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ClinicalTrials.gov public records Last synced Oct 20, 2026, 1:21 AM EDT

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Showing 49–72 of 340 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Standard Post-Operative Pain Control Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Acupuncture ACL (Anterior Cruciate Ligament)

NCT03711734
View directory record Official record
Conditions
ACL, ACL Injury, Anterior Cruciate Ligament Injury, Anterior Cruciate Ligament Rupture, Anesthesia
Interventions
Acupuncture + Standard of Care
Other
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
12 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 27, 2024 · Synced Oct 20, 2026, 1:21 AM EDT
Terminated Early Phase 1 Interventional Accepts healthy volunteers

Pain Management Following Sinus Surgery

NCT03822962
View directory record Official record
Conditions
Nasal Sinus; Inflammation, Opioid Abuse, Pain, Postoperative
Interventions
Ibuprofen 600Mg Tablet, Standard Regimen | Tylenol
Drug · Other
Lead sponsor
University of Nebraska
Other
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
2
States / cities
Omaha, Nebraska • Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 6, 2023 · Synced Oct 20, 2026, 1:21 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Marcaine Post-Operative Pain Study

NCT04494880
View directory record Official record
Conditions
Effect of Drug
Interventions
Bupivacaine Injection
Drug
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
Up to 89 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Dec 15, 2023 · Synced Oct 20, 2026, 1:21 AM EDT
Recruiting Not applicable Interventional

Psychological Assessment of Scoliosis Patients Undergoing Surgical Management

NCT05774002
View directory record Official record
Conditions
Adolescent Idiopathic Scoliosis (AIS), Mental Health
Interventions
Aims to Decrease Anxiety and Pain Treatment (ADAPT)
Behavioral
Lead sponsor
Montefiore Medical Center
Other
Eligibility
10 Years to 19 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Oct 20, 2026, 1:21 AM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Optimizing Pain Control in Transurethral Resection of the Prostate

NCT04102566
View directory record Official record
Conditions
Pain, BPH With Urinary Obstruction, BPH With Urinary Obstruction With Other Lower Urinary Tract Symptoms
Interventions
Ibuprofen 600 mg, Education
Drug · Behavioral
Lead sponsor
Benaroya Research Institute
Other
Eligibility
18 Years and older · Male only
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Sep 27, 2019 · Synced Oct 20, 2026, 1:21 AM EDT
Not listed Phase 4 Interventional

The Effect of Liposomal Bupivacaine Nerve Block (Exparel) in Rotator Cuff Surgery

NCT06139666
View directory record Official record
Conditions
Rotator Cuff Tears, Postoperative Pain, Opioid Use
Interventions
Exparel Injectable Solution, Bupivacaine Injectable Solution
Drug
Lead sponsor
The Cooper Health System
Other
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
Camden, New Jersey
Source: ClinicalTrials.gov public record
Updated Aug 20, 2024 · Synced Oct 20, 2026, 1:21 AM EDT
Terminated Not applicable Interventional

Preoperative Education in Hand and Wrist Surgery

NCT05237531
View directory record Official record
Conditions
Distal Radius Fracture
Interventions
Standardized Preoperative Education, Standard of care, Preoperative and postoperative questionnaires
Behavioral
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 22, 2024 · Synced Oct 20, 2026, 1:21 AM EDT
Completed Not applicable Interventional Results available

The Impact of IV Acetaminophen on Pain After Appendectomy for Perforated Appendicitis

NCT02881996
View directory record Official record
Conditions
Perforated Appendicitis
Interventions
IV tylenol, No IV tylenol, Ketorolac
Drug
Lead sponsor
Children's Mercy Hospital Kansas City
Other
Eligibility
2 Years to 17 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 12, 2021 · Synced Oct 20, 2026, 1:21 AM EDT
Terminated Phase 4 Interventional Results available

Liposomal Bupivacaine in Vaginal Hysterectomy

NCT03907033
View directory record Official record
Conditions
Vaginal Hysterectomy
Interventions
Liposomal bupivacaine, Bupivacaine Hydrochloride
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 85 Years · Female only
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Oct 15, 2021 · Synced Oct 20, 2026, 1:21 AM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers

Rectal Acetaminophen Use During Oocyte Retrievals to Reduce Post-Operative Opioid Utilization

NCT03732469
View directory record Official record
Conditions
Opioid Use
Interventions
Acetaminophen, Fentanyl, Propofol
Drug
Lead sponsor
University of South Florida
Other
Eligibility
18 Years to 56 Years · Female only
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Jun 18, 2021 · Synced Oct 20, 2026, 1:21 AM EDT
Completed Not applicable Interventional Results available

Effect of Ibuprofen on Postoperative Opiate Medication Use and Shoulder Functional Outcomes

NCT02588027
View directory record Official record
Conditions
Rotator Cuff Tear Arthropathy
Interventions
Ibuprofen, Placebo
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2022
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Dec 6, 2024 · Synced Oct 20, 2026, 1:21 AM EDT
Not yet recruiting Not applicable Interventional

Lavender Sandalwood Aromatherapy Study

NCT07737392
View directory record Official record
Conditions
Pain, Mood, Patient Satisfaction, Scheduled Cesarean Sections
Interventions
Lavender-sandalwood aromatherapy tabs
Other
Lead sponsor
Memorial Hermann Health System
Other
Eligibility
18 Years and older · Female only
Enrollment
182 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 12, 2026 · Synced Oct 20, 2026, 1:21 AM EDT
Withdrawn Phase 4 Interventional

