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ClinicalTrials.gov public records Last synced Sep 25, 2026, 9:56 PM EDT

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Showing 1–24 of 35 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Standard of care fracture reduction Clear all
Completed Phase 2 Interventional

Feasibility And Safety Study Of rhBMP-2/CPM For Hip Fractures

NCT00384358
View directory record Official record
Conditions
Fractures
Interventions
rhBMP-2/CPM, surgical intervention alone
Drug · Other
Lead sponsor
Wyeth is now a wholly owned subsidiary of Pfizer
Industry
Eligibility
55 Years and older
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
8
States / cities
Aurora, Colorado • New Haven, Connecticut • Clearwater, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Feb 27, 2013 · Synced Sep 25, 2026, 9:56 PM EDT
Completed Phase 3 Interventional Results available

Topical Antibiotic Therapy to Reduce Infection After Operative Treatment of Fractures at High Risk of Infection: TOBRA

NCT04597008
View directory record Official record
Conditions
Post Operative Surgical Site Infection
Interventions
Treatment group, Control group
Drug
Lead sponsor
Major Extremity Trauma Research Consortium
Other
Eligibility
18 Years to 80 Years
Enrollment
1,660 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
41
States / cities
Birmingham, Alabama • Los Angeles, California • Redwood City, California + 35 more
Source: ClinicalTrials.gov public record
Updated Jul 21, 2026 · Synced Sep 25, 2026, 9:56 PM EDT
Withdrawn Early Phase 1 Interventional Accepts healthy volunteers

IN Dexmedetomidine for Procedural Sedation in Pediatric Closed Reductions for Distal Forearm Fractures

NCT03466242
View directory record Official record
Conditions
Conscious Sedation, Distal Radius Fracture
Interventions
Dexmedetomidine, Ketamine
Drug
Lead sponsor
Phoenix Children's Hospital
Other
Eligibility
2 Years to 18 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Nov 23, 2025 · Synced Sep 25, 2026, 9:56 PM EDT
Terminated Not applicable Interventional Results available

Computer-Assisted Fixation of Trochanteric Femur Fractures

NCT04528459
View directory record Official record
Conditions
Hip Fractures
Interventions
Stryker© ADAPT™ platform, Traditional fluoroscopy
Device · Radiation
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 3, 2025 · Synced Sep 25, 2026, 9:56 PM EDT
Completed Phase 4 Interventional Results available

Efficacy of Multimodal Periarticular Injections in Operatively Treated Ankle Fractures

NCT02967172
View directory record Official record
Conditions
Pain, Postoperative, Ankle Fractures
Interventions
Ropivacaine, Epinephrine, Morphine, 0.9% sodium chloride solution
Drug
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 100 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Dec 14, 2023 · Synced Sep 25, 2026, 9:56 PM EDT
Completed Not applicable Interventional Results available

A Multicenter Randomized Trial Comparing IM Nails and Plate Fixation in Proximal Tibial Fractures

NCT00429585
View directory record Official record
Conditions
Tibial Fractures
Interventions
reamed, interlocking intramedullary nail, locking periarticular plate
Device
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2020
U.S. locations
27
States / cities
Birmingham, Alabama • Davis, California • San Francisco, California + 22 more
Source: ClinicalTrials.gov public record
Updated Nov 1, 2021 · Synced Sep 25, 2026, 9:56 PM EDT
Active, not recruiting Not applicable Interventional

3D Printed Models for Mandibular Fracture Repair

NCT05733221
View directory record Official record
Conditions
Mandible Fracture, Maxillofacial Trauma
Interventions
3D Printed Model
Device
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
2
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Sep 25, 2026, 9:56 PM EDT
Completed Phase 3 Interventional Results available

Local Antibiotic Therapy to Reduce Infection After Operative Treatment of Fractures at High Risk of Infection: A Multicenter Randomized, Controlled Trial (VANCO)

