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Conditions: Essential Tremor
Interventions: Not listed
Lead sponsor: University of Florida; Other
Eligibility: 21 Years to 85 Years
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Laryngeal Papilloma
Interventions: Celebrex, PDL, CO2 laser or microsurgery; Drug · Device · Procedure
Lead sponsor: Boston University; Other
Eligibility: 18 Years to 64 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2009
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Facial Paralysis
Interventions: BES, Standard of Care surgery; Procedure
Lead sponsor: The Cleveland Clinic; Other
Eligibility: 18 Years to 80 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Invasive Breast Carcinoma, Triple-Negative Breast Carcinoma
Interventions: Bevacizumab, Everolimus, Laboratory Biomarker Analysis, Pegylated Liposomal Doxorubicin Hydrochloride; Biological · Drug · Other
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years and older · Female only
Enrollment: 17 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2023
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Down Syndrome, Congenital Heart Disease
Interventions: Stanford Binet Intelligence Scales, Fifth Edition, Vineland Adaptive Behavior Scales Third Edition, Peabody Picture Vocabulary Test, Fifth Edition, Expressive Vocabulary Test, Third Edition, Leiter International Performance Scale, Third Edition, Social Communication Questionnaire, Current Form, Aberrant Behavior Checklist, Repetitive Behavior Scale, Revised; Other
Lead sponsor: Carelon Research; Other
Eligibility: 60 Months to 155 Months
Enrollment: 273 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 13
States / cities: Wilmington, Delaware • Washington D.C., District of Columbia • Atlanta, Georgia + 10 more

Conditions: Aphthous Stomatitis, Burning Mouth Syndrome, Lichen Planus, Mouth Disease, Temporomandibular Joint Disorder
Interventions: Electrocardiogram, Biopsies, Diagnostic imaging; Procedure
Lead sponsor: National Institute of Dental and Craniofacial Research (NIDCR); NIH
Eligibility: Not listed
Enrollment: 999 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1997 – 2002
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Adolescent Idiopathic Scoliosis (AIS), Mental Health
Interventions: Aims to Decrease Anxiety and Pain Treatment (ADAPT); Behavioral
Lead sponsor: Montefiore Medical Center; Other
Eligibility: 10 Years to 19 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2028
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Amputation Stumps, Pain
Interventions: Procedure/Surgery: Enriched Fat grafting; Procedure
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years and older
Enrollment: 5 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2016
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Urinary Bladder Cancer, Muscle-invasive
Interventions: Pembrolizumab, Surgery (radical cystectomy (RC) plus Pelvic Lymph Node Dissection [PLND]), Enfortumab Vedotin; Drug · Procedure
Lead sponsor: Merck Sharp & Dohme LLC; Industry
Eligibility: 18 Years and older
Enrollment: 595 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2027
U.S. locations: 39
States / cities: Mobile, Alabama • Little Rock, Arkansas • Fullerton, California + 31 more

Conditions: Chronic Subdural Hematoma
Interventions: embolization therapy Bilateral, embolization therapy Unilateral; Device
Lead sponsor: Lahey Clinic; Other
Eligibility: 18 Years and older
Enrollment: 400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Burlington, Massachusetts

Conditions: Enhanced Recovery After Surgery, Gynecologic Disease
Interventions: Enhanced Recovery After Surgery (ERAS) Counseling to Patients, Enhanced Recovery After Surgery (ERAS) Counseling to Caregiver; Other
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 9 Years to 17 Years · Female only
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2028
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Rotator Cuff Injuries
Interventions: Band Connect, Physical Therapy; Device · Behavioral
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years and older
Enrollment: 68 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: New York, New York

Conditions: Mesothelioma
Interventions: Biospecimen Collection, Cryosurgery; Procedure
Lead sponsor: Jonsson Comprehensive Cancer Center; Other
Eligibility: Not listed
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Pulmonary Disease
Interventions: Institutional standard of care, Biosamples of airway and blood; Other
Lead sponsor: Boston University; Other
Eligibility: 46 Years and older
Enrollment: 85 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2026
U.S. locations: 19
States / cities: Birmingham, Alabama • Los Angeles, California • San Diego, California + 13 more

Conditions: Prosthetic Joint Infection
Interventions: VT-X7 Treatment System with Tobramycin Sulfate, Standard of Care, Two-stage exchange arthroplasty, VT-X7 Treatment System with Vancomycin Hydrochloride; Combination Product · Drug · Procedure
Lead sponsor: Osteal Therapeutics, Inc.; Industry
Eligibility: 22 Years to 84 Years
Enrollment: 76 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 17
States / cities: Phoenix, Arizona • Torrance, California • Washington D.C., District of Columbia + 13 more

