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Showing 1–24 of 37 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Standard of Care Concussion Treatment Clear all
Recruiting Not applicable Interventional

CBT-I vs. MBTI for Traumatic Brain Injury (TBI)-Related Insomnia and Post-Traumatic Stress Symptoms

NCT05663034
View directory record Official record
Conditions
Traumatic Brain Injury, Insomnia, Depression, Post-traumatic Stress, Sleep, Memory Impairment, Cognitive Behavioral Therapy, Concussion, Brain, Head Injury, Brain Injury Traumatic Mild
Interventions
Mindfulness-based treatment for insomnia (MBTI), Cognitive behavioral therapy for insomnia (CBT-I)
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
360 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
5
States / cities
Eglin Air Force Base, Florida • Bethesda, Maryland • Fort Bragg, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Sep 25, 2026, 10:59 PM EDT
Completed Early Phase 1 Interventional Results available

The Effectiveness of Osteopathic Manipulative Medicine in the Management of Headaches Associated With Post Concussion Syndrome

NCT04732338
View directory record Official record
Conditions
Headache, Post-Concussion Syndrome
Interventions
Osteopathic Manipulative Therapy
Other
Lead sponsor
Hackensack Meridian Health
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Edison, New Jersey
Source: ClinicalTrials.gov public record
Updated May 24, 2021 · Synced Sep 25, 2026, 10:59 PM EDT
Recruiting Not applicable Interventional

Wearable Technology to Characterize and Treat mTBI Subtypes: Biofeedback-Based Precision Rehabilitation

NCT06381674
View directory record Official record
Conditions
Mild Traumatic Brain Injury, Concussion, Rehabilitation, Balance Impairment
Interventions
Vestibular therapy for mTBI augmented with audio and visual real-time biofeedback, Vestibular therapy for mTBI
Other
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 60 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
3
States / cities
Portland, Oregon • San Antonio, Texas • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Oct 13, 2025 · Synced Sep 25, 2026, 10:59 PM EDT
Terminated Not applicable Interventional

Effects of Early Vestibular Rehabilitation in Patients With Dizziness and Balance Disorders After Sport Concussion

NCT02945605
View directory record Official record
Conditions
Brain Concussion
Interventions
Early Vestibular Rehabilitation, Standard of Care
Other
Lead sponsor
University of Michigan
Other
Eligibility
14 Years to 50 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 29, 2018 · Synced Sep 25, 2026, 10:59 PM EDT
Enrolling by invitation Not applicable Interventional

PET-MRI in Chronic Traumatic Brain Injury (CTBI)

NCT03241732
View directory record Official record
Conditions
Chronic Traumatic Brain Injury
Interventions
Anti-inflammatory Diet, N-acetyl Cysteine, Neuro Emotive Technique
Other · Dietary Supplement · Behavioral
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years to 80 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2027
U.S. locations
2
States / cities
Philadelphia, Pennsylvania • Villanova, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 28, 2025 · Synced Sep 25, 2026, 10:59 PM EDT
Completed Early Phase 1 Interventional

Quetiapine Augmentation of PE Therapy for the Treatment of Co-occurring PTSD and Mild Traumatic Brain Injury

NCT04280965
View directory record Official record
Conditions
Post Traumatic Stress Disorder
Interventions
Quetiapine Fumarate, Standard of care meducations
Drug · Other
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated May 8, 2023 · Synced Sep 25, 2026, 10:59 PM EDT
Completed Phase 2 Interventional Results available

Hyperbaric Oxygen Therapy (HBO2) for Persistent Post-concussive Symptoms After Mild Traumatic Brain Injury (mTBI)

NCT01306968
View directory record Official record
Conditions
Post-concussive Symptoms, Traumatic Brain Injury
Interventions
hyperbaric oxygen, sham hyperbaric air
Drug · Other
Lead sponsor
U.S. Army Medical Research and Development Command
Federal
Eligibility
18 Years to 65 Years
Enrollment
79 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
5
States / cities
Camp Pendleton, California • Fort Carson, Colorado • Fort Gordon, Georgia + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 4, 2014 · Synced Sep 25, 2026, 10:59 PM EDT
Withdrawn Not applicable Interventional

