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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Spinal Manipulation Clear all
Completed Phase 2 Interventional

Thrust Manipulation Versus Non-Thrust Manipulation

NCT01438203
View directory record Official record
Conditions
Mechanical Low Back Pain
Interventions
Thrust manipulation, Non-thrust manipulation
Procedure
Lead sponsor
Walsh University
Other
Eligibility
18 Years and older
Enrollment
149 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
North Canton, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 4, 2012 · Synced Sep 3, 2026, 4:19 AM EDT
Completed Phase 1Phase 2 Interventional Results available

The Mechanisms of Manual Therapy in the Treatment of Low Back Pain

NCT01168999
View directory record Official record
Conditions
Low Back Pain
Interventions
spinal manipulation, sham spinal manipulation, Enhanced sham spinal manipulation
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 60 Years
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 27, 2015 · Synced Sep 3, 2026, 4:19 AM EDT
Completed Not applicable Interventional Results available

Chiropractic for Hypertension in Patients

NCT01020435
View directory record Official record
Conditions
Hypertension
Interventions
Spinal Manipulation, Sham Spinal Manipulation
Other
Lead sponsor
Palmer College of Chiropractic
Other
Eligibility
21 Years to 75 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Davenport, Iowa
Source: ClinicalTrials.gov public record
Updated Feb 6, 2018 · Synced Sep 3, 2026, 4:19 AM EDT
Completed Not applicable Interventional

A Comparison of Two Different Methods of Physical Therapy to Treat Acute and Subacute Low Back Pain

NCT02060617
View directory record Official record
Conditions
Low Back Pain
Interventions
Patient Education, Manual therapy of the thoracolumbosacral spine and hips, Motor control exercises, Treatment-Based Classification intervention
Behavioral · Procedure
Lead sponsor
Hendricks Regional Health
Other
Eligibility
18 Years to 80 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Plainfield, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 28, 2016 · Synced Sep 3, 2026, 4:19 AM EDT
Completed Not applicable Interventional

Validation of the Cervicothoracic Differentiation Test

NCT06287242
View directory record Official record
Conditions
Neck Pain
Interventions
spinal manipulation
Other
Lead sponsor
University of Hartford
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
West Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 10, 2024 · Synced Sep 3, 2026, 4:19 AM EDT
Not listed Not applicable Interventional

Effects of Spinal Cord Injury on Female Sexual Response

NCT00142714
View directory record Official record
Conditions
Female Sexual Dysfunction, Multiple Sclerosis, Spinal Cord Injury
Interventions
Sympathetic manipulation on sexual arousal in women
Procedure
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
18 Years to 55 Years · Female only
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2005
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Oct 15, 2006 · Synced Sep 3, 2026, 4:19 AM EDT
Completed Not applicable Interventional

The Effect of Lumbopelvic Non-Thrust Spinal Manipulation on Individuals With Low Back Pain

NCT04646018
View directory record Official record
Conditions
Low Back Pain
Interventions
Lumbar Spine Manipulation, Sham Manipulation
Other
Lead sponsor
Alvernia University
Other
Eligibility
18 Years and older
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Reading, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 26, 2020 · Synced Sep 3, 2026, 4:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Integrated Supported Biopsychosocial Self-Management for Back Related Leg Pain

NCT05022121
View directory record Official record
Conditions
Low Back Pain, Sciatica, Back Related Leg Pain, Pain, Chronic, Intervertebral Disc Displacement
Interventions
Supported Biopsychosocial Self-Management (SBSM), Medical Care
Behavioral · Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
2
States / cities
Minneapolis, Minnesota • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 14, 2024 · Synced Sep 3, 2026, 4:19 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The Effect of Spinal Cord Stimulators on Restless Leg Syndrome

NCT07179406
View directory record Official record
Conditions
Restless Leg Syndrome (RLS), Spinal Cord Stimulation (SCS)
Interventions
H-Reflex, Somatosensory evoked potential (SSEP), Vibratory Electrophysiological Response Potential (ERP), Transcranial Magnetic Stimulation (TMS), Spinal Cord Stimulator (SCS) manipulation
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Sep 3, 2026, 4:19 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Impact of Practitioner and Instructional Set on Subject Perceptions and Expectations of Cervical Spine Manipulation

NCT03509649
View directory record Official record
Conditions
Neck Pain
Interventions
Cervical spine manipulation
Procedure
Lead sponsor
University of Nevada, Las Vegas
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Apr 17, 2019 · Synced Sep 3, 2026, 4:19 AM EDT
Completed Phase 2Phase 3 Interventional

Chiropractic and Exercise for Low Back Pain in Adolescents

NCT01096628
View directory record Official record
Conditions
Low Back Pain
Interventions
Chiropractic + Exercise, Exercise
Other
Lead sponsor
Northwestern Health Sciences University
Other
Eligibility
12 Years to 18 Years
Enrollment
185 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
2
States / cities
Bloomington, Minnesota • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jan 30, 2014 · Synced Sep 3, 2026, 4:19 AM EDT
Completed No phase listed Observational

Clinical Correlates of Pressure Pain Thresholds in Back and Leg Pain

NCT06653920
View directory record Official record
Conditions
Segmental Dysfunction of the Lumbar Spine, Back Pain, Leg Pain
Interventions
Chiropractic, Exercise, Cryotherapy, Spinalator
Other · Device
Lead sponsor
Leach Chiropractic Clinic
Other
Eligibility
18 Years to 75 Years
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Starkville, Mississippi
Source: ClinicalTrials.gov public record
Updated Oct 21, 2024 · Synced Sep 3, 2026, 4:19 AM EDT
Suspended Not applicable Interventional

