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ClinicalTrials.gov public records Last synced Oct 5, 2026, 3:34 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 49–72 of 77 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Spherical contact lenses Clear all
Completed Not applicable Interventional Results available

Three Daily Wear Monthly Replacement Silicone Hydrogel Contact Lenses With Two Multi-purpose Disinfecting Solution Combinations

NCT04789382
View directory record Official record
Conditions
Refractive Errors
Interventions
LID018869+RepleniSH, LID018869+Biotrue, Biofinity+RepleniSH, PV+Biotrue
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Maitland, Florida
Source: ClinicalTrials.gov public record
Updated May 25, 2022 · Synced Oct 5, 2026, 3:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Surface Refractive Index Shift of Kalifilcon A Compared With Dailies Total1 and Precision1 Lenses

NCT04840563
View directory record Official record
Conditions
Contact Lens Wear
Interventions
kalifilcon A daily disposable spherical soft contact lens, Dailies Total1 (delefilcon A) daily disposable spherical soft contact lens, Precision1 (verofilcon A) daily disposable spherical soft contact lens
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Oct 5, 2026, 3:34 PM EDT
Completed Not applicable Interventional Results available

Clinical Characterization of an Investigational Frequent Replacement Daily Wear Silicone Hydrogel Sphere Contact Lens

NCT04702984
View directory record Official record
Conditions
Refractive Errors
Interventions
LID021201 contact lenses, OPTI-FREE multipurpose solution
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
3
States / cities
Maitland, Florida • Memphis, Tennessee • Wichita Falls, Texas
Source: ClinicalTrials.gov public record
Updated Mar 16, 2022 · Synced Oct 5, 2026, 3:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

How Does DT1 Sphere Perform in Current and Successful Acuvue MAX Wearers?

NCT06847230
View directory record Official record
Conditions
Contact Lens Comfort and Successful Refitting
Interventions
Dailies total 1 contact lenses
Device
Lead sponsor
Southern College of Optometry
Other
Eligibility
18 Years to 40 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 12, 2025 · Synced Oct 5, 2026, 3:34 PM EDT
Completed Not applicable Interventional Results available

Clinical Comparison of 4 Daily Disposable Soft Contact Lenses

NCT03349632
View directory record Official record
Conditions
Refractive Error
Interventions
verofilcon A contact lenses, senofilcon A contact lenses, stenfilcon A contact lenses, etafilcon A contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
3
States / cities
Maitland, Florida • Pensacola, Florida • Johns Creek, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 22, 2019 · Synced Oct 5, 2026, 3:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Dailies Total 1 Sphere Contact Lenses

NCT05239494
View directory record Official record
Conditions
Dry Eye, Contact Lens Complication
Interventions
DT1 Sphere Contact Lenses
Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 40 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
4
States / cities
Birmingham, Alabama • Pittsburg, Kansas • Granville, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 1, 2024 · Synced Oct 5, 2026, 3:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Corneal Refractive Therapy Design Comparison for -4 to -6 Diopter Treatment for Overnight Wear for Myopia

NCT05438615
View directory record Official record
Conditions
Myopia
Interventions
Corneal Refractive Therapy-spherical, Corneal Refractive Therapy-aspherical
Other
Lead sponsor
CooperVision International Limited (CVIL)
Industry
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 20, 2026 · Synced Oct 5, 2026, 3:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Accommodative Relief for Uncomfortable Non-Presbyopes

NCT03544216
View directory record Official record
Conditions
Asthenopia
Interventions
Multifocal Contact Lens, Single Vision Contact Lens
Device
Lead sponsor
Ohio State University
Other
Eligibility
30 Years to 40 Years
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 15, 2019 · Synced Oct 5, 2026, 3:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Wear Experience With Daily Contact Lenses Over a Long Day

NCT04535310
View directory record Official record
Conditions
Contact Lens
Interventions
Precision1® Daily Disposable Contact Lens
Device
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 40 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 8, 2023 · Synced Oct 5, 2026, 3:34 PM EDT
Terminated No phase listed Observational

Post-market Clinical Follow-up Study of Alcon TOTAL30® Contact Lenses (Lehfilcon A)

NCT06408649
View directory record Official record
Conditions
Ametropia, Myopia, Hyperopia, Astigmatism
Interventions
Lehfilcon A spherical contact lenses, Lehfilcon A toric contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
7 Years and older
Enrollment
129 participants
Timeline
2024 – 2025
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Jul 20, 2025 · Synced Oct 5, 2026, 3:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Total30 Sphere Contact Lenses

NCT05183022
View directory record Official record
Conditions
Contact Lens Complication, Dry Eye
Interventions
Total30 Sphere Contact Lenses
Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 45 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
2
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 16, 2022 · Synced Oct 5, 2026, 3:34 PM EDT
Terminated No phase listed Observational

Post-market Clinical Follow-up Study of Alcon PRECISION1™ Spherical and PRECISION1™ for Astigmatism Soft Contact Lenses

NCT06462456
View directory record Official record
Conditions
Refractive Errors
Interventions
Verofilcon A spherical soft contact lenses, Verofilcon A toric soft contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
7 Years and older
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
12
States / cities
San Diego, California • Jacksonville, Florida • Orlando, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated Jul 20, 2025 · Synced Oct 5, 2026, 3:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of Two Marketed Multifocal Contact Lenses

