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Showing 1–24 of 31 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Spinal Fentanyl and Bupivacaine Clear all
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Bupivacaine With Epidural Volume Extension

NCT03110003
View directory record Official record
Conditions
Spinal Anesthesia, Epidural; Anesthesia
Interventions
10 mg Bupivacaine, 5 mg Bupivacaine
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 18, 2018 · Synced Sep 29, 2026, 10:26 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Effect of Neuraxial Analgesia on Maternal Breastfeeding

NCT01074190
View directory record Official record
Conditions
Pain, Breastfeeding
Interventions
Group 1, Group 2, Group 3
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older · Female only
Enrollment
345 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2016
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 4, 2022 · Synced Sep 29, 2026, 10:26 PM EDT
Completed Phase 2Phase 3 Interventional Results available

Quadratus Lumborum Block Versus Control for Total Hip Arthroplasty

NCT03408483
View directory record Official record
Conditions
Total Hip Arthroplasty
Interventions
Quadratus Lumborum Block (QLB), Standard of Care
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 8, 2021 · Synced Sep 29, 2026, 10:26 PM EDT
Enrolling by invitation No phase listed Observational

Evaluation of the Typical Spinal Block During Cesarean Delivery

NCT06206044
View directory record Official record
Conditions
Cesarean Section, Anesthesia, Obstetric
Interventions
Intrathecal 1.6 ml 0.75% bupivacaine in 8.25% dextrose combined with 15 mcg fentanyl and 150 mcg preservative-free morphine
Drug
Lead sponsor
Oregon Health and Science University
Other
Eligibility
15 Years to 55 Years · Female only
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Nov 19, 2024 · Synced Sep 29, 2026, 10:26 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Comparative Analysis of Spinal Anesthesia Versus General Anesthesia for vNOTES

NCT05688943
View directory record Official record
Conditions
Anesthesia, Tubal Ligation
Interventions
Spinal Anesthesia, General Anesthesia
Procedure
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
21 Years and older · Female only
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Jun 4, 2025 · Synced Sep 29, 2026, 10:26 PM EDT
Terminated Not applicable Interventional

Epidural Technique: Does it Really Matter to the Patient?

NCT03539796
View directory record Official record
Conditions
Anesthesia
Interventions
Dural puncture epidurals (DPE), Traditional epidurals (EPI), Combined-spinal epidural technique (CSE)
Procedure
Lead sponsor
Emory University
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 11, 2023 · Synced Sep 29, 2026, 10:26 PM EDT
Completed Not applicable Interventional

Shaping Anesthetic Techniques to Reduce Post-operative Delirium

NCT03133845
View directory record Official record
Conditions
Delirium, Lumbar Radiculopathy, Lumbar Osteoarthritis, Lumbar Spine Disc Degeneration
Interventions
Light sedation with propofol, Induction with propofol, Maintenance anesthetic using a volatile anesthetic, Muscle relaxant during maintenance anesthesia, Pain control with fentanyl, Bispectral Index (BIS) monitoring for depth of anesthesia, Spinal Anesthesia, Midazolam administered during spinal anesthesia, Cerebrospinal fluid collection, Administration of intrathecal morphine
Procedure
Lead sponsor
Johns Hopkins University
Other
Eligibility
65 Years and older
Enrollment
218 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 17, 2020 · Synced Sep 29, 2026, 10:26 PM EDT
Completed Phase 4 Interventional

Comparison of Epidural Labor Pain Relief Techniques on Maternal and Fetal Outcomes

NCT02008591
View directory record Official record
Conditions
Laboring Women Requesting Neuraxial Labor Analgesia
Interventions
Epidural Technique versus Dural Puncture Epidural Technique versus Combined Spinal Epidural Technique
Procedure
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 23, 2017 · Synced Sep 29, 2026, 10:26 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

The Association Between Decreasing Labor Analgesia Epidural Infusion and Forceps Delivery

NCT00443560
View directory record Official record
Conditions
Labor Pain, Pregnancy
Interventions
Case controlled analysis of epidural labor analgesia patterns
Other
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
2,162 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 13, 2014 · Synced Sep 29, 2026, 10:26 PM EDT
Terminated Phase 4 Interventional Results available

Epidural and Intravenous Patient-Controlled Analgesia Following Lumbar Spinal Fusion Surgery

NCT03115151
View directory record Official record
Conditions
Pain
Interventions
Bupivacaine, Hydromorphone, Fentanyl
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
2
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Oct 25, 2023 · Synced Sep 29, 2026, 10:26 PM EDT
Completed Not applicable Interventional Results available

Effects of Epidural Lidocaine on the Pharmacokinetic and Pharmacodynamic Profiles of DepoDur® After Cesarean Delivery

NCT00804609
View directory record Official record
Conditions
Epidural Analgesia, Obstetric
Interventions
DepoDur following epidural lidocaine, DepoDur following spinal anesthetic
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Oct 11, 2017 · Synced Sep 29, 2026, 10:26 PM EDT
Terminated Phase 4 Interventional Results available

Paravertebral Nerve Blocks in Neonates

NCT03408340
View directory record Official record
Conditions
Congenital Heart Disease
Interventions
Paravertebral Nerve Block, Standard of Care Anesthesia
Procedure · Drug
Lead sponsor
Emory University
Other
Eligibility
Up to 12 Months
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Mar 23, 2025 · Synced Sep 29, 2026, 10:26 PM EDT
Terminated Not applicable Interventional

