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ClinicalTrials.gov public records Last synced Oct 4, 2026, 11:44 AM EDT

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Showing 1–24 of 41 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Sodium monofluorophosphate dentifrice Clear all
Completed Phase 4 Interventional Accepts healthy volunteers

Comparative Efficacy of Floss and Essential Oil/CPC+Zn Mouthwashes in Reducing Dental Plaque and Gingivitis

NCT07029438
View directory record Official record
Conditions
Dental Plaque, Gingivitis
Interventions
Mouthwash, Floss, Toothbrush, Toothpaste
Drug · Device
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years and older
Enrollment
228 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Oct 30, 2025 · Synced Oct 4, 2026, 11:44 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Evaluate Inflammation Caused by Gingivitis in Adults

NCT00941668
View directory record Official record
Conditions
Gingivitis
Interventions
Triclosan/Copolymer/fluoride toothpaste, sodium monofluorophosphate toothpaste
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 60 Years
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 27, 2015 · Synced Oct 4, 2026, 11:44 AM EDT
Completed Not applicable Interventional

Brief Title: a Clinical Study to Assess Gingivitis

NCT06659471
View directory record Official record
Conditions
Gingival Diseases
Interventions
0.76% Sodium Monofluorophosphate Dentifrice, 0.454% Stannous Fluoride Dentifrice
Drug
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Oct 26, 2024 · Synced Oct 4, 2026, 11:44 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

A Clinical Study to Assess the Plaque and Gingivitis Effects of a Stannous Fluoride Dentifrice

NCT03936569
View directory record Official record
Conditions
Gingivitis
Interventions
Marketed Toothpaste, Marketed Cavity Protection Toothpaste
Drug
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Jun 8, 2023 · Synced Oct 4, 2026, 11:44 AM EDT
Active, not recruiting Phase 4 Interventional Accepts healthy volunteers

Assessing Gingivitis and Plaque From a Marketed Toothpaste

NCT07158112
View directory record Official record
Conditions
Gingivitis
Interventions
Stannous Fluoride Dentifrice, Test Stannous Fluoride Dentifrice, Sodium monofluorophosphate dentifrice
Drug
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Whitter, California
Source: ClinicalTrials.gov public record
Updated Sep 23, 2025 · Synced Oct 4, 2026, 11:44 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

The Efficacy of a Dentifrice in Providing Relief From the Pain of Dentinal Hypersensitivity

NCT01592864
View directory record Official record
Conditions
Dentine Hypersensitivity
Interventions
Stannous Fluoride, Sodium Monofluorophosphate
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Mar 10, 2014 · Synced Oct 4, 2026, 11:44 AM EDT
Active, not recruiting Phase 1 Interventional Accepts healthy volunteers

Evaluating Gingivitis and Systemic Biomarkers

NCT06962956
View directory record Official record
Conditions
Gingivitis
Interventions
0.76% Sodium Monofluorophosphate Dentifrice, 0.454% Stannous Fluoride Dentifrice
Drug
Lead sponsor
Procter and Gamble
Industry
Eligibility
25 Years to 65 Years
Enrollment
135 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 3, 2025 · Synced Oct 4, 2026, 11:44 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Clinical Study Investigating the Efficacy of a Mouthwash in Providing Long Term Relief From Dentinal Hypersensitivity

NCT02226562
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Potassium nitrate and sodium fluoride, Standard fluoride dentifrice
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 55 Years
Enrollment
191 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 27, 2018 · Synced Oct 4, 2026, 11:44 AM EDT
Recruiting Phase 4 Interventional

Clinical Study to Collect and Analyze Dental Plaque and Oral Health Measures in a Population With High Plaque/Low Gingivitis and High Plaque/High Gingivitis

NCT07614490
View directory record Official record
Conditions
Gingivitis, Plaque
Interventions
sodium monofluorophosphate toothpaste
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated May 29, 2026 · Synced Oct 4, 2026, 11:44 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Meta-analysis of Stannous Fluoride and the Effects on Enamel Erosion

NCT04006470
View directory record Official record
Conditions
Enamel Erosion
Interventions
Stannous fluoride dentifrice, Positive control dentifrice, Negative control dentifrice
Drug
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older
Enrollment
172 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 5, 2019 · Synced Oct 4, 2026, 11:44 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Dentin Hypersensitivity Reduction Efficacy Clinical

NCT07738198
View directory record Official record
Conditions
Dental Hypersensitivity
Interventions
0.454% stannous fluoride toothpaste, 5% potassium nitrate, 0.76% sodium monofluorophosphate
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 70 Years
Enrollment
116 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Costa Mesa, California
Source: ClinicalTrials.gov public record
Updated Jul 31, 2026 · Synced Oct 4, 2026, 11:44 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Clinical Study to Compare Dental Plaque Control

NCT00758394
View directory record Official record
Conditions
Dental Plaque
Interventions
Fluoride, Triclosan/Fluoride
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 53 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 15, 2013 · Synced Oct 4, 2026, 11:44 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

A Clinical Study to Assess the Effects of a Stannous Fluoride Dentifrice on Plaque and Gingivitis

