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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Spinal Manipulative Therapy Clear all
Completed Phase 3 Interventional Results available

Osteopathic Health Outcomes in Chronic Low Back Pain (OSTEOPATHIC) Trial

NCT00315120
View directory record Official record
Conditions
Low Back Pain
Interventions
A. Active OMT and active UST, B. Sham OMT and active UST, C. Active OMT and sham UST, D. Sham OMT and sham UST
Procedure
Lead sponsor
University of North Texas Health Science Center
Other
Eligibility
21 Years to 69 Years
Enrollment
455 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Jul 5, 2016 · Synced Sep 17, 2026, 3:47 AM EDT
Completed Not applicable Interventional

A Trial Comparing Mechanical Diagnosis and Treatment to Manual Therapy

NCT03049644
View directory record Official record
Conditions
Chronic Lower Back Pain
Interventions
Mechanical Diagnosis and Therapy, Manual Therapy
Procedure
Lead sponsor
Canandaigua VA Medical Center
Federal
Eligibility
18 Years to 89 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Apr 6, 2022 · Synced Sep 17, 2026, 3:47 AM EDT
Completed Phase 3 Interventional

Mind Body Intervention for Chronic Lower Back Pain

NCT01894282
View directory record Official record
Conditions
Chronic Lower Back Pain
Interventions
Manual Therapy, Mind Body Intervention
Procedure
Lead sponsor
Canandaigua VA Medical Center
Federal
Eligibility
18 Years to 69 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Mar 30, 2022 · Synced Sep 17, 2026, 3:47 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Spinal Manipulative Therapy: Dual-Task Performance

NCT00297934
View directory record Official record
Conditions
Balance
Interventions
Pro-adjuster mechanical spinal manipulative device
Device
Lead sponsor
Logan College of Chiropractic
Other
Eligibility
20 Years to 40 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006
U.S. locations
1
States / cities
Chesterfield, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 17, 2008 · Synced Sep 17, 2026, 3:47 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The Effect of Spinal Cord Stimulators on Restless Leg Syndrome

NCT07179406
View directory record Official record
Conditions
Restless Leg Syndrome (RLS), Spinal Cord Stimulation (SCS)
Interventions
H-Reflex, Somatosensory evoked potential (SSEP), Vibratory Electrophysiological Response Potential (ERP), Transcranial Magnetic Stimulation (TMS), Spinal Cord Stimulator (SCS) manipulation
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Sep 17, 2026, 3:47 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Muscle Activation Characteristics During Spinal Manipulation in Healthy and Low Back Pain Participants

NCT03483714
View directory record Official record
Conditions
Back Pain
Interventions
Spinal Manipulation
Procedure
Lead sponsor
University of Denver
Other
Eligibility
18 Years to 55 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2015
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 29, 2018 · Synced Sep 17, 2026, 3:47 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Thoracic Spine Manipulation on Peripheral Neurodynamic Mobility

NCT02842918
View directory record Official record
Conditions
Musculoskeletal Manipulations
Interventions
Spinal Manual Therapy, Spinal Range of Motion
Procedure
Lead sponsor
Shenandoah University
Other
Eligibility
18 Years to 70 Years
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Winchester, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 24, 2017 · Synced Sep 17, 2026, 3:47 AM EDT
Completed Not applicable Interventional

Comparison of Two Thoracic Manipulation Techniques to Improve Neck Pain

NCT02245425
View directory record Official record
Conditions
Neck Pain
Interventions
Supine Thoracic Spine Manipulation, Prone Thoracic Spine Manipulation
Other
Lead sponsor
A.T. Still University of Health Sciences
Other
Eligibility
22 Years to 50 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Mesa, Arizona
Source: ClinicalTrials.gov public record
Updated Nov 8, 2018 · Synced Sep 17, 2026, 3:47 AM EDT
Completed Not applicable Interventional Results available

Care Outcomes for Chiropractic Outpatient Veterans

NCT03254719
View directory record Official record
Conditions
Low Back Pain, PTSD, Depression, Anxiety
Interventions
Study assessments
Other
Lead sponsor
Palmer College of Chiropractic
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
4
States / cities
Coralville, Iowa • Davenport, Iowa • Iowa City, Iowa + 1 more
Source: ClinicalTrials.gov public record
Updated May 17, 2020 · Synced Sep 17, 2026, 3:47 AM EDT
Completed Not applicable Interventional Results available

Veterans Response to Dosage in Chiropractic Therapy

NCT04087291
View directory record Official record
Conditions
Low Back Pain, Patient Acceptance of Health Care, Veterans Health
Interventions
Chiropractic Care
Other
Lead sponsor
Palmer College of Chiropractic
Other
Eligibility
18 Years and older
Enrollment
766 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
4
States / cities
Los Angeles, California • West Haven, Connecticut • Iowa City, Iowa + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 10, 2026 · Synced Sep 17, 2026, 3:47 AM EDT
Completed Not applicable Interventional

Validation of the Cervicothoracic Differentiation Test

NCT06287242
View directory record Official record
Conditions
Neck Pain
Interventions
spinal manipulation
Other
Lead sponsor
University of Hartford
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
West Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 10, 2024 · Synced Sep 17, 2026, 3:47 AM EDT
Not listed Not applicable Interventional

Effect of Lumbar Manipulation on Intervertebral Motion, Pain, and Disability

NCT06294132
View directory record Official record
Conditions
Low Back Pain
Interventions
Lumbar Manipulation, Sham Lumbar Manipulation
Procedure
Lead sponsor
Ithaca College
Other
Eligibility
18 Years to 60 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Ithaca, New York
Source: ClinicalTrials.gov public record
Updated Mar 7, 2024 · Synced Sep 17, 2026, 3:47 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Nutrient Nutritional Advise for Low Back Pain Patients Seeking Chiropractic Care

