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ClinicalTrials.gov public records Last synced Oct 23, 2026, 1:12 AM EDT

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Showing 1–24 of 50 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Staple Closure Clear all
Terminated No phase listed Observational Accepts healthy volunteers

Dermabond Skin Adhesives vs Skin Staples for Closure of Repeat Cesarean Section Skin Incisions

NCT00505856
View directory record Official record
Conditions
Pregnancy
Interventions
Not listed
Lead sponsor
Texas Tech University Health Sciences Center
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007
U.S. locations
1
States / cities
Lubbock, Texas
Source: ClinicalTrials.gov public record
Updated Dec 12, 2008 · Synced Oct 23, 2026, 1:12 AM EDT
Completed Phase 2 Interventional Results available

Randomized Clinical Trial of Skin Closure With Staples Versus Suture

NCT01977612
View directory record Official record
Conditions
Wound Infection, Wound Complication
Interventions
4-0 monofilament suture, Stainless steel staples
Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 85 Years · Female only
Enrollment
173 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 31, 2017 · Synced Oct 23, 2026, 1:12 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Outcomes Comparing Different Methods of Skin Closure in Patients Undergoing Head and Neck Surgery.

NCT02936063
View directory record Official record
Conditions
Surgical Wound
Interventions
Surgical staples, Subcuticular sutures
Procedure
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 6, 2017 · Synced Oct 23, 2026, 1:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Comparison of INSORB Staples With Metal Staples in Total Hip Replacement

NCT00940446
View directory record Official record
Conditions
Erythema, Drainage, Bruising, Pain
Interventions
Insorb staples, metal staples (Ethicon metal stapler)
Device
Lead sponsor
Orthopaedic Research Foundation
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2010
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jan 30, 2018 · Synced Oct 23, 2026, 1:12 AM EDT
Completed No phase listed Observational

Post-Market Clinical Follow-Up of STRATAFIX™ Spiral PDS™ PLUS

NCT03937011
View directory record Official record
Conditions
Bariatric - Sleeve Gastrectomy Staple Line Reinforcement, Gynecology - Vaginal Cuff Closure
Interventions
Robotic Suturing of gastric sleeve oversew and vaginal cuff closure
Device
Lead sponsor
Ethicon, Inc.
Industry
Eligibility
18 Years and older
Enrollment
161 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
4
States / cities
Miami, Florida • Albany, New York • New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Oct 23, 2026, 1:12 AM EDT
Completed Not applicable Interventional Results available

Dermabond PRINEO for Total Shoulder Arthroplasty

NCT03860181
View directory record Official record
Conditions
Surgical Wound, Shoulder Arthritis, Surgical Incision
Interventions
Subcuticular Sutures - Surgeon 1, Metal Staples - Surgeon 2, PRINEO - Surgeon 1, PRINEO - Surgeon 2
Procedure · Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Oct 1, 2021 · Synced Oct 23, 2026, 1:12 AM EDT
Completed Not applicable Interventional Results available

NeoMend ProGEL™ Pleural Air Leak Sealant Post-Approval Study

NCT01394978
View directory record Official record
Conditions
Lung Cancer, Lung Tumor
Interventions
Control, ProGEL Pleural Air Leak Sealant with standard surgical closure, ProGEL Pleural Air Leak Sealant without standard surgical closure
Other · Device
Lead sponsor
C. R. Bard
Industry
Eligibility
18 Years and older
Enrollment
444 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
18
States / cities
Birmingham, Alabama • Jacksonville, Florida • Tampa, Florida + 10 more
Source: ClinicalTrials.gov public record
Updated Jul 15, 2021 · Synced Oct 23, 2026, 1:12 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

A Comparison of Metallic Staples Versus Absorbable Staples After a Cesarean Section (C-Section)

NCT01198691
View directory record Official record
Conditions
Cesarean Section
Interventions
Insorb absorbable staples, Insorb
Device
Lead sponsor
TriHealth Inc.
Other
Eligibility
18 Years and older · Female only
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 9, 2018 · Synced Oct 23, 2026, 1:12 AM EDT
Completed Not applicable Interventional Results available

Comparison of Staples Versus Subcuticular Suture in Class III Obese Women Undergoing Cesarean Delivery

NCT02466776
View directory record Official record
Conditions
Obesity, Severe, Cesarean Section
Interventions
Absorbable subcuticular suture, Stainless steel staples
Device
Lead sponsor
MemorialCare Health System
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
238 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
4
States / cities
Long Beach, California • Orange, California
Source: ClinicalTrials.gov public record
Updated Jan 9, 2024 · Synced Oct 23, 2026, 1:12 AM EDT
Terminated Not applicable Interventional Results available

The Use of Biologic Mesh vs Bioabsorbable Mesh During Ventral Hernia Repair in At-risk Patients

NCT01794338
View directory record Official record
Conditions
Ventral Hernia
Interventions
Strattice Arm, Bio-A Arm
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 15, 2022 · Synced Oct 23, 2026, 1:12 AM EDT
Completed Phase 4 Interventional Results available

PleuraSeal Post Market Study (Europe)

