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ClinicalTrials.gov public records Last synced Oct 20, 2026, 3:24 AM EDT

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Showing 73–96 of 340 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Standard Post-Operative Pain Control Clear all
Withdrawn Phase 4 Interventional

Improving Pain Management After Total Shoulder Replacement Using Bupivacaine Liposome

NCT04134442
View directory record Official record
Conditions
Osteoarthritis of the Shoulder, Shoulder Pain, Pain, Postoperative
Interventions
Bupivacaine Liposome Injection, Standard Therapy
Drug · Other
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 6, 2022 · Synced Oct 20, 2026, 3:24 AM EDT
Recruiting Not applicable Interventional

SCS for Patient With Painful Diabetic Neuropathy and Peripheral Arterial Disease

NCT06480786
View directory record Official record
Conditions
Peripheral Arterial Disease, Painful Diabetic Neuropathy, Diabetes Mellitus, Type 2, Chronic Pain, Spinal Cord Stimulation, Chronic Pain Syndrome, Limb Pain
Interventions
Spinal cord stimulation, Sham stimulation
Device
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years to 89 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Oct 22, 2025 · Synced Oct 20, 2026, 3:24 AM EDT
Recruiting Phase 3 Interventional

Evaluation of Analgesia for Spine Fusion Elective Surgery in Children

NCT06626503
View directory record Official record
Conditions
Idiopathic Scoliosis
Interventions
Methadone based ERAS, Non-methadone based group
Drug
Lead sponsor
Senthil Sadhasivam
Other
Eligibility
10 Years to 18 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
4
States / cities
Indianapolis, Indiana • Cincinnati, Ohio • Pittsburgh, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 7, 2026 · Synced Oct 20, 2026, 3:24 AM EDT
Completed Phase 2 Interventional Results available

Lidocaine as an Endotracheal Tube (ETT) Cuff Media

NCT03343080
View directory record Official record
Conditions
Cardiac Disease
Interventions
1.8% lidocaine plus 0.76% sodium bicarbonate, Air
Drug · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 27, 2019 · Synced Oct 20, 2026, 3:24 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Effect of Over-the-counter Analgesics on Postoperative Pain

NCT06948513
View directory record Official record
Conditions
Pain Management
Interventions
Naproxen, Acetaminophen (Standard of Care), ibuprofen
Drug
Lead sponsor
Zitelli & Brodland Skin Cancer Center
Other
Eligibility
Not listed
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Clairton, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 29, 2025 · Synced Oct 20, 2026, 3:24 AM EDT
Enrolling by invitation Phase 2Phase 3 Interventional

Analgesic Requirement for Post-Operative Pain Control in TLIP Interbody Fusion

NCT06350981
View directory record Official record
Conditions
Back Pain, Surgery-Complications, Narcotic Use, Physical Stress, Post Operative Pain
Interventions
Exparel, Bupivacain
Drug
Lead sponsor
Foundation for Orthopaedic Research and Education
Other
Eligibility
18 Years and older
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Sep 9, 2026 · Synced Oct 20, 2026, 3:24 AM EDT
Completed Not applicable Interventional

Battlefield Acupuncture Following Shoulder Surgery

NCT04094246
View directory record Official record
Conditions
Shoulder Injuries, Pain, Postoperative, Acupuncture, Ear, Pain Management
Interventions
Battlefield Acupuncture, Standard post-surgical rehabilitation
Procedure
Lead sponsor
Keller Army Community Hospital
Federal
Eligibility
17 Years to 55 Years
Enrollment
95 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
West Point, New York
Source: ClinicalTrials.gov public record
Updated Feb 25, 2025 · Synced Oct 20, 2026, 3:24 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Do Elastic Abdominal Binders Reduce Post Operative Pain and Blood Loss?

NCT01786330
View directory record Official record
Conditions
Postpartum Hemorrhage, Pain
Interventions
Procare abdominal binder, Standard of Care
Device · Other
Lead sponsor
Zachary Kuhlmann, DO
Other
Eligibility
18 Years to 39 Years · Female only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
2
States / cities
Wichita, Kansas
Source: ClinicalTrials.gov public record
Updated Apr 11, 2016 · Synced Oct 20, 2026, 3:24 AM EDT
Terminated Not applicable Interventional Results available

BRIDGE Device for Post-operative Pain Control

NCT03265249
View directory record Official record
Conditions
Liver Failure, Liver Diseases, Alcoholic, Liver Diseases, Pain, Postoperative, Transplant; Failure, Liver, Liver Cirrhosis, Biliary
Interventions
BRIDGE device
Device
Lead sponsor
Duke University
Other
Eligibility
18 Years to 70 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated May 29, 2026 · Synced Oct 20, 2026, 3:24 AM EDT
Terminated Phase 3 Interventional Accepts healthy volunteers Results available

Determining the Effect of an "Alternate Recovery Protocol" Versus Current Standard of Care After Cesarean Section

NCT03330119
View directory record Official record
Conditions
Pregnancy Related, Narcotic Use
Interventions
Alternate Management, Control
Drug
Lead sponsor
Brest, Norman A., M.D.
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
1,494 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Wynnewood, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 2, 2021 · Synced Oct 20, 2026, 3:24 AM EDT
Withdrawn Not applicable Interventional

Hypnotherapy in Major Surgical Procedures

NCT02376634
View directory record Official record
Conditions
Scoliosis, Pectus Excavatum
Interventions
Hypnosis
Behavioral
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
10 Years to 21 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 9, 2016 · Synced Oct 20, 2026, 3:24 AM EDT
Completed Phase 4 Interventional Results available

