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Showing 1–24 of 114 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Standard Care for Substance Use Disorder Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Mobile Enhanced Prevention Support for People Leaving Jail

NCT04036396
View directory record Official record
Conditions
HIV Infections, Sexually Transmitted Diseases, Bacterial, Hepatitis C, Substance Use Disorders
Interventions
Mobile Enhanced Prevention Support, Usual Care plus Customized Referrals
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 49 Years · Male only
Enrollment
233 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2024
U.S. locations
3
States / cities
Los Angeles, California • Santa Fe Springs, California
Source: ClinicalTrials.gov public record
Updated May 19, 2026 · Synced Sep 20, 2026, 6:22 AM EDT
Completed Not applicable Interventional Results available

Life Care Specialists (LCS) With a Focus on Patient Pain Management and Prevention of Substance Misuse

NCT04154384
View directory record Official record
Conditions
Opioid Use
Interventions
Life Care Specialist (LCS) Intervention, Clinical Coordination with Referrals, Pilot Study of Pain Management Strategies
Behavioral · Other
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
333 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Nov 20, 2024 · Synced Sep 20, 2026, 6:22 AM EDT
Not yet recruiting Not applicable Interventional

Written Exposure in Substance Treatment (WEST 3.0): Randomized Controlled Trial

NCT07782268
View directory record Official record
Conditions
Posttraumatic Stress Disorder (PTSD), Substance Use Disorder (SUD)
Interventions
Written Exposure Therapy, Treatment as Usual
Behavioral
Lead sponsor
Potomac Health Foundations
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 23, 2026 · Synced Sep 20, 2026, 6:22 AM EDT
Recruiting Not applicable Interventional

Effectiveness of the SoundHeal Multi-Sensory Integrative Therapy Among Justice-Involved Youth

NCT07364799
View directory record Official record
Conditions
Emotional Dysregulation, Therapeutic Alliance, Depression Disorder, Anxiety Disorders, Stress Disorders, Substance Use Disorders, Mental Health Disorders
Interventions
Multi-sensory emotional regulation intervention (Heal)
Behavioral
Lead sponsor
SoundHeal
Industry
Eligibility
12 Years to 18 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
San Luis Obispo, California
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Sep 20, 2026, 6:22 AM EDT
Completed Not applicable Interventional

Microcurrent Neurofeedback as an Adjunct to Standard Care for Substance Use Disorders

NCT07737652
View directory record Official record
Conditions
Depression, Anxiety, Substance Use Disorder (SUD), Post Traumatic Stress Disorder
Interventions
Microcurrent Neurofeedback (MCN), Standard Care for Substance Use Disorder
Device · Behavioral
Lead sponsor
University of Alabama, Tuscaloosa
Other
Eligibility
18 Years to 65 Years
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Tuscaloosa, Alabama
Source: ClinicalTrials.gov public record
Updated Jul 29, 2026 · Synced Sep 20, 2026, 6:22 AM EDT
Completed Not applicable Interventional

CPT for Offenders With SUD

NCT01277939
View directory record Official record
Conditions
Computer-assisted, Evidence-based Psychosocial Intervention, for Substance Abuse Treatment
Interventions
Therapeutic Education System (TES), Standard Care
Behavioral
Lead sponsor
National Development and Research Institutes, Inc.
Other
Eligibility
18 Years and older
Enrollment
376 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
10
States / cities
Cañon City, Colorado • Denver, Colorado • Model, Colorado + 5 more
Source: ClinicalTrials.gov public record
Updated Sep 1, 2013 · Synced Sep 20, 2026, 6:22 AM EDT
Completed Phase 1 Interventional

Intensive Outpatient Services for Teens

NCT01732601
View directory record Official record
Conditions
Depression, Suicide
Interventions
Intensive Outpatient CBT, Standard Care
Behavioral
Lead sponsor
Brown University
Other
Eligibility
12 Years to 18 Years
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jan 22, 2018 · Synced Sep 20, 2026, 6:22 AM EDT
Completed Not applicable Interventional Results available

SUPER Study (Substance Use and PTSD Treatment Effectiveness Research Study)