A Comparison of Two Thoracic Manipulation Techniques to Improve Neck Pain

NCT02972710
View directory record Official record
Conditions
Neck Pain
Interventions
Supine thoracic spine thrust manipulation, Seated thoracic spine thrust manipulation
Other
Lead sponsor
Northern Arizona University
Other
Eligibility
20 Years to 50 Years
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Flagstaff, Arizona
Source: ClinicalTrials.gov public record
Updated Mar 12, 2018 · Synced Sep 3, 2026, 4:19 AM EDT
Terminated Not applicable Interventional

Effect of Spinal Manipulation on Vulvar Pain

NCT04016467
View directory record Official record
Conditions
Vulvodynia, Perineal Pain, Vulvar Pain
Interventions
Thoracic manipulation, Sham thoracic treatment
Other
Lead sponsor
University of Mary Hardin-Baylor
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Copperas Cove, Texas
Source: ClinicalTrials.gov public record
Updated May 15, 2024 · Synced Sep 3, 2026, 4:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Chiropractic Force Versus Touch

NCT05249530
View directory record Official record
Conditions
Healthy
Interventions
Chiropractic spinal adjustment, Non-force simulation
Other
Lead sponsor
Life University
Other
Eligibility
18 Years to 50 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 1, 2024 · Synced Sep 3, 2026, 4:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Thoracic Spine Manipulation on Peripheral Neurodynamic Mobility

NCT02842918
View directory record Official record
Conditions
Musculoskeletal Manipulations
Interventions
Spinal Manual Therapy, Spinal Range of Motion
Procedure
Lead sponsor
Shenandoah University
Other
Eligibility
18 Years to 70 Years
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Winchester, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 24, 2017 · Synced Sep 3, 2026, 4:19 AM EDT
Completed Not applicable Interventional

Changes in Pain, Spasticity, and Quality of Life After Use of Counterstrain Treatment in Individuals With SCI

NCT05559255
View directory record Official record
Conditions
Pain, Spasticity, Muscle, Quality of Life
Interventions
Counterstrain manual manipulative treatment
Other
Lead sponsor
William Carey University
Other
Eligibility
21 Years to 70 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Hattiesburg, Mississippi
Source: ClinicalTrials.gov public record
Updated Aug 5, 2024 · Synced Sep 3, 2026, 4:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Neuroendocrine Changes in Cervical Spinal Manipulation and Mobilization Non-specific Mechanical Neck Pain

NCT04911608
View directory record Official record
Conditions
Neck Pain
Interventions
cervical spinal manipulation, cervical spinal mobilization
Other
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 60 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jan 19, 2023 · Synced Sep 3, 2026, 4:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Predicting Patients' Response to Spinal Manipulation

NCT00285649
View directory record Official record
Conditions
Low Back Pain
Interventions
HVLA-SM, LVVA-SM, Usual Medical Care
Other
Lead sponsor
Palmer College of Chiropractic
Other
Eligibility
21 Years to 55 Years
Enrollment
192 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2007
U.S. locations
1
States / cities
Davenport, Iowa
Source: ClinicalTrials.gov public record
Updated Aug 15, 2017 · Synced Sep 3, 2026, 4:19 AM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers

Chiropractic and Exercise Management of Spinal Dysfunction in Seniors

NCT01057706
View directory record Official record
Conditions
Neck Disability, Back Disability
Interventions
chiropractic, exercise
Other · Behavioral
Lead sponsor
Northwestern Health Sciences University
Other
Eligibility
65 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
1
States / cities
Bloomington, Minnesota
Source: ClinicalTrials.gov public record
Updated May 5, 2015 · Synced Sep 3, 2026, 4:19 AM EDT
Completed Phase 3 Interventional

Mind Body Intervention for Chronic Lower Back Pain

NCT01894282
View directory record Official record
Conditions
Chronic Lower Back Pain
Interventions
Manual Therapy, Mind Body Intervention
Procedure
Lead sponsor
Canandaigua VA Medical Center
Federal
Eligibility
18 Years to 69 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Mar 30, 2022 · Synced Sep 3, 2026, 4:19 AM EDT
Completed Not applicable Interventional

Chiropractic and Self-care for Back-Related Leg Pain

NCT00494065
View directory record Official record
Conditions
Sub-acute and Chronic Back-related Leg Pain
Interventions
Home exercise, Chiropractic Spinal Manipulative Therapy + Home exercise
Other
Lead sponsor
Northwestern Health Sciences University
Other
Eligibility
21 Years and older
Enrollment
192 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
2
States / cities
Davenport, Iowa • Bloomington, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 30, 2014 · Synced Sep 3, 2026, 4:19 AM EDT
Completed Not applicable Interventional

A Trial Comparing Mechanical Diagnosis and Treatment to Manual Therapy

NCT03049644
View directory record Official record
Conditions
Chronic Lower Back Pain
Interventions
Mechanical Diagnosis and Therapy, Manual Therapy
Procedure
Lead sponsor
Canandaigua VA Medical Center
Federal
Eligibility
18 Years to 89 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Apr 6, 2022 · Synced Sep 3, 2026, 4:19 AM EDT
Recruiting Phase 4 Interventional

Flex Appeal: Evaluating the Efficacy of Anesthetic Techniques for Manipulation of Knees Under Anesthesia

NCT07348614
View directory record Official record
Conditions
Knee Stiffness After Total Knee Arthroplasty
Interventions
Spinal Anesthesia, General Anesthesia, Propofol, Chloroprocaine
Procedure · Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 75 Years
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Sep 3, 2026, 4:19 AM EDT