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Showing 1–24 of 338 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Standard Smoking Cessation Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Hospitalized Smokers

NCT01305928
View directory record Official record
Conditions
Hospitalized Smokers
Interventions
Warm Hand-off, Fax
Other
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years and older
Enrollment
1,054 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2016
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Apr 25, 2016 · Synced Sep 14, 2026, 3:23 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Mobile Cessation Support for Latino Smokers

NCT03586596
View directory record Official record
Conditions
Smoking Cessation
Interventions
The Decídetext program, Standard Care Control
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
21 Years and older
Enrollment
457 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
3
States / cities
Kansas City, Kansas • Hackensack, New Jersey • Rochester, New York
Source: ClinicalTrials.gov public record
Updated Apr 11, 2024 · Synced Sep 14, 2026, 3:23 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Smoke-free Home Intervention in Permanent Supportive Housing

NCT04855357
View directory record Official record
Conditions
Smoking Cessation, Second Hand Tobacco Smoke
Interventions
Resident counselling, Staff Training
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
452 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Sep 14, 2026, 3:23 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Pilot Randomized Controlled Trial of a Smart Phone-Based Smoking Cessation Program

NCT04955639
View directory record Official record
Conditions
Smoking Cessation
Interventions
Control, Pivot
Other
Lead sponsor
Jennifer Marler, MD
Industry
Eligibility
21 Years and older
Enrollment
188 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
San Carlos, California
Source: ClinicalTrials.gov public record
Updated Jun 30, 2024 · Synced Sep 14, 2026, 3:23 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Project Q Pilot: Smoking Cessation for Light Smokers

NCT03416621
View directory record Official record
Conditions
Tobacco Use Cessation
Interventions
Cognitive behavioral cessation counseling, Counseling and placebo drug intervention, Counseling and active drug intervention
Behavioral · Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 65 Years
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 28, 2021 · Synced Sep 14, 2026, 3:23 AM EDT
Recruiting Not applicable Interventional

Wellness Intervention for Smoking and HIV

NCT04725617
View directory record Official record
Conditions
HIV, Sleep, Smoking Cessation, Cardiovascular Diseases
Interventions
Varenicline, Smoking Cessation Counseling, Health Approach 1 to Reduce Smoking, Health Approach 2 to Reduce Smoking
Drug · Behavioral · Other
Lead sponsor
University of Arizona
Other
Eligibility
18 Years to 75 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
2
States / cities
Phoenix, Arizona • Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Aug 18, 2025 · Synced Sep 14, 2026, 3:23 AM EDT
Recruiting Not applicable Interventional

Modulating Neural Mechanisms of Reward Processing in Tobacco Users

NCT07812753
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
PRIME TMS, Standard TMS
Device
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years to 60 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 9, 2026 · Synced Sep 14, 2026, 3:23 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Testing the Efficacy of A Scalable, Telephone-Delivered, Guided Imagery Tobacco Cessation Intervention

NCT05277831
View directory record Official record
Conditions
Smoking Cessation, Smoking, Smoking Reduction, Smoking, Cigarette, Smoking (Tobacco) Addiction, Smoking Habit
Interventions
Guided Imagery Intervention, Standard Behavioral Control
Other
Lead sponsor
University of Arizona
Other
Eligibility
18 Years and older
Enrollment
1,209 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Nov 23, 2025 · Synced Sep 14, 2026, 3:23 AM EDT
Recruiting Phase 4 Interventional

Varenicline and Accelerated Transcranial Magnetic Stimulation (TMS) for Quitting Nicotine Use (Pilot Study)

NCT07145866
View directory record Official record
Conditions
Nicotine Dependence, Transcranial Magnetic Stimulation, Vaping, Smoking Cessation, Smoking (Tobacco) Addiction
Interventions
Varenicline, Transcranial Magnetic Stimulation, Transcranial Magnetic Stimulation Sham, Nicotine Cessation Counseling, D-cycloserine
Drug · Device · Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Sep 14, 2026, 3:23 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Maintaining Nonsmoking

NCT01162239
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Varenicline, Initial Individual counseling, Check-ins with medical staff, Extended Individual Counseling - Health Model, Extended Individual Counseling - Relapse Prevention Model
Drug · Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
216 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2016
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Nov 11, 2020 · Synced Sep 14, 2026, 3:23 AM EDT
Terminated Phase 1 Interventional

Novel Treatments to Enhance Smoking Cessation Before Cancer Surgery: Effects on Smoking and Surgical Outcomes

NCT01479998
View directory record Official record
Conditions
Smoking Cessation
Interventions
standard care, standard care plus contingency management
Other
Lead sponsor
Yale University
Other
Eligibility
18 Years to 85 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
2
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 8, 2020 · Synced Sep 14, 2026, 3:23 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

UW Quitting Using Intensive Treatment Study (QUITS)

NCT03176784
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Varenicline, Nicotine patch, Placebo Patch, Placebo Pill
Drug · Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
1,251 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
2
States / cities
Madison, Wisconsin • Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jan 22, 2023 · Synced Sep 14, 2026, 3:23 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Feasibility of a Medical-Legal Partnership Model to Connect Coal Miners QuitAid