Addressing Sleep in Adolescents Post-Concussion ("ASAP Study")

NCT05736692
View directory record Official record
Conditions
Concussion, Brain, Sleep Disorder
Interventions
Brief Sleep Intervention
Behavioral
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
13 Years to 18 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 8, 2024 · Synced Sep 25, 2026, 10:59 PM EDT
Recruiting Not applicable Interventional

Postural Motor Activation Deficits After mTBI; Translating Laboratory Findings to Clinical Care

NCT07549529
View directory record Official record
Conditions
Mild Traumatic Brain Injury (mTBI), Concussion, Mild Traumatic Brain Injury
Interventions
Motor Activation Physical Therapy for mTBI, Standard of Care Physical Therapy for mTBI
Other
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 60 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
2
States / cities
Portland, Oregon • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Sep 23, 2026 · Synced Sep 25, 2026, 10:59 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Acute Concussion Therapy Intervention Training in Healthy and Concussed Participants

NCT02872480
View directory record Official record
Conditions
Cerebral Concussion
Interventions
ACTIVE Training
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 30 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 16, 2017 · Synced Sep 25, 2026, 10:59 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Can Early Initiation of Rehabilitation With Wearable Sensor Technology Improve Outcomes in mTBI?

NCT03479541
View directory record Official record
Conditions
Mild Traumatic Brain Injury, Balance; Distorted, Gait, Unsteady, Quality of Life, Veterans
Interventions
Timing of Rehabilitation, Biofeedback
Behavioral
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 60 Years
Enrollment
203 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jun 23, 2025 · Synced Sep 25, 2026, 10:59 PM EDT
Completed Not applicable Interventional

Collaborative Care Model for the Treatment of Persistent Symptoms After Concussion Among Youth

NCT03034720
View directory record Official record
Conditions
Concussion, Brain, TBI, Depression, Anxiety
Interventions
Collaborative Care
Behavioral
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
11 Years to 18 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Apr 7, 2021 · Synced Sep 25, 2026, 10:59 PM EDT
Completed Not applicable Interventional

Randomized Controlled Trial for Vestibular Treatment in Concussion

NCT03600324
View directory record Official record
Conditions
Vestibular Disorder, Mild Traumatic Brain Injury
Interventions
T-REV
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 50 Years
Enrollment
121 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
4
States / cities
Colorado Springs, Colorado • Marine Corps Base Camp Lejeune, North Carolina • Pittsburgh, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Sep 25, 2026, 10:59 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Clinical Evaluation of a Novel Balance, Vestibular and Oculomotor Assessment Tool

NCT02171312
View directory record Official record
Conditions
Mild Concussion, Post Concussion Syndrome, Vestibular Neuritis
Interventions
iDETECT Assessment, Routine Balance and Vestibular Testing
Device · Behavioral
Lead sponsor
Emory University
Other
Eligibility
12 Years and older
Enrollment
126 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 8, 2016 · Synced Sep 25, 2026, 10:59 PM EDT
Completed Not applicable Interventional

Efficacy of Brock String Therapy Post Concussion

NCT04076657
View directory record Official record
Conditions
Concussion, Brain, Near Point Convergence
Interventions
Brock String Therapy, Standard of Care
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
12 Years to 20 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 4, 2025 · Synced Sep 25, 2026, 10:59 PM EDT
Recruiting Phase 2Phase 3 Interventional

Randomized Controlled Trial of Treatment to Optimize Heart Rate Variability for Persistent Post-Concussion Symptoms

NCT07071350
View directory record Official record
Conditions
Autonomic Nervous System Disease, Concussive Injury, Mild Traumatic Brain Injury, Post Traumatic Stress Disorder, Persistent Post Concussion Syndrome
Interventions
HRV Coherence Ratio, NSI, Pittsburgh Sleep Quality Index (PSQI), Quantitative Sleep Measures, Patient Global Impression of Change (PGIC), Cognitive Performance/NIH Toolbox Cognitive Battery, Pain Interference/TBI-QoL Pain Interference Short-Form, Patient Health Questionnaire-9 (PHQ-9), PTSD Checklist for DSM-5 (PCL-5), HRV Biofeedback (HRV-B), Psychoeducational (Edu) Comparator Intervention
Other · Behavioral
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Enrollment
148 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 21, 2026 · Synced Sep 25, 2026, 10:59 PM EDT
Completed No phase listed Observational

