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ClinicalTrials.gov public records Last synced Oct 14, 2026, 1:01 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 289–312 of 500 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Standard of care analgesia Clear all
Completed Not applicable Interventional

Web-MAP Intervention for Youth With Sickle Cell Disease

NCT02511769
View directory record Official record
Conditions
Sickle Cell Disease
Interventions
WEB-MAP Educational Control Group, WEB-MAP CBT
Behavioral
Lead sponsor
Connecticut Children's Medical Center
Other
Eligibility
11 Years to 18 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 1, 2017 · Synced Oct 14, 2026, 1:01 PM EDT
Recruiting Not applicable Interventional

Low Pressure Pneumoperitoneum and Postoperative Ileus

NCT05344417
View directory record Official record
Conditions
Postoperative Ileus, Gastrointestinal Dysfunction
Interventions
Pneumoperitoneum Pressure, Neuromuscular blockade, Pneumoperitoneum insufflation device, Neuromuscular blockade reversal
Procedure · Device · Drug
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
2
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 3, 2025 · Synced Oct 14, 2026, 1:01 PM EDT
Enrolling by invitation Not applicable Interventional

Using Empowered Relief and Education To Help Postpartum Women Recover After Cesarean Delivery

NCT07192718
View directory record Official record
Conditions
Cesarean Section Complications, Postpartum Care
Interventions
Empowered Relief, Education
Behavioral · Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older · Female only
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Sep 21, 2026 · Synced Oct 14, 2026, 1:01 PM EDT
Completed Not applicable Interventional Results available

RelieVRx for Total Knee Arthroplasty (TKA) for the Reduction of Acute Postoperative Pain and Opioid Use

NCT04010266
View directory record Official record
Conditions
Opioid Use, Arthropathy of Knee, Pain, Postoperative
Interventions
RelieVRx headset, multi-modality pain management
Device · Drug
Lead sponsor
AppliedVR Inc.
Industry
Eligibility
18 Years and older
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
3
States / cities
Danville, Pennsylvania • Wilkes-Barre, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 14, 2024 · Synced Oct 14, 2026, 1:01 PM EDT
Recruiting Not applicable Interventional

Virtual Reality and Standard Care vs. Standard Care Alone for Acute MSK Pain in Geriatric ED Patients

NCT06685107
View directory record Official record
Conditions
Acute Musculoskeletal Pain
Interventions
Standard of Care Analgesia, Standard of Care Analgesia + Virtual Reality
Other
Lead sponsor
Antonios Likourezos
Other
Eligibility
65 Years to 120 Years
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Jan 16, 2026 · Synced Oct 14, 2026, 1:01 PM EDT
Not yet recruiting Phase 3 Interventional

A Study of Intravenous L-Citrulline in Patients Aged 6-21 Years Old With Sickle Cell Disease Presenting to Emergency Departments in Acute Vaso-Occlusive Crisis

NCT06989567
View directory record Official record
Conditions
Sickle Cell Disease
Interventions
L-citrulline, Placebo
Drug · Other
Lead sponsor
Asklepion Pharmaceuticals, LLC
Industry
Eligibility
6 Years to 21 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
6
States / cities
Washington D.C., District of Columbia • Coral Gables, Florida • Atlanta, Georgia + 3 more
Source: ClinicalTrials.gov public record
Updated May 29, 2025 · Synced Oct 14, 2026, 1:01 PM EDT
Completed Not applicable Interventional

Shared Decision-Making Tool for Opioid Prescribing After Ambulatory Hand Surgery in Veterans

NCT04625231
View directory record Official record
Conditions
Opioid Use, Surgery
Interventions
Educational Shared-Decision Making Tool
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 89 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 12, 2022 · Synced Oct 14, 2026, 1:01 PM EDT
Terminated Phase 3 Interventional Results available

Epidural Analgesia Versus IV Analgesia in Lumbar Spine Fusions

NCT01986946
View directory record Official record
Conditions
Lumbar Spine Fusion, Pain, Back Pain
Interventions
Epidural Catheter - Dilaudid, Dilaudid
Other · Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 23, 2017 · Synced Oct 14, 2026, 1:01 PM EDT
Not listed No phase listed Observational

