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ClinicalTrials.gov public records Last synced Oct 4, 2026, 1:12 PM EDT

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Showing 25–48 of 77 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Spherical contact lenses Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of A Marketed Silicone Hydrogel Spherical Lens Used for Monovision Correction of Presbyopia

NCT04073186
View directory record Official record
Conditions
Visual Acuity
Interventions
ACUVUE® OASYS with Transitions™
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
40 Years to 70 Years
Enrollment
91 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
5
States / cities
Jacksonville, Florida • Raytown, Missouri • New York, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 10, 2022 · Synced Oct 4, 2026, 1:12 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of Wear Experience With Daily Contact Lenses

NCT05096156
View directory record Official record
Conditions
Contact Lens
Interventions
Precision1® Daily Disposable Contact Lens
Device
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 40 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 8, 2023 · Synced Oct 4, 2026, 1:12 PM EDT
Completed Not applicable Interventional Results available

Clinical Validation of DACP Digital Design

NCT03567005
View directory record Official record
Conditions
Refractive Errors
Interventions
Nelfilcon A digital contact lenses, Nelfilcon A contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years to 35 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
5
States / cities
Bloomington, Illinois • Powell, Ohio • Brentwood, Tennessee + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 18, 2019 · Synced Oct 4, 2026, 1:12 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of Approved and Investigational Contact Lenses

NCT03228212
View directory record Official record
Conditions
Visual Acuity
Interventions
CONTROL, TEST
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 49 Years
Enrollment
133 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
5
States / cities
Jacksonville, Florida • East Lansing, Michigan • Pickens, South Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Dec 13, 2018 · Synced Oct 4, 2026, 1:12 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Apioc Toric/Spherical Single Vision Contact Lens

NCT03970512
View directory record Official record
Conditions
Refractive Errors
Interventions
Apioc-A and Apioc-S Contact Lenses
Device
Lead sponsor
Lentechs, LLC
Industry
Eligibility
18 Years to 35 Years
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
2
States / cities
Athens, Ohio • Powell, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 19, 2022 · Synced Oct 4, 2026, 1:12 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Evaluation of Visual Performance With Contact Lenses

NCT03705130
View directory record Official record
Conditions
Myopia
Interventions
Single Vision Contact Lens, Multifocal Contact Lens 1, Multifocal Contact Lens 2
Device
Lead sponsor
University of Houston
Other
Eligibility
18 Years to 39 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 15, 2018 · Synced Oct 4, 2026, 1:12 PM EDT
Active, not recruiting Not applicable Interventional

Acuity 200™ (Fluoroxyfocon A) Orthokeratology Contact Lens for Overnight Wear

NCT06009458
View directory record Official record
Conditions
Myopia
Interventions
Acuity 200™ (fluoroxyfocon A) Orthokeratology Contact Lens for Overnight Wear
Device
Lead sponsor
Acuity Polymers, Inc.
Industry
Eligibility
7 Years and older
Enrollment
387 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
9
States / cities
Mission Viejo, California • Oakland, California • San Francisco, California + 6 more
Source: ClinicalTrials.gov public record
Updated Jan 14, 2025 · Synced Oct 4, 2026, 1:12 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Surface Refractive Index Shift of Kalifilcon A Compared With Dailies Total1 and Precision1 Lenses

NCT04840563
View directory record Official record
Conditions
Contact Lens Wear
Interventions
kalifilcon A daily disposable spherical soft contact lens, Dailies Total1 (delefilcon A) daily disposable spherical soft contact lens, Precision1 (verofilcon A) daily disposable spherical soft contact lens
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Oct 4, 2026, 1:12 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Comfort Evaluation of Two Marketed Spherical Contact Lenses

NCT02356692
View directory record Official record
Conditions
Astigmatism
Interventions
enfilcon A, senofilcon A
Device
Lead sponsor
CooperVision, Inc.
Industry
Eligibility
18 Years to 38 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
3
States / cities
Birmingham, Alabama • Jacksonville, Florida • Lafayette, Louisiana
Source: ClinicalTrials.gov public record
Updated Nov 23, 2020 · Synced Oct 4, 2026, 1:12 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Central Corneal Swelling With Silicone Hydrogel Materials

NCT02328937
View directory record Official record
Conditions
Corneal Swelling
Interventions
etafilcon A, lotrafilcon B, comfilcon A
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 19, 2018 · Synced Oct 4, 2026, 1:12 PM EDT
Completed Not applicable Interventional Results available

Performance of Wearers of Stenfilcon A Contact Lenses After A Refit With Test Lenses

NCT03496701
View directory record Official record
Conditions
Myopia
Interventions
Test lens, control lens
Device
Lead sponsor
CooperVision, Inc.
Industry
Eligibility
18 Years to 35 Years
Enrollment
77 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
4
States / cities
San Diego, California • Whittier, California • Sarasota, Florida + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 30, 2021 · Synced Oct 4, 2026, 1:12 PM EDT
Completed Not applicable Interventional Results available

Clinical Performance Assessment of Two Silicone Hydrogel Daily Disposable Contact Lenses

NCT05725317
View directory record Official record
Conditions
Refractive Errors, Myopia
Interventions
LID220365 contact lens, LID006961 contact lens
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
114 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
7
States / cities
Maitland, Florida • Orlando, Florida • Franklin Park, Illinois + 4 more
Source: ClinicalTrials.gov public record
Updated Aug 6, 2024 · Synced Oct 4, 2026, 1:12 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Study to Evaluate the Safety and Effectiveness of a Silicone Hydrogel Custom Contact Lens When Compared to Alden Optical HP Sphere Lens

