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Showing 1–24 of 184 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Sodium Fluoride (NaF) Clear all
Completed Phase 3 Interventional Accepts healthy volunteers

Clinical Study to Assess the Efficacy of New Toothpaste Containing SnF as Compared to Colgate Cavity Protection Toothpaste on the Reduction of Enamel Erosion

NCT07442136
View directory record Official record
Conditions
Enamel Erosion
Interventions
New Toothpaste Containing SnF, Fluoride Toothpaste
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 70 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Sep 24, 2026, 4:30 AM EDT
Completed Early Phase 1 Interventional

SDF Application in Oral Cancer Patients to Prevent Dental Caries

NCT05403125
View directory record Official record
Conditions
Dental Caries
Interventions
silver diamine fluoride, 38%, Sodium fluoride gel, 5000 PPM
Device
Lead sponsor
Texas A & M University Baylor College Of Dentistry
Other
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Sep 16, 2025 · Synced Sep 24, 2026, 4:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Fluoride Varnish for Treatment of White Spot Lesions

NCT01500187
View directory record Official record
Conditions
White Spot Lesions
Interventions
Vanish Varnish, Pediagel
Device
Lead sponsor
Solventum US LLC
Industry
Eligibility
12 Years to 16 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 1, 2024 · Synced Sep 24, 2026, 4:30 AM EDT
Active, not recruiting Not applicable Interventional

Post-Radiation Oral Health in Underserved Head and Neck Cancer Patients

NCT07556367
View directory record Official record
Conditions
Head and Neck Cancer, Head and Neck Carcinoma, Head and Neck Neoplasms
Interventions
Surveys, Saliva Collection, Intra-oral photographs, Fluoride Varnish Treatment, Interview (Participant)
Other · Procedure · Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 31, 2026 · Synced Sep 24, 2026, 4:30 AM EDT
Completed Not applicable Interventional Results available

A Real-World Evidence Study to Evaluate Oral Health Related Quality of Life Using an Anti-Sensitivity Toothpaste

NCT04964063
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Potassium Nitrate + Sodium Fluoride
Other
Lead sponsor
HALEON
Industry
Eligibility
18 Years to 65 Years
Enrollment
655 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Jan 21, 2024 · Synced Sep 24, 2026, 4:30 AM EDT
Completed Phase 4 Interventional

A Study of Mouth Rinses in Type 1 and Type 2 Diabetic Participants

NCT04449952
View directory record Official record
Conditions
Gingivits in Diabetics
Interventions
Listerine Cool Mint, 5% Hydroalcohol Mouth Rinse, Colgate Cavity Protection Toothpaste, Alcohol-Free Essential Oil Containing (AFEO) Mouth Rinse Lead Formula, Concept Curve Winter Series Toothbrush, Listerine Cool Mint Floss
Other · Device
Lead sponsor
Johnson & Johnson Consumer Inc. (J&JCI)
Industry
Eligibility
18 Years and older
Enrollment
154 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 6, 2023 · Synced Sep 24, 2026, 4:30 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Evaluation of Plaque Fluid Fluoride Retention From Fluoride Toothpastes

NCT00708305
View directory record Official record
Conditions
Dental Caries
Interventions
Sodium Fluoride (NaF), Placebo
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
65 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Dec 31, 2014 · Synced Sep 24, 2026, 4:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Study of Treatments Used for White Spot Lesions After Orthodontic Treatment.