Are Opioids Needed After ACL Reconstruction

NCT04285853
View directory record Official record
Conditions
Anterior Cruciate Ligament Rupture
Interventions
Oxycodone, Placebo oral tablet
Drug
Lead sponsor
Emory University
Other
Eligibility
14 Years to 40 Years
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
3
States / cities
Atlanta, Georgia • Tucker, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 11, 2023 · Synced Oct 20, 2026, 3:24 AM EDT
Completed Not applicable Interventional

Paravertebral Catheters for Pancreatic Surgery

NCT02363777
View directory record Official record
Conditions
Acute Pain
Interventions
Epidural, Paravertebral catheters
Procedure
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 85 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 31, 2017 · Synced Oct 20, 2026, 3:24 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Patient Education and Use of Post Operative Pain Medication in Ambulatory Hand Surgery: a Randomized Controlled Trial

NCT03219177
View directory record Official record
Conditions
Ambulatory Hand Surgery
Interventions
Patient education regarding indications for opioid use and side effects of opioid use after hand surgery, Standard of care post-operative counseling
Behavioral · Other
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 16, 2022 · Synced Oct 20, 2026, 3:24 AM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

A Comparison Trial Between PCA and Epidural Analgesia for Pectus Excavatum Repair

NCT02056301
View directory record Official record
Conditions
Pectus Excavatum
Interventions
Hydromorphone, Morphine
Drug
Lead sponsor
Baylor College of Medicine
Other
Eligibility
8 Years to 18 Years
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2019
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 11, 2020 · Synced Oct 20, 2026, 3:24 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Trial of Liposomal Bupivacaine for TKA

NCT05635916
View directory record Official record
Conditions
Knee Replacement, Total Knee Arthroplasty, Post-Operative Pain
Interventions
Liposomal bupivacaine, Bupivacaine
Drug
Lead sponsor
Northern Light Mercy Hospital
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Portland, Maine
Source: ClinicalTrials.gov public record
Updated Jul 7, 2023 · Synced Oct 20, 2026, 3:24 AM EDT
Completed Not applicable Interventional

Enhanced Recovery After Surgery: A RCT of Perioperative Management of Gynecologic Patients

NCT02357251
View directory record Official record
Conditions
Laparotomy, Gynecologic Diseases
Interventions
Enhanced recovery protocol
Other
Lead sponsor
Case Comprehensive Cancer Center
Other
Eligibility
18 Years and older · Female only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 12, 2017 · Synced Oct 20, 2026, 3:24 AM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Enhanced Recovery Strategies in Elective Breast Surgery

NCT03187080
View directory record Official record
Conditions
Pain, Acute, Nausea, Vomiting, Postoperative, Opioid Use, Satisfaction
Interventions
Paravertebral block procedure using either local anesthetic (0.25% bupivacaine) or sterile saline, Enhanced recovery after breast surgery (ERABS) strategies, Sham paravertebral block using saline, Paravertebral block using local anesthetic
Procedure · Other · Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older · Female only
Enrollment
113 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Aug 23, 2024 · Synced Oct 20, 2026, 3:24 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Meditation Effects on Discomfort, Pain InTerference, and AnxieTy After urEteroscopy

NCT06783946
View directory record Official record
Conditions
Kidney Stone, Pain, Postoperative, Anxiety Postoperative
Interventions
Meditation
Behavioral
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
12 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
2
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 4, 2025 · Synced Oct 20, 2026, 3:24 AM EDT
Completed Not applicable Interventional

Coping After Pediatric Scoliosis Surgery

NCT04063670
View directory record Official record
Conditions
Adolescent Idiopathic Scoliosis
Interventions
Video Intervention, Control
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
11 Years to 18 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 2, 2025 · Synced Oct 20, 2026, 3:24 AM EDT
Not yet recruiting Not applicable Interventional

NEUROCUPLE™ as an Opioid Alternative Following Total Knee Arthroplasty

NCT07439666
View directory record Official record
Conditions
Total Knee Arthroplasty Postoperative Pain, Opioid Reduction After TKA
Interventions
NEUROCUPLE™ Patch, Sham patch, Enhanced Recovery After Surgery (ERAS) Standard of Care
Device · Other
Lead sponsor
Jacques E. Chelly
Other
Eligibility
18 Years and older
Enrollment
274 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
3
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Oct 20, 2026, 3:24 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The ImPreSS Trial: Pharmacogenomic Decision Making at Time of Surgery

NCT03729180
View directory record Official record
Conditions
Surgery
Interventions
Routine Elective Surgery- In patient or out patient elective surgery, Blood test for genetic testing, Drug-genetic Profile
Procedure · Diagnostic Test · Other
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
1,900 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 24, 2026 · Synced Oct 20, 2026, 3:24 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Limb Occlusion Pressure Tourniquets to Decrease Pain After Surgery

NCT04390425
View directory record Official record
Conditions
Limb Occlusion Pressure
Interventions
Experimental - Limb Occlusion pressure
Device
Lead sponsor
The Methodist Hospital Research Institute
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Oct 20, 2026, 3:24 AM EDT
Completed Not applicable Interventional

Conditioned Open-label Placebo (COLP) for Peri-operative Pain Management in Patients With Head and Neck Cancer

NCT04973748
View directory record Official record
Conditions
Postoperative Pain, Opioid Use
Interventions
Conditioned open-label placebo (COLP), Surveys about pain, opioid use and depression symptoms
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 23, 2024 · Synced Oct 20, 2026, 3:24 AM EDT