NCT00265564
View directory record Official record
Conditions
Substance Use Disorders, Posttraumatic Stress Disorder
Interventions
Modified Seeking Safety integrated into std outpatient SUD care, Standard outpatient SUD care
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older · Male only
Enrollment
117 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Sep 6, 2020 · Synced Sep 20, 2026, 6:22 AM EDT
Completed Not applicable Interventional

Effectiveness of an Integrated Treatment to Address Smoking Cessation and Anxiety/ Depression in People Living With HIV

NCT03904186
View directory record Official record
Conditions
Human Immunodeficiency Virus, Smoking Cessation, Smoking, Cigarette, Smoking, Anxiety, Depression, Nicotine Dependence
Interventions
QUIT, Time-Matched Control (TM)
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 79 Years
Enrollment
131 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
3
States / cities
Boston, Massachusetts • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 8, 2026 · Synced Sep 20, 2026, 6:22 AM EDT
Completed Not applicable Interventional

Peer Navigation for Individuals With Serious Mental Illness Leaving Jail

NCT04256954
View directory record Official record
Conditions
Individuals With Serious Mental Illness Leaving Jails
Interventions
Peer navigation intervention
Behavioral
Lead sponsor
Michigan State University
Other
Eligibility
18 Years and older
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Flint, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 9, 2025 · Synced Sep 20, 2026, 6:22 AM EDT
Completed No phase listed Observational Results available

Effect of VarIthena on Wound Healing in Venous Leg Ulcers (VLU)

NCT03257254
View directory record Official record
Conditions
Venous Leg Ulcer
Interventions
Varithena
Drug
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years and older
Enrollment
76 participants
Timeline
2017 – 2020
U.S. locations
13
States / cities
Palo Alto, California • Sacramento, California • Darien, Connecticut + 10 more
Source: ClinicalTrials.gov public record
Updated Dec 13, 2021 · Synced Sep 20, 2026, 6:22 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The Collaborative Care PrTNER Study

NCT06585631
View directory record Official record
Conditions
HIV, Substance Use Disorders, Substance Use, AIDS
Interventions
CC PrTNER
Behavioral
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
15 Years to 29 Years · Male only
Enrollment
275 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
2
States / cities
Baltimore, Maryland • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 17, 2026 · Synced Sep 20, 2026, 6:22 AM EDT
Completed Not applicable Interventional Results available

Brief Therapy Intervention for Heavy/Hazardous Drinking in HIV-Positive Women

NCT00127231
View directory record Official record
Conditions
HIV Infections, Alcoholism
Interventions
Brief alcohol intervention based on Project Treat, Standard care
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
Female only
Enrollment
148 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 5, 2017 · Synced Sep 20, 2026, 6:22 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Treating Smokeless Tobacco Use in Rural Veterans

NCT02994082
View directory record Official record
Conditions
Smokeless Tobacco, Nicotine Dependence
Interventions
Tailored behavioral intervention, Behavioral activation for elevated depressive symptoms, Post-cessation weight gain management, Alcohol use risk reduction, Nicotine replacement therapy - transdermal nicotine patch, Nicotine replacement therapy - nicotine lozenge, Nicotine replacement therapy - nicotine gum, Bupropion sustained release, Varenicline, Combination nicotine replacement therapy, Combination nicotine replacement therapy + bupropion, Tobacco quit line, Educational materials
Behavioral · Drug
Lead sponsor
Mark Vander Weg
Federal
Eligibility
18 Years to 99 Years
Enrollment
123 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jul 23, 2019 · Synced Sep 20, 2026, 6:22 AM EDT
Completed Not applicable Interventional

Dual Reinforcement Contingency Management for Alcohol Use Disorders

NCT04064463
View directory record Official record
Conditions
Alcohol Use Disorder, Contingency Management
Interventions
Standard care, Contingency management
Behavioral
Lead sponsor
UConn Health
Other
Eligibility
18 Years and older
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 8, 2026 · Synced Sep 20, 2026, 6:22 AM EDT
Completed Not applicable Interventional