Post-Operative Pain Control in Opioid Tolerant Patients: Fentanyl Challenge Protocol Versus Standard of Care

NCT02324933
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Fentanyl
Drug
Lead sponsor
Bassett Healthcare
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2014
U.S. locations
1
States / cities
Cooperstown, New York
Source: ClinicalTrials.gov public record
Updated Nov 2, 2015 · Synced Oct 20, 2026, 1:21 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Intrathecal Hydromorphone for Pain Control After Cesarean Section

NCT02096003
View directory record Official record
Conditions
Pain, Cesarean Section
Interventions
Intrathecal morphine, Intrathecal hydromorphone
Drug
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 20, 2019 · Synced Oct 20, 2026, 1:21 AM EDT
Not yet recruiting Phase 4 Interventional

RCT: Suzetrigine vs Norco for Post-op Pain

NCT07195669
View directory record Official record
Conditions
Pain Control
Interventions
Suzetrigine (SUZ), Norco
Drug
Lead sponsor
Jacob Lensing
Other
Eligibility
18 Years to 45 Years
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Sep 29, 2025 · Synced Oct 20, 2026, 1:21 AM EDT
Recruiting Phase 4 Interventional

Methadone in the Management of Post-Operative Pain in Total Knee Replacement

NCT07485803
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Methadone
Drug
Lead sponsor
AdventHealth
Other
Eligibility
21 Years to 75 Years
Enrollment
192 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Oct 20, 2026, 1:21 AM EDT
Recruiting Phase 4 Interventional

Exparel and Education to Avoid Opioids After Carpal Tunnel Release

NCT03867539
View directory record Official record
Conditions
Carpal Tunnel Syndrome
Interventions
Differing pain management strategy
Drug
Lead sponsor
Kettering Health Network
Other
Eligibility
18 Years and older
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
2
States / cities
Dayton, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Oct 20, 2026, 1:21 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Methadone vs. Fentanyl Administration on Postoperative Pain Control in Pediatric Patients Undergoing Cardiac Surgery

NCT02747875
View directory record Official record
Conditions
Opioid Use, Unspecified
Interventions
Methadone, Fentanyl
Drug
Lead sponsor
Andrew Waberski
Other
Eligibility
2 Years to 7 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jun 1, 2021 · Synced Oct 20, 2026, 1:21 AM EDT
Completed Not applicable Interventional Results available

Patient Controlled Analgesia Pump Cues on Patient Satisfaction

NCT02456909
View directory record Official record
Conditions
Postoperative Pain
Interventions
Patient-Controlled Analgesia pump with Cues, Patient-Controlled Analgesia pump without Cues, Morphine
Device · Drug
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
7 Years to 18 Years
Enrollment
176 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Sep 8, 2021 · Synced Oct 20, 2026, 1:21 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Preoperative Use of Darifenacin (Enablex) to Alleviate Postoperative Ureteral Stent Pain

NCT01189071
View directory record Official record
Conditions
Overactive Bladder, Renal Colic, Pain, Postoperative
Interventions
Darifenacin
Drug
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Nov 21, 2016 · Synced Oct 20, 2026, 1:21 AM EDT
Enrolling by invitation Phase 3 Interventional Accepts healthy volunteers

NSAIDS Following Elective Lumbar Spine Fusion

NCT07743606
View directory record Official record
Conditions
NSAID (Non-Steroidal Anti-Inflammatory Drug), Lumbar Spine Fusion, Ketorolac, Postoperative Pain
Interventions
Ketorolac, Naproxen, Standard Postoperative Pain Management
Drug · Other
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
428 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 4, 2026 · Synced Oct 20, 2026, 1:21 AM EDT
Completed Phase 3 Interventional Results available

Postoperative Consequences of Intraoperative NOL Titration

NCT04679818
View directory record Official record
Conditions
Anesthesia; Adverse Effect
Interventions
Routine opioid management, PMD-200 Nol-guided opioid administration
Drug · Device
Lead sponsor
The Cleveland Clinic
Other
Eligibility
21 Years to 85 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 21, 2024 · Synced Oct 20, 2026, 1:21 AM EDT
Not listed Phase 3 Interventional

Liposomal Bupivacaine Use in Alveolar Bone Graft Patients

NCT06284434
View directory record Official record
Conditions
Cleft Lip and Palate
Interventions
Liposomal Bupivacaine, Bupivacain, Epinephrine
Drug
Lead sponsor
Kerry O'Rourke
Other
Eligibility
6 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 3, 2024 · Synced Oct 20, 2026, 1:21 AM EDT
Completed No phase listed Observational

Impact of Opioid Avoidance Protocol for ACL Reconstruction

NCT06340932
View directory record Official record
Conditions
ACL Tear, Post Operative Pain
Interventions
Iovera, Celecoxib, Acetaminophen, Oxycodone, Tramadol, Bupivacaine Hydrochloride, Acetaminophen 500Mg Cap
Device · Drug
Lead sponsor
Matthew Varacallo
Other
Eligibility
15 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
DuBois, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 7, 2025 · Synced Oct 20, 2026, 1:21 AM EDT