NCT03936556
View directory record Official record
Conditions
Gingivitis
Interventions
Marketed toothpaste, Marketed Cavity Protection Toothpaste
Drug
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Whittier, California
Source: ClinicalTrials.gov public record
Updated Dec 4, 2019 · Synced Oct 4, 2026, 11:44 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Exploratory Study to Evaluate the Efficacy of an Occlusion Based Dentifrice in Relief of Dentinal Hypersensitivity

NCT01831817
View directory record Official record
Conditions
Dentinal Hypersensitivity
Interventions
5% calcium sodium phosphosilicate/ sodium monofluorophosphate dentifrice, 0% calcium sodium phosphosilicate/ sodium monofluorophosphate dentifrice, Sodium monofluorophosphate dentifrice, Sodium Fluoride dentifrice
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 55 Years
Enrollment
140 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 26, 2015 · Synced Oct 4, 2026, 11:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Study in Dentinal Hypersensitivity (DH) Participants to Assess the Efficacy of an Occluding Dentifrice.

NCT02753075
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Experimental Oral Rinse 1, Experimental Oral Rinse 2, Placebo Oral Rinse, Fluoride toothpaste
Device · Other · Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 55 Years
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 27, 2018 · Synced Oct 4, 2026, 11:44 AM EDT
Completed No phase listed Observational

Meta-analysis of Stannous Fluoride and the Effects on Dental Plaque

NCT04006483
View directory record Official record
Conditions
Dental Plaque
Interventions
Stannous fluoride dentifrice, Positive control dentifrice, Negative control dentifrice
Drug
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older
Enrollment
2,359 participants
Timeline
2018
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 18, 2023 · Synced Oct 4, 2026, 11:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Clinical Study to Assess the Gingivitis Effects of Various Dentifrices

NCT06140771
View directory record Official record
Conditions
Gingivitis
Interventions
0.76% Sodium Monofluorophosphate Dentifrice, 1.15% Sodium Monofluorophosphate Dentifrice, 0.454% Stannous Fluoride Dentifrice
Drug
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older
Enrollment
115 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Whittier, California
Source: ClinicalTrials.gov public record
Updated Nov 20, 2023 · Synced Oct 4, 2026, 11:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Pilot Study to Investigate the Efficacy of a Toothpaste in Providing Relief From Dentinal Hypersensitivity

NCT01494649
View directory record Official record
Conditions
Dentinal Sensitivity, Hypersensitivity
Interventions
Test Toothpaste, Negative Control Toothpaste
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
118 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated May 8, 2013 · Synced Oct 4, 2026, 11:44 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Gingivitis Reduction After Use of 0.45% Stannous Fluoride Toothpaste

NCT06300866
View directory record Official record
Conditions
Gingivitis, Plaque, Dental
Interventions
Test, Control
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 70 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Mar 8, 2024 · Synced Oct 4, 2026, 11:44 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Clinical Investigation of a Toothpaste Containing Stannous Fluoride as Compared to Colgate Fluoride Toothpaste

NCT04033575
View directory record Official record
Conditions
Gingivitis
Interventions
Colgate Total SF, Colgate Cavity Protection toothpaste
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 70 Years
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Melbourne, Florida
Source: ClinicalTrials.gov public record
Updated Sep 27, 2022 · Synced Oct 4, 2026, 11:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of Efficacy of Sodium Monofluorophosphate (SMPF) Toothpastes on Enamel Lesion Remineralisation

NCT04155658
View directory record Official record
Conditions
Enamel Caries
Interventions
Experimental Toothpaste containing 1450ppm SMFP, Toothpaste containing 1450ppm SMFP, Toothpaste with no fluoride
Other
Lead sponsor
Unilever R&D
Industry
Eligibility
18 Years to 85 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated May 18, 2020 · Synced Oct 4, 2026, 11:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Clinical Study to Assess the Effects of Various Dentifrice Technologies on Dentinal Hypersensitivity

NCT03965039
View directory record Official record
Conditions
Dentin Hypersensitivity
Interventions
Dipotassium oxalate toothpaste, Stannous fluoride toothpaste, Potassium nitrate toothpaste, Sodium monofluorophosphate toothpaste
Device · Drug
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Oct 30, 2020 · Synced Oct 4, 2026, 11:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Study to Evaluate the Effect of a Stannous Fluoride Toothpaste on the Oral Microbiome

NCT06048809
View directory record Official record
Conditions
Oral Health
Interventions
Stannous Fluoride Toothpaste (Sensodyne Repair and Protect), Regular Fluoride Toothpaste (Colgate Cavity Protection)
Other
Lead sponsor
HALEON
Industry
Eligibility
18 Years to 65 Years
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Jul 10, 2025 · Synced Oct 4, 2026, 11:44 AM EDT
Completed Not applicable Interventional

Randomized Trial of a Gum Health Formulation

NCT03196648
View directory record Official record
Conditions
Periodontal Diseases, Gingivitis, Periodontitis, Halitosis
Interventions
Gingival health formulation in an accelerating device, Gingival health formulation on a toothbrush, OTC fluoride toothpaste
Other
Lead sponsor
Glo Science, Inc.
Industry
Eligibility
18 Years to 55 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 23, 2017 · Synced Oct 4, 2026, 11:44 AM EDT