Biometrics and Self-reported Health Changes in Adults Receiving Behavioral Treatments for Chronic Pain

NCT05812703
View directory record Official record
Conditions
Chronic Pain, Sedentary Time
Interventions
Cognitive Behavioral Therapy, Acceptance and Commitment Therapy (ACT), Moderate to high Intensity Group Exercise
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Redwood City, California
Source: ClinicalTrials.gov public record
Updated May 7, 2024 · Synced Oct 14, 2026, 1:01 PM EDT
Active, not recruiting Not applicable Interventional

Self-Hypnosis for the Enhanced Recovery After Surgery in Patients With Gynecologic Cancer

NCT04266886
View directory record Official record
Conditions
Malignant Female Reproductive System Neoplasm, Recurrent Malignant Female Reproductive System Neoplasm, Metastatic Cervical Cancer
Interventions
Best Practice, Hypnotherapy, Quality-of-Life Assessment, Questionnaire Administration
Other · Procedure
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older · Female only
Enrollment
152 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 18, 2026 · Synced Oct 14, 2026, 1:01 PM EDT
Completed Not applicable Interventional

Combined Cryotherapy With Compression Versus Cryotherapy Alone After Orthopaedic Surgery

NCT05011084
View directory record Official record
Conditions
Cryotherapy Effect, Compression, Postoperative Pain Management
Interventions
Game Ready Cryotherapy with Compression Group, Control Cryotherapy Group
Device · Other
Lead sponsor
Walter Reed National Military Medical Center
Federal
Eligibility
18 Years and older
Enrollment
348 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 30, 2026 · Synced Oct 14, 2026, 1:01 PM EDT
Completed Phase 4 Interventional

Home Care Management of Pediatric Pain

NCT00251628
View directory record Official record
Conditions
Tonsillectomy
Interventions
Standard Care, ATC Dosing, Structured Pain Management Program, As needed dosing
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
6 Years to 15 Years
Enrollment
211 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2012
U.S. locations
1
States / cities
Madera, California
Source: ClinicalTrials.gov public record
Updated Jun 8, 2012 · Synced Oct 14, 2026, 1:01 PM EDT
Not listed Not applicable Interventional

Impact of a Behavioral Tele-health Program on the Quality of Recovery for Patients Undergoing Total Joint Replacement Surgery

NCT05367050
View directory record Official record
Conditions
Opioid Dependence, Opioid Use, Pain, Joint
Interventions
Lucid Lane Therapy Program, Surgical Preparedness Course
Behavioral
Lead sponsor
Lucid Lane, Inc
Industry
Eligibility
21 Years to 90 Years
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated May 10, 2022 · Synced Oct 14, 2026, 1:01 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

E-Tailored Pain Management Support for Dementia Family Caregivers: Feasibility of the PACE-app

NCT07032350
View directory record Official record
Conditions
Care Giving Burden, Dementia, Chronic Pain, Pain Management, Palliative Care
Interventions
Web-based pain management support tool, Usual Pain Management Care
Other · Behavioral
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 100 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jun 29, 2025 · Synced Oct 14, 2026, 1:01 PM EDT
Active, not recruiting Phase 4 Interventional Accepts healthy volunteers

Personalized Post-Operative Pain Management

NCT06669650
View directory record Official record
Conditions
Persistent Post Operative Opioid Use, Post-surgical Pain
Interventions
PGx guided personalized post-operative pain management, Oxycodone, Hydromorphone
Other · Drug
Lead sponsor
University of Tennessee Graduate School of Medicine
Other
Eligibility
18 Years to 85 Years
Enrollment
208 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 1, 2024 · Synced Oct 14, 2026, 1:01 PM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Pain Control for Undergoing Costal Cartilage Harvesting