A Trial Comparing Transversus Abdominis Plane Catheter Versus Epidural After Esophagectomy

NCT03570996
View directory record Official record
Conditions
Esophageal Cancer, Pain, Postoperative
Interventions
Esophagectomy, Transversus abdominis plane catheter, Epidural
Procedure
Lead sponsor
Swedish Medical Center
Other
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 22, 2023 · Synced Sep 29, 2026, 10:26 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Optimizing Dose of Bupivacaine in Combined Spinal Epidurals To Reduce Side Effects

NCT02159807
View directory record Official record
Conditions
Pregnancy
Interventions
Bupivacaine, Fentanyl
Drug
Lead sponsor
St. Luke's-Roosevelt Hospital Center
Other
Eligibility
18 Years to 48 Years · Female only
Enrollment
170 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 2, 2019 · Synced Sep 29, 2026, 10:26 PM EDT
Completed Phase 3 Interventional Results available

Evaluation of Anterior Quadratus Lumborum Block for Postoperative Analgesia in Hip Arthroscopy

NCT03432650
View directory record Official record
Conditions
Hip Disease
Interventions
Bupivacaine + dexamethasone, Ultrasound
Drug · Device
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 80 Years
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 18, 2022 · Synced Sep 29, 2026, 10:26 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Combined Spinal-Epidural Versus Traditional Labor Epidural

NCT00151346
View directory record Official record
Conditions
Labour Pain
Interventions
Bupivacaine and Fentanyl (for CSE), Bupivacaine and Fentanyl (for traditional epidural)
Drug
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
127 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2006
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 17, 2008 · Synced Sep 29, 2026, 10:26 PM EDT
Withdrawn Not applicable Interventional

A Study Comparing Two Spinal Techniques for for Cesarean Delivery Anesthesia

NCT00990574
View directory record Official record
Conditions
Hypotension, Headache
Interventions
Wiley Spinal Catheter, Spinal Anesthesia Group (SAG)
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 45 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2015
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Oct 7, 2015 · Synced Sep 29, 2026, 10:26 PM EDT
Completed Not applicable Interventional Results available

High Pain Intervention in Cesarean Sections

NCT01298778
View directory record Official record
Conditions
Other Chronic Postoperative Pain
Interventions
Duramorph 150, Acetaminophen, Duramorph 300
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 9, 2018 · Synced Sep 29, 2026, 10:26 PM EDT
Withdrawn Phase 4 Interventional

GA/Spinal vs. GA/Spinal/NMB for Operative Repair of Hip Fracture

NCT03226080
View directory record Official record
Conditions
Hip Fractures, Anesthesia, Spinal, Anesthesia, General, Neuromuscular Blockade
Interventions
Rocuronium, Sugammadex, Normal saline
Drug
Lead sponsor
Loyola University
Other
Eligibility
55 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Maywood, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 19, 2019 · Synced Sep 29, 2026, 10:26 PM EDT
Enrolling by invitation Phase 3 Interventional Accepts healthy volunteers

GA + ESP vs. SA + ESP in Lumbar Decompression Surgeries

NCT05444751
View directory record Official record
Conditions
Lumbar Disc Herniation, Lumbar Disc Disease, Lumbar Radiculopathy
Interventions
General anesthetic, SA + ESP
Drug
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 80 Years
Enrollment
142 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 27, 2026 · Synced Sep 29, 2026, 10:26 PM EDT
Completed Phase 4 Interventional

Genicular and Anterior Femoral Cutaneous Nerve Blocks for Total Knee Arthroplasty

NCT05980546
View directory record Official record
Conditions
Total Knee Replacement, Genicular Nerve Block, Opioid Use
Interventions
Bupivacaine Injection, Dexamethasone injection, Fentanyl, Mepivacaine
Drug
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 80 Years
Enrollment
244 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 7, 2025 · Synced Sep 29, 2026, 10:26 PM EDT
Not listed Phase 4 Interventional

Comparison of Intrathecal Versus Epidural Fentanyl on Fetal Bradycardia in Labor Combined Spinal Epidural Analgesia

NCT03623256
View directory record Official record
Conditions
Labor Pain, Obstetric Pain
Interventions
Spinal fentanyl, Spinal bupivacaine, Spinal Fentanyl and Bupivacaine, Epidural fentanyl /spinal bupivacaine
Drug
Lead sponsor
Augusta University
Other
Eligibility
18 Years and older · Female only
Enrollment
558 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Augusta, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 21, 2021 · Synced Sep 29, 2026, 10:26 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Does Spinal Anesthesia for Prolapse Surgery With Lead to Urinary Retention?

NCT02547155
View directory record Official record
Conditions
Urinary Retention, Uterine Prolapse
Interventions
Spinal anesthesia, General anesthesia
Procedure
Lead sponsor
The Cleveland Clinic
Other
Eligibility
40 Years and older · Female only
Enrollment
68 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Weston, Florida
Source: ClinicalTrials.gov public record
Updated Apr 19, 2017 · Synced Sep 29, 2026, 10:26 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Intravenous Methadone Versus Intrathecal Morphine for Analgesia Following Cesarean Delivery

NCT06826742
View directory record Official record
Conditions
Cesarean Delivery
Interventions
Intravenous line (IV) Methadone, Intrathecal Morphine
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older · Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 4, 2026 · Synced Sep 29, 2026, 10:26 PM EDT