NCT03322423
View directory record Official record
Conditions
Visual Performance
Interventions
Multifocal Contact Lens 1, Multifocal Contact Lens 2, Spherical Contact Lens 2
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
40 Years to 70 Years
Enrollment
78 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
5
States / cities
Sarasota, Florida • Albuquerque, New Mexico • Vestal, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 8, 2019 · Synced Oct 5, 2026, 3:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Evaluation of a Reusable Multifocal Optical Design in a Presbyopic Population Phase 2

NCT03586648
View directory record Official record
Conditions
Visual Acuity
Interventions
senofilcon A Multifocal, senofilcon A Sphere, etafilcon A Multifocal, etafilcon A Sphere
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
40 Years to 70 Years
Enrollment
71 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
6
States / cities
Whittier, California • Jacksonville, Florida • Maitland, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated May 13, 2020 · Synced Oct 5, 2026, 3:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Handling Comparison Between Two Contact Lens Types

NCT02310126
View directory record Official record
Conditions
Presbyopia
Interventions
etafilcon A (multi-focal), etafilcon A (sphere)
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
40 Years to 70 Years
Enrollment
195 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
8
States / cities
Jacksonville, Florida • Sarasota, Florida • Winter Park, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated Jun 19, 2018 · Synced Oct 5, 2026, 3:34 PM EDT
Completed Not applicable Interventional Results available

Bifocal Lenses In Nearsighted Kids

NCT02255474
View directory record Official record
Conditions
Refractive Errors
Interventions
Biofinity Multifocal D +1.50 add, Biofinity Multifocal D +2.50 add, Biofinity
Device
Lead sponsor
Ohio State University
Other
Eligibility
7 Years to 11 Years
Enrollment
294 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
2
States / cities
Columbus, Ohio • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 10, 2021 · Synced Oct 5, 2026, 3:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluating and Improving Functional Driving Vision of Patients With Astigmatism

NCT02624791
View directory record Official record
Conditions
Astigmatism
Interventions
1-DAY ACUVUE® MOIST contact lenses, 1-DAY ACUVUE® MOIST for ASTIGMATISM contact lenses, No contact lenses
Device · Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 39 Years
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 6, 2020 · Synced Oct 5, 2026, 3:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Validation of Senofilcon A With New UV / HEV Filter

NCT05099380
View directory record Official record
Conditions
Visual Acuity
Interventions
senofilcon A C3, senofilcon A
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 39 Years
Enrollment
296 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
17
States / cities
Cupertino, California • San Francisco, California • Jacksonville, Florida + 14 more
Source: ClinicalTrials.gov public record
Updated Feb 6, 2023 · Synced Oct 5, 2026, 3:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of Approved and Investigational Contact Lenses

NCT03228212
View directory record Official record
Conditions
Visual Acuity
Interventions
CONTROL, TEST
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 49 Years
Enrollment
133 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
5
States / cities
Jacksonville, Florida • East Lansing, Michigan • Pickens, South Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Dec 13, 2018 · Synced Oct 5, 2026, 3:34 PM EDT
Completed Not applicable Interventional Results available

Clinical Comparison of 2 Daily Disposable Contact Lenses - Pilot Study 1

NCT04527978
View directory record Official record
Conditions
Refractive Errors, Myopia
Interventions
Verofilcon A contact lenses, Nesofilcon A contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
4
States / cities
Maitland, Florida • Medina, Minnesota • Powell, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Nov 23, 2021 · Synced Oct 5, 2026, 3:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

APIOC Sphere and APIOC Astigmatism

NCT04806802
View directory record Official record
Conditions
Myopia, Hyperopia, Astigmatism
Interventions
APIOC Sphere and APIOC Astigmatism
Device
Lead sponsor
Lentechs, LLC
Industry
Eligibility
18 Years to 35 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
6
States / cities
San Diego, California • Orlando, Florida • Lexington, Kentucky + 3 more
Source: ClinicalTrials.gov public record
Updated Jan 19, 2022 · Synced Oct 5, 2026, 3:34 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of DW Silicone Hydrogel Lens Compared to DW Silicone Hydrogel Lens

NCT01386008
View directory record Official record
Conditions
Myopia
Interventions
senfilcon A contact lens, investigational enfilcon A
Device
Lead sponsor
CooperVision, Inc.
Industry
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
Berkeley, California
Source: ClinicalTrials.gov public record
Updated Sep 4, 2019 · Synced Oct 5, 2026, 3:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Evaluation of Lapsed Contact Lens Wearers Who Are Re-fit Into Senofilcon A Contact Lenses

NCT01990664
View directory record Official record
Conditions
Lapsed Contact Lens Wear
Interventions
senofilcon A, senofilcon A for Astigmatism
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 40 Years
Enrollment
199 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
10
States / cities
Jacksonville, Florida • Saint Augustine, Florida • Sarasota, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated Jun 19, 2018 · Synced Oct 5, 2026, 3:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Characterization of Symptomatic Populations

NCT03319212
View directory record Official record
Conditions
Ametropia
Interventions
senofilcon A contact lenses
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 55 Years
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 15, 2019 · Synced Oct 5, 2026, 3:34 PM EDT