NCT01059058
View directory record Official record
Conditions
Tooth Demineralization
Interventions
MI Paste Plus, PreviDent Fluoride Varnish, Normal Home Care
Procedure
Lead sponsor
University of Washington
Other
Eligibility
12 Years to 20 Years
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 16, 2015 · Synced Sep 24, 2026, 4:30 AM EDT
Recruiting Phase 4 Interventional

Clinical Study to Collect and Analyze Dental Plaque and Oral Health Measures in a Population With High Plaque/Low Gingivitis and High Plaque/High Gingivitis

NCT07614490
View directory record Official record
Conditions
Gingivitis, Plaque
Interventions
sodium monofluorophosphate toothpaste
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Sep 24, 2026, 4:30 AM EDT
Completed Phase 4 Interventional Results available

Baseline Oral Health Study: UnCoVer the Connections to General Health

NCT04954313
View directory record Official record
Conditions
Cardiovascular Diseases, Diabetes Type 2
Interventions
Subgingival chlorhexidine irrigation, Dental Supplies, Periodonal Treatment
Drug · Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
786 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
2
States / cities
Chapel Hill, North Carolina • Kannapolis, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 11, 2026 · Synced Sep 24, 2026, 4:30 AM EDT
Terminated Phase 1 Interventional

NaF/FDG PET/MRI in Measuring Response to Radium Ra 223 Dichloride in Patients With Metastatic Hormone-Resistant Prostate Cancer

NCT02429804
View directory record Official record
Conditions
Hormone-Resistant Prostate Cancer, Metastatic Malignant Neoplasm in the Bone, Metastatic Prostate Carcinoma
Interventions
Contrast-enhanced Magnetic Resonance Imaging, Fludeoxyglucose F-18, Fluorine F 18 Sodium Fluoride, Magnetic Resonance Imaging, Positron Emission Tomography
Procedure · Drug
Lead sponsor
Stanford University
Other
Eligibility
19 Years and older · Male only
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated May 29, 2017 · Synced Sep 24, 2026, 4:30 AM EDT
Terminated Phase 2 Interventional Accepts healthy volunteers Results available

Antiviral Efficacy and Acceptability of Mouth Rinses for Inactivation of COVID-19

NCT04748783
View directory record Official record
Conditions
COVID19, Coronavirus Infection, SARS CoV-2 Infection
Interventions
Water, Peroxyl, Periogard, Colgate Total Zero
Other · Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 65 Years
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 15, 2022 · Synced Sep 24, 2026, 4:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Effect of Experimental Dentifrices on Remineralization of Caries Lesions In-situ

NCT02195583
View directory record Official record
Conditions
Oral Hygiene
Interventions
Sodium fluoride (1426 ppm), Sodium fluoride (1150 ppm), Sodium fluoride (250 ppm), Sodium fluoride (1426 ppm) + zinc base A, Sodium fluoride (1426 ppm) + zinc base B, Fluoride (0 ppm)
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Apr 30, 2015 · Synced Sep 24, 2026, 4:30 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Clinical Investigation to Examine Toothpaste Effect on Oral Bacteria

NCT02194621
View directory record Official record
Conditions
Oral Bacteria Levels in the Mouth
Interventions
Total Flavor option 1, Total Flavor option 2, Placebo toothpaste: Crest Cavity Protection toothpaste
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
22 Years to 58 Years
Enrollment
128 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 14, 2016 · Synced Sep 24, 2026, 4:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Study of Detergents in the Pathogenesis of Eosinophilic Esophagitis

NCT05482256
View directory record Official record
Conditions
Eosinophilic Esophagitis
Interventions
Esophageal String Test (EST), Colgate, High Resolution Esophageal Manometry (HREM)
Diagnostic Test · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Scottsdale, Arizona
Source: ClinicalTrials.gov public record
Updated Oct 23, 2025 · Synced Sep 24, 2026, 4:30 AM EDT
Not listed Early Phase 1 Interventional Accepts healthy volunteers

Effectiveness Silver Diamine Fluoride Versus Sodium Fluoride in Arresting Caries Around Crown Margins in Older Adults

NCT04255251
View directory record Official record
Conditions
Caries Roots, Flouride Varnish, Caries; Dentin, Caries Arrested
Interventions
Silver Diammine Fluoride, Fluoride Varnishes
Drug
Lead sponsor
University of New England
Other
Eligibility
65 Years to 85 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Portland, Maine
Source: ClinicalTrials.gov public record
Updated Oct 4, 2021 · Synced Sep 24, 2026, 4:30 AM EDT
Completed Phase 2 Interventional Results available

