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Showing 1–24 of 41 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Sodium monofluorophosphate toothpaste Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Assessing the Effects of Three Oral Care Regimens

NCT02940821
View directory record Official record
Conditions
Dental Plaque, Gingivitis
Interventions
Toothbrushing, Fluoridated Dentifrice (.15% sodium monofluorophosphate), Fluoridated Dentifrice Whitening System (.454% stannous fluoride with 2% hydrogen peroxide), Whitening (4.5% hydrogen peroxide), Other Fluoridated Dentifrice (.454% stannous fluoride)
Other
Lead sponsor
Pearl Network
Network
Eligibility
18 Years to 70 Years
Enrollment
142 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Emerson, New Jersey
Source: ClinicalTrials.gov public record
Updated Nov 13, 2017 · Synced Sep 28, 2026, 8:59 AM EDT
Recruiting Phase 4 Interventional

Clinical Study to Collect and Analyze Dental Plaque and Oral Health Measures in a Population With High Plaque/Low Gingivitis and High Plaque/High Gingivitis

NCT07614490
View directory record Official record
Conditions
Gingivitis, Plaque
Interventions
sodium monofluorophosphate toothpaste
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Sep 28, 2026, 8:59 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

A Phase 3 Clinical Study Investigating the Gingivitis Efficacy of a Test Dentifrice Containing Stannous Fluoride

NCT04123665
View directory record Official record
Conditions
Gingivitis
Interventions
Stannous fluoride, Sodium monofluorophosphate
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years and older
Enrollment
98 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Jan 30, 2020 · Synced Sep 28, 2026, 8:59 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Evaluate Inflammation Caused by Gingivitis in Adults

NCT00941668
View directory record Official record
Conditions
Gingivitis
Interventions
Triclosan/Copolymer/fluoride toothpaste, sodium monofluorophosphate toothpaste
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 60 Years
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 26, 2015 · Synced Sep 28, 2026, 8:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Potential of Stannous Fluoride Toothpaste to Reduce Gum Disease

NCT02750943
View directory record Official record
Conditions
Gingivitis
Interventions
Stannous Fluoride, Sodium Monofluorophosphate
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years and older
Enrollment
253 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Oct 25, 2017 · Synced Sep 28, 2026, 8:59 AM EDT
Completed No phase listed Observational

Meta-analysis of Stannous Fluoride and the Effects on Dental Plaque

NCT04006483
View directory record Official record
Conditions
Dental Plaque
Interventions
Stannous fluoride dentifrice, Positive control dentifrice, Negative control dentifrice
Drug
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older
Enrollment
2,359 participants
Timeline
2018
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 17, 2023 · Synced Sep 28, 2026, 8:59 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Meta-analysis of Stannous Fluoride Dentifrice and the Effects on Dentine Hypersensitivity

NCT04005417
View directory record Official record
Conditions
Dentine Hypersensitivity
Interventions
Stannous fluoride dentifrice, Positive control dentifrice, Negative control dentifrice
Drug
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older
Enrollment
1,036 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 1, 2019 · Synced Sep 28, 2026, 8:59 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Gingivitis Reduction After Use of 0.45% Stannous Fluoride Toothpaste

NCT06300866
View directory record Official record
Conditions
Gingivitis, Plaque, Dental
Interventions
Test, Control
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 70 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Mar 7, 2024 · Synced Sep 28, 2026, 8:59 AM EDT
Completed Not applicable Interventional

Brief Title: a Clinical Study to Assess Gingivitis

NCT06659471
View directory record Official record
Conditions
Gingival Diseases
Interventions
0.76% Sodium Monofluorophosphate Dentifrice, 0.454% Stannous Fluoride Dentifrice
Drug
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Oct 25, 2024 · Synced Sep 28, 2026, 8:59 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Enamel Remineralization Potential of Dentifrices in Situ

NCT01128946
View directory record Official record
Conditions
Dental Caries
Interventions
NaF, SnF, NaMFP
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 80 Years
Enrollment
83 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Dec 31, 2014 · Synced Sep 28, 2026, 8:59 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Clinical Investigation of a Toothpaste Containing Stannous Fluoride as Compared to Colgate Fluoride Toothpaste

NCT04033575
View directory record Official record
Conditions
Gingivitis
Interventions
Colgate Total SF, Colgate Cavity Protection toothpaste
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 70 Years
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Melbourne, Florida
Source: ClinicalTrials.gov public record
Updated Sep 26, 2022 · Synced Sep 28, 2026, 8:59 AM EDT
Active, not recruiting Phase 4 Interventional Accepts healthy volunteers

Assessing Gingivitis and Plaque From a Marketed Toothpaste

NCT07158112
View directory record Official record
Conditions
Gingivitis
Interventions
Stannous Fluoride Dentifrice, Test Stannous Fluoride Dentifrice, Sodium monofluorophosphate dentifrice
Drug
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Whitter, California
Source: ClinicalTrials.gov public record
Updated Sep 22, 2025 · Synced Sep 28, 2026, 8:59 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