NCT03897712
View directory record Official record
Conditions
Contact Lens Wear
Interventions
Custom Samfilcon B Contact Lenses, Alden Optical HP Sphere Contact Lens, ReNu MultiPlus Lubricating and Rewetting Drops, Biotrue Multi-Purpose Solution
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years to 40 Years
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
7
States / cities
San Francisco, California • Denver, Colorado • Sarasota, Florida + 4 more
Source: ClinicalTrials.gov public record
Updated Nov 14, 2022 · Synced Oct 4, 2026, 1:12 PM EDT
Completed Not applicable Interventional Results available

Clinical Comparison of 2 Daily Disposable Contact Lenses - Pilot Study 2

NCT04528017
View directory record Official record
Conditions
Refractive Errors, Myopia
Interventions
Verofilcon A contact lenses, Somofilcon A contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
4
States / cities
Maitland, Florida • Medina, Minnesota • Powell, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Nov 11, 2021 · Synced Oct 4, 2026, 1:12 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Toric Contact Lens Digital Performance and Comfort Study

NCT04772560
View directory record Official record
Conditions
Astigmatism
Interventions
Precision1 for Astigmatism, Precision1 Sphere
Device
Lead sponsor
Kathryn Richdale
Other
Eligibility
18 Years to 39 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 10, 2022 · Synced Oct 4, 2026, 1:12 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

How Does DT1 Sphere Perform in Current and Successful Acuvue MAX Wearers?

NCT06847230
View directory record Official record
Conditions
Contact Lens Comfort and Successful Refitting
Interventions
Dailies total 1 contact lenses
Device
Lead sponsor
Southern College of Optometry
Other
Eligibility
18 Years to 40 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 12, 2025 · Synced Oct 4, 2026, 1:12 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Euclid Phoenix Lens Design Trial 2

NCT06392607
View directory record Official record
Conditions
Myopia, Cornea
Interventions
Euclid orthokeratology (standard coating), Euclid orthokeratology (enhanced coating)
Device
Lead sponsor
Euclid Systems Corporation
Industry
Eligibility
6 Years to 35 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
5
States / cities
Edina, Minnesota • Sartell, Minnesota • North Brunswick, New Jersey + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 30, 2024 · Synced Oct 4, 2026, 1:12 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Characterization of Symptomatic Populations

NCT03319212
View directory record Official record
Conditions
Ametropia
Interventions
senofilcon A contact lenses
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 55 Years
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 15, 2019 · Synced Oct 4, 2026, 1:12 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Euclid Phoenix Lens Design Trial

NCT06389916
View directory record Official record
Conditions
Myopia, Cornea
Interventions
Euclid orthokeratology MAX (current design), Euclid orthokeratology MAX Phoenix (new design)
Device
Lead sponsor
Euclid Systems Corporation
Industry
Eligibility
6 Years to 18 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
5
States / cities
Costa Mesa, California • Saint Johns, Florida • Edina, Minnesota + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 29, 2024 · Synced Oct 4, 2026, 1:12 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Performance Comparison Between Fanfilcon A and Senofilcon A Sphere Lenses

NCT02956460
View directory record Official record
Conditions
Myopia
Interventions
fanfilcon A, senofilcon A
Device
Lead sponsor
CooperVision, Inc.
Industry
Eligibility
18 Years to 40 Years
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
4
States / cities
San Diego, California • Sarasota, Florida • Pittsburg, Kansas + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 2, 2018 · Synced Oct 4, 2026, 1:12 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

High Refractive Index Material 510(k)

NCT00766168
View directory record Official record
Conditions
Myopia, Hyperopia
Interventions
HDS HI 1.54; pahrifocon A, FluoroPerm 30 RGP; paflufocon C
Other · Device
Lead sponsor
CooperVision International Limited (CVIL)
Industry
Eligibility
12 Years and older
Enrollment
76 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008
U.S. locations
8
States / cities
Lake Elsinore, California • Englewood, Colorado • East Lansing, Michigan + 5 more
Source: ClinicalTrials.gov public record
Updated Jun 14, 2012 · Synced Oct 4, 2026, 1:12 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Total30 For Contact Lens Dropouts

NCT06967298
View directory record Official record
Conditions
Dry Eye, Contact Lens Complication, Contact Lenses
Interventions
T30 Contact lenses
Device
Lead sponsor
Southern College of Optometry
Other
Eligibility
18 Years to 40 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 3, 2025 · Synced Oct 4, 2026, 1:12 PM EDT
Completed Not applicable Interventional Results available

Clinical Comparison of Two Daily Disposable Contact Lenses

NCT04865354
View directory record Official record
Conditions
Refractive Errors
Interventions
Verofilcon A contact lenses, Somofilcon A contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
170 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
8
States / cities
San Francisco, California • Maitland, Florida • Tallahassee, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Jul 6, 2022 · Synced Oct 4, 2026, 1:12 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluating and Improving Functional Driving Vision of Patients With Astigmatism

NCT02624791
View directory record Official record
Conditions
Astigmatism
Interventions
1-DAY ACUVUE® MOIST contact lenses, 1-DAY ACUVUE® MOIST for ASTIGMATISM contact lenses, No contact lenses
Device · Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 39 Years
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 6, 2020 · Synced Oct 4, 2026, 1:12 PM EDT