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ClinicalTrials.gov public records Last synced Sep 10, 2026, 1:32 AM EDT

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Showing 1–24 of 57 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Standard amputation procedure Clear all
Recruiting Not applicable Interventional

Bio Leg: Advancing Mobility (BAM)

NCT07613502
View directory record Official record
Conditions
Amputation of Lower Limb Above Knee, Amputee, Amputation
Interventions
Bio Leg
Device
Lead sponsor
University of Florida
Other
Eligibility
40 Years to 70 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 5, 2026 · Synced Sep 10, 2026, 1:32 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Evaluation of a Powered Ankle Prosthesis Capable of Bidirectional Control Via Neural Recording and Cutaneous Stimulation in Free-Space and Walking Tasks

NCT07645729
View directory record Official record
Conditions
Amputation
Interventions
Powered Prosthesis, Prescribed Prosthesis
Device
Lead sponsor
Massachusetts Institute of Technology
Other
Eligibility
18 Years to 70 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2031
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 11, 2026 · Synced Sep 10, 2026, 1:32 AM EDT
Terminated Not applicable Interventional

NEOX® CORD 1K vs Standard of Care in Non-healing Diabetic Foot Ulcers

NCT02166294
View directory record Official record
Conditions
Foot Ulcer, Diabetic
Interventions
NEOX® CORD 1K, Standard of Care (Pressure Bandage)
Other · Procedure
Lead sponsor
Amniox Medical, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
3
States / cities
Tucson, Arizona • Castro Valley, California • Newnan, Georgia
Source: ClinicalTrials.gov public record
Updated Jun 26, 2017 · Synced Sep 10, 2026, 1:32 AM EDT
Recruiting Not applicable Interventional

Noraxon myoRESEARCH™ Software Gait Analysis Evaluation and Orthotic Gait Correction in Reducing Diabetic Foot Ulceration Or Subsequent Amputation in Patients With a History of a Diabetic Foot Ulceration

NCT04164641
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
Noraxon myoRESEARCH™ Software Gait Analysis Evaluation and Orthotic
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 90 Years
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 15, 2025 · Synced Sep 10, 2026, 1:32 AM EDT
Recruiting Not applicable Interventional

Non-Contact Low-Frequency Ultrasound Vs Standard LaLonde Protocol for Fingertip Injury Wound Healing

NCT06813430
View directory record Official record
Conditions
Non-contact Low Frequency Ultrasound, Lalonde Protocol, Fingertip Amputation
Interventions
Non-contact Low Frequency Ultrasound, Lalonde Protocol (standard of care)
Device · Other
Lead sponsor
St. Luke's Hospital, Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Bethlehem, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 14, 2025 · Synced Sep 10, 2026, 1:32 AM EDT
Active, not recruiting Not applicable Interventional

The TRIABETES - ARMMS-T2D Study: A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes

NCT01047735
View directory record Official record
Conditions
Type 2 Diabetes Mellitus, Obesity
Interventions
Roux-en-Y Gastric Bypass Surgery, Laparoscopic Adjustable Gastric Banding, Lifestyle Weight Loss Intervention
Procedure · Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
25 Years to 55 Years
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2028
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 10, 2026 · Synced Sep 10, 2026, 1:32 AM EDT
Withdrawn Not applicable Interventional

Surgical Treatments for Neuroma Pain in Amputees

NCT04204668
View directory record Official record
Conditions
Pain, Neuropathic, Amputation Neuroma, Phantom Limb Pain
Interventions
TMR, RPNI, VDMT
Procedure
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 2, 2025 · Synced Sep 10, 2026, 1:32 AM EDT
Completed Not applicable Interventional

Pilot Study to Determine Percent Tissue Perfusion and Cellular Viability Using SPY Imaging

NCT01522495
View directory record Official record
Conditions
Peripheral Vascular Disease
Interventions
SPY Imaging, ICG dye (0.2 - 0.5 mg/kg), SPY Imaging
Device
Lead sponsor
Georgetown University
Other
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Mar 10, 2020 · Synced Sep 10, 2026, 1:32 AM EDT
Completed Not applicable Interventional Results available

