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Showing 1–24 of 58 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Conditions
Total Knee Arthroplasty (TKA)
Interventions
Total IntraVenous Anesthesia (TIVA), Spinal-Block, Electroencephalogram (EEG)
Combination Product · Device
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Conditions
Cesarean Section, Anesthesia, Obstetric
Interventions
Intrathecal 1.6 ml 0.75% bupivacaine in 8.25% dextrose combined with 15 mcg fentanyl and 150 mcg preservative-free morphine
Drug
Lead sponsor
Oregon Health and Science University
Other
Eligibility
15 Years to 55 Years · Female only
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Portland, Oregon
Conditions
Labor Pain, Obstetric Pain
Interventions
Spinal fentanyl, Spinal bupivacaine, Spinal Fentanyl and Bupivacaine, Epidural fentanyl /spinal bupivacaine
Drug
Lead sponsor
Augusta University
Other
Eligibility
18 Years and older · Female only
Enrollment
558 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Augusta, Georgia
Conditions
Postoperative Complications, Hip Fracture, Delirium
Interventions
General endotracheal anesthesia, Regional (spinal) Anesthesia
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Conditions
Pain Levels
Interventions
25G Dural Puncture Epidural, Standard Epidural
Device
Lead sponsor
University of Arkansas
Other
Eligibility
18 Years and older · Female only
Enrollment
280 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Little Rock, Arkansas
Conditions
Cesarean Delivery
Interventions
Intravenous line (IV) Methadone, Intrathecal Morphine
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older · Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Rochester, Minnesota
Conditions
Vaginal Delivery
Interventions
saline, fentanyl/bupivacaine/epinephrine
Drug
Lead sponsor
Ochsner Health System
Other
Eligibility
18 Years to 34 Years · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
New Orleans, Louisiana
Withdrawn Not applicable Interventional Accepts healthy volunteers

Epidural Loading: High Volume, Low Concentration

NCT02803450
Conditions
Labor and Delivery
Interventions
Epidural needle, Catheter Administration, Standard of Care Epidural Administration
Procedure
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 89 Years · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Columbus, Ohio
Conditions
Anesthesia
Interventions
Dural puncture epidurals (DPE), Traditional epidurals (EPI), Combined-spinal epidural technique (CSE)
Procedure
Lead sponsor
Emory University
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Atlanta, Georgia
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Bupivacaine With Epidural Volume Extension

NCT03110003
Conditions
Spinal Anesthesia, Epidural; Anesthesia
Interventions
10 mg Bupivacaine, 5 mg Bupivacaine
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Birmingham, Alabama
Conditions
Hip Fractures, Anesthesia, Spinal, Anesthesia, General, Neuromuscular Blockade
Interventions
Rocuronium, Sugammadex, Normal saline
Drug
Lead sponsor
Loyola University
Other
Eligibility
55 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Maywood, Illinois
Conditions
Persistent Spinal Pain Syndrome
Interventions
Pain pump, Bupivacain 0.625%/Fentanyl 2mcg/ml, Spinal Cord Stimulator (SCS)
Device · Drug
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
30 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Cleveland, Ohio
Conditions
Epidural Analgesia, Obstetric
Interventions
DepoDur following epidural lidocaine, DepoDur following spinal anesthetic
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Stanford, California
Conditions
Delirium, Lumbar Radiculopathy, Lumbar Osteoarthritis, Lumbar Spine Disc Degeneration
Interventions
Light sedation with propofol, Induction with propofol, Maintenance anesthetic using a volatile anesthetic, Muscle relaxant during maintenance anesthesia, Pain control with fentanyl, Bispectral Index (BIS) monitoring for depth of anesthesia, Spinal Anesthesia, Midazolam administered during spinal anesthesia, Cerebrospinal fluid collection, Administration of intrathecal morphine
Procedure
Lead sponsor
Johns Hopkins University
Other
Eligibility
65 Years and older
Enrollment
218 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Baltimore, Maryland
Completed Phase 4 Interventional Results available

Cryoanalgesia vs. Epidural in the Nuss Procedure

NCT02721017
Conditions
Pectus Excavatum, Funnel Chest
Interventions
Cryoanalgesia, Thoracic epidural (ropivicaine, fentanyl)
Device · Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
13 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
San Francisco, California
Withdrawn Not applicable Interventional Accepts healthy volunteers

Depodur vs Fentanyl Infusion for Post-C/S Analgesia

NCT00762554
Conditions
Analgesia
Interventions
Depodur, Fentanyl
Drug
Lead sponsor
Goodman, Evan, M.D.
Individual
Eligibility
18 Years to 45 Years · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Cleveland, Ohio
Conditions
Total Hip Arthroplasty
Interventions
Quadratus Lumborum Block (QLB), Standard of Care
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Birmingham, Alabama
Conditions
Pain
Interventions
Bupivacaine, Hydromorphone, Fentanyl
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
2
States / cities
Dallas, Texas
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Chloroprocaine Spinal Anesthesia for Cervical Cerclage (CP Spinal)

NCT02862912
Conditions
Adverse Reaction to Spinal Anesthetic, Maternal Care for Cervical Incompetence
Interventions
Chloroprocaine, Bupivacaine, Fentanyl, Saline
Drug
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older · Female only
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
New York, New York
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Comparison of Chloroprocaine vs Lidocaine for Epidural Anesthesia in Cesarean Delivery

NCT03414359
Conditions
Surgical Anesthesia, Cesarean Section
Interventions
2% Lidocaine, 3% Chloroprocaine
Drug
Lead sponsor
University of Arkansas
Other
Eligibility
18 Years to 99 Years · Female only
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Little Rock, Arkansas
Conditions
Total Knee Replacement, Genicular Nerve Block, Opioid Use
Interventions
Bupivacaine Injection, Dexamethasone injection, Fentanyl, Mepivacaine
Drug
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 80 Years
Enrollment
244 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
New York, New York
Completed No phase listed Observational Accepts healthy volunteers Results available

The Association Between Decreasing Labor Analgesia Epidural Infusion and Forceps Delivery

NCT00443560
Conditions
Labor Pain, Pregnancy
Interventions
Case controlled analysis of epidural labor analgesia patterns
Other
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
2,162 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006
U.S. locations
1
States / cities
Chicago, Illinois
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Comparative Analysis of Spinal Anesthesia Versus General Anesthesia for vNOTES

NCT05688943
Conditions
Anesthesia, Tubal Ligation
Interventions
Spinal Anesthesia, General Anesthesia
Procedure
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
21 Years and older · Female only
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Kansas City, Kansas
Completed Not applicable Interventional Accepts healthy volunteers Results available

CSE v. Epidural for Postpartum Depression

NCT03022526
Conditions
Depression, Postpartum, Labor Pain
Interventions
CSE, Epidural, Bupivacaine / fentaNYL
Procedure · Drug
Lead sponsor
Grace Lim, MD, MS
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
61 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania