smoking Decision Study

NCT04595279
View directory record Official record
Conditions
Tobacco Smoking
Interventions
Smoking sessions
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 29 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 14, 2025 · Synced Sep 8, 2026, 8:01 PM EDT
Completed Not applicable Interventional

"Natural" and "Organic" Cigarette Descriptors: Association With Expectancies, Subjective Effects, Topography, and Biomarkers of Exposure Among Daily Smokers

NCT05468333
View directory record Official record
Conditions
Smoking Behaviors
Interventions
Cigarette trial
Other
Lead sponsor
University of Nevada, Reno
Other
Eligibility
21 Years to 65 Years
Enrollment
184 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
3
States / cities
Reno, Nevada • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 30, 2025 · Synced Sep 8, 2026, 8:01 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

COPD E-cigarette Topography Training

NCT05510154
View directory record Official record
Conditions
Pulmonary Disease, Chronic Obstructive, Tobacco Smoking
Interventions
Brief advice, Single Training, Training to Competency
Behavioral
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
21 Years and older
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 26, 2023 · Synced Sep 8, 2026, 8:01 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Effects of Tobacco Flavoring and Liquid Composition on Vaping Topography

NCT05876091
View directory record Official record
Conditions
Tobacco-Related Carcinoma
Interventions
Vaping, Biospecimen Collection, Questionnaire Administration
Other · Procedure
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
21 Years to 55 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Dec 21, 2025 · Synced Sep 8, 2026, 8:01 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Concurrent Hookah and Alcohol Consumption on Smoking Topography and Toxicant Exposure

NCT03096860
View directory record Official record
Conditions
Alcohol Use, Unspecified, Hookah Smoking
Interventions
Active alcohol consumption, Placebo consumption
Other
Lead sponsor
Oklahoma State University
Other
Eligibility
21 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Oct 12, 2017 · Synced Sep 8, 2026, 8:01 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Switching to Reduced Oxidant or Nicotine Content Cigarettes in Smokers

NCT02415270
View directory record Official record
Conditions
Tobacco Smoking Behavior
Interventions
Reduced Nicotine Cigarettes, Reduced ROS/RNS, Control
Other
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
21 Years to 65 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 26, 2018 · Synced Sep 8, 2026, 8:01 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Measuring Smoking Behavior in People With Schizophrenia and Bipolar Disorder

NCT00382915
View directory record Official record
Conditions
Schizophrenia, Bipolar Disorder
Interventions
CReSSmicro handheld topography device
Device
Lead sponsor
University of Medicine and Dentistry of New Jersey
Other
Eligibility
18 Years to 75 Years
Enrollment
276 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2010
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated May 26, 2013 · Synced Sep 8, 2026, 8:01 PM EDT
Not yet recruiting Not applicable Interventional

Evaluating the Effect of Nicotine on Eye Movements and Related Behaviors in Electronic Cigarette Users, NICS-EYES Trial

NCT07604246
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Avoidance, Biospecimen Collection, Cigarette Smoking, Eye Movement Measurement, Healthcare Activity, Questionnaire Administration, Refrain from Smoking, Vaping, Standardized E-Cigarette Nicotine Administration
Behavioral · Procedure · Other + 1 more
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years to 50 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Sep 8, 2026, 8:01 PM EDT
Completed No phase listed Observational

Behavioral Pharmacology Associated With Cigar Smoking

NCT02218840
View directory record Official record
Conditions
Cigar Smoking
Interventions
Smoking topography
Other
Lead sponsor
Food and Drug Administration (FDA)
Federal
Eligibility
18 Years to 99 Years
Enrollment
77 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Feb 27, 2023 · Synced Sep 8, 2026, 8:01 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Impact of Novel vs. Usual Brand Menthol Cigarettes on Abuse Liability

NCT07564648
View directory record Official record
Conditions
Cigarette Addiction, Tobacco Use Disorder
Interventions
Biospecimen Collection, Questionnaire Administration, Cigarette Purchase Task, Cross-Price Elasticity Task, Daily Diary Surveys, Progressive Ratio Task
Behavioral
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years and older
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 21, 2026 · Synced Sep 8, 2026, 8:01 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Effects of Filter Ventilation on Sensory Response, Smoking Topography, and Inhalation in Current Every Day Cigarette Smokers

NCT04060446
View directory record Official record
Conditions
Cigarette Smoker, Current Every Day Smoker
Interventions
Medical Device, Questionnaire Administration, Tobacco Smoking
Device · Other · Behavioral
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
18 Years to 69 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Jul 14, 2022 · Synced Sep 8, 2026, 8:01 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Use and Harm Exposure in New Low Nicotine Cigarettes

NCT01202942
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Quest
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
21 Years to 65 Years
Enrollment
246 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2013
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 18, 2013 · Synced Sep 8, 2026, 8:01 PM EDT
Withdrawn Phase 1Phase 2 Interventional

Study of Varencline Effects on Cigarette Smoking Reward and Craving During a Model of Brief Quit Attempt

NCT00571805
View directory record Official record
Conditions
Nicotine Dependence
Interventions
varencline, placebo
Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2007
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 8, 2015 · Synced Sep 8, 2026, 8:01 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Perceptions of Vaping Products

NCT06868368
View directory record Official record
Conditions
Abuse Tobacco, Exposure
Interventions
Biospecimen Collection, Survey Administration, Vaping Topography, Participant's Own Preferred E-cigarette, Nicotine E-cigarette, 6-methyl-nicotine (metatine) e-cigarette
Other · Behavioral
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years to 34 Years
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 7, 2026 · Synced Sep 8, 2026, 8:01 PM EDT
Completed Not applicable Interventional Results available

Puff Biofeedback to Reduce Smoking Reinforcement

NCT05644002
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Puff Topography Biofeedback Training, Control
Behavioral
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
19 Years to 55 Years
Enrollment
154 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Feb 23, 2025 · Synced Sep 8, 2026, 8:01 PM EDT