NCT02227446
View directory record Official record
Conditions
Post Operative Surgical Site Infection
Interventions
Vancomycin antibiotic powder
Drug
Lead sponsor
Major Extremity Trauma Research Consortium
Other
Eligibility
18 Years to 80 Years
Enrollment
1,036 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 5, 2026 · Synced Sep 25, 2026, 9:56 PM EDT
Terminated Not applicable Interventional

Comminuted Intra-Articular Distal Tibia Fracture Fixation Using Computer Techniques

NCT02845245
View directory record Official record
Conditions
Tibial Fractures
Interventions
3D printed plastic model prototype, 3D CT scan, Plain film radiographs
Other
Lead sponsor
Inova Health Care Services
Other
Eligibility
18 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Falls Church, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 11, 2020 · Synced Sep 25, 2026, 9:56 PM EDT
Recruiting Phase 4 Interventional

Nonopioid Pain Control Regimen After Open Reduction and Internal Fixation of Traumatic Fractures

NCT06113211
View directory record Official record
Conditions
Opioid Use, Fractures, Bone, Trauma
Interventions
Narcotic pain medication, Nonnarcotic pain medications
Drug
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years to 80 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Sep 25, 2026, 9:56 PM EDT
Recruiting Phase 1 Interventional

Genicular Nerve Block After Open Reduction Internal Fixation of Tibial Plateau

NCT06639503
View directory record Official record
Conditions
Tibial Plateau Fractures
Interventions
Bupivacain
Drug
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 4, 2026 · Synced Sep 25, 2026, 9:56 PM EDT
Completed No phase listed Observational

Focused Registry to Collect Clinical Data on the MatrixWAVE System

NCT03405389
View directory record Official record
Conditions
Mandibular Fractures
Interventions
MatrixWAVE MMF System
Procedure
Lead sponsor
AO Innovation Translation Center
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 15, 2025 · Synced Sep 25, 2026, 9:56 PM EDT
Not listed Not applicable Interventional

Intraoperative Monitoring of Femoral Head Perfusion

NCT04110639
View directory record Official record
Conditions
Femoral Neck Fractures
Interventions
Intracranial pressure (ICP) monitor, Standard of Care
Device · Other
Lead sponsor
Children's Healthcare of Atlanta
Other
Eligibility
1 Year to 18 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 4, 2021 · Synced Sep 25, 2026, 9:56 PM EDT
Completed Phase 4 Interventional Results available

Ketamine Infusion Therapy for the Management of Acute Pain in Adult Rib Fracture Patients

NCT02432456
View directory record Official record
Conditions
Wounds and Injuries, Rib Fractures
Interventions
Ketamine, Placebo, Intercostal Nerve Block, Acetaminophen, Ibuprofen, Pantoprazole, Methocarbamol, Opioid
Drug · Procedure
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years and older
Enrollment
153 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 4, 2020 · Synced Sep 25, 2026, 9:56 PM EDT
Recruiting Not applicable Interventional

Virtual Reality in Reducing Acute Orthopedic Pain

NCT06624969
View directory record Official record
Conditions
Fractures
Interventions
virtual reality
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Sep 25, 2026, 9:56 PM EDT
Completed Not applicable Interventional Results available

Is Univalving or Bivalving of Long Arm Casts for Forearm Fractures Necessary?

NCT02614690
View directory record Official record
Conditions
Fracture of Shaft of Radius and/or Ulna, Metaphyseal Fracture of Bone of Upper Limb, Fracture of Upper Limb, Level Unspecified
Interventions
No Split Cast of forearm fractures, Univalve Split Cast of forearm fractures, Bivalve Split Cast of forearm fractures
Procedure
Lead sponsor
Connecticut Children's Medical Center
Other
Eligibility
3 Years to 12 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 13, 2022 · Synced Sep 25, 2026, 9:56 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Blood Flow Restriction Training in Patients With Lower Extremity Fractures

