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ClinicalTrials.gov public records Last synced Oct 15, 2026, 4:08 PM EDT

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Showing 553–576 of 601 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Standard of Care for Pain Management Clear all
Completed Not applicable Interventional Results available

Treatment of Adult Traumatic Rib Fractures With Percutaneous Cryoneurolysis

NCT05330611
View directory record Official record
Conditions
Rib Fractures
Interventions
Cryoneurolysis of Intercostal Nerves, Standard of Care
Device · Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 64 Years
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Apr 24, 2026 · Synced Oct 15, 2026, 4:08 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Living Organ Donor Recovery Enhancement Program

NCT03865264
View directory record Official record
Conditions
Living Liver and Kidney Donors
Interventions
Recovery Enhancement Program
Other
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2024
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 27, 2026 · Synced Oct 15, 2026, 4:08 PM EDT
Completed Not applicable Interventional Results available

Comparison of Extensible and Inextensible Lumbosacral Orthoses for Lower Back Pain

NCT01933399
View directory record Official record
Conditions
Low Back Pain
Interventions
Inextensible LSO (stiff back support), Extensible LSO, a back support that is flexible, Standard of Care
Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2013
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 30, 2015 · Synced Oct 15, 2026, 4:08 PM EDT
Completed Phase 2 Interventional

RCT Comparing ESPB Solutions in Breast Surgery

NCT04603911
View directory record Official record
Conditions
Breast Cancer
Interventions
Liposomal bupivacaine, Bupivacaine, epinephrine, dexamethasone, and clonidine
Drug
Lead sponsor
Tufts Medical Center
Other
Eligibility
18 Years to 75 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 10, 2025 · Synced Oct 15, 2026, 4:08 PM EDT
Active, not recruiting Not applicable Interventional

Non-Surgical Management of Knee Osteoarthritis in the Military Health System (MHS)

NCT03747393
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
DoD/VA CPG Core Set + PT, DoD/VA CPG Core Set
Behavioral
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
18 Years to 60 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
3
States / cities
San Antonio, Texas • Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Oct 15, 2026, 4:08 PM EDT
Recruiting Phase 2 Interventional

Group Music Therapy for Chronic Pain Management in Active Duty Service Members

NCT07755540
View directory record Official record
Conditions
Chronic Pain
Interventions
Music intervention
Behavioral
Lead sponsor
Henry M. Jackson Foundation for the Advancement of Military Medicine
Other
Eligibility
18 Years to 64 Years
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Anchorage, Alaska
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Oct 15, 2026, 4:08 PM EDT
Completed Not applicable Interventional

Healing Touch or Guided Imagery In Treating Pain, Fatigue, Nausea, and Anxiety in Patients Undergoing Chemotherapy

NCT01553578
View directory record Official record
Conditions
Anxiety Disorder, Fatigue, Malignant Neoplasm, Nausea and Vomiting, Pain
Interventions
questionnaire administration, therapeutic touch, management of therapy complications, standard follow-up care
Other · Procedure · Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
244 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 5, 2018 · Synced Oct 15, 2026, 4:08 PM EDT
Completed Not applicable Interventional Results available

Self-management Intervention for Children With Chronic Medical Complexity: Pilot Feasibility Trial

NCT04470193
View directory record Official record
Conditions
Children With Medical Complexity
Interventions
MyChildCMC app
Other
Lead sponsor
University of Utah
Other
Eligibility
1 Year to 20 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Oct 4, 2024 · Synced Oct 15, 2026, 4:08 PM EDT
Completed Not applicable Interventional Results available

RelieVRx for Total Knee Arthroplasty (TKA) for the Reduction of Acute Postoperative Pain and Opioid Use

NCT04010266
View directory record Official record
Conditions
Opioid Use, Arthropathy of Knee, Pain, Postoperative
Interventions
RelieVRx headset, multi-modality pain management
Device · Drug
Lead sponsor
AppliedVR Inc.
Industry
Eligibility
18 Years and older
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
3
States / cities
Danville, Pennsylvania • Wilkes-Barre, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 14, 2024 · Synced Oct 15, 2026, 4:08 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Simultaneous mRNA COVID-19 and IIV4 Vaccination Study

NCT05028361
View directory record Official record
Conditions
Quality of Life, Injection Site Reaction, Adverse Drug Event, Systemic Reaction
Interventions
mRNA COVID-19, IIV4, Placebo (saline)
Biological · Other
Lead sponsor
Duke University
Other
Eligibility
5 Years and older
Enrollment
348 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
3
States / cities
Baltimore, Maryland • Durham, North Carolina • Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 19, 2024 · Synced Oct 15, 2026, 4:08 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Continuous Cryotherapy in Shoulder Arthroplasty Patients

NCT04861441
View directory record Official record
Conditions
Pain, Shoulder
Interventions
Aircast Cryo Cuff (Shoulder) and Aircast Cryo Cuff I/C Motorized Cooler, Icepacks
Device
Lead sponsor
D. Patrick Williams
Other
Eligibility
55 Years to 80 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Erie, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 23, 2023 · Synced Oct 15, 2026, 4:08 PM EDT
Completed Not applicable Interventional

Thoracic Blocks Versus Thoracic Epidural and Patient Controlled Anesthesia in Traumatic Rib Fracture Patients