Eyetracking and Neurovision Rehabilitation of Oculomotor Dysfunction in Mild Traumatic Brain Injury

NCT03319966
View directory record Official record
Conditions
Mild Traumatic Brain Injury, Brain Concussion, Convergence Insufficiency, Accommodative Insufficiency, Saccadic Eye Movement Deficiency, Oculomotor Dysfunction
Interventions
Not listed
Lead sponsor
Hennepin Healthcare Research Institute
Other
Eligibility
13 Years to 55 Years
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 18, 2020 · Synced Sep 25, 2026, 10:59 PM EDT
Recruiting Not applicable Interventional

GyroStim for Post Concussion Syndrome

NCT07527663
View directory record Official record
Conditions
Post Concussion Syndrome
Interventions
Sensorimotor Multi-axis Automated Rotational Therapy (SMART) utilizing GyroStim device, Physical therapy and speech therapy/cognitive rehabilitation therapy
Device · Other
Lead sponsor
Neuroscience Group
Other
Eligibility
18 Years and older
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Appleton, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Sep 25, 2026, 10:59 PM EDT
Recruiting Not applicable Interventional

Vestibular Rehabilitation App for Adults With Dizziness Related to mTBI

NCT06222450
View directory record Official record
Conditions
Mild Traumatic Brain Injury, Dizziness
Interventions
Vestibular Rehabilitation Therapy (VRT)
Behavioral
Lead sponsor
Mountain Home Research & Education Corporation
Other
Eligibility
18 Years and older
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
3
States / cities
Tampa, Florida • Durham, North Carolina • Mountain Home, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 16, 2025 · Synced Sep 25, 2026, 10:59 PM EDT
Completed Phase 4 Interventional

The Study of Cognitive Rehabilitation Effectiveness for Mild Traumatic Brain Injury

NCT01339806
View directory record Official record
Conditions
Traumatic Brain Injury With Brief Loss of Consciousness, Traumatic Brain Injury With No Loss of Consciousness
Interventions
Cognitive Rehab, Brainworks, Informational Handout/Provider Visits
Behavioral
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
18 Years and older
Enrollment
143 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Feb 8, 2015 · Synced Sep 25, 2026, 10:59 PM EDT
Completed Not applicable Interventional

Stationary Bike Study

NCT02640599
View directory record Official record
Conditions
Vertigo, Concussion, Dizziness
Interventions
Vestibular Rehabilitation + Aerobic Exercise, Vestibular Rehabilitation
Other
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 70 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 8, 2020 · Synced Sep 25, 2026, 10:59 PM EDT
Recruiting Not applicable Interventional

Pro-2-Cool Pivotal Trial II

NCT06929923
View directory record Official record
Conditions
Concussion, Mild
Interventions
Pro2Cool Device, Sham Cooling Garment Device
Device
Lead sponsor
TecTraum Inc.
Industry
Eligibility
13 Years to 21 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
3
States / cities
Ann Arbor, Michigan • Akron, Ohio • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Sep 25, 2026, 10:59 PM EDT
Terminated Not applicable Interventional

Cervical Spine Focused Treatment for Patients With Persistent Concussion Symptoms and Neck Pain

NCT06616272
View directory record Official record
Conditions
Brain Concussion, Neck Pain
Interventions
Cervical rehabilitation, Standard Concussion Care
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
12 Years to 50 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania • Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Sep 25, 2026, 10:59 PM EDT
Not listed Not applicable Interventional

Online Treatment Recovery Assistance for Concussion in Kids

NCT05065099
View directory record Official record
Conditions
Concussion, MTBI - Mild Traumatic Brain Injury
Interventions
Online Treatment Recovery Assistance for Concussion in Kids (OnTRACK)
Device
Lead sponsor
Children's National Research Institute
Other
Eligibility
8 Years to 17 Years
Enrollment
408 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Rockville, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 10, 2022 · Synced Sep 25, 2026, 10:59 PM EDT