A Clinical Study to Assess the Plaque and Gingivitis Effects of a Stannous Fluoride Dentifrice

NCT03936569
View directory record Official record
Conditions
Gingivitis
Interventions
Marketed Toothpaste, Marketed Cavity Protection Toothpaste
Drug
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Jun 7, 2023 · Synced Sep 28, 2026, 8:59 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Investigation of Dental Plaque and Gingival Index

NCT00759031
View directory record Official record
Conditions
Dental Plaque
Interventions
Sodium Monofluorophosphate, Triclosan/Fluoride/Copolymer
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 65 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 12, 2012 · Synced Sep 28, 2026, 8:59 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Investigating the Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity

NCT02832375
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
stannous fluoride, sodium monofluorophosphate
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
242 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated May 24, 2017 · Synced Sep 28, 2026, 8:59 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Investigating the Efficacy of a Dentifrice in Providing Long Term Relief From Dentinal Hypersensitivity

NCT01827670
View directory record Official record
Conditions
Dentine Hypersensitivity
Interventions
Stannous fluoride, Sodium monofluorophosphate
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
119 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Jan 25, 2015 · Synced Sep 28, 2026, 8:59 AM EDT
Completed Not applicable Interventional

Randomized Trial of a Gum Health Formulation

NCT03196648
View directory record Official record
Conditions
Periodontal Diseases, Gingivitis, Periodontitis, Halitosis
Interventions
Gingival health formulation in an accelerating device, Gingival health formulation on a toothbrush, OTC fluoride toothpaste
Other
Lead sponsor
Glo Science, Inc.
Industry
Eligibility
18 Years to 55 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 22, 2017 · Synced Sep 28, 2026, 8:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of Efficacy of Sodium Monofluorophosphate (SMPF) Toothpastes on Enamel Lesion Remineralisation

NCT04155658
View directory record Official record
Conditions
Enamel Caries
Interventions
Experimental Toothpaste containing 1450ppm SMFP, Toothpaste containing 1450ppm SMFP, Toothpaste with no fluoride
Other
Lead sponsor
Unilever R&D
Industry
Eligibility
18 Years to 85 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated May 17, 2020 · Synced Sep 28, 2026, 8:59 AM EDT
Completed Phase 2 Interventional Results available

Exploratory Study to Evaluate an Occlusion Based Dentifrice in Relief of Dentinal Hypersensitivity

NCT01691560
View directory record Official record
Conditions
Dentine Hypersensitivity
Interventions
5% calcium sodium phosphosilicate/ sodium monofluorophosphate dentifrice, 0% calcium sodium phosphosilicate/sodium monofluorophosphate dentifrice, Sodium monofluorophosphate dentifrice, Sodium fluoride dentifrice
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 55 Years
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated May 28, 2014 · Synced Sep 28, 2026, 8:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Study in Dentinal Hypersensitivity (DH) Participants to Assess the Efficacy of an Occluding Dentifrice.

NCT02753075
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Experimental Oral Rinse 1, Experimental Oral Rinse 2, Placebo Oral Rinse, Fluoride toothpaste
Device · Other · Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 55 Years
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 26, 2018 · Synced Sep 28, 2026, 8:59 AM EDT
Active, not recruiting Phase 1 Interventional Accepts healthy volunteers

Evaluating Gingivitis and Systemic Biomarkers

NCT06962956
View directory record Official record
Conditions
Gingivitis
Interventions
0.76% Sodium Monofluorophosphate Dentifrice, 0.454% Stannous Fluoride Dentifrice
Drug
Lead sponsor
Procter and Gamble
Industry
Eligibility
25 Years to 65 Years
Enrollment
135 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 2, 2025 · Synced Sep 28, 2026, 8:59 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Evaluation of Plaque Fluid Fluoride Retention From Fluoride Toothpastes

NCT00708305
View directory record Official record
Conditions
Dental Caries
Interventions
Sodium Fluoride (NaF), Placebo
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
65 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Dec 31, 2014 · Synced Sep 28, 2026, 8:59 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Anti-caries Potential of a Sodium Monofluorophosphate and Calcium Sodium Phosphosilicate Dentifrice

NCT01657877
View directory record Official record
Conditions
Caries
Interventions
Calcium sodium phosphosilicate, Sodium monoflurophosphate, Placebo
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 30, 2014 · Synced Sep 28, 2026, 8:59 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Meta-analysis of Stannous Fluoride and the Effects on Enamel Erosion

NCT04006470
View directory record Official record
Conditions
Enamel Erosion
Interventions
Stannous fluoride dentifrice, Positive control dentifrice, Negative control dentifrice
Drug
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older
Enrollment
172 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 4, 2019 · Synced Sep 28, 2026, 8:59 AM EDT