Conditions: Pancreatic Ductal Adenocarcinoma
Interventions: Fecal Microbiota Transplantation, Fecal Microbiota Transplantation Capsule, Questionnaire Administration, Resection, Therapeutic Colonoscopy; Procedure · Drug · Other
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2026
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Cardiovascular Diseases, Coronary Disease, Heart Failure, Congestive, Heart Diseases
Interventions: CABG surgery plus MED, Active Medication Alone, CABG plus MED and SVR; Procedure · Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 100 Years
Enrollment: 2,136 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2015
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging, PEOX-based Polymer Encapsulated Paclitaxel FID-007, Tumor Resection; Procedure · Drug
Lead sponsor: University of Southern California; Other
Eligibility: 18 Years and older
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 2
States / cities: Los Angeles, California

Conditions: Lung Cancer
Interventions: educational intervention, medical chart review, questionnaire administration, end-of-life treatment/management, psychosocial assessment and care, quality-of-life assessment, management of therapy complications, assessment of therapy complications; Other · Procedure
Lead sponsor: City of Hope Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 280 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2014
U.S. locations: 1
States / cities: Duarte, California

Conditions: Lung Cancer
Interventions: 4DCT-Ventilation; Diagnostic Test
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 18 Years to 100 Years
Enrollment: 65 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2022
U.S. locations: 2
States / cities: Aurora, Colorado • Colorado Springs, Colorado

Conditions: Hallux Valgus
Interventions: conventional surgical technique - Chevron-type distal metatarsal osteotomy, minimally invasive surgical technique; Procedure
Lead sponsor: Henry DeGroot, M.D.; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2018
U.S. locations: 1
States / cities: Newton, Massachusetts

Conditions: Cutaneous Angiosarcoma
Interventions: Paclitaxel, Radiation therapy, Research blood draw; Drug · Radiation · Procedure
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 18 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2028
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Cardiac Surgery
Interventions: Sucrosomial Iron (SI); Dietary Supplement
Lead sponsor: Englewood Hospital and Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Englewood, New Jersey

Conditions: Opioid Use, Pain, Post Operative
Interventions: nCAP Signal Relief Patch, Standard of Care; Device · Other
Lead sponsor: Jacques E. Chelly; Other
Eligibility: 18 Years and older
Enrollment: 79 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

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Deep Brain Stimulation Effects in Essential Tremor

Celebrex (Celecoxib) Treatment of Laryngeal Papilloma

Intraoperative Electrical Stimulation to Improve Nerve Grafting Outcome

Liposomal Doxorubicin, Bevacizumab, and Everolimus in Patients With Locally Advanced TNBC With Tumors Predicted Insensitive to Standard Chemotherapy; A Moonshot Initiative

Congenital Heart Disease: Impact on Learning and Development in Down Syndrome (CHILD-DS)

Evaluation and Treatment of Oral Soft Tissue Diseases

Psychological Assessment of Scoliosis Patients Undergoing Surgical Management

Enriched Autologous Fat Grafting for Treating Pain at Amputation Sites

Perioperative Pembrolizumab (MK-3475) Plus Cystectomy or Perioperative Pembrolizumab Plus Enfortumab Vedotin Plus Cystectomy Versus Cystectomy Alone in Participants Who Are Cisplatin-ineligible or Decline Cisplatin With Muscle-invasive Bladder Cancer (MK-3475-905/KEYNOTE-905/EV-303)

Assessing Outcomes of Coil Embolization for Unilateral vs Bilateral Chronic Subdural Hematomas

ERAS in Pediatric & Adolescent Gynecology Preoperative Counseling

Telerehabilitation for Shoulder Surgery Recovery

Cryoablation for the Promotion of Local Tumor Infiltration in Patients With Mesothelioma

DECAMP 1 PLUS: Prediction of Lung Cancer Using Noninvasive Biomarkers

Abbreviated Protocol for Two-Stage Exchange

Fecal Microbial Transplants for the Treatment of Pancreatic Cancer

Comparison of Surgical and Medical Treatment for Congestive Heart Failure and Coronary Artery Disease

FID-007 Followed by Standard of Care Surgery in Head and Neck Cancer

Effects of Palliative Care on Quality of Life and Symptom Control in Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer That Cannot Be Removed by Surgery

A Novel Lung Function Imaging Modality As a Preoperative Evaluation Tool (LIME)

Prospective Trial of Minimally Invasive Surgery Versus Standard Surgery for Correction of Hallux Valgus

Induction Paclitaxel Followed by Concurrent Paclitaxel and Radiation Therapy for Cutaneous Angiosarcoma

Pilot Study Evaluating the Advantages of Sucrosomial® Iron Post-operative Supplementation vs Standard of Care After Cardiac Surgery

A Pilot Study Investigating the nCAP Signal Relief Patch in Subjects Undergoing Primary Hip or Knee Replacement Surgery