NCT04134013
View directory record Official record
Conditions
Low Back Pain, Nutrition Poor
Interventions
Combination: Nutrition AND Chiropractic Adjustment, Chiropractic Adjustment: Spinal Manipulation Therapy
Dietary Supplement · Other
Lead sponsor
Parker University
Other
Eligibility
21 Years to 65 Years
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Plano, Texas
Source: ClinicalTrials.gov public record
Updated Jan 13, 2022 · Synced Sep 17, 2026, 3:47 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Study of a Potential Mechanisms of Spinal Manipulation in the Treatment of Low Back Pain

NCT00922220
View directory record Official record
Conditions
Low Back Pain
Interventions
stationary bike, lumbar extension exercise, spinal manipulative therapy
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 60 Years
Enrollment
94 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2008
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Dec 21, 2011 · Synced Sep 17, 2026, 3:47 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

MIST3: Active Patient Safety Reporting

NCT04161677
View directory record Official record
Conditions
Safety Issues
Interventions
Not listed
Lead sponsor
Parker University
Other
Eligibility
18 Years to 65 Years
Enrollment
161 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Feb 15, 2021 · Synced Sep 17, 2026, 3:47 AM EDT
Completed Not applicable Interventional Results available

Validation of the STarT Back Screening Tool in the Military

NCT03127826
View directory record Official record
Conditions
Low Back Pain, Lumbago, Radiculopathy, Intervertebral Disc Disorder
Interventions
Risk Stratified Care, Usual Care
Procedure
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
18 Years to 50 Years
Enrollment
290 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jun 23, 2026 · Synced Sep 17, 2026, 3:47 AM EDT
Completed Not applicable Interventional Results available

Comparative Effectiveness of Early Physical Therapy Versus Usual Care for Low Back Pain

NCT01556581
View directory record Official record
Conditions
Low Back Pain
Interventions
Usual Care (UC), Early Physical Therapy (PT)
Procedure
Lead sponsor
Madigan Army Medical Center
Federal
Eligibility
18 Years to 60 Years
Enrollment
119 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated Jul 13, 2020 · Synced Sep 17, 2026, 3:47 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Spinal Manipulation on Central Nervous System Activity Measured by Reflexive Calf Muscle Recruitment

NCT02848456
View directory record Official record
Conditions
Subluxation of Joint of Lumbar Spine
Interventions
Spinal Manipulation, Max Voluntary Isometric Contraction, SM+MVIC
Procedure
Lead sponsor
Grant Sanders
Other
Eligibility
20 Years to 35 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Apr 18, 2017 · Synced Sep 17, 2026, 3:47 AM EDT
Completed Phase 2 Interventional

Chiropractic Care, Medication, and Self-Care for Neck Pain

NCT00029770
View directory record Official record
Conditions
Neck Pain
Interventions
Chiropractic spinal manipulation, Acetaminophen, Self-care, Non-Steroidal anti-inflammatory drugs (NSAIDS), Tylenol with codeine
Procedure · Drug · Behavioral
Lead sponsor
National Center for Complementary and Integrative Health (NCCIH)
NIH
Eligibility
18 Years to 65 Years
Enrollment
270 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2007
U.S. locations
1
States / cities
Bloomington, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 24, 2008 · Synced Sep 17, 2026, 3:47 AM EDT
Completed Not applicable Interventional

Subacute Effects of Spinal Mobilization to Treat Subacromial Impingement

NCT01753271
View directory record Official record
Conditions
Subacromial Impingement Syndrome
Interventions
thoracic mobilization & shoulder mobilization & exercise, shoulder mobilization & exercise
Other
Lead sponsor
High Point University
Other
Eligibility
18 Years to 50 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2012
U.S. locations
3
States / cities
Chicago, Illinois • Elizabethton, Tennessee • Johnson City, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 19, 2015 · Synced Sep 17, 2026, 3:47 AM EDT
Recruiting Not applicable Interventional

Manipulation and Dry Needling in Patients With Cervicogenic Headache and WAD II

NCT06502951
View directory record Official record
Conditions
Cervicogenic Headache, Whiplash Injuries
Interventions
Dry Needling,Thrust Manipulation, Exercise,Non-thrust Mobilization
Other
Lead sponsor
Alabama Physical Therapy & Acupuncture
Other
Eligibility
18 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Montgomery, Alabama
Source: ClinicalTrials.gov public record
Updated May 10, 2025 · Synced Sep 17, 2026, 3:47 AM EDT
Completed Not applicable Interventional Results available

The Effects of Chiropractic in a Population With High Central Adiposity

NCT06208163
View directory record Official record
Conditions
Abdominal Obesity
Interventions
Chiropractic
Procedure
Lead sponsor
Life University
Other
Eligibility
18 Years to 65 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Marietta, Georgia
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Sep 17, 2026, 3:47 AM EDT
Suspended Not applicable Interventional

The Effects of Chiropractic in Adults With Metabolic Syndrome

NCT05884437
View directory record Official record
Conditions
Metabolic Syndrome
Interventions
Chiropractic adjustment
Procedure
Lead sponsor
Life University
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Marietta, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 26, 2024 · Synced Sep 17, 2026, 3:47 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Integrated Supported Biopsychosocial Self-Management for Back Related Leg Pain

NCT05022121
View directory record Official record
Conditions
Low Back Pain, Sciatica, Back Related Leg Pain, Pain, Chronic, Intervertebral Disc Displacement
Interventions
Supported Biopsychosocial Self-Management (SBSM), Medical Care
Behavioral · Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
2
States / cities
Minneapolis, Minnesota • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 14, 2024 · Synced Sep 17, 2026, 3:47 AM EDT