NCT00704171
View directory record Official record
Conditions
Lung Disease, Pulmonary Lobectomy
Interventions
Standard Tissue Closure Techniques, PleuraSeal Lung Sealant System
Procedure · Device
Lead sponsor
Integra LifeSciences Corporation
Industry
Eligibility
18 Years and older
Enrollment
121 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
1
States / cities
Bedford, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 27, 2016 · Synced Oct 23, 2026, 1:12 AM EDT
Withdrawn Not applicable Interventional

A Randomized Controlled Trial Comparing Sutures vs Staples for High Tension Closures

NCT06638736
View directory record Official record
Conditions
Surgery, Skin Cancer, Suture; Complications, Infection or Inflammation
Interventions
Wound Closure with sutures vs staples
Other
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Oct 15, 2024 · Synced Oct 23, 2026, 1:12 AM EDT
Completed Not applicable Interventional

Wound Closure Techniques in Primary Spine Surgery

NCT04396613
View directory record Official record
Conditions
Spinal Injuries
Interventions
Closure technique
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 17, 2026 · Synced Oct 23, 2026, 1:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Zip® Surgical Skin Closure Device vs. Staples for Skin Closure in Subjects Having Undergone Bilateral Knee Arthroplasty

NCT02460172
View directory record Official record
Conditions
Arthroplasty, Knee Replacement, Wound Healing
Interventions
Zip Surgical Skin Closure, Steel Staples
Device
Lead sponsor
ZipLine Medical Inc.
Industry
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 5, 2019 · Synced Oct 23, 2026, 1:12 AM EDT
Completed Not applicable Interventional Results available

Prospective Randomized Trial of Dermabond Prineo in Total Knee Arthroplasty

NCT03285542
View directory record Official record
Conditions
Wound Heal
Interventions
DERMABOND, Staples
Device
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 13, 2021 · Synced Oct 23, 2026, 1:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Perfusion Assessment of Wound Closure Techniques in Primary Total Knee Arthroplasty

NCT01924403
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Staple Closure, Vertical Mattress Closure, Running Subcuticular Closure
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 16, 2015 · Synced Oct 23, 2026, 1:12 AM EDT
Completed Not applicable Interventional Results available

Safety and Efficacy Study of BondEase to Treat Traumatic Lacerations and Surgical Incisions

NCT01716013
View directory record Official record
Conditions
Traumatic Lacerations or Surgical Incisions
Interventions
BondEase, CWCD
Device · Procedure
Lead sponsor
OptMed, Inc.
Industry
Eligibility
18 Years and older
Enrollment
162 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
6
States / cities
Orlando, Florida • Chicago, Illinois • Chevy Chase, Maryland + 3 more
Source: ClinicalTrials.gov public record
Updated Jan 9, 2017 · Synced Oct 23, 2026, 1:12 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Use of Insorb Absorbable Vicryl Staples in Skin Closure for Cesarean Section

NCT01446627
View directory record Official record
Conditions
Wound Infection
Interventions
There is no intervention for this study
Other
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
14 Years to 50 Years · Female only
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 3, 2013 · Synced Oct 23, 2026, 1:12 AM EDT
Terminated Not applicable Interventional Results available

Closure of Fasciotomy Wounds: A Prospective, Observational Study of a Continuous External Tissue Expander

NCT01171534
View directory record Official record
Conditions
Wounds and Injuries, Compartment Syndrome
Interventions
DermaClose fasciotomy closure, Vessel loop
Device
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 29, 2018 · Synced Oct 23, 2026, 1:12 AM EDT
Terminated Phase 3 Interventional

PleuraSeal Pivotal Study (US)

NCT00748124
View directory record Official record
Conditions
Open Thoracotomy
Interventions
PleuraSeal Sealant System, Standard Tissue Closure Techniques
Device · Procedure
Lead sponsor
Integra LifeSciences Corporation
Industry
Eligibility
18 Years and older
Enrollment
230 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Bedford, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 11, 2014 · Synced Oct 23, 2026, 1:12 AM EDT
Completed Not applicable Interventional

A Randomized Trial of Ostomy Closure Techniques

NCT01713452
View directory record Official record
Conditions
Wound Infection
Interventions
Purse string closure, Primary closure
Procedure
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 1, 2019 · Synced Oct 23, 2026, 1:12 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Post-Operative Cesarean Section Cosmesis

NCT06412978
View directory record Official record
Conditions
Cesarean Delivery
Interventions
absorbable subcuticular polyglycolic acid staples (INSORB), subcuticular, polyglecaprone suture (Monocryl)
Procedure
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 44 Years · Female only
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 16, 2026 · Synced Oct 23, 2026, 1:12 AM EDT
Completed Phase 4 Interventional Results available

Use of Negative Pressure Wound Therapy in High Risk Surgical Closed Incisions

NCT02137447
View directory record Official record
Conditions
High Risk Abdominal Wounds
Interventions
Negative Pressure treatment
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 95 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 18, 2017 · Synced Oct 23, 2026, 1:12 AM EDT
Active, not recruiting Not applicable Interventional

Suture Versus Staples for Wound Closure in Orthopaedic Trauma Surgery

NCT06586814
View directory record Official record
Conditions
Lower Extremity Fracture
Interventions
Suture, Staple
Other
Lead sponsor
University of Southern California
Other
Eligibility
18 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 27, 2026 · Synced Oct 23, 2026, 1:12 AM EDT