NCT05285566
View directory record Official record
Conditions
Nasal Surgery
Interventions
Exparel, Xylocaine
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 11, 2026 · Synced Oct 14, 2026, 1:01 PM EDT
Recruiting Phase 4 Interventional

Exparel and Education to Avoid Opioids After Carpal Tunnel Release

NCT03867539
View directory record Official record
Conditions
Carpal Tunnel Syndrome
Interventions
Differing pain management strategy
Drug
Lead sponsor
Kettering Health Network
Other
Eligibility
18 Years and older
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
2
States / cities
Dayton, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Oct 14, 2026, 1:01 PM EDT
Not yet recruiting Not applicable Interventional

Headache Education and Awareness vs. Daily Mindfulness Strategies - Understanding Pain

NCT07513662
View directory record Official record
Conditions
Migraine, Migraine in Adolescence
Interventions
BREATHE with Headache (BREATHE-HA), Enhanced Standard-of-Care: Headache Education
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
12 Years to 17 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 10, 2026 · Synced Oct 14, 2026, 1:01 PM EDT
Not yet recruiting Phase 2 Interventional

NAC-REPAIR for Post-surgical Pain

NCT07227649
View directory record Official record
Conditions
Carpal Tunnel Surgery, Trigger Finger Disorder, De Quervain Syndrome, Guyon's Canal, Dupuytren Contracture, Morton Neuroma, Tarsal Tunnel Syndrome, Plantar Fasciopathy, Peroneal Nerve Entrapment
Interventions
NAC, NAC 0mg/day (Placebo)
Drug
Lead sponsor
University of Arizona
Other
Eligibility
18 Years to 75 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Jul 17, 2026 · Synced Oct 14, 2026, 1:01 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

A Prospective Randomized Double-Blind Trial Comparing 3 Doses of Intravenous Ketorolac for Pain Management

NCT02078492
View directory record Official record
Conditions
Pain
Interventions
10 mg of Ketorolac, 15 mg of Ketorolac, 30 mg of Ketorolac
Drug
Lead sponsor
Antonios Likourezos
Other
Eligibility
18 Years to 64 Years
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Apr 10, 2017 · Synced Oct 14, 2026, 1:01 PM EDT
Recruiting Not applicable Interventional

A Randomized Controlled Trial (RCT) to Determine the Efficacy of a Multidisciplinary CBT Based Pain Management Program for the Treatment of Aromatase Inhibitor Associated Musculoskeletal Symptoms (AIMSS) in Breast Cancer Survivors

NCT06831838
View directory record Official record
Conditions
Breast Cancer
Interventions
Cognitive Behavioral Therapy based Pain Management Program
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
116 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Aug 4, 2026 · Synced Oct 14, 2026, 1:01 PM EDT
Completed No phase listed Observational

Prospective Observational Clinical Study to Evaluate Patient Outcomes Following Pharmacogenetic Testing of Patients Undergoing Elective Surgical Procedures

NCT02605343
View directory record Official record
Conditions
Acute Pain, Surgery
Interventions
NeuroIDgenetix Test Panel
Other
Lead sponsor
AltheaDx
Industry
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 6, 2016 · Synced Oct 14, 2026, 1:01 PM EDT
Completed Not applicable Interventional

Genomic Opioid Optimization of Dosing and Selections (GOODS) Study

NCT03579121
View directory record Official record
Conditions
Perioperative/Postoperative Complications
Interventions
Pharmacogenomic (PGx), Review results
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 80 Years
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Jun 15, 2022 · Synced Oct 14, 2026, 1:01 PM EDT
Recruiting Phase 4 Interventional

Low-Dose Short-Term Ketorolac to Reduce Chronic Opioid Use in Orthopaedic Polytrauma Patients

NCT06201676
View directory record Official record
Conditions
Orthopaedic Trauma, Chronic Opioid Use
Interventions
Ketorolac Injection, Standard of Care (SOC) Multimodal Analgesia
Drug · Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 70 Years
Enrollment
458 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
2
States / cities
Boston, Massachusetts • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Oct 14, 2026, 1:01 PM EDT