NCT07694492
View directory record Official record
Conditions
Tobacco Use Cessation, Tobacco Use Disorder, Nicotine Dependence, Smokeless Tobacco Use
Interventions
QuitAid (pharmacist-delivered MTM), Nicotine Replacement Therapy (NRT)
Behavioral · Drug
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Sep 14, 2026, 3:23 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Development of Positive Psychotherapy for Smoking Cessation

NCT01451814
View directory record Official record
Conditions
Smoking
Interventions
Positive Psychotherapy for smoking cessation, Nicotine polacrilex, Relaxation training, Behavioral smoking cessation treatment
Behavioral · Drug
Lead sponsor
Brown University
Other
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Mar 17, 2015 · Synced Sep 14, 2026, 3:23 AM EDT
Completed Not applicable Interventional Results available

Improving Medication Compliance and Smoking Cessation Treatment Outcomes for African American Smokers

NCT00781599
View directory record Official record
Conditions
Smokers
Interventions
Chantix, Adherence Counseling, Standard Counseling
Drug · Behavioral
Lead sponsor
Nikki Nollen, PhD, MA
Other
Eligibility
18 Years to 75 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Jul 10, 2012 · Synced Sep 14, 2026, 3:23 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Mechanisms of Mindfulness for Smoking Cessation

NCT02943499
View directory record Official record
Conditions
Smoking Cessation
Interventions
App/Training, Smartphone
Behavioral · Device
Lead sponsor
Brown University
Other
Eligibility
21 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 18, 2019 · Synced Sep 14, 2026, 3:23 AM EDT
Completed Not applicable Interventional Results available

Randomized Pilot Study of a mHealth App for Ambivalent Smokers Living With HIV

NCT05339659
View directory record Official record
Conditions
Smoking, Smoking Cessation
Interventions
mHealth Intervention
Device
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Mar 31, 2024 · Synced Sep 14, 2026, 3:23 AM EDT
Completed Phase 4 Interventional Results available

Health Systems Reach Interventions Project

NCT04199117
View directory record Official record
Conditions
Smoking, Cigarette, Smoking Cessation
Interventions
Varenicline, Combination nicotine patch and nicotine mini-lozenge treatment, Monetary incentives for initiating treatment, Automated tailored outreach, Care management, Wisconsin Tobacco Quit Line referral, Primary care provider referral, Untailored outreach, Multiple smoking cessation coaching calls
Drug · Behavioral · Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
210 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Sep 23, 2025 · Synced Sep 14, 2026, 3:23 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Biomarkers of Molecular Risk in Smokers

NCT00598143
View directory record Official record
Conditions
Smoking Cessation
Interventions
Vignette, questionnaires and Saliva Samples, Urine Collection, Smoking cessation treatment
Behavioral
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2015
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 27, 2015 · Synced Sep 14, 2026, 3:23 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Examination of Sleep, Smoking Cessation, and Cardiovascular Health

NCT02941718
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Sleep Advancement Counseling, General Health Information
Behavioral
Lead sponsor
University of Delaware
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Aug 29, 2019 · Synced Sep 14, 2026, 3:23 AM EDT
Completed Phase 2 Interventional Results available

Behavioral Activation Intervention for Smoking Cessation in Smokers With Depressive Symptoms

NCT01199380
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Standard Treatment, Behavioral Activation Treatment for Smoking, Transdermal Nicotine Patch
Behavioral · Drug
Lead sponsor
University of Maryland, College Park
Other
Eligibility
18 Years to 65 Years
Enrollment
184 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
1
States / cities
College Park, Maryland
Source: ClinicalTrials.gov public record
Updated May 17, 2022 · Synced Sep 14, 2026, 3:23 AM EDT
Completed Not applicable Interventional

Smoking Cessation Intervention for Diabetic Patients

NCT01501877
View directory record Official record
Conditions
Smoking, Type 2 Diabetes
Interventions
Acceptance and Commitment Therapy, Standard smoking cessation intervention
Behavioral
Lead sponsor
Rhode Island Hospital
Other
Eligibility
21 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Apr 11, 2017 · Synced Sep 14, 2026, 3:23 AM EDT
Completed Not applicable Interventional Results available

Integrating Use of Self-Affirmation Content Into a Mobile App to Promote Quit Attempts With Text-Based Smoking Cessation Intervention Messaging

NCT03027466
View directory record Official record
Conditions
Number of Quit Attempts
Interventions
Self-affirmation induction
Behavioral
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
18 Years to 99 Years
Enrollment
7,899 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 22, 2021 · Synced Sep 14, 2026, 3:23 AM EDT
Not yet recruiting Phase 2Phase 3 Interventional Accepts healthy volunteers

A Stepped Care Approach to Treating Tobacco Use in Rural Veterans

NCT04501016
View directory record Official record
Conditions
Tobacco Cessation
Interventions
Tailored behavioral counseling, Tobacco cessation pharmacotherapy
Behavioral · Drug
Lead sponsor
Iowa City Veterans Affairs Medical Center
Federal
Eligibility
18 Years to 99 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Aug 5, 2020 · Synced Sep 14, 2026, 3:23 AM EDT