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Showing 1–18 of 18 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Spaceflight Clear all
Completed No phase listed Observational Accepts healthy volunteers

Space Flight Simulation to Study Effects of Micro-gravity Through Bed Rest

NCT00891449
View directory record Official record
Conditions
Weightlessness
Interventions
Not listed
Lead sponsor
National Aeronautics and Space Administration (NASA)
Federal
Eligibility
24 Years to 55 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Galveston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 16, 2015 · Synced Sep 2, 2026, 9:30 AM EDT
Completed Phase 3 Interventional

Behavioral Treatment for Obese Preschoolers

NCT01546727
View directory record Official record
Conditions
Obesity
Interventions
Behavioral Family Intervention, Motivational Interviewing
Behavioral
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
2 Years to 5 Years
Enrollment
167 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 27, 2016 · Synced Sep 2, 2026, 9:30 AM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

B-Complex: A Nutraceutical SANS Countermeasure

NCT05366933
View directory record Official record
Conditions
Optic Disc Edema, Endothelial Dysfunction
Interventions
Vitamin B-Complex Supplement
Drug
Lead sponsor
National Aeronautics and Space Administration (NASA)
Federal
Eligibility
20 Years to 100 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2032
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 21, 2025 · Synced Sep 2, 2026, 9:30 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Neurobehavioral Changes Following Spaceflight Stressors

NCT07293494
View directory record Official record
Conditions
Stressor, Individual, Alcohol Impairment, Sleep Deprivation, Impairment, Cognitive
Interventions
Alcohol Administration, Sleep Deprivation, Control
Other · Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
21 Years to 60 Years
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Sep 2, 2026, 9:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluating Risk Factors and Biomarkers for Adaptation and Resilience to Spaceflight

NCT03786016
View directory record Official record
Conditions
Resilience, Mood, Performance, Stress, Psychological
Interventions
8-Days in an Isolation, Confinement Unit
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
30 Years to 55 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 5, 2025 · Synced Sep 2, 2026, 9:30 AM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

A Multiphase Operational and Environmental Assessment of Lunar Surface Habitation, Lunar Gateway Transit Systems, and Acceleration Pathways for Sustained Human Habitation of the Martian Surface

NCT07546461
View directory record Official record
Conditions
Extraterrestrial Habitation Systems, Lunar Surface Habitation, Lunar Water-Ice Resource Assessment, In-Situ Resource Utilization (ISRU), Lunar Gateway Transit Architecture, Martian Surface Habitation Readiness, Environmental Control and Life-Support Systems (ECLSS), Radiation Exposure Modeling, EVA Logistics and Mobility, Long-Duration Isolation and Behavioral Stability
Interventions
Habitat Systems Evaluation, Water-Ice Resource Utilization Assessment, EVA and Mobility Operations
Other
Lead sponsor
Truway Health, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 29, 2026 · Synced Sep 2, 2026, 9:30 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Effects of Long-Duration Spaceflight on General and Spatial Cognition and Its Neural Basis

NCT04856410
View directory record Official record
Conditions
Brain Structure, Cognitive Performance
Interventions
Spaceflight, Controls
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
Not listed
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2028
U.S. locations
2
States / cities
Philadelphia, Pennsylvania • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 9, 2025 · Synced Sep 2, 2026, 9:30 AM EDT
Completed No phase listed Observational

The Eye in Orbit: UCF Adaption

NCT06092359
View directory record Official record
Conditions
Spaceflight Associated Neuro-Ocular Syndrome, SANS
Interventions
Not listed
Lead sponsor
University of Central Florida
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Dec 5, 2024 · Synced Sep 2, 2026, 9:30 AM EDT
Completed Not applicable Interventional

Self-guided Depression Treatment on Long-duration Spaceflights: A Continuation Study

NCT00906581
View directory record Official record
Conditions
Depression
Interventions
Computer-based Problem-Solving Treatment
Behavioral
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
30 Years to 60 Years
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 12, 2017 · Synced Sep 2, 2026, 9:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Tolerance of Centrifuge-induced Acceleration in Subjects With Diabetes Mellitus and Cardiac Arrhythmia

NCT05404789
View directory record Official record
Conditions
Diabetes Mellitus, Arrhythmias, Cardiac
Interventions
Centrifugation
Other
Lead sponsor
The University of Texas Medical Branch, Galveston
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Galveston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 3, 2022 · Synced Sep 2, 2026, 9:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

NM Balance Regulation With ULLS and Loss of Sleep

NCT05956964
View directory record Official record
Conditions
Muscle Weakness, Quadriceps Muscle Atrophy, Sleep Disturbance
Interventions
Sleep Restriction, Sleep Adequate
Behavioral
Lead sponsor
Lance Bollinger
Other
Eligibility
18 Years to 50 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Sep 2, 2026, 9:30 AM EDT
Terminated No phase listed Observational

Echocardiographic Assessment of Cardiovascular Changes in Long Term Space Flight

NCT00598598
View directory record Official record
Conditions
Aortic Valve Insufficiency, Aortic Valve Stenosis
Interventions
Not listed
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2008
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Sep 2, 2026, 9:30 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Behavioral Rx & Nutrition in Pediatric Chronic Disease

NCT01018121
View directory record Official record
Conditions
Pediatric Obesity
Interventions
LAUNCH, Pediatrician Counseling
Behavioral · Other
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
2 Years to 5 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 22, 2009 · Synced Sep 2, 2026, 9:30 AM EDT
Terminated Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Ethylvinyl Acetate (EVA) Vaginal Ring Delivery System Study

NCT00706784
View directory record Official record
Conditions
Healthy
Interventions
Ethylvinyl Acetate (EVA) Vaginal Ring Delivery System
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 25, 2014 · Synced Sep 2, 2026, 9:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Dietary Intake Modifications to Protect Against Changes in Bone Metabolism

NCT01713634
View directory record Official record
Conditions
Bone Resorption
Interventions
Preflight, In-flight
Other
Lead sponsor
National Aeronautics and Space Administration (NASA)
Federal
Eligibility
Not listed
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2015
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 15, 2015 · Synced Sep 2, 2026, 9:30 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Human Research Program Flight Thigh Cuff

NCT06476106
View directory record Official record
Conditions
Healthy
Interventions
Venoconstrictive Thigh Cuff (VTC)
Device
Lead sponsor
National Aeronautics and Space Administration (NASA)
Federal
Eligibility
Not listed
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2030
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 31, 2025 · Synced Sep 2, 2026, 9:30 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

FIT Exercise in 30d of ULLS-induced Muscle Disuse

NCT06631053
View directory record Official record
Conditions
Muscle Atrophy, Muscle Weakness
Interventions
velocity-based FIT (VBFIT), No Exercise
Other
Lead sponsor
Lance Bollinger
Other
Eligibility
35 Years to 45 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Oct 23, 2025 · Synced Sep 2, 2026, 9:30 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Personalized Performance Optimization Platform

NCT06979570
View directory record Official record
Conditions
Sensory Science, Performance Assessment, Countermeasure Evaluation, Neurocognitive Function, Psychological Factors
Interventions
AttentivU
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 64 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
2
States / cities
Cambridge, Massachusetts • Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced Sep 2, 2026, 9:30 AM EDT