AMP30: Autologous Fat Grafting, Amputation Sites Pain: Randomized

NCT02076022
View directory record Official record
Conditions
Wounded Warrior, Limb Shortening, Amputation
Interventions
Enhanced Fat Grafting, Standard fat graft
Device · Procedure
Lead sponsor
J. Peter Rubin, MD
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 9, 2020 · Synced Sep 10, 2026, 1:32 AM EDT
Completed Not applicable Interventional Results available

Strength, Pain and Function in Operation Iraqi Freedom/Operation Enduring Freedom Amputees: A Nurse-Managed Program

NCT00942890
View directory record Official record
Conditions
Traumatic Amputation
Interventions
NMES (EMPI 300PV stimulator) plus standard of care, TMARP standard of care
Device · Behavioral
Lead sponsor
University of Tennessee
Other
Eligibility
18 Years to 55 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2015
U.S. locations
3
States / cities
San Diego, California • Bethesda, Maryland • Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 9, 2018 · Synced Sep 10, 2026, 1:32 AM EDT
Completed Not applicable Interventional

Online Wound Electronic Medical Record (OWEMR) to Decrease Amputations in Diabetics

NCT01371318
View directory record Official record
Conditions
Wounds, Diabetes Complications, Diabetic Foot, Foot Ulcer
Interventions
Online Wound Electronic Medical Record
Other
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
1,609 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
13
States / cities
Phoenix, Arizona • Tuscon, Arizona • Pomona, California + 8 more
Source: ClinicalTrials.gov public record
Updated Dec 30, 2014 · Synced Sep 10, 2026, 1:32 AM EDT
Recruiting Not applicable Interventional

Fuzzy Wale Compression Stockinet to Promote Healing Following Transtibial Amputation for Peripheral Arterial Disease

NCT06308562
View directory record Official record
Conditions
Peripheral Arterial Disease
Interventions
Fuzzy Wale Compression Stockinet
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 13, 2026 · Synced Sep 10, 2026, 1:32 AM EDT
Completed Not applicable Interventional Results available

Postoperative Peripheral Nerve Stimulation for Management of Post-amputation Pain

NCT03484429
View directory record Official record
Conditions
Phantom Limb Pain, Postoperative Pain, Neuroma, Acute Pain, Chronic Pain, Residual Limbs, Amputation
Interventions
Peripheral nerve stimulation, Standard Medical Therapy
Device · Other
Lead sponsor
Hunter Holmes Mcguire Veteran Affairs Medical Center
Federal
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 20, 2021 · Synced Sep 10, 2026, 1:32 AM EDT
Completed Phase 1 Interventional

A Clinical and Histological Analysis of Mesenchymal Stem Cells in Amputation

NCT02685098
View directory record Official record
Conditions
Ischemia, Peripheral Arterial Disease, Peripheral Vascular Disease, Vascular Disease, Arterial Occlusive Disease, Arteriosclerosis, Atherosclerosis, Cardiovascular Disease, Pathologic Processes, Orthopedic Procedures, Amputation
Interventions
Allogeneic bone marrow derived mesenchymal stem cells
Biological
Lead sponsor
Indiana University
Other
Eligibility
40 Years to 90 Years
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 22, 2025 · Synced Sep 10, 2026, 1:32 AM EDT
Completed Not applicable Interventional Results available

Crossing the Divide: Piloting Integrated Care to Reduce Amputations Among Rural Patients With Diabetic Foot Ulcers

NCT05203471
View directory record Official record
Conditions
Diabetic Foot, Diabetic Ulcer of Left Foot, Diabetic Ulcer of Right Foot, Amputation
Interventions
integrated care model
Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 89 Years
Enrollment
131 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Apr 26, 2026 · Synced Sep 10, 2026, 1:32 AM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