Delivery of Anxiety Disorder Treatment in Addictions Centers

NCT01764698
View directory record Official record
Conditions
Anxiety Disorders, Substance Use Disorders
Interventions
CALM-SUD, Treatment as usual
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 60 Years
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
2
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 25, 2017 · Synced Sep 20, 2026, 6:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Family Intervention for Teen Drinking in the ER

NCT01229748
View directory record Official record
Conditions
Alcohol Abuse
Interventions
Standard Care, Multidimensional Family Therapy, Family Motivational Interviewing Intervention
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
12 Years to 18 Years
Enrollment
104 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2015
U.S. locations
3
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Apr 30, 2015 · Synced Sep 20, 2026, 6:22 AM EDT
Completed Not applicable Interventional Results available

Effectiveness of an Evidence-based Stepped Care System for Alcohol and Other Drug Use Problems Among Congolese Refugees in Zambia

NCT05471921
View directory record Official record
Conditions
Alcohol and Substance-Related Mental Disorders
Interventions
SBIRT, Treatment as usual
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
15 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Sep 20, 2026, 6:22 AM EDT
Completed Not applicable Interventional

Tool to Improve Treatment Adherence and Outcomes at Grady Liver Clinic

NCT03831555
View directory record Official record
Conditions
Hepatitis C
Interventions
PREP-C
Behavioral
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 5, 2019 · Synced Sep 20, 2026, 6:22 AM EDT
Terminated Not applicable Interventional

ASK-PrEP (Assistance Services Knowledge-PrEP)

NCT05934877
View directory record Official record
Conditions
Substance Use Disorders, HIV
Interventions
PrEP navigation + text messaging, Standard of Care, Contingency Management
Behavioral
Lead sponsor
Friends Research Institute, Inc.
Other
Eligibility
18 Years and older · Male only
Enrollment
152 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 10, 2026 · Synced Sep 20, 2026, 6:22 AM EDT
Terminated Not applicable Interventional

Mobile Technologies Extending Reach of Primary Care for Substance Use Disorders

NCT06208839
View directory record Official record
Conditions
Substance-Related Disorders
Interventions
SBIRT/eIntervention for those with moderate risk drug or alcohol use, SBIRT/eIntervention those assessed with high risk., SBIRT/TAU for those with moderate risk drug or alcohol use, SBIRT/TAU for those assessed with high risk.
Device · Other
Lead sponsor
Chess Mobile Health
Industry
Eligibility
18 Years and older
Enrollment
117 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Kalamazoo, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 26, 2026 · Synced Sep 20, 2026, 6:22 AM EDT
Completed Not applicable Interventional Results available

HealthCall:Brief Intervention to Reduce Non-injecting Drug Use in HIV Primary Care Clinics

NCT01312181
View directory record Official record
Conditions
Mental and Behavioral Disorders Due to Harmful Drug Use
Interventions
HealthCall and Motivational Interviewing, Motivational Interviewing (MI), HIV/AIDS health education
Behavioral
Lead sponsor
Research Foundation for Mental Hygiene, Inc.
Other
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
2
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 16, 2021 · Synced Sep 20, 2026, 6:22 AM EDT
Completed Not applicable Interventional

Motivational Assessment Program to Initiate Treatment

NCT01891656
View directory record Official record
Conditions
Substance-Related Disorders
Interventions
Motivational Interviewing, Motivational Computer
Behavioral
Lead sponsor
University of North Texas Health Science Center
Other
Eligibility
18 Years and older
Enrollment
380 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
2
States / cities
Fort Worth, Texas • Fairfax, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 12, 2016 · Synced Sep 20, 2026, 6:22 AM EDT
Completed Phase 2 Interventional

Using Telephone Technology to Prevent Relapse After Alcoholism Treatment

NCT00132795
View directory record Official record
Conditions
Alcoholism
Interventions
Daily monitoring of alcohol & drug use, & therapy skills, control group
Behavioral
Lead sponsor
University of Vermont
Other
Eligibility
19 Years and older
Enrollment
158 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Jun 20, 2012 · Synced Sep 20, 2026, 6:22 AM EDT