NCT06496035
View directory record Official record
Conditions
Tibial Fractures, Lower Extremity Fracture
Interventions
Blood Flow Restriction with low load exercise, Therapeutic Exercise
Device · Other
Lead sponsor
Denver Health and Hospital Authority
Other
Eligibility
18 Years to 100 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Nov 20, 2025 · Synced Sep 25, 2026, 9:56 PM EDT
Not yet recruiting Phase 3 Interventional

Efficacy of Integrating Next Generation Sequencing for Treatment of Surgical Site Infection After Fracture Fixation:

NCT07458230
View directory record Official record
Conditions
Next Generation Sequencing (NGS), Surgical Site Infection (SSI), Fracture Fixation
Interventions
NGS diagnostic findings
Diagnostic Test
Lead sponsor
Johns Hopkins Bloomberg School of Public Health
Other
Eligibility
18 Years to 84 Years
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
18
States / cities
Tuscaloosa, Alabama • Los Angeles, California • San Francisco, California + 15 more
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Sep 25, 2026, 9:56 PM EDT
Terminated Not applicable Interventional Results available

Hemostasis in Kocher-Langenbeck Approaches for Acetabular Surgery Using a Topical Surgical Hemostat (Vitagel)

NCT01230931
View directory record Official record
Conditions
Fracture Fixation, Intra-Articular Fractures, Acetabulum
Interventions
Vitagel, Standard of care
Device · Procedure
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 65 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 10, 2018 · Synced Sep 25, 2026, 9:56 PM EDT
Enrolling by invitation Not applicable Interventional

Ultrasound-Guided Percutaneous Cryoneurolysis to Treat Pain Following Thoracic Trauma

NCT06069154
View directory record Official record
Conditions
Rib Fracture, Rib Fracture Multiple
Interventions
Cryoneurolysis, Local anesthetic peripheral nerve block, Sham Cryoneurolysis, Sham peripheral nerve block
Device · Procedure
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
5
States / cities
La Jolla, California • Bethesda, Maryland • Boston, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 23, 2026 · Synced Sep 25, 2026, 9:56 PM EDT
Completed No phase listed Observational Results available

MICRO Study: Detecting Bacterial Infections Related to Orthopaedic Surgical Implants

NCT03132246
View directory record Official record
Conditions
Open Reduction and Internal Fixation of Extremity Fractures
Interventions
Blood draws
Diagnostic Test
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years and older
Enrollment
260 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 14, 2020 · Synced Sep 25, 2026, 9:56 PM EDT
Terminated Not applicable Interventional Results available

Efficient Anterior Shoulder Ultrasound Reduction Multicenter Prospective Randomized Trial

NCT04820491
View directory record Official record
Conditions
Shoulder Dislocation
Interventions
X-Ray, Ultrasound
Diagnostic Test
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Nov 15, 2022 · Synced Sep 25, 2026, 9:56 PM EDT
Completed Phase 3 Interventional Results available

Liposomal Bupivacaine With Bupivacaine in Ankle Fracture Open Reduction Internal Fixation (ORIF)

NCT02480621
View directory record Official record
Conditions
Ankle Fracture
Interventions
Liposomal Bupivacaine with Bupivacaine
Drug
Lead sponsor
Jamaica Hospital Medical Center
Other
Eligibility
18 Years and older
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Jamaica, New York
Source: ClinicalTrials.gov public record
Updated Oct 19, 2017 · Synced Sep 25, 2026, 9:56 PM EDT
Withdrawn Phase 4 Interventional

Duloxetine Tibial Plateau

NCT04639011
View directory record Official record
Conditions
Tibial Plateau Fracture, Pain, Postoperative
Interventions
Duloxetine, Placebo, Standard of care (SOC) for tibial plateau surgery
Drug · Other
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
2
States / cities
Boston, Massachusetts • Valhalla, New York
Source: ClinicalTrials.gov public record
Updated Nov 20, 2022 · Synced Sep 25, 2026, 9:56 PM EDT