Combined 18F-NaF/18F-FDG PET/MRI for Detection of Skeletal Metastases

NCT00375830
View directory record Official record
Conditions
Cancer
Interventions
Bone scan, 99mTc-methyl diphosphonate, Positron Emission Tomography (PET) scan, 18F-Fludeoxyglucose (18F-FDG), Computed Tomography (CT) scan, 18F-Sodium Fluoride (18F-NaF), Whole Body Magnetic Resonance Imaging (WB-MRI) scan, Gadopentetate dimeglumine, Gadofosveset, Gadobutrol
Procedure · Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
114 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2019
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Dec 11, 2023 · Synced Sep 24, 2026, 4:30 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Maximal Use Study to Determine the Pharmacokinetics of L-arginine After Exaggerated Oral Use of COL101

NCT06182267
View directory record Official record
Conditions
Caries,Dental
Interventions
L Arginine, Sodium Fluoride
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 65 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Fair Lawn, New Jersey
Source: ClinicalTrials.gov public record
Updated Jan 1, 2024 · Synced Sep 24, 2026, 4:30 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Evaluation of a Low-fluoride Anticaries Toothpaste

NCT01094210
View directory record Official record
Conditions
Tooth Abnormality
Interventions
Fluorides, Topical
Drug
Lead sponsor
Indiana Nanotech, LLC
Other
Eligibility
18 Years to 50 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Mar 24, 2015 · Synced Sep 24, 2026, 4:30 AM EDT
Completed Not applicable Interventional Results available

Xylitol for Caries Prevention in Inner-City Children

NCT01901250
View directory record Official record
Conditions
Dental Caries
Interventions
Xylitol gummy bears, Sugar free fiber gummy bears, Oral health education, Fluoride varnish, Dental sealant
Dietary Supplement · Behavioral · Device
Lead sponsor
Case Western Reserve University
Other
Eligibility
5 Years to 6 Years
Enrollment
562 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 11, 2014 · Synced Sep 24, 2026, 4:30 AM EDT
Completed No phase listed Observational

Imaging Biomarkers to Validate Response in Enzalutamide-Treated mCRPC

NCT02677376
View directory record Official record
Conditions
Prostatic Neoplasms
Interventions
18F-Sodium Fluoride (NaF)
Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older · Male only
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 25, 2020 · Synced Sep 24, 2026, 4:30 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

To Assess the Efficacy of a Toothpaste Containing 8% Arginine as Compared to Colgate Cavity Protection Toothpaste in the Reduction of Dentinal Hypersensitivity.

NCT07149376
View directory record Official record
Conditions
Sensitivity, Tooth
Interventions
TOMs of Maine Sensitive SLS Free Xtra Fresh, Colgate Cavity protection toothpaste
Device · Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 70 Years
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Costa Mesa, California
Source: ClinicalTrials.gov public record
Updated Nov 4, 2025 · Synced Sep 24, 2026, 4:30 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Efficacy of a Stannous Fluoride Toothpaste, Cetylpyridinium Chloride Mouthwash, and Battery Toothbrush Regimen in Reducing Established Dental Plaque and Gingivitis.

NCT07398846
View directory record Official record
Conditions
Plaque
Interventions
0.454%Stannous fluoride toothpaste, 0.075% Cetylpyridinium Chloride (CPC) and 0.28% zinc lactatmouthwashe, 0.76% Sodium Monofluorophosphate (Na MFP) toothpaste, 0.022% Sodium Fluoride mouthwash
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 70 Years
Enrollment
134 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Melbourne, Florida
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Sep 24, 2026, 4:30 AM EDT
Completed Phase 2 Interventional

18-F Sodium Fluoride (18F-NaF) PET for the Assessment of Bioprosthetic Aortic Valve Durability and Outcomes

NCT03095313
View directory record Official record
Conditions
Aortic Stenosis
Interventions
18F-NaF
Other
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
60 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 11, 2025 · Synced Sep 24, 2026, 4:30 AM EDT