Perioperative Mirror Therapy and Phantom Limb Pain

NCT02383979
View directory record Official record
Conditions
Phantom Limb Pain, Phantom Pain, Phantom Sensation, Pseudomelia
Interventions
Sham (Comparator) Plasma Ball, Mirror
Device
Lead sponsor
United States Naval Medical Center, San Diego
Federal
Eligibility
18 Years to 30 Years
Enrollment
115 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2019
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Aug 27, 2019 · Synced Sep 10, 2026, 1:32 AM EDT
Active, not recruiting Not applicable Interventional

Transfemoral Osseointegrated Prosthesis Limb-Load Symmetry Training

NCT05695911
View directory record Official record
Conditions
Amputation, Transfemoral Amputation, Osseointegration
Interventions
Limb Load Biofeedback Training Intervention, Attention Control
Behavioral · Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 26, 2026 · Synced Sep 10, 2026, 1:32 AM EDT
Completed Not applicable Interventional Results available

Evaluation of Closed Incision Negative Pressure Dressing (PREVENA) to Prevent Lower Extremity Amputation Wound Complications

NCT03773575
View directory record Official record
Conditions
Amputation, Amputation; Postoperative, Sequelae, Wound Dehiscence, Seroma, Wound Infection, Surgical, Lymph Leakage
Interventions
PREVENA™ PEEL & PLACE™ Dressing Kit
Device
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years and older
Enrollment
272 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
2
States / cities
Valhalla, New York • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Sep 10, 2026, 1:32 AM EDT
Completed No phase listed Observational

Clinical Implications of Peripheral Plaque Morphology

NCT00578422
View directory record Official record
Conditions
Peripheral Artery Disease
Interventions
Ivus (Intravascular Ultrasound) of Amputation Specimens, IVUS (Intravascular Ultrasound)
Other · Procedure
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
143 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2016
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 7, 2017 · Synced Sep 10, 2026, 1:32 AM EDT
Completed No phase listed Observational

Regenerative Peripheral Nerve Interfaces for the Treatment of Painful Neuromas in Major Limb Amputees

NCT07285486
View directory record Official record
Conditions
Amputation Neuroma
Interventions
Amputation with Regenerative Peripheral Nerve Interfaces (RPNI), Amputation Without RPNI
Procedure · Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
2
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 15, 2025 · Synced Sep 10, 2026, 1:32 AM EDT
Not listed Not applicable Interventional

Enhancement of Residual Limb Proprioception and Rehabilitation Training Methods With a Vibrotactile Device.

NCT02026570
View directory record Official record
Conditions
Transtibial Amputation
Interventions
Internal Focus of Attention, External Focus of Attention
Behavioral
Lead sponsor
Southern California Institute for Research and Education
Other
Eligibility
18 Years to 70 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
Long Beach, California
Source: ClinicalTrials.gov public record
Updated Apr 4, 2019 · Synced Sep 10, 2026, 1:32 AM EDT
Terminated Phase 4 Interventional

Prevention of Phantom Limb and Stump Pain Using Ambulatory Continuous Peripheral Nerve Blocks: A Pilot Study

NCT00771862
View directory record Official record
Conditions
Amputation, Phantom Limb Pain, Stump Pain
Interventions
perineural ropivicaine
Procedure
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2017
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 18, 2018 · Synced Sep 10, 2026, 1:32 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Agonist-Antagonist Myoneural Interface for Functional Limb Restoration After Transtibial Amputation

NCT03913273
View directory record Official record
Conditions
Amputation
Interventions
AMI transtibial amputation, Standard transtibial amputation
Procedure
Lead sponsor
Massachusetts Institute of Technology
Other
Eligibility
18 Years to 65 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced Sep 10, 2026, 1:32 AM EDT
Completed Not applicable Interventional

Comorbidity Screening and Referral by Prosthetists

NCT05410548
View directory record Official record
Conditions
Limb Ischemia, Low Back Pain, Depression, Neuropathy;Peripheral, Amputation
Interventions
Standard-of-Care, Clinical Screening
Other
Lead sponsor
University of Delaware
Other
Eligibility
18 Years to 85 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Dec 30, 2025 · Synced Sep 10, 2026, 1:32 AM EDT