NCT01599403
View directory record Official record
Conditions
Traumatic Rib Fracture
Interventions
Paravertebral Block, Intercostal Nerve Block, Epidural Block
Procedure
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 100 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 13, 2017 · Synced Oct 15, 2026, 4:08 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Efficacy of a Chronic Pain Treatment Prior to Gender-affirming Surgery

NCT06443164
View directory record Official record
Conditions
Pain Catastrophizing, Pain, Chronic, Gender Identity
Interventions
Empowered Relief, Standard of Care
Behavioral · Other
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 100 Years
Enrollment
78 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jul 31, 2025 · Synced Oct 15, 2026, 4:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Hypotension Prediction Index to Predict Epidural-labor Analgesia Induced Hypotension

NCT05906368
View directory record Official record
Conditions
Anesthesia, Epidural, Hypotension
Interventions
ClearSight HPI Monitoring system, Standard of Care Blood Pressure Monitoring
Diagnostic Test
Lead sponsor
Grace Lim, MD, MS
Other
Eligibility
18 Years and older · Female only
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 4, 2025 · Synced Oct 15, 2026, 4:08 PM EDT
Completed Not applicable Interventional Results available

Postoperative Virtual Clinical Encounters

NCT04138810
View directory record Official record
Conditions
Pelvic Organ Prolapse
Interventions
VCE, Survey
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older · Female only
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 24, 2020 · Synced Oct 15, 2026, 4:08 PM EDT
Completed Not applicable Interventional Results available

Battlefield Auricular Acupressure (BAApress) Feasibility Study

NCT05939388
View directory record Official record
Conditions
Pain
Interventions
Auricular Acupressure Pads
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 2, 2025 · Synced Oct 15, 2026, 4:08 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Enhanced Recovery After Surgery in Kidney Transplant Donors

NCT04110080
View directory record Official record
Conditions
Opioid Use, Kidney Diseases, Pain, Postoperative, Postoperative Complications, Postoperative Nausea and Vomiting
Interventions
multimodal pain management, goal directed fluid management, preoperative carbohydrate loading, Donor nephrectomy, regional anesthesia
Procedure · Other
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 18, 2023 · Synced Oct 15, 2026, 4:08 PM EDT
Completed Not applicable Interventional

Effect of Patient Preference for Intraoperative Opioid Use on Early Postoperative Quality of Recovery

NCT06855641
View directory record Official record
Conditions
Opioid Analgesia, Quality of Recovery (QoR-15), Outcome Assessment, Opioid Free Anesthesia
Interventions
Opioid based Anesthesia, opioid free anesthesia
Procedure
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
2
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jun 27, 2025 · Synced Oct 15, 2026, 4:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Nitrous Oxide for Pain Management of First Trimester Surgical Abortion

NCT02096575
View directory record Official record
Conditions
Abortion in First Trimester
Interventions
Nitrous oxide administration
Other
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older · Female only
Enrollment
140 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Apr 19, 2016 · Synced Oct 15, 2026, 4:08 PM EDT
Recruiting Phase 3 Interventional

Effect of NSAIDs on Union, Opioid Utilization and Pain Management for Tibia Fractures: A Pragmatic, Randomized Controlled Trial

NCT07006675
View directory record Official record
Conditions
Tibial Fractures, Pain
Interventions
600 mg Ibuprofen
Drug
Lead sponsor
Major Extremity Trauma Research Consortium
Other
Eligibility
18 Years to 80 Years
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
13
States / cities
Indianapolis, Indiana • Baltimore, Maryland • Cambridge, Massachusetts + 9 more
Source: ClinicalTrials.gov public record
Updated Jun 5, 2025 · Synced Oct 15, 2026, 4:08 PM EDT
Completed Not applicable Interventional

Dexmedetomidine Use in SZMN Blocks for Pediatric T&A Pain Control

NCT05208892
View directory record Official record
Conditions
Postoperative Pain, Opioid Use
Interventions
SZMN block, SZMN block with Dexmedetomidine
Procedure
Lead sponsor
Stanford University
Other
Eligibility
6 Months to 18 Years
Enrollment
114 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Mar 10, 2026 · Synced Oct 15, 2026, 4:08 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

FDM for Subacute and Chronic Extremity Pain in the ED

NCT04555239
View directory record Official record
Conditions
Myofascial Pain, Chronic Pain, Extremities Disorders, Osteopathic Manipulation
Interventions
Fascial Distortion Model (FDM), Standard Care
Procedure · Other
Lead sponsor
Carilion Clinic
Other
Eligibility
18 Years and older
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
4
States / cities
Christiansburg, Virginia • Lexington, Virginia • Roanoke, Virginia + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 4, 2022 · Synced Oct 15, 2026, 4:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Acupuncture ACL (Anterior Cruciate Ligament)

NCT03711734
View directory record Official record
Conditions
ACL, ACL Injury, Anterior Cruciate Ligament Injury, Anterior Cruciate Ligament Rupture, Anesthesia
Interventions
Acupuncture + Standard of Care
Other
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
12 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 27, 2024 · Synced Oct 15, 2026, 4:08 PM EDT
Recruiting Phase 4 Interventional

Methadone in the Management of Post-Operative Pain in Total Knee Replacement

NCT07485803
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Methadone
Drug
Lead sponsor
AdventHealth
Other
Eligibility
21 Years to 75 Years
Enrollment
192 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Oct 15, 2026, 4:08 PM EDT